Research Output

2010

Force-dependent polymorphism in type IV pili reveals hidden epitopes

Biais, N., Higashi, D. L., Brujić, J., So, M. & Sheetz, M. P., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11358-11363 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Genome sequencing reveals widespread virulence gene exchange among human Neisseria species

Marri, P. R., Paniscus, M., Weyand, N. J., Rendón, M. A., Calton, C. M., Hernández, D. R., Higashi, D. L., Sodergren, E., Weinstock, G. M., Rounsley, S. D. & So, M., Aug 20 2010, In : PloS one. 5, 7, e11835.

Research output: Contribution to journalArticle

115 Scopus citations

Immune memory and aging: An infinite or finite resource?

Nikolich-Žugich, J. & Rudd, B. D., Aug 1 2010, In : Current Opinion in Immunology. 22, 4, p. 535-540 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M. K., Wong, S. W. & Nikolich-Žugich, J., Dec 15 2010, In : PloS one. 5, 12, e15514.

Research output: Contribution to journalArticle

16 Scopus citations

In response

Gaballa, M., Harris, D. T. & Copeland, N., Jan 1 2010, In : Clinical Medicine, Journal of the Royal College of Physicians of London. 10, 1, p. 97-98 2 p.

Research output: Contribution to journalLetter

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

Čičin-Šain, L., Smyk-Paerson, S., Currier, N., Byrd, L., Koudelka, C., Robinson, T., Swarbrick, G., Tackitt, S., Legasse, A., Fischer, M., Nikolich-Žugich, D., Park, B., Hobbs, T., Doane, C. J., Mori, M., Axthelm, M. T., Lewinsohn, D. A. & Nikolich-Žugich, J., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 6739-6745 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling

Shin, D. M., Jeon, B. Y., Lee, H. M., Jin, H. S., Yuk, J. M., Song, C. H., Lee, S. H., Lee, Z. W., Cho, S. N., Kim, J. M., Friedman, R. L. & Jo, E. K., Dec 1 2010, In : PLoS pathogens. 6, 12, e1001230.

Research output: Contribution to journalArticle

184 Scopus citations
8 Scopus citations

Presenilin/γ-secretase cleaves CD46 in response to Neisseria infection

Weyand, N. J., Calton, C. M., Higashi, D. L., Kanack, K. J. & So, M., Jan 15 2010, In : Journal of Immunology. 184, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138

Grainger, L., Cicchini, L., Rak, M., Petrucelli, A., Fitzgerald, K. D., Semler, B. L. & Goodrum, F., Sep 2010, In : Journal of virology. 84, 18, p. 9472-9486 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

The effects of aerosolized JP-8 jet fuel exposure on the immune system: A review

Harris, D. T., Jan 1 2010, Jet Fuel Toxicology. CRC Press, p. 181-200 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2009

Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance

Nikolich-Žugich, J. & Lang, A., Jan 1 2009, Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, p. 219-233 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Characterization of a novel Golgi apparatus-localized latency determinant encoded by human cytomegalovirus

Petrucelli, A., Rak, M., Grainger, L. & Goodrum, F., Jun 1 2009, In : Journal of virology. 83, 11, p. 5615-5629 15 p.

Research output: Contribution to journalArticle

75 Scopus citations

Chimeric antigen receptors for stem cell based immunotherapy

Badowski, M. S., Zhang, T., Tsang, T. C. & Harris, D. T., Sep 22 2009, In : Journal of Experimental Therapeutics and Oncology. 8, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Differential HIV-1 integration targets more actively transcribed host genes in neonatal than adult blood mononuclear cells

Wellensiek, B. P., Ramakrishnan, R., Sundaravaradan, V., Mehta, R., Harris, D. T. & Ahmad, N., Mar 1 2009, In : Virology. 385, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus

Thomas, M. A., Broughton, R. S., Goodrum, F. D. & Ornelles, D. A., Mar 1 2009, In : Journal of virology. 83, 6, p. 2406-2416 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Human umbilical cord blood stem cells, myocardial infarction and stroke

Copeland, N., Harris, D. & Gaballa, M. A., Jan 1 2009, In : Clinical Medicine, Journal of the Royal College of Physicians of London. 9, 4, p. 342-345 4 p.

Research output: Contribution to journalReview article

32 Scopus citations

Increasing transduction efficiency by lentivirus vectors using heat shock and cell cycle specific integration

Badowski, M. & Harris, D. T., Dec 1 2009, In : Gene Therapy and Molecular Biology. 13, 2, p. 284-293 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Influence of type IV pilus retraction on the architecture of the Neisseria gonorrhoeae-infected cell cortex

Higashi, D. L., Zhang, G. H., Biais, N., Myers, L. R., Weyand, N. J., Elliott, D. A. & So, M., Dec 11 2009, In : Microbiology. 155, 12, p. 4084-4092 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Key research opportunities in immune system aging

Swain, S. L. & Nikolich-Zugich, J., Feb 1 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Key role of T cell defects in age-related vulnerability to West Nile virus

Brien, J. D., Uhrlaub, J. L., Hirsch, A., Wiley, C. A. & Nikolich-Žugich, J., Nov 23 2009, In : Journal of Experimental Medicine. 206, 12, p. 2735-2745 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Non-haematological uses of cord blood stem cells

Harris, D. T., Oct 1 2009, In : British Journal of Haematology. 147, 2, p. 177-184 8 p.

Research output: Contribution to journalReview article

64 Scopus citations

Pilin regulation in the pilT mutant of Neisseria gonorrhoeae strain MS11

Dietrich, M., Mollenkopf, H., So, M. & Friedrich, A., Jul 1 2009, In : FEMS Microbiology Letters. 296, 2, p. 248-256 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans

Messaoudi, I., Barron, A., Wellish, M., Engelmann, F., Legasse, A., Planer, S., Gilden, D., Nikolich-Zugich, J. & Mahalingam, R., Nov 1 2009, In : PLoS pathogens. 5, 11, e1000657.

Research output: Contribution to journalArticle

75 Scopus citations
45 Scopus citations

West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function

Medigeshi, G. R., Hirsch, A. J., Brien, J. D., Uhrlaub, J. L., Mason, P. W., Wiley, C., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2009, In : Journal of virology. 83, 12, p. 6125-6134 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections

Nikolich-Žugich, J., Jul 1 2008, In : Nature Reviews Immunology. 8, 7, p. 512-522 11 p.

Research output: Contribution to journalReview article

254 Scopus citations

Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses

Omsland, A., Miranda, K. M., Friedman, R. L. & Boitano, S., Jul 1 2008, In : FEMS Microbiology Letters. 284, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating

Smith, J. L., Campos, S. K., Wandinger-Ness, A. & Ozbun, M. A., Oct 1 2008, In : Journal of virology. 82, 19, p. 9505-9512 8 p.

Research output: Contribution to journalArticle

78 Scopus citations
8 Scopus citations

Cooperative retraction of bundled type IV pili enables nanonewton force generation

Biais, N., Ladoux, B., Higashi, D., So, M. & Sheetz, M., Apr 1 2008, In : PLoS biology. 6, 4, p. 907-913 7 p., e87.

Research output: Contribution to journalArticle

96 Scopus citations

Cord blood stem cells: A review of potential neurological applications

Harris, D. T., Dec 1 2008, In : Stem Cell Reviews. 4, 4, p. 269-274 6 p.

Research output: Contribution to journalReview article

64 Scopus citations

Cord blood stem cells: Worth the investment

Harris, D. T., Oct 1 2008, In : Nature Reviews Cancer. 8, 10, 1 p.

Research output: Contribution to journalLetter

12 Scopus citations

Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates

Rudd, B. D., Brien, J. D., Davenport, M. P. & Nikolich-Žugich, J., Jan 1 2008, In : Journal of Immunology. 181, 8, p. 5199-5203 5 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim

Howie, H. L., Shiflett, S. L. & So, M., Jun 1 2008, In : Infection and Immunity. 76, 6, p. 2715-2721 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic characterization of HIV type 1 long terminal repeat following vertical transmission

Mehta, R., Ramakrishnan, R., Doktor, K., Sundaravaradan, V. & Ahmad, N., Mar 1 2008, In : AIDS Research and Human Retroviruses. 24, 3, p. 437-445 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

JP-8 jet fuel exposure suppresses the immune response to viral infections

Harris, D., Sakiestewa, D., Titone, D., He, X., Hyde, J. & Witten, M., May 2008, In : Toxicology and Industrial Health. 24, 4, p. 209-216 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular Mechanisms of HIV-1 Vertical Transmission and Pathogenesis in Infants

Ahmad, N., Jan 1 2008, HIV-1: Molecular Biology and Pathogenesis. Jeang, K-T. (ed.). p. 453-508 56 p. (Advances in Pharmacology; vol. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Mutations generated in human immunodeficiency virus type 1 long terminal repeat during vertical transmission correlate with viral gene expression

Mehta, R., Sundaravaradan, V. & Ahmad, N., May 25 2008, In : Virology. 375, 1, p. 170-181 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates

Messaoudi, I., Fischer, M., Warner, J., Park, B., Mattison, J., Ingram, D. K., Totonchy, T., Mori, M. & Nikolich-Žugich, J., Dec 4 2008, In : Aging Cell. 7, 6, p. 908-919 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Regenerative medicine of the eye: A short review

Harris, D. T., He, X., Badowski, M. & Nichols, J. C., Jan 1 2008, Stem Cell Repair and Regeneration: Volume 3. Imperial College Press, p. 211-225 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Roles for MicroRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1

Man, L. Y., Yasunaga, J. I., Bennasser, Y., Dusetti, N., Harris, D., Ahmad, N., Matsuoka, M. & Jeang, K. T., Nov 1 2008, In : Cancer Research. 68, 21, p. 8976-8985 10 p.

Research output: Contribution to journalArticle

139 Scopus citations

Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen

Smithey, M. J., Brandt, S., Freitag, N. E., Higgins, D. E. & Bouwer, H. G. A., Mar 1 2008, In : Journal of Immunology. 180, 5, p. 3406-3416 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of αvβ3 integrin

Medigeshi, G. R., Hirsch, A. J., Streblow, D. N., Nikolich-Zugich, J. & Nelson, J. A., Jun 1 2008, In : Journal of virology. 82, 11, p. 5212-5219 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection

Brien, J. D., Uhrlaub, J. L. & Nikolich-Zǔgich, J., Dec 15 2008, In : Journal of Immunology. 181, 12, p. 8568-8575 8 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations
2007

Analysis of adenovirus infections in synchronized cells.

Ornelles, D. A., Broughton-Shepard, R. N. & Goodrum, F. D., 2007, In : Methods in molecular medicine. 131, p. 83-101 19 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130

Yeh, N., Miller, J. P., Gaur, T., Capellini, T. D., Nikolich-Zugich, J., De La Hoz, C., Selleri, L., Bromage, T. G., Van Wijnen, A. J., Stein, G. S., Lian, J. B., Vidal, A. & Koff, A., Jul 1 2007, In : Molecular and cellular biology. 27, 14, p. 5161-5171 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Derivation of primary sequences and secondary structures of rev responsive element from HIV-1 infected mothers and infants following vertical transmission

Ramakrishnan, R. & Ahmad, N., Mar 1 2007, In : Virology. 359, 1, p. 201-211 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
8 Scopus citations