Research Output

2016

Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?

Doyle, K. & Buckwalter, M. S., May 24 2016, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

15 Scopus citations

Domain-swapped t cell receptors improve the safety of TCR gene therapy

Bethune, M. T., Gee, M. H., Bunse, M., Lee, M. S., Gschweng, E. H., Pagadala, M. S., Zhou, J., Cheng, D., Heath, J. R., Kohn, D. B., Kuhns, M. S., Uckert, W. & Baltimore, D., Nov 8 2016, In : eLife. 5, NOVEMBER2016, e19095.

Research output: Contribution to journalArticle

20 Scopus citations

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J. F., Vickers, I., Anzinger, J. J. & Nikolich-Žugich, J., Oct 2016, In : PLoS pathogens. 12, 10, e1005891.

Research output: Contribution to journalArticle

14 Scopus citations

Erratum: A transmembrane domain GGxxG motif in CD4 contributes to its lck-independent function but does not mediate CD4 Lmerization (PLoS ONE (2015) 10:7 (e0132333) DOI: 10.1371/journal.pone.0132333)

Parrish, H. L., Glassman, C. R., Keenen, M. M., Deshpande, N. R., Bronnimann, M. P. & Kuhns, M. S., Mar 1 2016, In : PLoS One. 11, 3, e0150876.

Research output: Contribution to journalArticle

1 Scopus citations

Functional evidence for TCR-intrinsic specificity for MHCII

Parrish, H. L., Deshpande, N. R., Vasic, J. & Kuhns, M. S., Mar 15 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 11, p. 3000-3005 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells

Teng, F., Klinger, C. N., Felix, K. M., Bradley, C. P., Wu, E., Tran, N. L., Umesaki, Y. & Wu, H-J. J., Apr 19 2016, In : Immunity. 44, 4, p. 875-888 14 p.

Research output: Contribution to journalArticle

94 Scopus citations

Host–Microbiota interplay in mediating immune disorders

Felix, K. M., Tahsin, S. & Wu, H-J. J., Jan 1 2016, In : Annals of the New York Academy of Sciences. 1417, 1, p. 57-70 14 p.

Research output: Contribution to journalReview article

11 Scopus citations

Human Cytomegalovirus Latency: Approaching the Gordian Knot

Goodrum, F., Sep 29 2016, In : Annual Review of Virology. 3, p. 333-357 25 p.

Research output: Contribution to journalReview article

47 Scopus citations

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Pulko, V., Davies, J. S., Martinez, C., Lanteri, M. C., Busch, M. P., Diamond, M. S., Knox, K., Bush, E. C., Sims, P. A., Sinari, S., Billheimer, D., Haddad, E. K., Murray, K. O., Wertheimer, A. M. & Nikolich-Žugich, J., Jul 19 2016, In : Nature immunology. 17, 8, p. 966-975 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H-J. J., Kasper, D. L., Benoist, C. & Mathis, D., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8141-E8150

Research output: Contribution to journalArticle

117 Scopus citations

Isolation and characterization of Neisseria musculi sp. nov., from the wild house mouse

Weyand, N. J., Ma, M., Phifer-Rixey, M., Taku, N. A., Rendón, M. A., Hockenberry, A. M., Kim, W. J., Agellon, A. B., Biais, N., Suzuki, T. A., Goodyer-Sait, L., Harrison, O. B., Bratcher, H. B., Nachman, M. W., Maiden, M. C. J. & So, M. M., Sep 1 2016, In : International Journal of Systematic and Evolutionary Microbiology. 66, 9, p. 3585-3593 9 p., 001237.

Research output: Contribution to journalArticle

12 Scopus citations

Long and short isoforms of the human cytomegalovirus UL138 protein silence IE transcription and promote latency

Lee, S. H., Caviness, K., Albright, E. R., Lee, J. H., Gelbmann, C. B., Rak, M., Goodrum, F. & Kalejta, R. F., Jan 1 2016, In : Journal of virology. 90, 20, p. 9483-9494 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue

Nguyen, T. V. V., Frye, J. B., Zbesko, J. C., Stepanovic, K., Hayes, M., Urzua, A., Serrano, G., Beach, T. G. & Doyle, K. P., Sep 6 2016, In : Acta neuropathologica communications. 4, 1, 1 p.

Research output: Contribution to journalArticle

16 Scopus citations

Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication

Buehler, J., Zeltzer, S., Reitsma, J., Petrucelli, A., Umashankar, M., Rak, M., Zagallo, P., Schroeder, J., Terhune, S. & Goodrum, F., May 2016, In : PLoS pathogens. 12, 5, e1005655.

Research output: Contribution to journalArticle

30 Scopus citations

PhiXing-it, displaying foreign peptides on bacteriophage ΦX174

Christakos, K. J., Chapman, J. A., Fane, B. A. & Campos, S. K., Jan 15 2016, In : Virology. 488, p. 242-248 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Preparing for an aging world: Engaging biogerontologists, geriatricians, and the society

Nikolich-Žugich, J., Goldman, D. P., Cohen, P. R., Cortese, D., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T., Perry, D., Richardson, A., Ritchie, C., Wertheimer, A. M., Faragher, R. G. A. & Fain, M. J., Apr 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 4, p. 435-444 10 p.

Research output: Contribution to journalReview article

18 Scopus citations

The CD4 and CD3 cytosolic juxtamembrane regions are proximal within a compact TCR-CD3-pMHC-CD4 macrocomplex

Glassman, C. R., Parrish, H. L., Deshpande, N. R. & Kuhns, M. S., Jun 1 2016, In : Journal of Immunology. 196, 11, p. 4713-4722 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia

Doyle, K., Feb 1 2016, In : Future Neurology. 11, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

2015

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

Lee, M. S., Glassman, C. R., Deshpande, N. R., Badgandi, H. B., Parrish, H. L., Uttamapinant, C., Stawski, P. S., Ting, A. Y. & Kuhns, M. S., Aug 18 2015, In : Immunity. 43, 2, p. 227-239 13 p., 3145.

Research output: Contribution to journalArticle

46 Scopus citations

A transmembrane domain GGxxG Motif in CD4 contributes to its lck-independent function but does not mediate CD4 dimerization

Parrish, H. L., Glassman, C. R., Keenen, M. M., Deshpande, N. R., Bronnimann, M. P. & Kuhns, M. S., Jul 6 2015, In : PLoS One. 10, 7, e0132333.

Research output: Contribution to journalArticle

5 Scopus citations

Big Data, Big Opportunities, and Big Challenges

Frelinger, J. A., Nov 1 2015, In : Journal of Investigative Dermatology Symposium Proceedings. 17, 2, p. 33-35 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

B-lymphocyte-mediated delayed cognitive impairment following stroke

Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T. V. V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., Schneider, J. A., Malenka, R. C. & Buckwalter, M. S., Jan 1 2015, In : Journal of Neuroscience. 35, 5, p. 2133-2145 13 p.

Research output: Contribution to journalArticle

102 Scopus citations

Depletion of alveolar macrophages in cd11c diphtheria toxin receptor mice produces an inflammatory response

Roberts, L. M., Ledvina, H. E., Tuladhar, S., Rana, D., Steele, S. P., Sempowski, G. D. & Frelinger, J. A., Jan 1 2015, In : Immunity Inflammation and Disease. 3, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants

Powell, D. A., Roberts, L. M., Ledvina, H. E., Sempowski, G. D., Curtiss, R. & Frelinger, J. A., Sep 1 2015, (Accepted/In press) In : Cellular Immunology.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., Park, B. S., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Nov 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of mild heat stress on the proliferative and differentiative ability of human mesenchymal stromal cells

Choudhery, M. S., Badowski, M., Muise, A. & Harris, D. T., Apr 1 2015, In : Cytotherapy. 17, 4, p. 359-368 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice

Doyle, K. P., Quach, L. N., Arceuil, H. E. D. & Buckwalter, M. S., Jan 1 2015, In : Neuroscience Letters. 584, p. 236-240 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata

Kranz, D., Ellison, A., Frelinger, J. A., Mackay-Wiggan, J. & Norris, D. A., Nov 1 2015, In : Journal of Investigative Dermatology Symposium Proceedings. 17, 2, p. 1-5 5 p.

Research output: Contribution to journalArticle

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., Hiscott, J. B., Diamond, M. S., Wertheimer, A. M., Nikolich-Zugich, J. & Haddad, E. K., Jun 1 2015, In : Aging Cell. 14, 3, p. 421-432 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

Human cytomegalovirus UL135 and UL136 genes are required for postentry tropism in endothelial cells

Bughio, F., Umashankar, M., Wilson, J. & Goodrum, F., Jan 1 2015, In : Journal of virology. 89, 13, p. 6536-6550 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Marandu, T. F., Oduro, J. D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J. L., Drabig, A., Kröger, A., Nikolich-Zugich, J. & Cicin-Sain, L., 2015, In : Journal of Virology. 89, 22, p. 11715-11717 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

IWAS - A novel approach to analyzing Next Generation Sequence data for immunology

Vincent, B., Buntzman, A., Hopson, B., McEwen, C., Cowell, L., Akoglu, A., Zhang, H. & Frelinger, J., Oct 1 2015, (Accepted/In press) In : Cellular Immunology.

Research output: Contribution to journalArticle

5 Scopus citations

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

Goldberg, E. L., Romero-Aleshire, M. J., Renkema, K. R., Ventevogel, M. S., Chew, W. M., Uhrlaub, J. L., Smithey, M. J., Limesand, K. H., Sempowski, G. D., Brooks, H. L. & Nikolich-Žugich, J., Feb 1 2015, In : Aging Cell. 14, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Lost in translation: mice, men and cutaneous immunity in old age

Smithey, M. J., Uhrlaub, J. L., Li, G., Vukmanovic-Stejic, M., Akbar, A. N. & Nikolich-Zugich, J., 2015, In : Biogerontology. 16, 2, p. 203-208 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peptide/MHC tetramer-based sorting of CD8 T cells to a Leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire

Hunsucker, S. A., McGary, C. S., Vincent, B. G., Enyenihi, A. A., Waugh, J. P., McKinnon, K. P., Bixby, L. M., Ropp, P. A., Coghill, J. M., Wood, W. A., Gabriel, D. A., Sarantopoulos, S., Shea, T. C., Serody, J. S., Alatrash, G., Rodriguez-Cruz, T., Lizee, G., Buntzman, A. S., Frelinger, J. A., Glish, G. L. & 1 others, Armistead, P. M., Mar 2015, In : Cancer Immunology Research. 3, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Self-recognition drives the preferential accumulation of promiscuous CD4+ t-cells in aged mice

Deshpande, N. R., Parrish, H. L. & Kuhns, M. S., Jun 14 2015, In : eLife. 4, JULY 2015, p. 1-12 12 p., e05949.

Research output: Contribution to journalArticle

12 Scopus citations

Subcutaneous adipose tissue-derived stem cell utility is independent of anatomical harvest site

Choudhery, M. S., Badowski, M., Muise, A., Pierce, J. & Harris, D. T., Jan 1 2015, In : BioResearch Open Access. 4, 1, p. 131-145 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Systemic human CD34<sup>+</sup> cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration

Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T. & Madhavan, L., Aug 1 2015, In : Regenerative Medicine. 10, 5, p. 563-577 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Viral infection at the endothelium

Goodrum, F. & Bughio, F., Jan 1 2015, In : Oncotarget. 6, 29, p. 26541-26542 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2014

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

Heger, K., Fierens, K., Vahl, J. C., Aszodi, A., Peschke, K., Schenten, D., Hammad, H., Beyaert, R., Saur, D., van Loo, G., Roers, A., Lambrecht, B. N., Kool, M. & Schmidt-Supprian, M., Jan 1 2014, In : PLoS biology. 12, 1, e1001762.

Research output: Contribution to journalArticle

42 Scopus citations

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Zugich, D., Kaye, J. & Nikolich-Zugich, J., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2143-2155 13 p.

Research output: Contribution to journalArticle

124 Scopus citations

Aging of the T cell compartment in mice and humans: From no naive expectations to foggy memories

Nikolich-Žugich, J., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 2622-2629 8 p.

Research output: Contribution to journalReview article

103 Scopus citations

Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi

Bashyal, B. P., Wellensiek, B. P., Ramakrishnan, R., Faeth, S. H., Ahmad, N. & Gunatilaka, A. A. L., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 6112-6116 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle

Li, G., Rak, M., Nguyen, C. C., Umashankar, M., Goodrum, F. D. & Kamil, J. P., Jun 2014, In : Journal of virology. 88, 11, p. 6047-6060 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection

Umashankar, M., Rak, M., Bughio, F., Zagallo, P., Caviness, K. & Goodrum, F. D., Jun 2014, In : Journal of virology. 88, 11, p. 5987-6002 16 p.

Research output: Contribution to journalArticle

25 Scopus citations

Collection, processing, and banking of umbilical cord blood

Harris, D. T., Apr 1 2014, Perinatal Stem Cells. Springer New York, p. 261-267 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

Kusne, Y., Goldberg, E. L., Parker, S. S., Hapak, S. M., Maskaykina, I. Y., Chew, W. M., Limesand, K. H., Brooks, H. L., Price, T. J., Sanai, N., Nikolich-Zugich, J. & Ghosh, S., Feb 2014, In : Age. 36, 1, p. 199-212 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cryopreservation can be used as an anti-aging strategy

Choudhery, M. S. & Harris, D. T., Dec 1 2014, In : Cytotherapy. 16, 12, p. 1771-1773 3 p.

Research output: Contribution to journalLetter

5 Scopus citations

Cryopreservation of whole adipose tissue for future use in regenerative medicine

Choudhery, M. S., Badowski, M., Muise, A., Pierce, J. & Harris, D. T., Mar 1 2014, In : Journal of Surgical Research. 187, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation

Choudhery, M. S., Badowski, M., Muise, A., Pierce, J. & Harris, D. T., Jan 7 2014, In : Journal of Translational Medicine. 12, 1, 8.

Research output: Contribution to journalArticle

210 Scopus citations