Viper Institute

2019

Antivenom effect on lymphatic absorption and pharmacokinetics of coral snake venom using a large animal model

Paniagua, D., Vergara, I., Román, R., Romero, C., Benard-Valle, M., Calderón, A., Jiménez, L., Bernas, M. J., Witte, M. H., Boyer, L. V. & Alagón, A., Aug 3 2019, In : Clinical Toxicology. 57, 8, p. 727-734 8 p.

Research output: Contribution to journal › Article

Antivenins

Elapidae

Snake Venoms

Pharmacokinetics

Venoms

2017

9 Citations (Scopus)

A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom

Barbosa, A. N., Boyer, L. V., Chippaux, J. P., Medolago, N. B., Caramori, C. A., Paixão, A. G., Poli, J. P. V., Mendes, M. B., dos Santos, L. D., Ferreira, R. S. & Barraviera, B., Mar 16 2017, In : Journal of Venomous Animals and Toxins Including Tropical Diseases. 23, 1, 14.

Research output: Contribution to journal › Article

antivenoms

Antivenins

Bees

Bites and Stings

Clinical Protocols

8 Citations (Scopus)

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, D. C., Dobson, J., Cochran, C., Dashevsky, D., Arbuckle, K., Benard, M., Boyer, L. V., Alagón, A., Hendrikx, I., Hodgson, W. C. & Fry, B. G., Oct 1 2017, In : Neurotoxicity Research. 32, 3, p. 487-495 9 p.

Research output: Contribution to journal › Article

Antivenins

Elapidae

Venoms

Snake Bites

2016

4 Citations (Scopus)

Biodistribution and lymphatic tracking of the main neurotoxin of micrurus fulvius venom by molecular imaging

Vergara, I., Castillo, E. Y., Romero-Piña, M. E., Torres-Viquez, I., Paniagua, D., Boyer, L. V., Alagón, A. & Medina, L. A., Mar 26 2016, In : Toxins. 8, 4, 85.

Research output: Contribution to journal › Article

Molecular imaging

Molecular Imaging

Neurotoxins

Acetic Acid

Elapidae

Pitviper Envenomation Guidelines Should Address Choice Between FDA-approved Treatments for Cases at Risk of Late Coagulopathy

Boyer, L. V. & Ruha, A. M., 2016, (Accepted/In press) In : Wilderness and Environmental Medicine.

Research output: Contribution to journal › Article

Crotalid Venoms

Viper Venoms

Antivenins

Snake Bites

Immunoglobulin Fab Fragments

The Reply

Boyer, L. V., Jun 1 2016, In : American Journal of Medicine. 129, 6, p. e31

Research output: Contribution to journal › Letter

7 Citations (Scopus)

Thrombelastographic characterization of the thrombin-like activity of Crotalus simus and Bothrops asper venoms

Nielsen, V. G., Boyer, L. V., Redford, D. T. & Ford, P., Jun 16 2016, (Accepted/In press) In : Blood Coagulation and Fibrinolysis.

Research output: Contribution to journal › Article

Bothrops

Crotalus

Venoms

Thrombin

Viper Venoms

3 Citations (Scopus)

Venom yield and its relationship with body size and fang separation of pit vipers from Argentina

de Roodt, A. R., Boyer, L. V., Lanari, L. C., Irazu, L., Laskowicz, R. D., Sabattini, P. L. & Damin, C. F., Oct 1 2016, In : Toxicon. 121, p. 22-29 8 p.

Research output: Contribution to journal › Article

Argentina

Venoms

Body Size

Punctures

Snakes

2015

Antivenom Research and Development: Evolution, Pathophysiology and Biodiscovery

Benard-Valle, M., Neri-Castro, E. E., Fry, B. G., Boyer, L., Cochran, C., Alam, M., Jackson, TNW., Paniagua, D., Olvera-Rodriguez, F., Koludarov, I., Sunagar, K. & Alagón, A., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 61-72

Research output: Chapter in Book/Report/Conference proceeding › Chapter

29 Citations (Scopus)

Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: A prospective, blinded, multicenter, randomized clinical trial

Bush, S. P., Ruha, A. M., Seifert, S. A., Morgan, D. L., Lewis, B. J., Arnold, T. C., Clark, R. F., Meggs, W. J., Toschlog, E. A., Borron, S. W., Figge, G. R., Sollee, D. R., Shirazi, F., Wolk, R., De Chazal, I., Quan, D., García-Ubbelohde, W., Alagón, A., Gerkin, R. D. & Boyer, L. V., Jan 1 2015, In : Clinical Toxicology. 53, 1, p. 37-45 9 p.

Research output: Contribution to journal › Article

Antivenins

Randomized Controlled Trials

Placebos

Half-Life

Maintenance

Ineffective traditional and modern techniques for the treatment of snakebite: Evolution, Pathophysiology and Biodiscovery

Bénard-Valle, M., Neri-Castro, E. E., Boyer, L., Jackson, TNW., Sunagar, K., Clarkson, M. & Fry, B. G., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 73-88

Research output: Chapter in Book/Report/Conference proceeding › Chapter

In Reply re: "Comparison of F(ab')₂ versus Fab antivenom for Pit Viper Envenomation: A Prospective, Blinded, Multicenter, Randomized Clinical Trial"

Bush, S. P., Ruha, A. M., Seifert, S. A., Sollee, D. R. & Boyer, L. V., May 1 2015, In : Clinical Toxicology. 53, 4, p. 414-415 2 p.

Research output: Contribution to journal › Letter

Crotalid Venoms

Antivenins

Immunoglobulin Fab Fragments

Animals

3 Citations (Scopus)

Iron and carbon monoxide attenuate Crotalus atrox venom-enhanced tissue-type plasminogen activator-initiated fibrinolysis

Nielsen, V. G., Boyer, L. V., Matika, R. W., Amos, Q. & Redford, D. T., Nov 7 2015, (Accepted/In press) In : Blood Coagulation and Fibrinolysis.

Research output: Contribution to journal › Article

Crotalus

Venoms

Fibrinolysis

Tissue Plasminogen Activator

Carbon Monoxide

11 Citations (Scopus)

Iron and carbon monoxide attenuate degradation of plasmatic coagulation by Crotalus atrox venom

Nielsen, V. G. & Boyer, L. V., Nov 7 2015, (Accepted/In press) In : Blood Coagulation and Fibrinolysis.

Research output: Contribution to journal › Article

Crotalus

Venoms

Carbon Monoxide

Iron

Antivenins

Maintaining venomous reptile collections: protocols and occupational safety: Evolution, Pathophysiology and Biodiscovery

Fry, B. G., Hendrikx, I., Rowley, P., Jackson, TNW., Van der Ploeg, H., Johnson, R., Sasa, M., Dunstan, N., Barve, S., Lock, B., Phillip, T., Zivkovic, M., Boyer, L., Wiley, K., Harrison, J., Carmichael, R., Morris, M. C., Brandl, D., Shankar, G., McCarthy, S. & 3 others, Sunagar, K., Pittman, J. & Cochran, C., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 89-131

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

On 1000-fold pharmaceutical price markups and why drugs cost more in the United States than in Mexico

Boyer, L. V., Dec 1 2015, In : American Journal of Medicine. 128, 12, p. 1265-1267 3 p.

Research output: Contribution to journal › Article

Government Financing

Antivenins

Drug Costs

Drug Industry

Mexico

3 Citations (Scopus)

Post-exposure treatment of Ebola virus using passive immunotherapy: Proposal for a new strategy

Chippaux, J. P., Boyer, L. V. & Alagón, A., Feb 15 2015, In : Journal of Venomous Animals and Toxins Including Tropical Diseases. 21, 1, 3.

Research output: Contribution to journal › Article

Ebolavirus

Passive Immunization

immunotherapy

Viruses

Ebola Hemorrhagic Fever

Signs, symptoms and treatment of envenomation: Evolution, Pathophysiology and Biodiscovery

Boyer, L., Alagón, A., Fry, B. G., Jackson, TNW., Sunagar, K. & Chippaux, J-P., 2015, Venomous Reptiles and their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). 1st ed. New York: Oxford University Press, p. 32-60

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Citations (Scopus)

Snake bites and antivenom shortage in Africa

Chippaux, J. P., Massougbodji, A., Diouf, A., Baldé, C. M. & Boyer, L. V., Dec 5 2015, In : The Lancet. 386, 10010, p. 2252-2253 2 p.

Research output: Contribution to journal › Article

Drug Utilization

Antivenins

Snake Bites

Health Services Accessibility

Africa South of the Sahara

De Roodt, A. R., Clement, H., Dolab, J. A., Litwin, S., Hajos, S. E., Boyer, L. V. & Alagón, A., 2014, In : Clinical Toxicology. 52, 6, p. 594-603 10 p.

Research output: Contribution to journal › Article

Antivenins

Assays

Proteins

Venoms

Crotalid Venoms

Role of the lymphatic system on snake venom absorption: review of mechanism and clinical implications

Paniagua, D., Vergara, I., Boyer, L. & Alagón, A., 2014, Snake Venoms. Gopalakrishnakone, P., Inagaki, H., Mukherjee, A. K., Rahmy, T. R. & Vogel, C-W. (eds.). Netherlands: Springer

Boyer, L. V., Chase, P. B., Degan, J. A., Figge, G., Buelna-Romero, A., Luchetti, C. & Alagón, A., Nov 2013, In : Toxicon. 74, p. 101-108 8 p.

Research output: Contribution to journal › Article

Antivenins

Venoms

Coagulation

Platelets

Fibrinogen

2012

18 Citations (Scopus)

Lymphatic route of transport and pharmacokinetics of Micrurus fulvius (coral snake) venom in sheep

Paniagua, D., Jiménez, L., Romero, C., Vergara, I., Calderón, A., Benard, M., Bernas, M. J., Rilo, H., De Roodt, A., D'Suze, G., Witte, M. H., Boyer, L. V. & Alagón, A., Dec 2012, In : Lymphology. 45, 4, p. 144-153 10 p.

Research output: Contribution to journal › Article

Elapidae

Snake Venoms

Venoms

Lymph

Thoracic Duct

2011

Spider Bite: Management of Wilderness and Environmental Emergen

Boyer, L., Binford, G. & Degan, J., 2011, Wilderness Medicine: Management of Wilderness and Environmental Emergen. Auerbach, P. (ed.). 6th ed. St. Louis: Mosby, p. 975-996

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2010

1 Citation (Scopus)

Editorial

Boyer, L. V., Nov 2010, In : International Immunopharmacology. 10, 11, p. 1317 1 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Scorpion antivenom administered by alternative infusions

Hiller, K. M., Jarrod, M. M., Franke, H. A., Degan, J., Boyer, L. V. & Fox, F. M., Sep 2010, In : Annals of Emergency Medicine. 56, 3, p. 309-310 2 p.

Research output: Contribution to journal › Article

Intraosseous Infusions

Scorpion Stings

Spider Bites

Scorpion Venoms

Antivenins

2 Citations (Scopus)

The 3 + 3 dose escalation design is not appropriate for antivenom dose finding

Chippaux, J. P. & Boyer, L. V., Jun 2010, In : Toxicon. 55, 7, p. 1408-1409 2 p.

Research output: Contribution to journal › Article

Drug Dose Response Relationship

Antivenins

Snake Bites

Maximum Tolerated Dose

Research Design

2009

47 Citations (Scopus)

AAPCC database characterization of native U.S. venomous snake exposures, 2001-2005

Seifert, S. A., Boyer, L. V., Benson, B. E. & Rogers, J. J., 2009, In : Clinical Toxicology. 47, 4, p. 327-335 9 p.

Research output: Contribution to journal › Article

Agkistrodon

Crotalus

Snakes

Poisons

Databases

105 Citations (Scopus)

Antivenom for critically ill children with neurotoxicity from scorpion stings

Boyer, L. V., Theodorou, A. A., Berg, R. A., Mallie, J., Chávez-Méndez, A., García-Ubbelohde, W., Hardiman, S. & Alagón, A., May 14 2009, In : New England Journal of Medicine. 360, 20, p. 2090-2098 9 p.

Research output: Contribution to journal › Article

Scorpion Stings

Antivenins

Scorpions

Critical Illness

Placebos

13 Citations (Scopus)

Serum levels and urine detection of Centruroides sculpturatus venom in significantly envenomated patients

Chase, P., Boyer, L. V., Mcnally, J., Vazquez, H. L., Theodorou, A. A., Walter, F. G. & Alagon, A., Feb 2009, In : Clinical Toxicology. 47, 1, p. 24-28 5 p.

Research output: Contribution to journal › Article

Venoms

Urine

Serum

Immunosorbents

Assays

2 Citations (Scopus)

The authors reply

Boyer, L. V., Alagón, A. & Theodorou, A. A., Aug 6 2009, In : New England Journal of Medicine. 361, 6, p. 632 1 p.

Research output: Contribution to journal › Article

2008

7 Citations (Scopus)

Toxicologic Information Resources for Reptile Envenomations

McNally, J., Boesen, K. J. & Boyer, L. V., May 2008, In : Veterinary Clinics of North America - Exotic Animal Practice. 11, 2, p. 389-401 13 p.

Research output: Contribution to journal › Article

Reptiles

information sources

reptiles

snakes

Snake Bites

2007

11 Citations (Scopus)

Toxic Exposure Surveillance System (TESS)-based characterization of U.S. non-native venomous snake exposures, 1995-2004

Seifert, S. A., Oakes, J. A. & Boyer, L. V., Jul 2007, In : Clinical Toxicology. 45, 5, p. 571-578 8 p.

Research output: Contribution to journal › Article

Snakes

Poisons

Databases

Antivenins

Intensive care units

2006

6 Citations (Scopus)

Resistance of antivenom proteins to foaming-induced denaturation

Kanavage, A. D., Boyer, L. V., McNally, J. & Osterhout, J. J., Mar 15 2006, In : Toxicon. 47, 4, p. 445-452 8 p.

Research output: Contribution to journal › Article

Antivenins

Denaturation

Proteins

Protein Unfolding

Protein Refolding

Spider Bite: Management of Wilderness and Environmental Emergen

Boyer, L., Binford, G. & McNally, J., 2006, Wilderness Medicine: Management of Wilderness and Environmental Emergen. Auerbach, P. (ed.). 5th ed. St. Louis: Mosby

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2005

Understanding the Hazards: Toxicity and Safety: A Museum Resource for Managing Contaminated Cultur

Boyer, L. V., Seifert, S., Odegaard, N., Pool, M. & Burroughs, G. E., 2005, Old Poisons, new Problems: A Museum Resource for Managing Contaminated Cultur. Odegaard, N. & Sadongei, A. (eds.). AltaMira Press, div of Rowman & Littlefield Publishers, Inc, p. 73-84

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2004

28 Citations (Scopus)

Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing

Valdez-Cruz, N. A., Dávila, S., Licea, A., Corona, M., Zamudio, F. Z., García-Valdes, J., Boyer, L. V. & Possani, L. D., Jun 2004, In : Biochimie. 86, 6, p. 387-396 10 p.

Research output: Contribution to journal › Article

Scorpions

Venoms

Molecular Biology

Wood

Genes

Lead

Dart, R., Hurlbut, K. & Boyer, L. V., 2004, Medical Toxicology. Dart, R. (ed.). Philadelphia: Lippincott Williams & Wilkins, p. 1423-1431

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Scorpion Envenomation

Boyer, L. V., 2004, Medical Toxicology. Dart, R. (ed.). 3rd ed. Philadelphia: Lippincott Williams & Wilkins, p. 1603-1605

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2003