Research Output

2012

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F. & Nikolich-Zugich, J., Aug 1 2012, In : PLoS pathogens. 8, 8, e1002849.

Research output: Contribution to journalArticle

72 Scopus citations

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K. P., Taravosh-Lahn, K., Cekanaviciute, E., Han, A., Goodman, J. Z., Jones, B., Jing, D., Massa, S. M., Longo, F. M. & Buckwalter, M. S., Jul 1 2012, In : Stroke. 43, 7, p. 1918-1924 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Human cytomegalovirus persistence

Goodrum, F., Caviness, K. & Zagallo, P., May 1 2012, In : Cellular Microbiology. 14, 5, p. 644-655 12 p.

Research output: Contribution to journalShort survey

68 Scopus citations

Human Papillomavirus L2 Facilitates Viral Escape from Late Endosomes via Sorting Nexin 17

Bergant Marušič, M., Ozbun, M. A., Campos, S. K., Myers, M. P. & Banks, L., Mar 1 2012, In : Traffic. 13, 3, p. 455-467 13 p.

Research output: Contribution to journalArticle

77 Scopus citations

IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis

Cataisson, C., Salcedo, R., Hakim, S., Moffitt B. Andrea, A., Wright, L., Yi, M., Stephens, R., Dai, R. M., Lyakh, L., Schenten, D., Yuspa, H. S. & Trinchieri, G., Aug 1 2012, In : Journal of Experimental Medicine. 209, 9, p. 1689-1702 14 p.

Research output: Contribution to journalArticle

72 Scopus citations

Induction of the cellular microRNA, Hs_154, by west nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

Smith, J. L., Grey, F. E., Uhrlaub, J. L., Nikolich-Zugich, J. & Hirsch, A. J., May 1 2012, In : Journal of virology. 86, 9, p. 5278-5287 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Interactions between proteins encoded within the human cytomegalovirus UL133-UL138 locus

Petrucelli, A., Umashankar, M., Zagallo, P., Rak, M. & Goodrum, F., Aug 1 2012, In : Journal of virology. 86, 16, p. 8653-8662 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Is volume the only factor that impacts cord blood processing efficiency?

Harris, D. T., Sep 2012, In : Cytotherapy. 14, 8, p. 1022-1023 2 p.

Research output: Contribution to journalLetter

Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration

Haley, K., Igyártó, B. Z., Ortner, D., Bobr, A., Kashem, S., Schenten, D. & Kaplan, D. H., May 1 2012, In : Journal of Immunology. 188, 9, p. 4334-4339 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life

Smithey, M. J., Li, G., Venturi, V., Davenport, M. P. & Nikolich-Žugich, J., Dec 1 2012, In : Journal of Immunology. 189, 11, p. 5356-5366 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Molecular mechanisms of HIV-1 infection in neonatal target cells

Ahmad, N., May 1 2012, In : Future Virology. 7, 5, p. 489-503 15 p.

Research output: Contribution to journalReview article

No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection

Frietze, K. M., Campos, S. K. & Kajon, A. E., Aug 14 2012, In : BMC research notes. 5, 429.

Research output: Contribution to journalArticle

1 Scopus citations

Opposing effects of bacitracin on human papillomavirus type 16 infection: Enhancement of binding and entry and inhibition of endosomal penetration

Campos, S. K., Chapman, J. A., Deymier, M. J., Bronnimann, M. P. & Ozbune, M. A., Apr 1 2012, In : Journal of virology. 86, 8, p. 4169-4181 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Optimizing cord blood sample cryopreservation

Harris, D. T., Mar 2012, In : Cytotherapy. 14, 3, p. 359-365 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Piecing together the family portrait of TCR-CD3 complexes

Kuhns, M. S. & Badgandi, H. B., Nov 1 2012, In : Immunological Reviews. 250, 1, p. 120-143 24 p.

Research output: Contribution to journalArticle

36 Scopus citations

Plexin-B2 and Plexin-D1 in dendritic cells: Expression and IL-12/IL-23p40 production

Holl, E. K., Roney, K. E., Allen, I. C., Steinbach, E., Arthur, J. C., Buntzman, A., Plevy, S., Frelinger, J. & Ting, J. P. Y., Aug 15 2012, In : PloS one. 7, 8, e43333.

Research output: Contribution to journalArticle

24 Scopus citations

TCR signaling emerges from the sum of many parts

Kuhns, M. S. & Davis, M. M., Dec 1 2012, In : Frontiers in immunology. 3, JUN, Article 159.

Research output: Contribution to journalReview article

42 Scopus citations

Techniques to measure pilus retraction forces

Biais, N., Higashi, D., So, M. & Ladoux, B., Jan 1 2012, Neisseria meningitidis: Advanced Methods and Protocols. Christodoulides, M. (ed.). p. 197-216 20 p. (Methods in Molecular Biology; vol. 799).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

The aging immune system: Challenges for the 21st century

Nikolich-Žugich, J., Oct 1 2012, In : Seminars in Immunology. 24, 5, p. 301-302 2 p.

Research output: Contribution to journalEditorial

11 Scopus citations

The genome architecture of the collaborative cross mouse genetic reference population

Iraqi, F. A., Mahajne, M., Salaymah, Y., Sandovski, H., Tayem, H., Vered, K., Balmer, L., Hall, M., Manship, G., Morahan, G., Pettit, K., Scholten, J., Tweedie, K., Wallace, A., Weerasekera, L., Cleak, J., Durrant, C., Goodstadt, L., Mott, R., Yalcin, B. & 110 others, Aylor, D. L., Baric, R. S., Bell, T. A., Bendt, K. M., Brennan, J., Brooks, J. D., Buus, R. J., Crowley, J. J., Calaway, J. D., Calaway, M. E., Cholka, A., Darr, D. B., Didion, J. P., Dorman, A., Everett, E. T., Ferris, M. T., Mathes, W. F., Fu, C. P., Gooch, T. J., Goodson, S. G., Gralinski, L. E., Hansen, S. D., Heise, M. T., Hoel, J., Hua, K., Kapita, M. C., Lee, S., Lenarcic, A. B., Liu, E. Y., Liu, H., McMillan, L., Magnuson, T. R., Manly, K. F., Miller, D. R., O'Brien, D. A., Odet, F., Pakatci, I. K., Pan, W., de Villena, F. P. M., Perou, C. M., Pomp, D., Quackenbush, C. R., Robinson, N. N., Sharpless, N. E., Shaw, G. D., Spence, J. S., Sullivan, P. F., Sun, W., Tarantino, L. M., Valdar, W., Wang, J., Wang, W., Welsh, C. E., Whitmore, A., Wiltshire, T., Wright, F. A., Xie, Y., Yun, Z., Zhabotynsky, V., Zhang, Z., Zou, F., Powell, C., Steigerwalt, J., Threadgill, D. W., Chesler, E. J., Churchill, G. A., Gatti, D. M., Korstanje, R., Svenson, K. L., Collins, F. S., Crawford, N., Hunter, K., Samir, N., Kelada, P., Peck, B. C. E., Reilly, K., Tavarez, U., Bottomly, D., Hitzeman, R., Mcweeney, S. K., Frelinger, J., Krovi, H., Phillippi, J., Spritz, R. A., Aicher, L., Katze, M., Rosenzweig, E., Shusterman, A., Nashef, A., Weiss, E. I., Houri-Haddad, Y., Soller, M., Williams, R. W., Schughart, K., Yang, H., French, J. E., Benson, A. K., Kim, J., Legge, R., Low, S. J., Ma, F., Martinez, I., Walter, J., Broman, K. W., Hallgrimsson, B., Klein, O., Weinstock, G., Warren, W. C., Yang, Y. V. & Schwartz, D., Feb 1 2012, In : Genetics. 190, 2, p. 389-401 13 p.

Research output: Contribution to journalArticle

266 Scopus citations

The LCMV gp33-specific memory T cell repertoire narrows with age

Bunztman, A., Vincent, B. G., Krovi, H., Steele, S. & Frelinger, J. A., Aug 15 2012, In : Immunity and Ageing. 9, 17.

Research output: Contribution to journalArticle

10 Scopus citations

The role of gut microbiota in immune homeostasis and autoimmunity

Wu, H. J. & Wu, E., Jan 1 2012, In : Gut microbes. 3, 1

Research output: Contribution to journalReview article

Open Access
259 Scopus citations

Translational research in immune senescence: Assessing the relevance of current models

High, K. P., Akbar, A. N. & Nikolich-Zugich, J., Oct 1 2012, In : Seminars in Immunology. 24, 5, p. 373-382 10 p.

Research output: Contribution to journalReview article

28 Scopus citations
2011

A broadly applicable approach to T cell epitope identification: Application to improving tumor associated epitopes and identifying epitopes in complex pathogens

Valentino, M. D., Abdul-Alim, C. S., Maben, Z. J., Skrombolas, D., Hensley, L. L., Kawula, T. H., Dziejman, M., Lord, E. M., Frelinger, J. A. & Frelinger, J. G., Oct 28 2011, In : Journal of Immunological Methods. 373, 1-2, p. 111-126 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D. C., Hamlin, K. L., Nelson, J. A., Fleming, W. H., Streblow, D. N. & Goodrum, F., Dec 1 2011, In : PLoS pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

77 Scopus citations

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A. W., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Evolution of the antigen-specific CD8+ TCR repertoire across the life span: Evidence for clonal homogenization of the old TCR repertoire

Rudd, B. D., Venturi, V., Davenport, M. P. & Nikolich-Žugich, J., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2056-2064 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Functional CD8 T cell memory responding to persistent latent infection is maintained for life

Lang, A. & Nikolich-Žugich, J., Oct 1 2011, In : Journal of Immunology. 187, 7, p. 3759-3768 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Genetic analysis of complex traits in the emerging Collaborative Cross

Aylor, D. L., Valdar, W., Foulds-Mathes, W., Buus, R. J., Verdugo, R. A., Baric, R. S., Ferris, M. T., Frelinger, J. A., Heise, M., Frieman, M. B., Gralinski, L. E., Bell, T. A., Didion, J. D., Hua, K., Nehrenberg, D. L., Powell, C. L., Steigerwalt, J., Xie, Y., Kelada, S. N. P., Collins, F. S. & 21 others, Yang, I. V., Schwartz, D. A., Branstetter, L. A., Chesler, E. J., Miller, D. R., Spence, J., Liu, E. Y., McMillan, L., Sarkar, A., Wang, J., Wang, W., Zhang, Q., Broman, K. W., Korstanje, R., Durrant, C., Mott, R., Iraqi, F. A., Pomp, D., Threadgill, D., De Villena, F. P. M. & Churchill, G. A., Aug 1 2011, In : Genome Research. 21, 8, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

228 Scopus citations
5 Scopus citations

HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/ γcnull/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells

Whitfield-Larry, F., Young, E. F., Talmage, G., Fudge, E., Azam, A., Patel, S., Largay, J., Byrd, W., Buse, J., Calikoglu, A. S., Shultz, L. D. & Frelinger, J. A., Jun 1 2011, In : Diabetes. 60, 6, p. 1726-1733 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets

Valentino, M. D., Maben, Z. J., Hensley, L. L., Woolard, M. D., Kawula, T. H., Frelinger, J. A. & Frelinger, J. G., Mar 1 2011, In : Immunology. 132, 3, p. 348-360 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Immune responses in the skin in old age

Vukmanovic-Stejic, M., Rustin, M. H. A., Nikolich-Zugich, J. & Akbar, A. N., Aug 1 2011, In : Current Opinion in Immunology. 23, 4, p. 525-531 7 p.

Research output: Contribution to journalReview article

38 Scopus citations
34 Scopus citations

Life in the MHC

Frelinger, J. A., Sep 1 2011, In : Journal of Immunology. 187, 5, p. 2035-2037 3 p.

Research output: Contribution to journalArticle

Molecular mechanisms of HIV-1 mother-to-child transmission and infection in neonatal target cells

Ahmad, N., May 23 2011, In : Life Sciences. 88, 21-22, p. 980-986 7 p.

Research output: Contribution to journalReview article

9 Scopus citations

N. elongata produces type IV pili that mediate interspecies gene transfer with N. gonorrhoeae

Higashi, D. L., Biais, N., Weyand, N. J., Agellon, A., Sisko, J. L., Brown, L. M. & So, M., Jun 27 2011, In : PloS one. 6, 6, e21373.

Research output: Contribution to journalArticle

20 Scopus citations

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

Kriegel, M. A., Sefik, E., Hill, J. A., Wu, H. J., Benoist, C. & Mathis, D., Jul 12 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 28, p. 11548-11553 6 p.

Research output: Contribution to journalArticle

272 Scopus citations

Nonrandom attrition of the naive CD8 + T-cell pool with aging governed by T-cell receptor: pMHC interactions

Rudd, B. D., Venturi, V., Li, G., Samadder, P., Ertelt, J. M., Way, S. S., Davenport, M. P. & Nikolich-Žugich, J., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. 13694-13699 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal west nile virus encephalitis

Uhrlaub, J. L., Brien, J. D., Widman, D. G., Mason, P. W. & Nikolich-Žugich, J., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 3882-3891 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Report from the second cytomegalovirus and immunosenescence workshop

Wills, M., Akbar, A., Beswick, M., Bosch, J. A., Caruso, C., Colonna-Romano, G., Dutta, A., Franceschi, C., Fulop, T., Gkrania-Klotsas, E., Goronzy, J., Griffiths, S. J., Henson, S. M., Herndler-Brandstetter, D., Hill, A., Kern, F., Klenerman, P., Macallan, D., Macaulay, R., Maier, A. B. & 19 others, Mason, G., Melzer, D., Morgan, M., Moss, P., Nikolich-Zugich, J., Pachnio, A., Riddell, N., Roberts, R., Sansoni, P., Sauce, D., Sinclair, J., Solana, R., Strindhall, J., Trzonkowski, P., van Lier, R., Vescovini, R., Wang, G., Westendorp, R. & Pawelec, G., Oct 28 2011, In : Immunity and Ageing. 8, 10.

Research output: Contribution to journalComment/debate

29 Scopus citations

Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-Ek

Newell, E. W., Ely, L. K., Kruse, A. C., Reay, P. A., Rodriguez, S. N., Lin, A. E., Kuhns, M. S., Garcia, K. C. & Davis, M. M., May 15 2011, In : Journal of Immunology. 186, 10, p. 5823-5832 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation

Ni Choileain, S., Weyand, N. J., Neumann, C., Thomas, J., So, M. & Astier, A. L., Feb 3 2011, In : PloS one. 6, 1, e16287.

Research output: Contribution to journalArticle

38 Scopus citations

The influence of hydrocarbon composition and exposure conditions on jet fuel-induced immunotoxicity

Hilgaertner, J. W., He, X., Camacho, D., Badowski, M., Witten, M. & Harris, D. T., Nov 1 2011, In : Toxicology and Industrial Health. 27, 10, p. 887-898 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Aging of the immune system across different species

Nikolich-Žugich, J. & Čičin-Šain, L., Dec 1 2010, The Comparative Biology of Aging. Springer Netherlands, p. 353-376 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Are embryonic stem cells really needed for regenerative medicine?

Harris, D. T., Jan 1 2010, Pluripotent Stem Cells. Nova Science Publishers, Inc., p. 185-190 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138

Tey, S. K., Goodrum, F. & Khanna, R., Aug 1 2010, In : Journal of General Virology. 91, 8, p. 2040-2048 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cost-effectiveness of private umbilical cord blood banking

Nietfeld, J. J. & Harris, D. T., May 1 2010, In : Obstetrics and gynecology. 115, 5, 1 p.

Research output: Contribution to journalLetter

4 Scopus citations

Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells

Sundaravaradan, V., Mehta, R., Harris, D. T., Zack, J. A. & Ahmad, N., Apr 25 2010, In : Virology. 400, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection

Rudd, B. D., Venturi, V., Smithey, M. J., Way, S. S., Davenport, M. P. & Nikolich-Žugich, J., Mar 15 2010, In : Journal of Immunology. 184, 6, p. 2958-2965 8 p.

Research output: Contribution to journalArticle

18 Scopus citations