Research Output 1991 2019

2019

Antivenom effect on lymphatic absorption and pharmacokinetics of coral snake venom using a large animal model

Paniagua, D., Vergara, I., Román, R., Romero, C., Benard-Valle, M., Calderón, A., Jiménez, L., Bernas, M. J., Witte, M. H., Boyer, L. V. & Alagón, A., Aug 3 2019, In : Clinical Toxicology. 57, 8, p. 727-734 8 p.

Research output: Contribution to journalArticle

Antivenins
Elapidae
Snake Venoms
Pharmacokinetics
Venoms
2017
9 Citations (Scopus)

A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom

Barbosa, A. N., Boyer, L. V., Chippaux, J. P., Medolago, N. B., Caramori, C. A., Paixão, A. G., Poli, J. P. V., Mendes, M. B., dos Santos, L. D., Ferreira, R. S. & Barraviera, B., Mar 16 2017, In : Journal of Venomous Animals and Toxins Including Tropical Diseases. 23, 1, 14.

Research output: Contribution to journalArticle

antivenoms
Antivenins
Bees
Bites and Stings
Clinical Protocols
7 Citations (Scopus)

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, D. C., Dobson, J., Cochran, C., Dashevsky, D., Arbuckle, K., Benard, M., Boyer, L. V., Alagón, A., Hendrikx, I., Hodgson, W. C. & Fry, B. G., Oct 1 2017, In : Neurotoxicity Research. 32, 3, p. 487-495 9 p.

Research output: Contribution to journalArticle

Antivenins
Elapidae
Venoms
Snake Bites
2016
4 Citations (Scopus)

Biodistribution and lymphatic tracking of the main neurotoxin of micrurus fulvius venom by molecular imaging

Vergara, I., Castillo, E. Y., Romero-Piña, M. E., Torres-Viquez, I., Paniagua, D., Boyer, L. V., Alagón, A. & Medina, L. A., Mar 26 2016, In : Toxins. 8, 4, 85.

Research output: Contribution to journalArticle

Molecular imaging
Molecular Imaging
Neurotoxins
Acetic Acid
Elapidae
Crotalid Venoms
Viper Venoms
Antivenins
Snake Bites
Immunoglobulin Fab Fragments

The Reply

Boyer, L. V., Jun 1 2016, In : American Journal of Medicine. 129, 6, p. e31

Research output: Contribution to journalLetter

7 Citations (Scopus)
Bothrops
Crotalus
Venoms
Thrombin
Viper Venoms
3 Citations (Scopus)

Venom yield and its relationship with body size and fang separation of pit vipers from Argentina

de Roodt, A. R., Boyer, L. V., Lanari, L. C., Irazu, L., Laskowicz, R. D., Sabattini, P. L. & Damin, C. F., Oct 1 2016, In : Toxicon. 121, p. 22-29 8 p.

Research output: Contribution to journalArticle

Argentina
Venoms
Body Size
Punctures
Snakes
2015

Antivenom Research and Development: Evolution, Pathophysiology and Biodiscovery

Benard-Valle, M., Neri-Castro, E. E., Fry, B. G., Boyer, L., Cochran, C., Alam, M., Jackson, TNW., Paniagua, D., Olvera-Rodriguez, F., Koludarov, I., Sunagar, K. & Alagón, A., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 61-72

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Citations (Scopus)

Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: A prospective, blinded, multicenter, randomized clinical trial

Bush, S. P., Ruha, A. M., Seifert, S. A., Morgan, D. L., Lewis, B. J., Arnold, T. C., Clark, R. F., Meggs, W. J., Toschlog, E. A., Borron, S. W., Figge, G. R., Sollee, D. R., Shirazi, F., Wolk, R., De Chazal, I., Quan, D., García-Ubbelohde, W., Alagón, A., Gerkin, R. D. & Boyer, L. V., Jan 1 2015, In : Clinical Toxicology. 53, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Antivenins
Randomized Controlled Trials
Placebos
Half-Life
Maintenance

Ineffective traditional and modern techniques for the treatment of snakebite: Evolution, Pathophysiology and Biodiscovery

Bénard-Valle, M., Neri-Castro, E. E., Boyer, L., Jackson, TNW., Sunagar, K., Clarkson, M. & Fry, B. G., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 73-88

Research output: Chapter in Book/Report/Conference proceedingChapter

In Reply re: "Comparison of F(ab')2 versus Fab antivenom for Pit Viper Envenomation: A Prospective, Blinded, Multicenter, Randomized Clinical Trial"

Bush, S. P., Ruha, A. M., Seifert, S. A., Sollee, D. R. & Boyer, L. V., May 1 2015, In : Clinical Toxicology. 53, 4, p. 414-415 2 p.

Research output: Contribution to journalLetter

Crotalid Venoms
Antivenins
Immunoglobulin Fab Fragments
Animals
3 Citations (Scopus)
Crotalus
Venoms
Fibrinolysis
Tissue Plasminogen Activator
Carbon Monoxide
11 Citations (Scopus)
Crotalus
Venoms
Carbon Monoxide
Iron
Antivenins

Maintaining venomous reptile collections: protocols and occupational safety: Evolution, Pathophysiology and Biodiscovery

Fry, B. G., Hendrikx, I., Rowley, P., Jackson, TNW., Van der Ploeg, H., Johnson, R., Sasa, M., Dunstan, N., Barve, S., Lock, B., Phillip, T., Zivkovic, M., Boyer, L., Wiley, K., Harrison, J., Carmichael, R., Morris, M. C., Brandl, D., Shankar, G., McCarthy, S. & 3 others, Sunagar, K., Pittman, J. & Cochran, C., 2015, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). New York: Oxford University Press, p. 89-131

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

On 1000-fold pharmaceutical price markups and why drugs cost more in the United States than in Mexico

Boyer, L. V., Dec 1 2015, In : American Journal of Medicine. 128, 12, p. 1265-1267 3 p.

Research output: Contribution to journalArticle

Government Financing
Antivenins
Drug Costs
Drug Industry
Mexico
3 Citations (Scopus)
Ebolavirus
Passive Immunization
immunotherapy
Viruses
Ebola Hemorrhagic Fever

Signs, symptoms and treatment of envenomation: Evolution, Pathophysiology and Biodiscovery

Boyer, L., Alagón, A., Fry, B. G., Jackson, TNW., Sunagar, K. & Chippaux, J-P., 2015, Venomous Reptiles and their Toxins: Evolution, Pathophysiology and Biodiscovery. Fry, B. G. (ed.). 1st ed. New York: Oxford University Press, p. 32-60

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Snake bites and antivenom shortage in Africa

Chippaux, J. P., Massougbodji, A., Diouf, A., Baldé, C. M. & Boyer, L. V., Dec 5 2015, In : The Lancet. 386, 10010, p. 2252-2253 2 p.

Research output: Contribution to journalArticle

Drug Utilization
Antivenins
Snake Bites
Health Services Accessibility
Africa South of the Sahara
2014

Erratum: Intraspecific differences in the immunochemical reactivity and neutralization of venom from Argentinean Bothrops (Rhinocerophis) alternatus by specific experimental antivenoms (Toxicon (2014) 85 (31-45))

Lanari, L. C., Olvera, A., Costa De Oliveira, V., Laskowicz, R. D., Boyer, L. V., Lago, N. R., Alagón, A. & De Roodt, A. R., Sep 15 2014, In : Toxicon. 88, p. 138 1 p.

Research output: Contribution to journalArticle

Bothrops
Antivenins
Venoms
3 Citations (Scopus)

Intraspecific differences in the immunochemical reactivity and neutralization of venom from Argentinean Bothrops (Rhinocerophis) alternatus by specific experimental antivenoms

Lanari, L. C., Olvera, A., Costa De Oliveira, V., Laskowicz, R. D., Boyer, L. V., Lago, N. R., Alejandro, A. & De Roodt, A. R., 2014, In : Toxicon. 85, p. 31-45 15 p.

Research output: Contribution to journalArticle

Bothrops
Antivenins
Venoms
Snake Venoms
Poisons
9 Citations (Scopus)

Non-native (exotic) snake envenomations in the U.S., 2005-2011

Warrick, B. J., Boyer, L. V. & Seifert, S. A., 2014, In : Toxins. 6, 10, p. 2899-2911 13 p.

Research output: Contribution to journalArticle

Coding errors
Antivenins
Snake Bites
Poisons
Snakes
4 Citations (Scopus)

Protein content of antivenoms and relationship with their immunochemical reactivity and neutralization assays

De Roodt, A. R., Clement, H., Dolab, J. A., Litwin, S., Hajos, S. E., Boyer, L. V. & Alagón, A., 2014, In : Clinical Toxicology. 52, 6, p. 594-603 10 p.

Research output: Contribution to journalArticle

Antivenins
Assays
Proteins
Venoms
Crotalid Venoms

Role of the lymphatic system on snake venom absorption: review of mechanism and clinical implications

Paniagua, D., Vergara, I., Boyer, L. & Alagón, A., 2014, Snake Venoms. Gopalakrishnakone, P., Inagaki, H., Mukherjee, A. K., Rahmy, T. R. & Vogel, C-W. (eds.). Netherlands: Springer

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Editorial: Scorpion venom and antivenom

Boyer, L. V., Dec 15 2013, In : Toxicon. 76, p. 327 1 p.

Research output: Contribution to journalArticle

Scorpion Venoms
Antivenins
9 Citations (Scopus)

Effectiveness of Centruroides scorpion antivenom compared to historical controls

Boyer, L. V., Theodorou, A. A., Chase, P. B., Osnaya, N., Berg, M., Mallie, J., Carbajal, Y., De Jesus-Hernandez, T., Olvera, F. & Alagón, A., Dec 15 2013, In : Toxicon. 76, p. 377-385 9 p.

Research output: Contribution to journalArticle

Antivenins
Scorpions
Placebos
Intensive care units
Midazolam
8 Citations (Scopus)

History of scorpion antivenom: One Arizonan's view

Boyer, L. V., Jul 2013, In : Toxicon. 69, p. 14-20 7 p.

Research output: Contribution to journalArticle

Antivenins
Scorpions
Venoms
Ancient History
History
16 Citations (Scopus)

Is scorpion antivenom cost-effective as marketed in the United States?

Armstrong, E. P., Bakall, M., Skrepnek, G. H. & Boyer, L. V., Dec 15 2013, In : Toxicon. 76, p. 394-398 5 p.

Research output: Contribution to journalArticle

Antivenins
Scorpions
Costs and Cost Analysis
Costs
Medicaid
24 Citations (Scopus)

Safety of intravenous equine F(ab')2: Insights following clinical trials involving 1534 recipients of scorpion antivenom

Boyer, L. V., Degan, J., Ruha, A. M., Mallie, J., Mangin, E. & Alagón, A., Dec 15 2013, In : Toxicon. 76, p. 386-393 8 p.

Research output: Contribution to journalArticle

Antivenins
Scorpions
Antigen-antibody reactions
Horses
Clinical Trials
24 Citations (Scopus)

Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab')2 antivenoms

Boyer, L. V., Chase, P. B., Degan, J. A., Figge, G., Buelna-Romero, A., Luchetti, C. & Alagón, A., Nov 2013, In : Toxicon. 74, p. 101-108 8 p.

Research output: Contribution to journalArticle

Antivenins
Venoms
Coagulation
Platelets
Fibrinogen
2012
18 Citations (Scopus)

Lymphatic route of transport and pharmacokinetics of Micrurus fulvius (coral snake) venom in sheep

Paniagua, D., Jiménez, L., Romero, C., Vergara, I., Calderón, A., Benard, M., Bernas, M. J., Rilo, H., De Roodt, A., D'Suze, G., Witte, M. H., Boyer, L. V. & Alagón, A., Dec 2012, In : Lymphology. 45, 4, p. 144-153 10 p.

Research output: Contribution to journalArticle

Elapidae
Snake Venoms
Venoms
Lymph
Thoracic Duct
2011

Spider Bite: Management of Wilderness and Environmental Emergen

Boyer, L., Binford, G. & Degan, J., 2011, Wilderness Medicine: Management of Wilderness and Environmental Emergen. Auerbach, P. (ed.). 6th ed. St. Louis: Mosby, p. 975-996

Research output: Chapter in Book/Report/Conference proceedingChapter

2010
1 Citation (Scopus)

Editorial

Boyer, L. V., Nov 2010, In : International Immunopharmacology. 10, 11, p. 1317 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Scorpion antivenom administered by alternative infusions

Hiller, K. M., Jarrod, M. M., Franke, H. A., Degan, J., Boyer, L. V. & Fox, F. M., Sep 2010, In : Annals of Emergency Medicine. 56, 3, p. 309-310 2 p.

Research output: Contribution to journalArticle

Intraosseous Infusions
Scorpion Stings
Spider Bites
Scorpion Venoms
Antivenins
2 Citations (Scopus)

The 3 + 3 dose escalation design is not appropriate for antivenom dose finding

Chippaux, J. P. & Boyer, L. V., Jun 2010, In : Toxicon. 55, 7, p. 1408-1409 2 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Antivenins
Snake Bites
Maximum Tolerated Dose
Research Design
2009
47 Citations (Scopus)

AAPCC database characterization of native U.S. venomous snake exposures, 2001-2005

Seifert, S. A., Boyer, L. V., Benson, B. E. & Rogers, J. J., 2009, In : Clinical Toxicology. 47, 4, p. 327-335 9 p.

Research output: Contribution to journalArticle

Agkistrodon
Crotalus
Snakes
Poisons
Databases
105 Citations (Scopus)

Antivenom for critically ill children with neurotoxicity from scorpion stings

Boyer, L. V., Theodorou, A. A., Berg, R. A., Mallie, J., Chávez-Méndez, A., García-Ubbelohde, W., Hardiman, S. & Alagón, A., May 14 2009, In : New England Journal of Medicine. 360, 20, p. 2090-2098 9 p.

Research output: Contribution to journalArticle

Scorpion Stings
Antivenins
Scorpions
Critical Illness
Placebos
13 Citations (Scopus)

Serum levels and urine detection of Centruroides sculpturatus venom in significantly envenomated patients

Chase, P., Boyer, L. V., Mcnally, J., Vazquez, H. L., Theodorou, A. A., Walter, F. G. & Alagon, A., Feb 2009, In : Clinical Toxicology. 47, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

Venoms
Urine
Serum
Immunosorbents
Assays
2 Citations (Scopus)

The authors reply

Boyer, L. V., Alagón, A. & Theodorou, A. A., Aug 6 2009, In : New England Journal of Medicine. 361, 6, p. 632 1 p.

Research output: Contribution to journalArticle

2008
7 Citations (Scopus)

Toxicologic Information Resources for Reptile Envenomations

McNally, J., Boesen, K. J. & Boyer, L. V., May 2008, In : Veterinary Clinics of North America - Exotic Animal Practice. 11, 2, p. 389-401 13 p.

Research output: Contribution to journalArticle

Reptiles
information sources
reptiles
snakes
Snake Bites
2007
11 Citations (Scopus)

Toxic Exposure Surveillance System (TESS)-based characterization of U.S. non-native venomous snake exposures, 1995-2004

Seifert, S. A., Oakes, J. A. & Boyer, L. V., Jul 2007, In : Clinical Toxicology. 45, 5, p. 571-578 8 p.

Research output: Contribution to journalArticle

Snakes
Poisons
Databases
Antivenins
Intensive care units
2006
6 Citations (Scopus)

Resistance of antivenom proteins to foaming-induced denaturation

Kanavage, A. D., Boyer, L. V., McNally, J. & Osterhout, J. J., Mar 15 2006, In : Toxicon. 47, 4, p. 445-452 8 p.

Research output: Contribution to journalArticle

Antivenins
Denaturation
Proteins
Protein Unfolding
Protein Refolding

Spider Bite: Management of Wilderness and Environmental Emergen

Boyer, L., Binford, G. & McNally, J., 2006, Wilderness Medicine: Management of Wilderness and Environmental Emergen. Auerbach, P. (ed.). 5th ed. St. Louis: Mosby

Research output: Chapter in Book/Report/Conference proceedingChapter

2005

Understanding the Hazards: Toxicity and Safety: A Museum Resource for Managing Contaminated Cultur

Boyer, L. V., Seifert, S., Odegaard, N., Pool, M. & Burroughs, G. E., 2005, Old Poisons, new Problems: A Museum Resource for Managing Contaminated Cultur. Odegaard, N. & Sadongei, A. (eds.). AltaMira Press, div of Rowman & Littlefield Publishers, Inc, p. 73-84

Research output: Chapter in Book/Report/Conference proceedingChapter

2004
28 Citations (Scopus)

Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing

Valdez-Cruz, N. A., Dávila, S., Licea, A., Corona, M., Zamudio, F. Z., García-Valdes, J., Boyer, L. V. & Possani, L. D., Jun 2004, In : Biochimie. 86, 6, p. 387-396 10 p.

Research output: Contribution to journalArticle

Scorpions
Venoms
Molecular Biology
Wood
Genes

Lead

Dart, R., Hurlbut, K. & Boyer, L. V., 2004, Medical Toxicology. Dart, R. (ed.). Philadelphia: Lippincott Williams & Wilkins, p. 1423-1431

Research output: Chapter in Book/Report/Conference proceedingChapter

Scorpion Envenomation

Boyer, L. V., 2004, Medical Toxicology. Dart, R. (ed.). 3rd ed. Philadelphia: Lippincott Williams & Wilkins, p. 1603-1605

Research output: Chapter in Book/Report/Conference proceedingChapter

2003

New Ideas for the Testing, Documentation, and Storage of Objects Previously Treated with Pesticides

Odegaard, N., Boyer, L., Huber, M. J., Kaplan, L., Kunioka, C., Moreno, T., Sadongei, A., Smith, D. R. & Zimmt, W., 2003, In : Objects Specialty Group Postprints. 10, p. 33-42

Research output: Contribution to journalArticle

Poison center medical error detection and prevention

Seifert, S. A., Boyer, L. V., Bronstein, A. C., Jacobitz, K. & McNally, J., 2003, In : Journal of Toxicology: Clinical Toxicology. 41, p. 685-686

Research output: Contribution to journalArticle

Venomous Reptile and Arthropod Bites and Stings

Boyer, L., 2003, Pediatric Dermatology. Schrachner, L. A. & Hansen, R. C. (eds.). 3rd ed. St. Louis: Mosby, p. 1260-1265

Research output: Chapter in Book/Report/Conference proceedingChapter