• 761 Citations
  • 15 h-Index
20072020

Research output per year

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Research Output

2020

Surfing the right ventricular pressure waveform: methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization

Vanderpool, R. R., Puri, R., Osorio, A., Wickstrom, K., Desai, A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Rischard, F. P., Jan 1 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension

Wang, Z., Yang, K., Zheng, Q., Zhang, C., Tang, H., Babicheva, A., Jiang, Q., Li, M., Chen, Y., Carr, S. G., Wu, K., Zhang, Q., Balistrieri, A., Wang, C., Song, S., Ayon, R. J., Desai, A., Black, S. M., Garcia, J. G. N., Makino, A. & 3 others, Yuan, J. X. J., Lu, W. & Wang, J., Jan 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 1, p. L216-L228

Research output: Contribution to journalArticle

3 Scopus citations

Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension

Rafikov, R., Nair, V., Sinari, S., Babu, H., Sullivan, J. C., Yuan, J. X. J., Desai, A. A. & Rafikova, O., Nov 1 2019, In : Antioxidants and Redox Signaling. 31, 13, p. 917-932 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium & US PAH Biobank Consortium, Mar 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction

Liu, Z., Barber, C., Gupta, A., Wan, L., Won, Y. W., Furenlid, L. R., Chen, Q., Desai, A. A., Zhao, M., Bull, D. A., Unger, E. C. & Martin, D. R., Mar 2019, In : Nuclear Medicine and Biology. 70, p. 67-77 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension

Whitaker, M. E., Nair, V., Sinari, S., Dherange, P. A., Natarajan, B., Trutter, L., Brittain, E. L., Hemnes, A. R., Austin, E. D., Patel, K., Black, S. M., Garcia, J. GN., Yuan, MD PhD, J. X., Vanderpool, R. R., Rischard, F., Makino, A., Bedrick, E. J. & Desai, A., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

3 Scopus citations

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H., Babicheva, A., McDermott, K., Gu, Y., Ayon, R. J., Song, S., Wang, Z., Gupta, A., Zhou, T., Sun, X., Dash, S., Wang, Z., Balistrieri, A., Zheng, Q., Cordery, A. G., Desai, A., Rischard, F., Khalpey, Z. I., Wang, J., Black, S. M. & 3 others, Garcia, J. GN., Makino, A. & Yuan, J., Feb 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

34 Scopus citations

Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients

Duarte, J. D., Kansal, M., Desai, A. A., Riden, K., Arwood, M. J., Yacob, A. A., Stamos, T. D., Cavallari, L. H., Zamanian, R. T., Shah, S. J. & Machado, R. F., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

2 Scopus citations

Hemolysis-induced lung vascular leakage contributes to the development of pulmonary hypertension

Rafikova, O., Williams, E. R., McBride, M. L., Zemskova, M., Srivastava, A., Nair, V., Desai, A., Langlais, P. R., Zemskov, E., Simon, M., Mandarino, L. J. & Rafikov, R., Sep 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 59, 3, p. 334-345 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Hypoxia-inducible PIM kinase expression promotes resistance to antiangiogenic agents

Casillas, A. L., Toth, R. K., Sainz, A. G., Singh, N., Desai, A., Kraft, A. & Warfel, N. A., Jan 1 2018, In : Clinical Cancer Research. 24, 1, p. 169-180 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18

Gross, C. M., Kellner, M., Wang, T., Lu, Q., Sun, X., Zemskov, E. A., Noonepalle, S., Kangath, A., Kumar, S., Gonzalez-Garay, M., Desai, A., Aggarwal, S., Gorshkov, B., Klinger, C., Verin, A. D., Catravas, J. D., Jacobson, J. R., Yuan, J. X. J., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 614-624 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

New cases of glucose-6-phosphate dehydrogenase deficiency in pulmonary arterial hypertension

Kurdyukov, S., Eccles, C. A., Desai, A. A., Gonzalez-Garay, M., Yuan, J. X. J., Garcia, J. G. N., Rafikova, O. & Rafikov, R., Aug 2018, In : PloS one. 13, 8, e0203493.

Research output: Contribution to journalArticle

5 Scopus citations

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Tang, H., Wu, K., Wang, J., Vinjamuri, S., Gu, Y., Song, S., Wang, Z., Zhang, Q., Balistrieri, A., Ayon, R. J., Rischard, F., Vanderpool, R., Chen, J., Zhou, G., Desai, A. A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Makino, A., Dec 2018, In : JACC: Basic to Translational Science. 3, 6, p. 744-762 19 p.

Research output: Contribution to journalArticle

8 Scopus citations

Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

Rafikova, O., Srivastava, A., Desai, A. A., Rafikov, R. & Tofovic, S. P., Apr 23 2018, In : Respiratory Research. 19, 1, 69.

Research output: Contribution to journalArticle

10 Scopus citations

Right ventricular afterload predicts long-term transition from parenteral to oral treprostinil in pulmonary arterial hypertension

Maestas, T., Hansen, L. M., Vanderpool, R. R., Desai, A. A., Airhart, S., Knapp, S. M., Cohen, A., Feldman, J. & Rischard, F. P., Oct 1 2018, In : Pulmonary Circulation. 8, 4

Research output: Contribution to journalArticle

2017

Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis

Marsh, K. M., Ferng, A. S., Pilikian, T., Desai, A. A., Avery, R., Friedman, M., Oliva, I., Jokerst, C., Schipper, D. & Khalpey, Z., Jan 26 2017, In : Journal of Cardiothoracic Surgery. 12, 1, 6.

Research output: Contribution to journalArticle

1 Scopus citations

Association of circulating transcriptomic profiles with mortality in sickle cell disease

Desai, A. A., Lei, Z., Bahroos, N., Maienschein-Cline, M., Saraf, S. L., Zhang, X., Shah, B. N., Nouraie, S. M., Abbasi, T., Patel, A. R., Lang, R. M., Lussier, Y., Garcia, J. G. N., Gordeuk, V. R. & Machado, R. F., Jun 1 2017, In : Blood. 129, 22, p. 3009-3016 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH

Song, S., Ayon, R. J., Yamamura, A., Yamamura, H., Dash, S., Babicheva, A., Tang, H., Sun, X., Cordery, A. G., Khalpey, Z. I., Black, S. M., Desai, A., Rischard, F., McDermott, K., Garcia, J. GN., Makino, A. & Yuan, J., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L309-L325

Research output: Contribution to journalArticle

9 Scopus citations

Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Ferng, A., Connell, A., Nunez, M., Johnson, K., Braunhut, B., Lick, S. D., Desai, A., Kazui, T., Runyan, R. B. & Khalpey, Z. I., Sep 1 2017, In : Annals of Thoracic Surgery. 104, 3, p. e239-e241

Research output: Contribution to journalArticle

3 Scopus citations

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Palumbo, S., Shin, Y. J., Ahmad, K., Desai, A., Quijada, H., Mohamed, M., Knox, A., Sammani, S., Colson, B. A., Wang, T., Garcia, J. G. N. & Hecker, L., Mar 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L297-L308

Research output: Contribution to journalArticle

10 Scopus citations

Endothelial cell signaling and ventilator-induced lung injury: Molecular mechanisms, genomic analyses, and therapeutic targets

Wang, T., Gross, C., Desai, A., Zemskov, E., Wu, X., Garcia, A. N., Jacobson, J. R., Yuan, J., Garcia, J. GN. & Black, S. M., Apr 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, p. L452-L476

Research output: Contribution to journalReview article

25 Scopus citations

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension

Vanderpool, R. R., Desai, A., Knapp, S. M., Simon, M. A., Abidov, A., Yuan, J., Garcia, J. GN., Hansen, L. M., Knoper, S. R., Naeije, R. & Rischard, F., Aug 1 2017, In : The European respiratory journal. 50, 2

Research output: Contribution to journalLetter

13 Scopus citations

Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A. A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J. X. J., Catravas, J. D., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., Jan 1 2017, In : Free Radical Biology and Medicine. 102, p. 217-228 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Hypoxia-induced pulmonary hypertension in type 2 diabetic mice

Pan, M., Han, Y., Si, R., Guo, R., Desai, A. & Makino, A., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 175-185 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

MicroRNAs in Inflammatory Lung Disease

Bime, C., Gurguis, C. I., Hecker, L., Desai, A. A., Wang, T. & Garcia, J. G. N., Jan 1 2017, Translating MicroRNAs to the Clinic. Elsevier Inc., p. 135-177 43 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Abnormalities in aortic properties: a potential link between left ventricular diastolic function and ventricular—aortic coupling in sickle cell disease

Bollache, E., Kachenoura, N., Lang, R. M., Desai, A. A., Mor-Avi, V. & Patel, A. R., Jun 1 2016, In : International Journal of Cardiovascular Imaging. 32, 6, p. 965-973 9 p.

Research output: Contribution to journalArticle

Association of Impaired Glucose Regulation and Insulin Resistance with Cardiac Structure and Function: Results from ECHO-SOL (Echocardiographic Study of Latinos)

Demmer, R. T., Allison, M. A., Cai, J., Kaplan, R. C., Desai, A., Hurwitz, B. E., Newman, J. C., Shah, S. J., Swett, K., Talavera, G. A., Thai, A., Youngblood, M. E. & Rodriguez, C. J., Oct 1 2016, In : Circulation: Cardiovascular Imaging. 9, 10, 005032.

Research output: Contribution to journalArticle

7 Scopus citations

Associations of prolonged QTc in sickle cell disease

Indik, J. H., Nair, V., Rafikov, R., Nyotowidjojo, I. S., Bisla, J., Kansal, M., Parikh, D. S., Robinson, M., Desai, A., Oberoi, M., Gupta, A., Abbasi, T., Khalpey, Z., Patel, A. R., Lang, R. M., Dudley, S. C., Choi, B. R., Garcia, J. G. N., Machado, R. F. & Desai, A. A., Oct 2016, In : PloS one. 11, 10, e0164526.

Research output: Contribution to journalArticle

4 Scopus citations

Asymmetric dimethylarginine stimulates Akt1 phosphorylation via heat shock protein 70-facilitated carboxyl-terminal modulator protein degradation in pulmonary arterial endothelial cells

Sun, X., Kellner, M., Desai, A., Wang, T., Lu, Q., Kangath, A., Qu, N., Klinger, C., Fratz, S., Yuan, J., Jacobson, J. R., Garcia, J. GN., Rafikov, R., Fineman, J. R. & Black, S. M., Aug 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Comparison of echocardiographic measures in a hispanic/latino population with the 2005 and 2015 American society of echocardiography reference limits (The Echocardiographic Study of Latinos)

Qureshi, W. T., Leigh, J. A., Swett, K., Dharod, A., Allison, M. A., Cai, J., Gonzalez, F., Hurwitz, B. E., Shah, S. J., Desai, A. A., Spevack, D. M. & Rodriguez, C. J., Jan 1 2016, In : Circulation: Cardiovascular Imaging. 9, 1, e003597.

Research output: Contribution to journalArticle

9 Scopus citations

Endotoxin- and mechanical stress–induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter

Elangovan, V. R., Camp, S. M., Kelly, G. T., Desai, A. A., Adyshev, D., Sun, X., Black, S. M., Wang, T. & Garcia, J. G. N., Dec 1 2016, In : Pulmonary Circulation. 6, 4, p. 539-544 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genome-wide analysis identifies IL-18 and FUCA2 as novel genes associated with diastolic function in african americans with sickle cell disease

Duarte, J. D., Desai, A. A., Sysol, J. R., Abbasi, T., Patel, A. R., Lang, R. M., Gupta, A., Garcia, J. G. N., Gordeuk, V. R. & Machado, R. F., Sep 2016, In : PloS one. 11, 9, e0163013.

Research output: Contribution to journalArticle

1 Scopus citations

Metabolic changes precede the development of pulmonary hypertension in the monocrotaline exposed rat lung

Rafikova, O., Meadows, M. L., Kinchen, J. M., Mohney, R. P., Maltepe, E., Desai, A., Yuan, J., Garcia, J. GN., Fineman, J. R., Rafikov, R. & Black, S. M., Mar 1 2016, In : PLoS One. 11, 3, 0150480.

Research output: Contribution to journalArticle

20 Scopus citations

Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension

Tang, H., Yamamura, A., Yamamura, H., Song, S., Fraidenburg, D. R., Chen, J., Gu, Y., Pohl, N. M., Zhou, T., Jiménez-Pérez, L., Ayon, R. J., Desai, A., Goltzman, D., Rischard, F., Khalpey, Z. I., Black, S. M., Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Mar 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L846-L859

Research output: Contribution to journalArticle

32 Scopus citations
2015

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells

Rafikov, R., Sun, X., Rafikova, O., Louise Meadows, M., Desai, A., Khalpey, Z. I., Yuan, J., Fineman, J. R. & Black, S. M., Dec 1 2015, In : Redox Biology. 6, p. 278-286 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Role of gadd45a in murine models of radiation- and bleomycin-induced lung injury

Mathew, B., Takekoshi, D., Sammani, S., Epshtein, Y., Sharma, R., Smith, B. D., Mitra, S., Desai, A., Weichselbaum, R. R., Garcia, J. GN. & Jacobson, J. R., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1420-L1429

Research output: Contribution to journalArticle

1 Scopus citations
2014

ARTS: Automated randomization of multiple traits for study design

Maienschein-Cline, M., Lei, Z., Gardeux, V., Abbasi, T., Machado, R. F., Gordeuk, V., Desai, A. A., Saraf, S., Bahroos, N. & Lussier, Y., Jun 1 2014, In : Bioinformatics. 30, 11, p. 1637-1639 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: A pilot trial

Gao, G., Brahmanandam, V., Raicu, M., Gu, L., Zhou, L., Kasturirangan, S., Shah, A., Negi, S. I., Wood, M. R., Desai, A. A., Tatooles, A., Schwartz, A. & Dudley, S. C., Jun 3 2014, In : Journal of the American College of Cardiology. 63, 21, p. 2261-2269 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Erratum: Impact of cardiovascular magnetic resonance on management and clinical decision-making in heart failure patients (Journal of Cardiovascular Magnetic Resonance)

Abbasi, S. A., Ertel, A., Shah, R. V., Dandekar, V., Chung, J., Bhat, G., Desai, A. A., Kwong, R. Y. & Farzaneh-Far, A., Feb 21 2014, In : Journal of Cardiovascular Magnetic Resonance. 16, 1, 20.

Research output: Contribution to journalComment/debate

2 Scopus citations

Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease

Zhang, X., Zhang, W., Ma, S. F., Desai, A. A., Saraf, S., Miasniakova, G., Sergueeva, A., Ammosova, T., Xu, M., Nekhai, S., Abbasi, T., Casanova, N. G., Steinberg, M. H., Baldwin, C. T., Sebastiani, P., Prchal, J. T., Kittles, R., Garcia, J. G. N., MacHado, R. F. & Gordeuk, V. R., Apr 22 2014, In : Circulation. 129, 16, p. 1650-1658 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mechanistic insights and characterization of sickle cell disease-associated cardiomyopathy

Desai, A. A., Patel, A. R., Ahmad, H., Groth, J. V., Thiruvoipati, T., Turner, K., Yodwut, C., Czobor, P., Artz, N., MacHado, R. F., Garcia, J. G. N. & Lang, R. M., Jul 2014, In : Circulation: Cardiovascular Imaging. 7, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regression of cardiac amyloidosis after stem cell transplantation assessed by cardiovascular magnetic resonance imaging

Brahmanandam, V., McGraw, S., Mirza, O., Desai, A. A. & Farzaneh-Far, A., Jun 3 2014, In : Circulation. 129, 22, p. 2326-2328 3 p.

Research output: Contribution to journalComment/debate

12 Scopus citations
2013

Association of Aldosterone Synthase Polymorphism (CYP11B2 -344T>C) and Genetic Ancestry with Atrial Fibrillation and Serum Aldosterone in African Americans with Heart Failure

Bress, A., Han, J., Patel, S. R., Desai, A. A., Mansour, I., Groo, V., Progar, K., Shah, E., Stamos, T. D., Wing, C., Garcia, J. G. N., Kittles, R. & Cavallari, L. H., Jul 30 2013, In : PloS one. 8, 7, e71268.

Research output: Contribution to journalArticle

9 Scopus citations

Feasibility of implementing a comprehensive warfarin pharmacogenetics service

Nutescu, E. A., Drozda, K., Bress, A. P., Galanter, W. L., Stevenson, J., Stamos, T. D., Desai, A. A., Duarte, J. D., Gordeuk, V., Peace, D., Kadkol, S. S., Dodge, C., Saraf, S., Garofalo, J., Krishnan, J. A., Garcia, J. G. N. & Cavallari, L. H., Nov 2013, In : Pharmacotherapy. 33, 11, p. 1156-1164 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Impact of cardiovascular magnetic resonance on management and clinical decision-making in heart failure patients

Abbasi, S. A., Ertel, A., Shah, R. V., Dandekar, V., Chung, J., Bhat, G., Desai, A. A., Kwong, R. Y. & Farzaneh-Far, A., Oct 10 2013, In : Journal of Cardiovascular Magnetic Resonance. 15, 1, 89.

Research output: Contribution to journalArticle

45 Scopus citations
2012

A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease

Desai, A. A., Zhou, T., Ahmad, H., Zhang, W., Mu, W., Trevino, S., Wade, M. S., Raghavachari, N., Kato, G. J., Peters-Lawrence, M. H., Thiruvoipati, T., Turner, K., Artz, N., Huang, Y., Patel, A. R., Yuan, J. X. J., Gordeuk, V. R., Lang, R. M., Garcia, J. G. N. & Machado, R. F., Aug 15 2012, In : American journal of respiratory and critical care medicine. 186, 4, p. 359-368 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Are men at risk? The role of testosterone in cardiovascular morbidity

Sundivakkam, P. C., Desai, A., Smith, K. A. & Yuan, J., Jul 1 2012, In : Pulmonary Circulation. 2, 3, p. 275-277 3 p.

Research output: Contribution to journalEditorial

Evaluation of myocardial deformation in patients with sickle cell disease and preserved ejection fraction using three-dimensional speckle tracking echocardiography

Ahmad, H., Gayat, E., Yodwut, C., Abduch, M. C., Patel, A. R., Weinert, L., Desai, A., Tsang, W., Garcia, J. G. N., Lang, R. M. & Mor-Avi, V., Sep 1 2012, In : Echocardiography. 29, 8, p. 962-969 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Diagnostic and therapeutic algorithm for pulmonary arterial hypertension

Desai, A. & Machado, R. F., Jan 1 2011, In : Pulmonary Circulation. 1, 1, p. 122-124 3 p.

Research output: Contribution to journalArticle

5 Scopus citations