Amanda F Baker

  • 2529 Citations
  • 28 h-Index
1978 …2018

Research output per year

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Research Output

  • 2529 Citations
  • 28 h-Index
  • 49 Article
  • 3 Review article
  • 2 Chapter
  • 1 Letter
2018

Characterization of carfilzomib-resistant non-small cell lung cancer cell lines

Hanke, N. T., Imler, E., Marron, M. T., Seligmann, B. E., Garland, L. L. & Baker, A. F., Jul 1 2018, In : Journal of Cancer Research and Clinical Oncology. 144, 7, p. 1317-1327 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Detecting in vivo urokinase plasminogen activator activity with a catalyCEST MRI contrast agent

Sinharay, S., Howison, C. M., Baker, A. F. & Pagel, M. M., Jul 1 2017, In : NMR in Biomedicine. 30, 7, e3721.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI

Akhenblit, P. J., Hanke, N. T., Gill, A., Persky, D. O., Howison, C. M., Pagel, M. M. & Baker, A. F., 2016, In : Molecular Imaging. 15

Research output: Contribution to journalArticle

10 Scopus citations

Best Practices in Evaluating Novel Biomarker Fit for Purpose and Translatability

Baker, A. F., Jan 1 2016, Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers. wiley, p. 489-494 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
17 Scopus citations

MR imaging biomarkers to monitor early response to hypoxia-activated prodrug TH-302 in pancreatic cancer xenografts

Zhang, X., Wojtkowiak, J. W., Martinez, G. V., Cornnell, H. H., Hart, C. P., Baker, A. F. & Gillies, R., May 1 2016, In : PloS one. 11, 5, e0155289.

Research output: Contribution to journalArticle

13 Scopus citations

Promoting adoption of the 3Rs through regulatory qualification

Walker, E. G., Baker, A. F. & Sauer, J. M., 2016, In : ILAR Journal. 57, 2, p. 221-225 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models

Chen, L. Q., Howison, C. M., Spier, C., Stopeck, A. T., Malm, S. W., Pagel, M. D. & Baker, A. F., May 1 2015, In : Leukemia and Lymphoma. 56, 5, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evaluation of a Hypoxia Regulated Gene Panel in Ovarian Cancer

Baker, A. F., Malm, S. W., Pandey, R., Laughren, C., Cui, H., Roe, D. & Chambers, S. K., May 22 2015, In : Cancer Microenvironment. 8, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Radiosensitization of Hs-766T pancreatic tumor xenografts in mice dosed with dodecafluoropentane nano-emulsion-preliminary findings

Johnson, J. L. H., Leos, R. A., Baker, A. F. & Unger, E. C., Feb 1 2015, In : Journal of Biomedical Nanotechnology. 11, 2, p. 274-281 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines

Malm, S. W., Hanke, N. T., Gill, A., Carbajal, L. & Baker, A. F., Apr 1 2015, In : Journal of Experimental and Clinical Cancer Research. 34, 1, 31.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

Baker, A. F., Hanke, N. T., Sands, B. J., Carbajal, L., Anderl, J. L. & Garland, L. L., Jan 1 2014, In : Journal of Experimental and Clinical Cancer Research. 33, 1, 111.

Research output: Contribution to journalArticle

22 Scopus citations

Clinical and economic burden of Richter syndrome in inpatient cases of chronic lymphocytic leukemia within the United States, 2001-2010

Skrepnek, G. H., Tate, W. R. & Baker, A. F., Apr 2014, In : Leukemia and Lymphoma. 55, 4, p. 834-840 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Detection of in vivo enzyme activity with CatalyCEST MRI

Yoo, B., Sheth, V. R., Howison, C. M., Douglas, M. J. K., Pineda, C. T., Maine, E. A., Baker, A. F. & Pagel, M. D., Mar 2014, In : Magnetic Resonance in Medicine. 71, 3, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug th-302 in pancreatic cancer

Bailey, K. M., Cornnell, H. H., Ibrahim-Hashim, A., Wojtkowiak, J. W., Hart, C. P., Zhang, X., Leos, R., Martinez, G. V., Baker, A. F. & Gillies, R. J., Dec 22 2014, In : PloS one. 9, 12

Research output: Contribution to journalArticle

9 Scopus citations

Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001)

Dragovich, T., Laheru, D., Dayyani, F., Bolejack, V., Smith, L., Seng, J., Burris, H., Rosen, P., Hidalgo, M., Ritch, P., Baker, A. F., Raghunand, N., Crowley, J. & Von Hoff, D. D., Aug 2014, In : Cancer Chemotherapy And Pharmacology. 74, 2, p. 379-387 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Reproducibility of magnetic resonance perfusion imaging

Zhang, X., Pagel, M. D., Baker, A. F. & Gillies, R. J., Feb 25 2014, In : PloS one. 9, 2, e89797.

Research output: Contribution to journalArticle

14 Scopus citations
2013

A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Baker, A. F., Adab, K. N., Raghunand, N., Chow, H. H. S., Stratton, S. P., Squire, S. W., Boice, M., Pestano, L. A., Kirkpatrick, D. L. & Dragovich, T., Jun 1 2013, In : Investigational New Drugs. 31, 3, p. 631-641 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Investigation of bendamustine HCL in a Phase 2 study in women with resistant ovarian cancer

Baker, A. F., Roe, D. J., Laughren, C., Cohen, J. L., Wright, H. M., Clouser, M. C., Cui, H., Alberts, D. S. & Chambers, S. K., Feb 1 2013, In : Investigational New Drugs. 31, 1, p. 160-166 7 p.

Research output: Contribution to journalArticle

Opportunities and challenges of safety biomarker qualification: perspectives from the predictive safety testing consortium

Dennis, E. H., Walker, E. G., Baker, A. F. & Miller, R. T., Mar 1 2013, In : Drug Development Research. 74, 2, p. 112-126 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines

Block, K. M., Hanke, N. T., Maine, E. A. & Baker, A. F., Jul 1 2012, In : Pancreas. 41, 5, p. 773-781 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model

Cárdenas-Rodríguez, J., Li, Y., Galons, J. P., Cornnell, H., Gillies, R. J., Pagel, M. D. & Baker, A. F., Sep 1 2012, In : Magnetic Resonance Imaging. 30, 7, p. 1002-1009 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging

Stephen, R. M., Pagel, M. D., Brown, K., Baker, A. F., Meuillet, E. J. & Gillies, R. J., Nov 1 2012, In : Experimental Biology and Medicine. 237, 11, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: Optimization of dosing regimens and schedules

Liu, Q., Sun, J. D., Wang, J., Ahluwalia, D., Baker, A. F., Cranmer, L. D., Ferraro, D., Wang, Y., Duan, J. X., Ammons, W. S., Curd, J. G., Matteucci, M. D. & Hart, C. P., Jun 1 2012, In : Cancer Chemotherapy And Pharmacology. 69, 6, p. 1487-1498 12 p.

Research output: Contribution to journalArticle

66 Scopus citations
2011

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase

Kim, Y. H., Coon, A., Baker, A. F. & Powis, G., Aug 1 2011, In : Cancer Chemotherapy And Pharmacology. 68, 2, p. 405-413 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination

Ramanathan, R. K., Abbruzzese, J., Dragovich, T., Kirkpatrick, L., Guillen, J. M., Baker, A. F., Pestano, L. A., Green, S. & Von Hoff, D. D., Mar 1 2011, In : Cancer Chemotherapy And Pharmacology. 67, 3, p. 503-509 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Management strategies in pancreatic cancer

Campen, C. J., Dragovich, T. & Baker, A. F., Apr 1 2011, In : American Journal of Health-System Pharmacy. 68, 7, p. 573-584 12 p.

Research output: Contribution to journalReview article

22 Scopus citations
2010

Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer

Chambers, S. K., Clouser, M. C., Baker, A. F., Roe, D. J., Cui, H., Brewer, M. A., Hatch, K. D., Gordon, M. S., Janicek, M. F., Isaacs, J. D., Gordon, A. N., Nagle, R. B., Wright, H. M., Cohen, J. L. & Alberts, D. S., Nov 1 2010, In : Clinical Cancer Research. 16, 21, p. 5320-5328 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

The development of pharmacodynamic endpoint models for evaluation of therapeutics in pancreatic cancer

Baker, A. F. & Dragovich, T., Dec 1 2010, Drug Discovery in Pancreatic Cancer: Models and Techniques. Springer New York, p. 271-289 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1α-induced gene in pancreatic cancer

Baker, A. F., Koh, M. Y., Williams, R. R., James, B., Wang, H., Tate, W. R., Gallegos, A., Von Hoff, D. D., Han, H. & Powis, G., Mar 1 2008, In : Pancreas. 36, 2, p. 178-186 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

A phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors

Ramanathan, R. K., Kirkpatrick, D. L., Belani, C. P., Friedland, D., Green, S. B., Chow, H. H. S., Cordova, C. A., Stratton, S. P., Shadow, E. R., Baker, A. & Dragovich, T., Apr 1 2007, In : Clinical Cancer Research. 13, 7, p. 2109-2114 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

The antitumor agent imexon activates antioxidant gene expression: Evidence for an oxidative stress response

Baker, A. F., Landowski, T., Dorr, R., Tate, W. R., Gard, J. M. C., Tavenner, B. E., Dragovich, T., Coon, A. & Powis, G., Jun 1 2007, In : Clinical Cancer Research. 13, 11, p. 3388-3394 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2006

Lenalidomide: Targeted anemia therapy for myelodysplastic syndromes

List, A. F., Baker, A. F., Green, S. & Bellamy, W., Dec 1 2006, In : Cancer Control. 13, SUPPL., p. 4-11 8 p.

Research output: Contribution to journalReview article

35 Scopus citations

Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127

Dragovich, T., McCoy, S., Fenoglio-Preiser, C. M., Wang, J., Benedetti, J. K., Baker, A. F., Hackett, C. B., Urba, S. G., Zaner, K. S., Blanke, C. D. & Abbruzzese, J. L., Oct 20 2006, In : Journal of Clinical Oncology. 24, 30, p. 4922-4927 6 p.

Research output: Contribution to journalArticle

289 Scopus citations

Suppressor of cytokine signaling-3 is overexpressed in erythroid precursors of myelodysplastic syndrome [2]

Baker, A. F., Bellamy, W., Tate, W. R., Bair, W. B., Heaton, R. & List, A. F., Sep 2006, In : Leukemia. 20, 9, p. 1620-1621 2 p.

Research output: Contribution to journalLetter

3 Scopus citations

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma

Baker, A. F., Dragovich, T., Tate, W. R., Ramanathan, R. K., Roe, D., Hsu, C. H., Kirkpatrick, D. L. & Powis, G., Feb 1 2006, In : Journal of Laboratory and Clinical Medicine. 147, 2, p. 83-90 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling

Williams, R., Baker, A. F., Ihle, N. T., Winkler, A. R., Kirkpatrick, L. & Powis, G., Oct 1 2006, In : Cancer Chemotherapy And Pharmacology. 58, 4, p. 444-450 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1α using PX-478

Jordan, B. F., Runquist, M., Raghunand, N., Baker, A., Williams, R., Kirkpatrick, L., Powis, G. & Gillies, R. J., May 2005, In : Neoplasia. 7, 5, p. 475-485 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Stability of phosphoprotein as a biological marker of tumor signaling

Baker, A. F., Dragovich, T., Ihle, N. T., Williams, R., Fenoglio-Preiser, C. & Powis, G., Jun 15 2005, In : Clinical Cancer Research. 11, 12, p. 4338-4340 3 p.

Research output: Contribution to journalArticle

134 Scopus citations

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

Ihle, N. T., Paine-Murrieta, G., Berggren, M. I., Baker, A., Tate, W. R., Wipf, P., Abraham, R. T., Kirkpatrick, D. L. & Powis, G., Sep 2005, In : Molecular Cancer Therapeutics. 4, 9, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

142 Scopus citations

The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging

Jordan, B. F., Runquist, M., Raghunand, N., Gillies, R. J., Tate, W. R., Powis, G. & Baker, A. F., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 529-536 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2004

In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316

Meuillet, E. J., Ihle, N., Baker, A. F., Gard, J. M., Stamper, C., Williams, R., Coon, A., Mahadevan, D., George, B. L., Kirkpatrick, L. & Powis, G., Jan 1 2004, In : Oncology Research. 14, 10, p. 513-527 15 p.

Research output: Contribution to journalArticle

54 Scopus citations
2001

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth

Tome, M. E., Baker, A. F., Powis, G., Payne, C. M. & Briehl, M. M., Mar 15 2001, In : Cancer Research. 61, 6, p. 2766-2773 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Drug interactions with the taxanes: Clinical implications

Baker, A. F. & Dorr, R. T., Jan 1 2001, In : Cancer Treatment Reviews. 27, 4, p. 221-233 13 p.

Research output: Contribution to journalArticle

48 Scopus citations
98 Scopus citations
2000

Redox control of caspase-3 activity by thioredoxin and other reduced proteins

Baker, A., Santos, B. D. & Powis, G., Feb 5 2000, In : Biochemical and Biophysical Research Communications. 268, 1, p. 78-81 4 p.

Research output: Contribution to journalArticle

44 Scopus citations
1998

Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Dorr, R. T., Bellamy, W., Liddil, J. D., Baker, A. & Bair, K. W., Oct 1 1998, In : Anti-Cancer Drug Design. 13, 7, p. 825-835 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Thioredoxin redox control of cell growth and death and the effects of inhibitors

Powis, G., Kirkpatrick, D. L., Angulo, M. & Baker, A., Apr 24 1998, In : Chemico-Biological Interactions. 111-112, p. 23-34 12 p.

Research output: Contribution to journalArticle

89 Scopus citations
1997

Modulation of antioxidant defenses during apoptosis

Briehl, M. M., Baker, A. F., Siemankowski, L. M. & Morreale, J., Dec 1 1997, In : Oncology Research. 9, 6-7, p. 281-285 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Redox signaling and the control of cell growth and death.

Powis, G., Gasdaska, J. R. & Baker, A., 1997, In : Advances in Pharmacology. 38, p. 329-359 31 p.

Research output: Contribution to journalArticle