Andrew Kraft

  • 10100 Citations
  • 55 h-Index
1978 …2020

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2020

PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth

Singh, N., Padi, S. K. R., Bearss, J. J., Pandey, R., Okumura, K., Beltran, H., Song, J. H., Kraft, A. S. & Olive, V., 2020, (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth

Padi, S. K. R., Singh, N., Bearss, J. J., Olive, V., Song, J. H., Cardó-Vila, M., Kraft, A. S. & Okumura, K., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20505-20510 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Song, J. H., Kang, H. J., Luevano, L. A., Gokhale, V., Wu, K., Pandey, R., Sherry Chow, H. H., Hurley, L. H. & Kraft, A. S., Aug 15 2019, In : Cell Chemical Biology. 26, 8, p. 1110-1121.e4

Research output: Contribution to journalArticle

7 Scopus citations

Targeting PIM kinase with PD1 inhibition improves immunotherapeutic antitumor t-cell response

Chatterjee, S., Chakraborty, P., Daenthanasanmak, A., Iamsawat, S., Andrejeva, G., Luevano, L. A., Wolf, M., Baliga, U., Krieg, C., Beeson, C. C., Mehrotra, M., Hill, E. G., Rathmell, J. C., Yu, X. Z., Kraft, A. S. & Mehrotra, S., Feb 1 2019, In : Clinical Cancer Research. 25, 3, p. 1036-1049 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Hypoxia-inducible PIM kinase expression promotes resistance to antiangiogenic agents

Casillas, A. L., Toth, R. K., Sainz, A. G., Singh, N., Desai, A., Kraft, A. & Warfel, N. A., Jan 1 2018, In : Clinical Cancer Research. 24, 1, p. 169-180 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanisms behind resistance to PI3K inhibitor treatment induced by the PIM kinase

Song, J. H., Singh, N., Luevano, L. A., Padi, S. K. R., Okumura, K., Olive, V., Black, S. M., Warfel, N. A., Goodrich, D. W. & Kraft, A. S., Dec 2018, In : Molecular Cancer Therapeutics. 17, 12, p. 2710-2721 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

Daenthanasanmak, A., Wu, Y., Iamsawat, S., Nguyen, H. D., Bastian, D., Zhang, M. M., Sofi, M. H., Chatterjee, S., Hill, E. G., Mehrotra, S., Kraft, A. S. & Yu, X. Z., Jul 2 2018, In : Journal of Clinical Investigation. 128, 7, p. 2787-2801 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Angiosarcoma treated successfully with anti-PD-1 therapy - a case report

Sindhu, S., Gimber, L. H., Cranmer, L., McBride, A. & Kraft, A. S., Jul 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 58.

Research output: Contribution to journalArticle

37 Scopus citations

Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset

Padi, S. K. R., Luevano, L. A., An, N., Pandey, R., Singh, N., Song, J. H., Aster, J. C., Yu, X. Z., Mehrotra, S. & Kraft, A. S., 2017, In : Oncotarget. 8, 18, p. 30199-30216 18 p.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

Song, J. H., Padi, S. K. R., Luevano, L. A., Minden, M. D., DeAngelo, D. J., Hardiman, G., Ball, L. E., Warfel, N. A. & Kraft, A. S., Apr 12 2016, In : Oncotarget. 7, 15, p. 20152-20165 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Pim1 kinase regulates c-Kit gene translation

An, N., Cen, B., Cai, H., Song, J. H., Kraft, A. & Kang, Y., Dec 30 2016, In : Experimental Hematology and Oncology. 5, 1, 31.

Research output: Contribution to journalArticle

9 Scopus citations

PIM Kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species

Warfel, N. A., Sainz, A. G., Song, J. H. & Kraft, A., Jul 1 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1637-1647 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Activation of pim kinases is sufficient to promote resistance to MET small-molecule inhibitors

An, N., Xiong, Y., LaRue, A. C., Kraft, A. S. & Cen, B., Dec 15 2015, In : Cancer Research. 75, 24, p. 5318-5328 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing

Song, J. H., An, N., Chatterjee, S., Kistner-Griffin, E., Mahajan, S., Mehrotra, S. & Kraft, A., Jul 1 2015, In : Oncogene. 34, 28, p. 3728-3736 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of prostate stromal fibroblasts by the PIM1 protein kinase

Zemskova, M. Y., Song, J. H., Cen, B., Cerda-Infante, J., Montecinos, V. P. & Kraft, A. S., Jan 1 2015, In : Cellular Signalling. 27, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Metabolic dysfunction consistent with premature aging results from deletion of pim kinases

Din, S., Konstandin, M. H., Johnson, B., Emathinger, J., Völkers, M., Toko, H., Collins, B., Ormachea, L., Samse, K., Kubli, D. A., De La Torre, A., Kraft, A. S., Gustafsson, A. B., Kelly, D. P. & Sussman, M. A., Jul 18 2014, In : Circulation research. 115, 3, p. 376-387 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phase I trial of weekly docetaxel, total androgen blockade, and image-guided intensity-modulated radiotherapy for localized high-risk prostate adenocarcinoma

Marshall, D. T., Ramey, S., Golshayan, A. R., Keane, T. E., Kraft, A. S. & Chaudhary, U., Apr 2014, In : Clinical Genitourinary Cancer. 12, 2, p. 80-86 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Reducing CD73 expression by IL1β-programmed Th17 cells improves immunotherapeutic control of tumors

Chatterjee, S., Thyagarajan, K., Kesarwani, P., Song, J. H., Soloshchenko, M., Fu, J., Bailey, S. R., Vasu, C., Kraft, A. S., Paulos, C. M., Yu, X. Z. & Mehrotra, S., Nov 1 2014, In : Cancer Research. 74, 21, p. 6048-6059 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling

Cen, B., Xiong, Y., Song, J. H., Mahajan, S., DuPont, R., McEachern, K., DeAngelo, D. J., Cortes, J. E., Minden, M. D., Ebens, A., Mims, A., LaRue, A. C. & Kraft, A. S., Jul 2014, In : Molecular and cellular biology. 34, 13, p. 2517-2532 16 p.

Research output: Contribution to journalArticle

34 Scopus citations

The PIM family of oncoproteins: Small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets

Saurabh, K., Scherzer, M. T., Shah, P. P., Mims, A. S., Lockwood, W. W., Kraft, A. S. & Beverly, L. J., 2014, In : Oncotarget. 5, 18, p. 8503-8514 12 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2013

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

An, N., Kraft, A. S. & Kang, Y., Jan 31 2013, In : Journal of Hematology and Oncology. 6, 1, 12.

Research output: Contribution to journalArticle

27 Scopus citations

A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy

Twardowski, P. W., Beumer, J. H., Chen, C. S., Kraft, A. S., Chatta, G. S., Mitsuhashi, M., Ye, W., Christner, S. M. & Lilly, M. B., Aug 1 2013, In : Anti-cancer drugs. 24, 7, p. 743-753 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: A multicentre, open-label, phase 2 trial

Schwartz, G. K., Tap, W. D., Qin, L. X., Livingston, M. B., Undevia, S. D., Chmielowski, B., Agulnik, M., Schuetze, S. M., Reed, D. R., Okuno, S. H., Ludwig, J. A., Keedy, V., Rietschel, P., Kraft, A. S., Adkins, D., Van Tine, B. A., Brockstein, B., Yim, V., Bitas, C., Abdullah, A. & 8 others, Antonescu, C. R., Condy, M., Dickson, M. A., Vasudeva, S. D., Ho, A. L., Doyle, L. A., Chen, H. X. & Maki, R. G., Apr 2013, In : The Lancet Oncology. 14, 4, p. 371-382 12 p.

Research output: Contribution to journalArticle

126 Scopus citations

Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1

Cen, B., Mahajan, S., Wang, W. & Kraft, A. S., Jun 1 2013, In : Cancer Research. 73, 11, p. 3402-3411 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells

An, N., Lin, Y. W., Mahajan, S., Kellner, J. N., Wang, Y., Li, Z., Kraft, A. S. & Kang, Y., Jun 1 2013, In : Stem Cells. 31, 6, p. 1202-1212 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeted glycoprotein enrichment and identification in stromal cell secretomes using azido sugar metabolic labeling

Roper, S. M., Zemskova, M., Neely, B. A., Martin, A., Gao, P., Jones, E. E., Kraft, A. S. & Drake, R. R., Jun 2013, In : Proteomics - Clinical Applications. 7, 5-6, p. 367-371 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Collaboration of kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer

Cai, H., Memarzadeh, S., Stoyanova, T., Beharry, Z., Kraft, A. S. & Witte, O. N., Sep 15 2012, In : Cancer Research. 72, 18, p. 4672-4681 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation

Yoshimi, M., Goyama, S., Kawazu, M., Nakagawa, M., Ichikawa, M., Imai, Y., Kumano, K., Asai, T., Mulloy, J. C., Kraft, A. S., Takahashi, T., Shirafuji, N. & Kurokawa, M., Apr 2012, In : European Journal of Immunology. 42, 4, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737

Song, J. H. & Kraft, A. S., Jan 1 2012, In : Cancer Research. 72, 1, p. 294-303 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2011

Combination therapy of recurrent prostate cancer with the proteasome inhibitor bortezomib plus hormone blockade

Kraft, A. S., Garrett-Mayer, E., Wahlquist, A. E., Golshayan, A., Chen, C. S., Butler, W., Bearden, J. & Lilly, M., Jul 15 2011, In : Cancer Biology and Therapy. 12, 2, p. 119-124 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The BH3 mimetic ABT-737 induces cancer cell senescence

Song, J. H., Kandasamy, K., Zemskova, M., Lin, Y. W. & Kraft, A. S., Jan 15 2011, In : Cancer Research. 71, 2, p. 506-515 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

The Pim protein kinases regulate energy metabolism and cell growth

Beharry, Z., Mahajan, S., Zemskova, M., Lin, Y. W., Tholanikunnel, B. G., Xia, Z., Smith, C. D. & Kraft, A. S., Jan 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 540-545 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

The Pim protein kinases regulate energy metabolism and cell growth.

Beharry, Z., Mahajan, S., Zemskova, M., Lin, Y. W., Tholanikunnel, B. G., Xia, Z., Smith, C. D. & Kraft, A. S., Jan 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 528-533 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2010

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

Lin, Y. W., Beharry, Z. M., Hill, E. G., Song, J. H., Wang, W., Xia, Z., Zhang, Z., Aplan, P. D., Aster, J. C., Smith, C. D. & Kraft, A. S., Jan 28 2010, In : Blood. 115, 4, p. 824-833 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase

Zemskova, M., Lilly, M. B., Lin, Y. W., Song, J. H. & Kraft, A. S., Aug 2010, In : Molecular Cancer Research. 8, 8, p. 1126-1141 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of Skp2 levels by the Pim-1 protein kinase

Cen, B., Mahajan, S., Zemskova, M., Beharry, Z., Lin, Y. W., Cramer, S. D., Lilly, M. B. & Kraft, A. S., Sep 17 2010, In : Journal of Biological Chemistry. 285, 38, p. 29128-29137 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

Beharry, Z., Zemskova, M., Mahajan, S., Zhang, F., Ma, J., Xia, Z., Lilly, M., Smith, C. D. & Kraft, A. S., Jun 1 2009, In : Molecular Cancer Therapeutics. 8, 6, p. 1473-1483 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Phase II study of sorafenib in patients with metastatic or recurrent sarcomas

Maki, R. G., D'Adamo, D. R., Keohan, M. L., Saulle, M., Schuetze, S. M., Undevia, S. D., Livingston, M. B., Cooney, M. M., Hensley, M. L., Mita, M. M., Takimoto, C. H., Kraft, A. S., Elias, A. D., Brockstein, B., Blachère, N. E., Edgar, M. A., Schwartz, L. H., Qin, L. X., Antonescu, C. R. & Schwartz, G. K., Jul 1 2009, In : Journal of Clinical Oncology. 27, 19, p. 3133-3140 8 p.

Research output: Contribution to journalArticle

389 Scopus citations

PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

Zhang, F., Beharry, Z. M., Harris, T. E., Lilly, M. B., Smith, C. D., Mahajan, S. & Kraft, A. S., May 1 2009, In : Cancer Biology and Therapy. 8, 9, p. 846-853 8 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Synthesis and evaluation of novel inhibitors of pim-1 and pim-2 protein kinases

Xia, Z., Knaak, C., Jian, M., Beharry, Z. M., McInnes, C., Wang, W., Kraft, A. S. & Smith, C. D., Jan 8 2009, In : Journal of Medicinal Chemistry. 52, 1, p. 74-86 13 p.

Research output: Contribution to journalArticle

145 Scopus citations
2008

ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis

Song, J. H., Kandasamy, K. & Kraft, A. S., Sep 5 2008, In : Journal of Biological Chemistry. 283, 36, p. 25003-25013 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Hypoxia-inducible factor-2α regulates the expression of TRAIL receptor DR5 in renal cancer cells

Mahajan, S., Dammai, V., Hsu, T. & Kraft, A. S., Sep 22 2008, In : Carcinogenesis. 29, 9, p. 1734-1741 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3′-untranslated region

Kandasamy, K. & Kraft, A. S., Oct 13 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

Bortezomib in combination with celecoxib in patients with advanced solid tumors: A phase I trial

Hayslip, J., Chaudhary, U., Green, M., Meyer, M., Dunder, S., Sherman, C., Salzer, S., Kraft, A. & Montero, A. J., Dec 3 2007, In : BMC Cancer. 7, 221.

Research output: Contribution to journalArticle

11 Scopus citations

Cell cycle dependent antagonistic interactions between paclitaxel and carboplatin in combination therapy

Xiong, X., Sui, M., Fan, W. & Kraft, A. S., Jul 2007, In : Cancer Biology and Therapy. 6, 7, p. 1067-1073 7 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Fatal rhabdomyolysis as a complication of ET-743 (Yondelis) chemotherapy for sarcoma

Skorupa, A., Beldner, M., Kraft, A. & Montero, A. J., Jul 2007, In : Cancer Biology and Therapy. 6, 7, p. 1015-1017 3 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Negative regulation of Pim-1 protein kinase levels by the B56β subunit of PP2A

Ma, J., Arnold, H. K., Lilly, M. B., Sears, R. C. & Kraft, A. S., Aug 2 2007, In : Oncogene. 26, 35, p. 5145-5153 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

Beldner, M. A., Sherman, C. A., Green, M. R., Garrett-Mayer, E., Chaudhary, U., Meyer, M. L., Kraft, A. S. & Montero, A. J., Dec 20 2007, In : BMC Cancer. 7, 231.

Research output: Contribution to journalArticle

4 Scopus citations

Regulation of RUNX1/AML1 during the G2/M transition

Wang, S., Zhang, Y., Soosairajah, J. & Kraft, A. S., Jun 1 2007, In : Leukemia Research. 31, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2006

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex

Biggs, J. R., Peterson, L. F., Zhang, Y., Kraft, A. S. & Zhang, D. E., Oct 2006, In : Molecular and cellular biology. 26, 20, p. 7420-7429 10 p.

Research output: Contribution to journalArticle

55 Scopus citations