Research Output

2020

Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis

Knapp, S., Kehring, A., Stepp, J., Calton, C. M., Gephart, S. M., Bandlamuri, S., Boyle, K. E., Dietz, G. I., Johnson, H., Romo, R. E., Spencer, M., Bedrick, A. D. & Halpern, M. D., Dec 1 2020, In : Scientific reports. 10, 1, 249.

Research output: Contribution to journalArticle

Open Access

Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice with Dendritic Cell-Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction

Jamwal, D. R., Marati, R. V., Harrison, C. A., Midura-Kiela, M. T., Figliuolo Paz, V. R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jan 6 2020, In : Inflammatory bowel diseases. 26, 2, p. 229-241 13 p.

Research output: Contribution to journalArticle

2019

Bendamustine with Total Body Irradiation Limits Murine Graft-versus-Host Disease in Part Through Effects on Myeloid-Derived Suppressor Cells

Stokes, J., Hoffman, E. A., Molina, M. S., Eremija, J., Larmonier, N., Zeng, Y. & Katsanis, E., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. 405-416 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Beyond the tumour microenvironment

Laplane, L., Duluc, D., Bikfalvi, A., Larmonier, N. & Pradeu, T., Jan 1 2019, In : International Journal of Cancer.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Rapid downregulation of DAB2 by toll-like receptor activation contributes to a pro-inflammatory switch in activated dendritic cells

Paz, V. F., Jamwal, D. R., Gurney, M., Midura-Kiela, M., Harrison, C. A., Cox, C., Wilson, J. M., Ghishan, F. K. & Kiela, P. R., 2019, In : Frontiers in immunology. 10, FEB, 304.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Role of lymphatic deficiency in the pathogenesis and progression of inflammatory bowel disease to colorectal cancer in an experimental mouse model

Daley, S. K., Witte, M. H., Washington, J., Bernas, M., Kiela, P., Thorn, J., Tanoue, N. & Alexander, J. S., Dec 1 2019, In : Inflammatory bowel diseases. 25, 12, p. 1919-1926 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis

Harrison, C. A., Laubitz, D., Midura-Kiela, M. T., Jamwal, D. R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Journal of Crohn's & colitis. 13, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges

Jash, A., Zhou, Y. W., Gerardo, D. K., Ripperger, T. J., Parikh, B. A., Piersma, S., Jamwal, D. R., Kiela, P. R., Boon, A. C. M., Yokoyama, W. M., Hsieh, C. S. & Bhattacharya, D., Dec 1 2019, In : Scientific reports. 9, 1, 15257.

Research output: Contribution to journalArticle

Open Access
2018

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

Li, T., Li, Q., Wu, W., Li, Y., Hou, D. X., Xu, H., Zheng, B., Zeng, S., Shan, Y., Lu, X., Deng, F. & Qin, S., Nov 17 2018, In : Acta Biochimica et Biophysica Sinica. 51, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice

Harrison, C. A., Laubitz, D., Ohland, C. L., Midura-Kiela, M. T., Patil, K., Besselsen, D. G., Jamwal, D. R., Jobin, C., Ghishan, F. K. & Kiela, P. R., Sep 1 2018, In : Mucosal Immunology. 11, 5, p. 1329-1341 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Molecular Physiology of Gastrointestinal Function During Development

Xu, H. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 235-269 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Na+/H+ Exchange in Mammalian Digestive Tract

Kiela, P. R. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1273-1316 44 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Significance of NF-kappaB signaling and PARP1 activity in the TNF-induced inhibition of PHEX gene expression in human osteoblasts

Kędzierska, U., Banasiak, Ł., Kiela, P. & Majewski, P. M., Nov 15 2018, In : Acta biochimica Polonica. 65, 4, p. 573-571 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Multiple Layers of the Tumor Environment

Laplane, L., Duluc, D., Larmonier, N., Pradeu, T. & Bikfalvi, A., Dec 2018, In : Trends in Cancer. 4, 12, p. 802-809 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Transforming growth factor beta signaling in dendritic cells is required for immunotolerance to sperm in the epididymis

Pierucci-Alves, F., Midura-Kiela, M. T., Fleming, S. D., Schultz, B. D. & Kiela, P. R., Aug 16 2018, In : Frontiers in immunology. 9, AUG, 1882.

Research output: Contribution to journalArticle

8 Scopus citations

Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei, X., Cai, L., Li, X., Xu, H., Geng, C. & Wang, C., May 2018, In : Korean Journal of Physiology and Pharmacology. 22, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Immune checkpoint inhibitors and elderly people: A review

Daste, A., Domblides, C., Gross-goupil, M., Chakiba, C., Quivy, A., Cochin, V., de Mones, E., Larmonier, N., Soubeyran, P. & Ravaud, A., Sep 2017, In : European Journal of Cancer. 82, p. 155-166 12 p.

Research output: Contribution to journalReview article

64 Scopus citations

Pathophysiology of Intestinal Na+/H+ Exchange

Gurney, M. A., Laubitz, D., Ghishan, F. K. & Kiela, P. R., Jan 1 2017, In : CMGH. 3, 1, p. 27-40 14 p.

Research output: Contribution to journalReview article

20 Scopus citations

Phosphorus: Basic Nutritional Aspects

Kiela, P. R., Radhakrishnan, V. M. & Ghishan, F. K., Jan 1 2017, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., p. 413-427 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Vitamins and Minerals in Inflammatory Bowel Disease

Ghishan, F. K. & Kiela, P. R., 2017, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Expression of Cav1.3 calcium channel in the human and mouse colon: Posttranscriptional inhibition by IFNγ

Radhakrishnan, V. M., Gilpatrick, M. M., Parsa, N. A., Kiela, P. R. & Ghishan, F. K., Dec 8 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 1, p. G77-G84

Research output: Contribution to journalArticle

1 Scopus citations

Generation and expansion of T helper 17 lymphocytes ex vivo

Alizadeh, D. & Larmonier, N., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1371. p. 101-113 13 p. (Methods in Molecular Biology; vol. 1371).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
10 Scopus citations

Physiology of intestinal absorption and secretion

Kiela, P. R. & Ghishan, F. K., Apr 1 2016, In : Best Practice and Research: Clinical Gastroenterology. 30, 2, p. 145-159 15 p.

Research output: Contribution to journalArticle

118 Scopus citations

Post-transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation

Stokes, J., Hoffman, E. A., Zeng, Y., Larmonier, N. & Katsanis, E., Jul 1 2016, In : British Journal of Haematology. 174, 1, p. 102-116 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Reduced epithelial Na+/H+exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

Laubitz, D., Harrison, C. A., Midura-Kiela, M. T., Ramalingam, R., Larmonier, C. B., Chase, J. H., Caporaso, J. G., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Apr 2016, In : PloS one. 11, 4, e0152044.

Research output: Contribution to journalArticle

19 Scopus citations

Sodium: Basic Nutritional Aspects

Laubitz, D., Ghishan, F. K. & Kiela, P. R., Sep 29 2016, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., p. 489-501 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

16 Scopus citations

Transcriptional reprogramming and resistance to colonic mucosal injury in poly (ADP-ribose) polymerase 1 (PARP1) deficient mice

Larmonier, C. B., Shehab, K. W., Laubitz, D., Jamwal, D. R., Ghishan, F. K. & Kiela, P. R., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 8918-8930 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015
22 Scopus citations

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

15 Scopus citations

Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules

Radhakrishnan, V. M., Kojs, P., Ramalingam, R., Midura-Kiela, M. T., Angeli, P., Kiela, P. R. & Ghishan, F. K., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8964-8974 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Functional aortic stiffness: Role of CD4<sup>+</sup> T lymphocytes

Majeed, B. A., Eberson, L. S., Tawinwung, S., Larmonier, N., Secomb, T. W. & Larson, D. F., 2015, In : Frontiers in Physiology. 6, Aug, 235.

Research output: Contribution to journalArticle

Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: A pilot study

Wang, A., Ling, Z., Yang, Z., Kiela, P. R., Wang, T., Wang, C., Cao, L., Geng, F., Shen, M., Ran, X., Su, Y., Cheng, T. & Wang, J., May 1 2015, In : PloS one. 10, 5, 0126312.

Research output: Contribution to journalArticle

50 Scopus citations

Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes

Janikashvili, N., Trad, M., Gautheron, A., Samson, M., Lamarthée, B., Bonnefoy, F., Lemaire-Ewing, S., Ciudad, M., Rekhviashvili, K., Seaphanh, F., Gaugler, B., Perruche, S., Bateman, A., Martin, L., Audia, S., Saas, P., Larmonier, N. & Bonnotte, B., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1614-1624.e4

Research output: Contribution to journalArticle

6 Scopus citations

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

18 Scopus citations

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

11 Scopus citations
12 Scopus citations

The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention

Mcfadden, R. M. T., Larmonier, C. B., Shehab, K. W., Midura-Kiela, M., Ramalingam, R., Harrison, C. A., Besselsen, D. G., Chase, J. H., Caporaso, J. G., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jul 25 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

The role of intestinal epithelial barrier function in the development of NEC

Halpern, M. D. & Denning, P. W., 2015, In : Tissue Barriers. 3, 1

Research output: Contribution to journalReview article

61 Scopus citations

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

Larmonier, C. B., Shehab, K. W., Ghishan, F. K. & Kiela, P. R., 2015, In : BioMed research international. 2015, 504638.

Research output: Contribution to journalArticle

22 Scopus citations

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1

Trad, M., Gautheron, A., Fraszczak, J., Alizadeh, D., Larmonier, C., Lacasse, C. J., Centuori, S., Audia, S., Samson, M., Ciudad, M., Bonnefoy, F., Lemaire-Ewing, S., Katsanis, E., Perruche, S., Saas, P. & Bonnotte, B., 2015, In : BioMed research international. 2015, 891236.

Research output: Contribution to journalArticle

2 Scopus citations

T Lymphocyte Plasticity in Autoimmunity and Cancer

Janikashvili, N., Chikovani, T., Audia, S., Bonnotte, B. & Larmonier, N., 2015, In : BioMed research international. 2015, 540750.

Research output: Contribution to journalEditorial

1 Scopus citations
2014

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

336 Scopus citations

Chemotherapeutic targeting of cancer-induced immunosuppressive cells

Alizadeh, D. & Larmonier, N., May 15 2014, In : Cancer Research. 74, 10, p. 2663-2668 6 p.

Research output: Contribution to journalReview article

78 Scopus citations

Chemotherapeutic targeting of myeloid-derived suppressor cells

Alizadeh, D., Katsanis, E. & Larmonier, N., Jan 1 2014, In : OncoImmunology. 3, 1, e27338.

Research output: Contribution to journalArticle

10 Scopus citations

Discrimination of GutCheck NEC: A clinical risk index for necrotizing enterocolitis

Gephart, S. M., Spitzer, A. R., Effken, J. A., Dodd, E., Halpern, M. & McGrath, J. M., Jun 2014, In : Journal of Perinatology. 34, 6, p. 468-475 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer

Alizadeh, D., Trad, M., Hanke, N. T., Larmonier, C. B., Janikashvili, N., Bonnotte, B., Katsanis, E. & Larmonier, N., Jan 1 2014, In : Cancer Research. 74, 1, p. 104-118 15 p.

Research output: Contribution to journalArticle

163 Scopus citations