• 1495 Citations
  • 22 h-Index
1987 …2019
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Research Output 1987 2019

  • 1495 Citations
  • 22 h-Index
  • 63 Article
  • 3 Chapter
2019

Recessive Host Range Mutants and Unsusceptible Cells That Inactivate Virions without Genome Penetration: Ecological and Technical Implications

Roznowski, A. P., Young, R. J., Love, S. D., Andromita, A. A., Guzman, V. A., Wilch, M. H., Block, A., McGill, A., Lavelle, M., Romanova, A., Sekiguchi, A., Wang, M., Burch, A. D. & Fane, B. A., Feb 1 2019, In : Journal of virology. 93, 3

Research output: Contribution to journalArticle

Host Specificity
virion
host range
Virion
Genome
2017
1 Citation (Scopus)

Coat protein mutations that alter the flux of morphogenetic intermediates through the ϕ X174 early assembly pathway

Blackburn, B. J., Li, S., Roznowski, A. P., Perez, A. R., Villarreal, R. H., Johnson, C. J., Hardy, M., Tuckerman, E. C., Burch, A. D. & Fane, B. A., Dec 1 2017, In : Journal of Virology. 91, 24, e01384-17.

Research output: Contribution to journalArticle

scaffolding proteins
Capsid Proteins
coat proteins
mutation
Mutation
3 Citations (Scopus)

Elevating fitness after a horizontal gene exchange in bacteriophage φX174

Doore, S. M., Schweers, N. J. & Fane, B. A., Jan 15 2017, In : Virology. 501, p. 25-34 10 p.

Research output: Contribution to journalArticle

Bacteriophages
Genes
GTP-Binding Proteins
Proteins
Microvirus
18 Citations (Scopus)

Hawkmoths use nectar sugar to reduce oxidative damage from flight

Levin, E., Lopez-Martinez, G., Fane, B. A. & Davidowitz, G., Feb 17 2017, In : Science. 355, 6326, p. 733-735 3 p.

Research output: Contribution to journalArticle

Plant Nectar
Moths
Pentose Phosphate Pathway
Muscles
Antioxidants
7 Citations (Scopus)

Structural changes of tailless bacteriophage Φx174 during penetration of bacterial cell walls

Sun, Y., Roznowski, A. P., Tokuda, J. M., Klose, T., Mauney, A., Pollack, L., Fane, B. A. & Rossmann, M. G., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. 13708-13713 6 p.

Research output: Contribution to journalArticle

Bacteriophages
Cell Wall
Lipopolysaccharides
Genome
Cryoelectron Microscopy
2 Citations (Scopus)

φX174 procapsid assembly: Effects of an inhibitory external scaffolding protein and resistant coat proteins in vitro

Cherwa, J. E., Tyson, J., Bedwell, G. J., Brooke, D., Edwards, A. G., Dokland, T., Prevelige, P. E. & Fane, B. A., 2017, In : Journal of Virology. 91, 1, e01878-16.

Research output: Contribution to journalArticle

scaffolding proteins
Capsid Proteins
coat proteins
mutation
kinetics
2016
2 Citations (Scopus)

PhiXing-it, displaying foreign peptides on bacteriophage ΦX174

Christakos, K. J., Chapman, J. A., Fane, B. A. & Campos, S. K., Jan 15 2016, In : Virology. 488, p. 242-248 7 p.

Research output: Contribution to journalArticle

Bacteriophages
Virion
Peptides
G12-G13 GTP-Binding Protein alpha Subunits
Proteins
3 Citations (Scopus)

Structure-function analysis of the φX174 DNA-piloting protein using length-altering mutations

Roznowski, A. P. & Fane, B. A., 2016, In : Journal of Virology. 90, 17, p. 7956-7966 11 p.

Research output: Contribution to journalArticle

mutation
Mutation
DNA
Proteins
proteins
8 Citations (Scopus)

The microviridae: Diversity, assembly, and experimental evolution

Doore, S. M. & Fane, B. A., Apr 1 2016, In : Virology. 491, p. 45-55 11 p.

Research output: Contribution to journalArticle

Microviridae
Viruses
Proteins
Capsid Proteins
Morphogenesis
2015
10 Citations (Scopus)

The kinetic and thermodynamic aftermath of horizontal gene transfer governs evolutionary recovery

Doore, S. M. & Fane, B. A., Oct 1 2015, In : Molecular Biology and Evolution. 32, 10, p. 2571-2584 14 p.

Research output: Contribution to journalArticle

Horizontal Gene Transfer
gene transfer
Thermodynamics
thermodynamics
chimerism
2014
6 Citations (Scopus)

High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration

Sun, L., Rossmann, M. G. & Fane, B. A., 2014, In : Journal of Virology. 88, 18, p. 10276-10279 4 p.

Research output: Contribution to journalArticle

DNA
crystal structure
bacteriophages
Bacteriophages
Cell Wall
49 Citations (Scopus)

Icosahedral bacteriophage Φx174 forms a tail for DNA transport during infection

Sun, L., Young, L. N., Zhang, X., Boudko, S. P., Fokine, A., Zbornik, E., Roznowski, A. P., Molineux, I. J., Rossmann, M. G. & Fane, B. A., 2014, In : Nature. 505, 7483, p. 432-435 4 p.

Research output: Contribution to journalArticle

Bacteriophages
Periplasm
DNA
Genome
Infection
6 Citations (Scopus)

Mutations in the N terminus of the øX174 DNA pilot protein H confer defects in both assembly and host cell attachment

Young, L. N., Hockenberry, A. M. & Fane, B. A., Feb 2014, In : Journal of Virology. 88, 3, p. 1787-1794 8 p.

Research output: Contribution to journalArticle

mutation
Mutation
Temperature
DNA
temperature
4 Citations (Scopus)

The evolution of genes within genes and the control of DNA replication in microviruses

Doore, S. M., Baird, C. D., Roznowski, A. P. & Fane, B. A., 2014, In : Molecular Biology and Evolution. 31, 6, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

Microviridae
Microvirus
gene
Genes
genes
2013
6 Citations (Scopus)

Effects of an early conformational switch defect during φX174 morphogenesis are belatedly manifested late in the assembly pathway

Gordon, E. B. & Fane, B. A., Mar 2013, In : Journal of Virology. 87, 5, p. 2518-2525 8 p.

Research output: Contribution to journalArticle

scaffolding proteins
Capsid Proteins
coat proteins
Morphogenesis
Aromatic Amino Acids

Phi (ϕ)X174, Genetics of

Fane, B. A., Feb 27 2013, Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., p. 304-307 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genes
Genome
genome
Reading Frames
single-stranded DNA
2012
38 Citations (Scopus)

Building the machines: Scaffolding protein functions during bacteriophage morphogenesis

Prevelige, P. E. & Fane, B. A., 2012, Advances in Experimental Medicine and Biology. Vol. 726. p. 325-350 26 p. (Advances in Experimental Medicine and Biology; vol. 726).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacteriophages
Morphogenesis
Capsid Proteins
Viruses
Proteins
10 Citations (Scopus)

Conformational switch-defective ΦX174 internal scaffolding proteins kinetically trap assembly intermediates before procapsid formation

Gordon, E. B., Knuff, C. J. & Fane, B. A., Sep 2012, In : Journal of Virology. 86, 18, p. 9911-9918 8 p.

Research output: Contribution to journalArticle

scaffolding proteins
traps
Morphogenesis
morphogenesis
Capsid Proteins
2011
2 Citations (Scopus)

From resistance to stimulation: The evolution of a virus in the presence of a dominant lethal inhibitory scaffolding protein

Cherwa, J. E. & Fane, B. A., Jul 2011, In : Journal of Virology. 85, 13, p. 6589-6593 5 p.

Research output: Contribution to journalArticle

scaffolding proteins
lethal genes
Viruses
mutation
viruses
16 Citations (Scopus)

In vitro assembly of the øx174 procapsid from external scaffolding protein oligomers and early pentameric assembly intermediates

Cherwa, J. E., Organtini, L. J., Ashley, R. E., Hafenstein, S. L. & Fane, B. A., Sep 23 2011, In : Journal of Molecular Biology. 412, 3, p. 387-396 10 p.

Research output: Contribution to journalArticle

Morphogenesis
Proteins
Satellite Viruses
In Vitro Techniques
Capsid Proteins
14 Citations (Scopus)

Uncoupling the functions of a multifunctional protein: The isolation of a DNA pilot protein mutant that affects particle morphogenesis

Cherwa, J. E., Young, L. N. & Fane, B. A., Mar 1 2011, In : Virology. 411, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Mutant Proteins
Morphogenesis
DNA
Proteins
Amber
2009
17 Citations (Scopus)

Complete virion assembly with scaffolding proteins altered in the ability to perform a critical conformational switch

Cherwa, J. E. & Fane, B. A., Aug 2009, In : Journal of Virology. 83, 15, p. 7391-7396 6 p.

Research output: Contribution to journalArticle

scaffolding proteins
virion
Virion
Proteins
proteins
13 Citations (Scopus)

N-terminal deletions of the øX174 external scaffolding protein affect the timing and fidelity of assembly

Uchiyama, A., Heiman, P. & Fane, B. A., Apr 10 2009, In : Virology. 386, 2, p. 303-309 7 p.

Research output: Contribution to journalArticle

Proteins
Capsid Proteins
Microviridae
Plasmids
Gene Deletion
13 Citations (Scopus)

The expression of N-terminal deletion DNA pilot proteins inhibits the early stages of φX174 replication

Ruboyianes, M. V., Chen, M., Dubrava, M. S., Cherwa, J. E. & Fane, B. A., Oct 2009, In : Journal of Virology. 83, 19, p. 9952-9956 5 p.

Research output: Contribution to journalArticle

protein synthesis
DNA
Proteins
proteins
viral proteins
16 Citations (Scopus)

Viral adaptation to an antiviral protein enhances the fitness level to above that of the uninhibited wild type

Cherwa, J. E., Sanchez-Soria, P., Birkholz, J. A., Dineen, H. A., Grippi, D. C., Kempton, T. L., Kwan, J., Patel, N. N., Toussaint, B. M., Wichman, H. A. & Fane, B. A., Nov 2009, In : Journal of Virology. 83, 22, p. 11746-11750 5 p.

Research output: Contribution to journalArticle

antiviral proteins
antiviral agents
Antiviral Agents
Capsid
capsid
2008
17 Citations (Scopus)

Behind the chlamydial cloak: The replication cycle of chlamydiaphage Chp2, revealed

Salim, O., Skilton, R. J., Lambden, P. R., Fane, B. A. & Clarke, I. N., Aug 1 2008, In : Virology. 377, 2, p. 440-445 6 p.

Research output: Contribution to journalArticle

Life Cycle Stages
Microvirus
Immunochemistry
Bacterial Structures
Chlamydia

Icosahedral ssDNA Bacterial Viruses

Fane, B. A., Chen, M., Cherwa, J. E. & Uchiyama, A., Jan 1 2008, Encyclopedia of Virology. Elsevier Ltd., p. 13-20 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microvirus
Viruses
Microviridae
Bacteriophages
Parasites
24 Citations (Scopus)

Scaffolding proteins altered in the ability to perform a conformational switch confer dominant lethal assembly defects

Cherwa, J. E., Uchiyama, A. & Fane, B. A., Jun 2008, In : Journal of Virology. 82, 12, p. 5774-5780 7 p.

Research output: Contribution to journalArticle

scaffolding proteins
lethal genes
mutants
Proteins
proteins
2007
15 Citations (Scopus)

Characterization and function of putative substrate specificity domain in microvirus external scaffolding proteins

Uchiyama, A., Chen, M. & Fane, B. A., Aug 2007, In : Journal of Virology. 81, 16, p. 8587-8592 6 p.

Research output: Contribution to journalArticle

Microvirus
scaffolding proteins
substrate specificity
Substrate Specificity
recombinant fusion proteins
21 Citations (Scopus)

Eliminating the Requirement of an Essential Gene Product in an Already Very Small Virus: Scaffolding Protein B-free øX174, B-free

Chen, M., Uchiyama, A. & Fane, B. A., Oct 19 2007, In : Journal of Molecular Biology. 373, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

Essential Genes
Viruses
Virus Assembly
Proteins
Mutation
9 Citations (Scopus)

Intracellular parasitism of chlamydiae: Specific infectivity of chlamydiaphage Chp2 in Chlamydophila abortus

Skilton, R. J., Cutcliffe, L. T., Pickett, M. A., Lambden, P. R., Fane, B. A. & Clarke, I. N., Jul 2007, In : Journal of Bacteriology. 189, 13, p. 4957-4959 3 p.

Research output: Contribution to journalArticle

Chlamydophila
Chlamydia
Bacteriophages
2005

A four-dimensional structure of T4 infection

Fane, B. A., Sep 2005, In : Nature Structural and Molecular Biology. 12, 9, p. 739-740 2 p.

Research output: Contribution to journalArticle

Computer-Assisted Image Processing
Tail
Molecular Biology
Equipment and Supplies
Infection
27 Citations (Scopus)
scaffolding proteins
DNA Packaging
coat proteins
Morphogenesis
morphogenesis
2004
10 Citations (Scopus)

Chlamydiaphage Chp2, a skeleton in the φX174 closet: Scaffolding protein and procapsid identification

Clarke, I. N., Cutcliffe, L. T., Everson, J. S., Garner, S. A., Lambden, P. R., Pead, P. J., Pickett, M. A., Brentlinger, K. L. & Fane, B. A., Nov 2004, In : Journal of Bacteriology. 186, 22, p. 7571-7574 4 p.

Research output: Contribution to journalArticle

Skeleton
Microviridae
Proteins
Chlamydophila
Coliphages
19 Citations (Scopus)

Conformational switching by the scaffolding protein D directs the assembly of bacteriophage φX174

Morais, M. C., Fisher, M., Kanamaru, S., Przybyla, L., Burgner, J., Fane, B. A. & Rossmann, M. G., Sep 24 2004, In : Molecular Cell. 15, 6, p. 991-997 7 p.

Research output: Contribution to journalArticle

Bacteriophages
Proteins
Macromolecular Substances
X Ray Crystallography
Morphogenesis
9 Citations (Scopus)
DNA-Binding Proteins
Amino Acid Substitution
Proline
Glycine
DNA
35 Citations (Scopus)

Isolation, molecular characterisation and genome sequence of a bacteriophage (Chp3) from Chlamydophila pecorum

Garner, S. A., Everson, J. S., Lambden, P. R., Fane, B. A. & Clarke, I. N., Mar 2004, In : Virus Genes. 28, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

Chlamydophila
Microviridae
Bacteriophages
Genome
Spiroplasma
20 Citations (Scopus)
Reading Frames
Proteins
Capsid Proteins
Morphogenesis
Molecular Biology
15 Citations (Scopus)

The φX174 protein J mediates DNA packaging and viral attachment to host cells

Bernal, R. A., Hafenstein, S., Esmeralda, R., Fane, B. A. & Rossmann, M. G., Apr 9 2004, In : Journal of Molecular Biology. 337, 5, p. 1109-1122 14 p.

Research output: Contribution to journalArticle

DNA Packaging
Proteins
Microvirus
Capsid
DNA-Binding Proteins
2003
15 Citations (Scopus)

Genetic analyses of putative conformation switching and cross-species inhibitory domains in Microviridae external scaffolding proteins

Burch, A. D. & Fane, B. A., May 25 2003, In : Virology. 310, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Microviridae
Proteins
Phenotype
Capsid
Coinfection
25 Citations (Scopus)

Host Range of Chlamydiaphages φCPAR39 and Chp3

Everson, J. S., Garner, S. A., Lambden, P. R., Fane, B. A. & Clarke, I. N., Nov 2003, In : Journal of Bacteriology. 185, 21, p. 6490-6492 3 p.

Research output: Contribution to journalArticle

Chlamydophila
Host Specificity
Bacteriophages
Felis
Endopeptidase K
89 Citations (Scopus)

Mechanism of scaffolding-assisted viral assembly

Fane, B. A. & Prevelige, P. E., 2003, In : Advances in Protein Chemistry. 64, p. 259-299 41 p.

Research output: Contribution to journalArticle

Virus Assembly
42 Citations (Scopus)

Structural studies of bacteriophage α3 assembly

Bernal, R. A., Hafenstein, S., Olson, N. H., Bowman, V. D., Chipman, P. R., Baker, T. S., Fane, B. A. & Rossmann, M. G., 2003, In : Journal of Molecular Biology. 325, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Bacteriophages
DNA-Binding Proteins
Capsid Proteins
Virion
Cryoelectron Microscopy
2002
21 Citations (Scopus)

Biological properties and cell tropism of Chp2, a bacteriophage of the obligate intracellular bacterium Chlamydophila abortus

Everson, J. S., Garner, S. A., Fane, B. A., Liu, B. L., Lambden, P. R. & Clarke, I. N., 2002, In : Journal of Bacteriology. 184, 10, p. 2748-2754 7 p.

Research output: Contribution to journalArticle

Chlamydophila
Tropism
Chlamydia
Bacteriophages
Bacteria
12 Citations (Scopus)

Characterization of mutant spectra generated by a forward mutational assay for gene A of ΦX174 from ENU-treated transgenic mouse embryonic cell line PX-2

Valentine, C. R., Montgomery, B. A., Miller, S. G., Delongchamp, R. R., Fane, B. A. & Malling, H. V., 2002, In : Environmental and Molecular Mutagenesis. 39, 1, p. 55-68 14 p.

Research output: Contribution to journalArticle

Transgenic Mice
mutation
Assays
Genes
Cells
48 Citations (Scopus)

Microviridae, a family divided: Isolation, characterization, and genome sequence of φMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus

Brentlinger, K. L., Hafenstein, S., Novak, C. R., Fane, B. A., Borgon, R., McKenna, R. & Agbandje-McKenna, M., 2002, In : Journal of Bacteriology. 184, 4, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

Microviridae
Bacteriophages
Genome
Bacteria
Single-Stranded DNA
24 Citations (Scopus)
capsid
Capsid
Morphogenesis
virion
Virion
2000
12 Citations (Scopus)

Efficient complementation by chimeric Microviridae internal scaffolding proteins is a function of the COOH-terminus of the encoded protein

Burch, A. D. & Fane, B. A., May 10 2000, In : Virology. 270, 2, p. 286-290 5 p.

Research output: Contribution to journalArticle

Microviridae
Proteins
Capsid Proteins
Genes
Temperature
21 Citations (Scopus)

Foreign and chimeric external scaffolding proteins as inhibitors of Microviridae morphogenesis

Burch, A. D. & Fane, B. A., 2000, In : Journal of Virology. 74, 20, p. 9347-9352 6 p.

Research output: Contribution to journalArticle

Microviridae
scaffolding proteins
recombinant fusion proteins
Morphogenesis
morphogenesis
44 Citations (Scopus)

Molecular characterization of a bacteriophage (Chp2) from Chlamydia psittaci

Liu, B. L., Everson, J. S., Fane, B. A., Giannikopoulou, P., Vretou, E., Lambden, P. R. & Clarke, I. N., 2000, In : Journal of Virology. 74, 8, p. 3464-3469 6 p.

Research output: Contribution to journalArticle

Chlamydophila psittaci
bacteriophages
Bacteriophages
Open Reading Frames
open reading frames