Research Output 1990 2019

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2019
1 Citation (Scopus)

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Protein Isoforms
Neoplasms
Catenins
2 Citations (Scopus)

Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells

Figliuolo da Paz, V., Jamwal, D. R., Gurney, M., Midura-Kiela, M., Harrison, C. A., Cox, C., Wilson, J. M., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 2
Dendritic Cells
Down-Regulation
Phenotype
Colitis

Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model

Daley, S. K., Witte, M. H., Washington, J., Bernas, M., Kiela, P., Thorn, J., Tanoue, N. & Alexander, J. S., Nov 14 2019, In : Inflammatory bowel diseases. 25, 12, p. 1919-1926 8 p.

Research output: Contribution to journalArticle

Angiopoietin-2
Inflammatory Bowel Diseases
Colorectal Neoplasms
Theoretical Models
Knockout Mice

Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis

Harrison, C. A., Laubitz, D., Midura-Kiela, M. T., Jamwal, D. R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Journal of Crohn's & colitis. 13, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Colitis
Sex Characteristics
Anti-Bacterial Agents
T-Lymphocytes
Adoptive Transfer

ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges

Jash, A., Zhou, Y. W., Gerardo, D. K., Ripperger, T. J., Parikh, B. A., Piersma, S., Jamwal, D. R., Kiela, P. R., Boon, A. C. M., Yokoyama, W. M., Hsieh, C. S. & Bhattacharya, D., Dec 1 2019, In : Scientific reports. 9, 1, 15257.

Research output: Contribution to journalArticle

Open Access
Muromegalovirus
Cytomegalovirus Infections
Antibody Formation
B-Lymphocytes
Infection
2018
1 Citation (Scopus)

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

Li, T., Li, Q., Wu, W., Li, Y., Hou, D. X., Xu, H., Zheng, B., Zeng, S., Shan, Y., Lu, X., Deng, F. & Qin, S., Nov 17 2018, In : Acta Biochimica et Biophysica Sinica. 51, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Antioxidant Response Elements
Seed
Seeds
Skin

Significance of NF-kappaB signaling and PARP1 activity in the TNF-induced inhibition of PHEX gene expression in human osteoblasts

Kędzierska, U., Banasiak, Ł., Kiela, P. R. & Majewski, P. M., Nov 15 2018, In : Acta Biochimica Polonica. 65, 4, p. 573-571 3 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
NF-kappa B
Osteoblasts
Gene expression
Genes
1 Citation (Scopus)

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 1 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Electrolytes
Genes
Gastrointestinal Tract
Antiporters
5 Citations (Scopus)

Transforming growth factor beta signaling in dendritic cells is required for immunotolerance to sperm in the epididymis

Pierucci-Alves, F., Midura-Kiela, M. T., Fleming, S. D., Schultz, B. D. & Kiela, P. R., Aug 16 2018, In : Frontiers in Immunology. 9, AUG, 1882.

Research output: Contribution to journalArticle

Epididymis
Transforming Growth Factor beta
Dendritic Cells
Spermatozoa
Blood-Testis Barrier

Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei, X., Cai, L., Li, X., Xu, H., Geng, C. & Wang, C., May 1 2018, In : Korean Journal of Physiology and Pharmacology. 22, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Somatostatin
Diarrhea
Protein Isoforms
2017
9 Citations (Scopus)

Vitamins and Minerals in Inflammatory Bowel Disease

Ghishan, F. K. & Kiela, P. R., 2017, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Vitamins
Minerals
Avitaminosis
Vitamin A
2016
1 Citation (Scopus)

Expression of Cav1.3 calcium channel in the human and mouse colon: Posttranscriptional inhibition by IFNγ

Radhakrishnan, V. M., Gilpatrick, M. M., Parsa, N. A., Kiela, P. R. & Ghishan, F. K., Dec 8 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 1, p. G77-G84

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colon
Colitis
Trinitrobenzenes
HCT116 Cells
8 Citations (Scopus)
Goblet Cells
HT29 Cells
Enterocytes
Mucins
Mucus
62 Citations (Scopus)

Physiology of intestinal absorption and secretion

Kiela, P. R. & Ghishan, F. K., Apr 1 2016, In : Best Practice and Research: Clinical Gastroenterology. 30, 2, p. 145-159 15 p.

Research output: Contribution to journalArticle

Intestinal Secretions
Intestinal Absorption
Food
Lipids
Oxalates
6 Citations (Scopus)

Post-transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation

Stokes, J., Hoffman, E. A., Zeng, Y. ., Larmonier, N. & Katsanis, E., Jul 1 2016, In : British Journal of Haematology. 174, 1, p. 102-116 15 p.

Research output: Contribution to journalArticle

Experimental Leukemias
Graft vs Host Disease
Bone Marrow Transplantation
Transplants
Cyclophosphamide
15 Citations (Scopus)

Reduced epithelial Na+/H+exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

Laubitz, D., Harrison, C. A., Midura-Kiela, M. T., Ramalingam, R., Larmonier, C. B., Chase, J. H., Caporaso, J. G., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Apr 1 2016, In : PLoS One. 11, 4, e0152044.

Research output: Contribution to journalArticle

Dysbiosis
T-cells
colitis
Colitis
intestinal microorganisms
16 Citations (Scopus)

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colitis
Somatostatin
Octreotide
seglitide
7 Citations (Scopus)

Transcriptional reprogramming and resistance to colonic mucosal injury in poly (ADP-ribose) polymerase 1 (PARP1) deficient mice

Larmonier, C. B., Shehab, K. W., Laubitz, D., Jamwal, D. R., Ghishan, F. K. & Kiela, P. R., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 8918-8930 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Colitis
Wounds and Injuries
Adenosine Diphosphate Ribose
Dextran Sulfate
2015
16 Citations (Scopus)
Cardiopulmonary Bypass
Fatty Acid-Binding Proteins
Heart Diseases
Citrulline
Claudin-3
14 Citations (Scopus)

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

Leydig Cells
Testis
LH Receptors
Testosterone
Sodium-Hydrogen Antiporter
4 Citations (Scopus)

Experimental colitis is associated with transcriptional inhibition of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules

Radhakrishnan, V. M., Kojs, P., Ramalingam, R., Midura-Kiela, M. T., Angeli, P., Kiela, P. R. & Ghishan, F. K., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8964-8974 11 p.

Research output: Contribution to journalArticle

Distal Kidney Tubule
Colitis
Interferons
Minerals
Protein Isoforms

Functional aortic stiffness: Role of CD4<sup>+</sup> T lymphocytes

Majeed, B. A., Eberson, L. S., Tawinwung, S., Larmonier, N., Secomb, T. W. & Larson, D. F., 2015, In : Frontiers in Physiology. 6, Aug, 235.

Research output: Contribution to journalArticle

Vascular Stiffness
Angiotensin II
T-Lymphocytes
Pulse Wave Analysis
Blood Vessels
35 Citations (Scopus)

Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: A pilot study

Wang, A., Ling, Z., Yang, Z., Kiela, P. R., Wang, T., Wang, C., Cao, L., Geng, F., Shen, M., Ran, X., Su, Y., Cheng, T. & Wang, J., May 1 2015, In : PLoS One. 10, 5, 0126312.

Research output: Contribution to journalArticle

Dysbiosis
Pelvic Neoplasms
Radiotherapy
radiotherapy
intestinal microorganisms
5 Citations (Scopus)

Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes

Janikashvili, N., Trad, M., Gautheron, A., Samson, M., Lamarthée, B., Bonnefoy, F., Lemaire-Ewing, S., Ciudad, M., Rekhviashvili, K., Seaphanh, F., Gaugler, B., Perruche, S., Bateman, A., Martin, L., Audia, S., Saas, P., Larmonier, N. & Bonnotte, B., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1614-1624 11 p.

Research output: Contribution to journalArticle

CD8-Positive T-Lymphocytes
Forkhead Transcription Factors
Graft vs Host Disease
Monocytes
Regulatory T-Lymphocytes
14 Citations (Scopus)
Regulatory T-Lymphocytes
Antigen-Antibody Complex
Angiotensin II
Interleukin-2
Vascular Stiffness
12 Citations (Scopus)

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

Dextran Sulfate
Goblet Cells
Paneth Cells
Colon
Intestinal Mucosa
10 Citations (Scopus)

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

Lacrimal Apparatus
Epithelial Cells
Conjunctiva
Tears
Cornea
11 Citations (Scopus)
Butyric Acid
Butyrates
Sodium
Genetic Promoter Regions
Epithelial Cells
44 Citations (Scopus)

The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention

Mcfadden, R. M. T., Larmonier, C. B., Shehab, K. W., Midura-Kiela, M., Ramalingam, R., Harrison, C. A., Besselsen, D. G., Chase, J. H., Caporaso, J. G., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jul 25 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

Curcumin
Microbiota
Colitis
Colonic Neoplasms
Interleukin-10
20 Citations (Scopus)

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

Larmonier, C. B., Shehab, K. W., Ghishan, F. K. & Kiela, P. R., 2015, In : BioMed Research International. 2015, 504638.

Research output: Contribution to journalArticle

T-cells
Microbiota
Inflammatory Bowel Diseases
T-Lymphocytes
Immune system
2 Citations (Scopus)

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1

Trad, M., Gautheron, A., Fraszczak, J., Alizadeh, D., Larmonier, C. B., Lacasse, C. J., Centuori, S., Audia, S., Samson, M., Ciudad, M., Bonnefoy, F., Lemaire-Ewing, S., Katsanis, E., Perruche, S., Saas, P. & Bonnotte, B., 2015, In : BioMed Research International. 2015, 891236.

Research output: Contribution to journalArticle

Arginase
T-cells
Dendritic Cells
Tumors
T-Lymphocytes
2014
292 Citations (Scopus)

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

Colitis
Mucus
Ulcerative Colitis
Colon
Bacteria
69 Citations (Scopus)

Chemotherapeutic targeting of cancer-induced immunosuppressive cells

Alizadeh, D. & Larmonier, N., May 15 2014, In : Cancer Research. 74, 10, p. 2663-2668 6 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Neoplasms
Tumor Escape
Tumor Microenvironment
Cytostatic Agents
7 Citations (Scopus)

Chemotherapeutic targeting of myeloid-derived suppressor cells

Alizadeh, D., Katsanis, E. & Larmonier, N., 2014, In : OncoImmunology. 3, 1, e27338.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Doxorubicin
Neoplasms
Myeloid-Derived Suppressor Cells
Therapeutics
33 Citations (Scopus)

Discrimination of GutCheck NEC: A clinical risk index for necrotizing enterocolitis

Gephart, S. M., Spitzer, A. R., Effken, J. A., Dodd, E., Halpern, M. D. & McGrath, J. M., 2014, In : Journal of perinatology : official journal of the California Perinatal Association. 34, 6, p. 468-475 8 p.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Calibration
Area Under Curve
Confidence Intervals
Logistic Models
138 Citations (Scopus)

Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer

Alizadeh, D., Trad, M., Hanke, N. T., Larmonier, C. B., Janikashvili, N., Bonnotte, B., Katsanis, E. & Larmonier, N., Jan 1 2014, In : Cancer Research. 74, 1, p. 104-118 15 p.

Research output: Contribution to journalArticle

Adoptive Transfer
Doxorubicin
Breast Neoplasms
T-Lymphocytes
Neoplasms
32 Citations (Scopus)

Epithelial transport in inflammatory bowel diseases

Ghishan, F. K. & Kiela, P. R., 2014, In : Inflammatory Bowel Diseases. 20, 6, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Food
Epithelium
Bacterial Antigens
Micronutrients
2 Citations (Scopus)

PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15

Hanke, N. T., Lacasse, C. J., Larmonier, C. B., Alizadeh, D., Trad, M., Janikashvili, N., Bonnotte, B., Katsanis, E. & Larmonier, N., 2014, In : European Journal of Immunology. 44, 8, p. 2489-2499 11 p.

Research output: Contribution to journalArticle

Interleukin-15
Dendritic Cells
Interferons
Interleukin-4
Cancer Vaccines
20 Citations (Scopus)

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)

Radhakrishnan, V. M., Kojs, P., Young, G., Ramalingam, R., Jagadish, B., Mash, E. A., Martinez, J. D., Ghishan, F. K. & Kiela, P. R., Jan 22 2014, In : PLoS One. 9, 1, e85796.

Research output: Contribution to journalArticle

Cortactin
Non-Receptor Type 1 Protein Tyrosine Phosphatase
protein-tyrosine-phosphatase
Curcumin
curcumin
22 Citations (Scopus)

Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis

Weitkamp, J. H., Rosen, M. J., Zhao, Z., Koyama, T., Geem, D., Denning, T. L., Rock, M. T., Moore, D. J., Halpern, M. D., Matta, P. & Denning, P. W., Jun 6 2014, In : PLoS One. 9, 6, e99042.

Research output: Contribution to journalArticle

enterocolitis
Necrotizing Enterocolitis
T-cells
Lymphocytes
T-Cell Antigen Receptor
21 Citations (Scopus)

Somatostatin regulates tight junction proteins expression in colitis mice

Li, X. X., Wang, Q., Xu, H., Tao, L., Lu, J., Cai, L. & Wang, C., 2014, In : International Journal of Clinical and Experimental Pathology. 7, 5, p. 2153-2162 10 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Claudin-3
Colitis
Somatostatin
Citrobacter rodentium
2013
27 Citations (Scopus)

Dendritic cell tumor killing activity and its potential applications in cancer immunotherapy

Hanke, N., Alizadeh, D., Katsanis, E. & Larmonier, N., 2013, In : Critical Reviews in Immunology. 33, 1, p. 1-21 21 p.

Research output: Contribution to journalArticle

Immunotherapy
Dendritic Cells
Neoplasms
T-Lymphocytes
Natural Killer T-Cells
9 Citations (Scopus)

High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

Larmonier, C. B., McFadden, R. M. T., Hill, F. M., Schreiner, R., Ramalingam, R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jul 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 1

Research output: Contribution to journalArticle

Adoptive Transfer
Cholecalciferol
Colitis
Diet
T-Lymphocytes
23 Citations (Scopus)

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1

Research output: Contribution to journalArticle

Bacterial Adhesion
Knockout Mice
Dextran Sulfate
Colon
Salmonella typhimurium
16 Citations (Scopus)

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3

Research output: Contribution to journalArticle

Stomach
Adenoma
Stomach Ulcer
Sodium-Hydrogen Antiporter
Sodium Bicarbonate
19 Citations (Scopus)

Post-translational loss of renal trpv5 calcium channel expression, Ca 2+ wasting, and bone loss in experimental colitis

Radhakrishnan, V. M., Ramalingam, R., Larmonier, C. B., Thurston, R. D., Laubitz, D., Midura-Kiela, M. T., McFadden, R. M. T., Kuro-O, M., Kiela, P. R. & Ghishan, F. K., Sep 2013, In : Gastroenterology. 145, 3, p. 613-624 12 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Colitis
Calcium Channels
Kidney
Bone and Bones
29 Citations (Scopus)

Preferential splenic CD8(+) T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia.

Audia, S., Samson, M., Mahévas, M., Ferrand, C., Trad, M., Ciudad, M., Gautheron, A., Seaphanh, F., Leguy, V., Berthier, S., Salles, B., Martin, L., Lorcerie, B., Ortega-Deballon, P., Facy, O., Caillot, D., Soudry-Faure, A., Michel, M., Godeau, B., Larmonier, N. & 3 others, Saas, P., Janikashvili, N. & Bonnotte, B., Oct 3 2013, In : Blood. 122, 14, p. 2477-2486 10 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
T-cells
Chemical activation
T-Lymphocytes
Spleen
41 Citations (Scopus)

Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice

Larmonier, C. B., Laubitz, D., Hill, F. M., Shehab, K. W., Lipinski, L., Midura-Kiela, M. T., McFadden, R. M. T., Ramalingam, R., Hassan, K. A., Golebiewski, M., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Nov 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 10

Research output: Contribution to journalArticle

Colitis
Microbiota
Dysbiosis
Inflammation
Dextran Sulfate
4 Citations (Scopus)

SPECT imaging of inflammatory response in ischemic-reperfused rat hearts using a 99mTc-labeled dual-domain cytokine ligand

Liu, Z., Barber, C., Wan, L., Liu, S., Hui, M. M., Furenlid, L. R., Xu, H. & Woolfenden, J. M., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Interleukin 1 Receptor Antagonist Protein
Single-Photon Emission-Computed Tomography
Cytokines
Ligands
15 Citations (Scopus)

The hepatic bile acid transporters ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis

Cherrington, N. J., Estrada, T. E., Frisk, H. A., Canet, M. J., Hardwick, R. N., Dvorak, B., Lux, K. & Halpern, M. D., Jan 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 1

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Down-Regulation
Liver
Interleukin-18
Tumor Necrosis Factor-alpha