• 5643 Citations
  • 43 h-Index
1978 …2020

Research output per year

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Research Output

2020

DNA methylation biomarkers discovered in silico detect cancer in liquid biopsies from non-small cell lung cancer patients

Vrba, L., Oshiro, M. M., Kim, S. S., Garland, L. L., Placencia, C., Mahadevan, D., Nelson, M. A. & Futscher, B. W., Apr 2 2020, In : Epigenetics. 15, 4, p. 419-430 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019
Open Access
2018

A suite of DNA methylation markers that can detect most common human cancers

Vrba, L. & Futscher, B. W., Feb 1 2018, (Accepted/In press) In : Epigenetics. p. 1-12 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Epigenetic silencing of lncRNA MORT in 16 TCGA cancer types

Vrba, L. & Futscher, B. W., 2018, In : F1000Research. 7, 211.

Research output: Contribution to journalArticle

17 Scopus citations
2017
7 Scopus citations
2016

Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression

Black, S. A., Nelson, A. C., Gurule, N. J., Futscher, B. W. & Lyons, T. R., Sep 29 2016, In : Oncogene. 35, 39, p. 5170-5178 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2015

Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells

Lee, J. K., Garbe, J. C., Vrba, L., Miyano, M., Futscher, B. W., Stampfer, M. R. & LaBarge, M. A., Mar 11 2015, In : Frontiers in Cell and Developmental Biology. 3, MAR, 13.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

Vrba, L., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., Jan 1 2015, In : Epigenetics. 10, 11, p. 1074-1083 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of a novel radiation-induced sarcoma cell line

Lang, J., Zhu, W., Nokes, B., Sheth, G., Novak, P., Fuchs, L., Watts, G., Futscher, B., Mineyev, N., Ring, A., Lebeau, L., Nagle, R. & Cranmer, L., May 1 2015, In : Journal of Surgical Oncology. 111, 6, p. 669-682 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Differentially expressed MicroRNAs in postpartum breast cancer in Hispanic women

Muñoz-Rodríguez, J. L., Vrba, L., Futscher, B. W., Hu, C., Komenaka, I. K., Meza-Montenegro, M. M., Gutierrez-Millan, L. E., Daneri-Navarro, A., Thompson, P. A. & Martinez, M. E., Apr 13 2015, In : PloS one. 10, 4, e0124340.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease

Clarke, J. D., Novak, P., Lake, A. D., Shipkova, P., Aranibar, N., Robertson, D., Severson, P. L., Reily, M. D., Futscher, B. W., Lehman-Mckeeman, L. D. & Cherrington, N. J., Feb 1 2014, In : Digestive diseases and sciences. 59, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells

Severson, P. L., Vrba, L., Stampfer, M. R. & Futscher, B. W., Dec 1 2014, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 775-776, p. 48-54 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

Vorrink, S. U., Severson, P. L., Kulak, M. V., Futscher, B. W. & Domann, F. E., Feb 1 2014, In : Toxicology and Applied Pharmacology. 274, 3, p. 408-416 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations

Garbe, J. C., Vrba, L., Sputova, K., Fuchs, L., Novak, P., Brothman, A. R., Jackson, M., Chin, K., La Barge, M. A., Watts, G., Futscher, B. W. & Stampfer, M. R., Nov 1 2014, In : Cell Cycle. 13, 21, p. 3423-3435 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
2013

Arsenic exposure induces the warburg effect in cultured human cells

Zhao, F., Severson, P., Pacheco, S., Futscher, B. W. & Klimecki, W. T., Aug 5 2013, In : Toxicology and Applied Pharmacology. 271, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation

Severson, P. L., Tokar, E. J., Vrba, L., Waalkes, M. P. & Futscher, B. W., Oct 2013, In : Epigenetics. 8, 10, p. 1080-1088 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Epigenetic changes during cell transformation

Futscher, B. W., Jan 1 2013, Epigenetic Alterations in Oncogenesis. Karpf, A. (ed.). p. 179-194 16 p. (Advances in Experimental Medicine and Biology; vol. 754).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

In vitro assessment of the inflammatory breast cancer cell line SUM 149: Discovery of 2 single nucleotidepolymorphisms in the Rnase L gene

Nokes, B. T., Cunliffe, H. E., LaFleur, B., Mount, D. W., Livingston, R. B., Futscher, B. W. & Lang, J. E., Aug 30 2013, In : Journal of Cancer. 4, 2, p. 104-116 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes

Cyr, A. R., Brown, K. E., McCormick, M. L., Coleman, M. C., Case, A. J., Watts, G. S., Futscher, B. W., Spitz, D. R. & Domann, F. E., Jan 1 2013, In : Redox Biology. 1, 1, p. 172-177 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast Cancer

Vrba, L., Muñoz-Rodríguez, J. L., Stampfer, M. R. & Futscher, B. W., Jan 16 2013, In : PloS one. 8, 1, e54398.

Research output: Contribution to journalArticle

87 Scopus citations
2012

Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation

Severson, P. L., Tokar, E. J., Vrba, L., Waalkes, M. P. & Futscher, B. W., Nov 2012, In : Epigenetics. 7, 11, p. 1238-1248 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity

Novak, P., Stampfer, M. R., Munoz-Rodriguez, J. L., Garbe, J. C., Ehrich, M., Futscher, B. W. & Jensen, T. J., Dec 20 2012, In : PloS one. 7, 12, e52299.

Research output: Contribution to journalArticle

16 Scopus citations

Epigenomic Actions of Environmental Arsenicals

Severson, P. L. & Futscher, B. W., Aug 8 2012, Toxicology and Epigenetics. John Wiley and Sons, p. 129-148 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis

Teoh-Fitzgerald, M. L. T., Fitzgerald, M. P., Jensen, T. J., Futscher, B. W. & Domann, F. E., Jan 1 2012, In : Molecular Cancer Research. 10, 1, p. 40-51 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
2011

Arsenic toxicology: Translating between experimental models and human pathology

States, J. C., Barchowsky, A., Cartwright, I. L., Reichard, J. F., Futscher, B. W. & Lantz, R. C., Oct 1 2011, In : Environmental health perspectives. 119, 10, p. 1356-1363 8 p.

Research output: Contribution to journalReview article

66 Scopus citations

Epigenetic regulation of normal human mammary cell type-specific miRNAs

Vrba, L., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., Dec 2011, In : Genome Research. 21, 12, p. 2026-2037 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer

Radhakrishnan, V. M., Jensen, T. J., Cui, H., Futscher, B. W. & Martinez, J. D., Oct 1 2011, In : Genes Chromosomes and Cancer. 50, 10, p. 830-836 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure

Wnek, S. M., Jensen, T. J., Severson, P. L., Futscher, B. W. & Gandolfi, A. J., Apr 7 2010, In : Toxicological Sciences. 116, 1, p. 44-57 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

Vrba, L., Jensen, T. J., Garbe, J. C., Heimark, R. L., Cress, A. E., Dickinson, S., Stampfer, M. R. & Futscher, B. W., Jan 13 2010, In : PloS one. 5, 1, e8697.

Research output: Contribution to journalArticle

231 Scopus citations
2009
38 Scopus citations

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

Jensen, T. J., Wozniak, R. J., Eblin, K. E., Wnek, S. M., Gandolfi, A. J. & Futscher, B. W., Feb 15 2009, In : Toxicology and Applied Pharmacology. 235, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

70 Scopus citations

Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling

Eblin, K. E., Jensen, T. J., Wnek, S. M., Buffington, S. E., Futscher, B. W. & Gandolfi, A. J., Jan 8 2009, In : Toxicology. 255, 1-2, p. 107-114 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization

Novak, P., Jensen, T. J., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., Jun 15 2009, In : Cancer Research. 69, 12, p. 5251-5258 8 p.

Research output: Contribution to journalArticle

87 Scopus citations
2008

Agglomerative epigenetic aberrations are a common event in human breast cancer

Novak, P., Jensen, T., Oshiro, M. M., Watts, G. S., Kim, C. J. & Futscher, B. W., Oct 15 2008, In : Cancer Research. 68, 20, p. 8616-8625 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells

Junk, D. J., Vrba, L., Watts, G. S., Oshiro, M. M., Martinez, J. D. & Futscher, B. W., May 2008, In : Neoplasia. 10, 5, p. 450-461 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Epigenetic remodeling during arsenical-induced malignant transformation

Jensen, T. J., Novak, P., Eblin, K. E., Gandolfi, J. A. & Futscher, B. W., Aug 22 2008, In : Carcinogenesis. 29, 8, p. 1500-1508 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

p53 induces distinct epigenetic states at its direct target promoters

Vrba, L., Junk, D. J., Novak, P. & Futscher, B. W., Oct 15 2008, In : BMC genomics. 9, 486.

Research output: Contribution to journalArticle

36 Scopus citations

The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies

Eblin, K. E., Hau, A. M., Jensen, T. J., Futscher, B. W. & Gandolfi, A. J., Aug 19 2008, In : Toxicology. 250, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2007
138 Scopus citations

Optimal search-based gene subset selection for gene array cancer classification

Li, J., Su, H., Chen, H. & Futscher, B. W., Jul 1 2007, In : IEEE Transactions on Information Technology in Biomedicine. 11, 4, p. 398-405 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors

Beltran, A., Parikh, S., Liu, Y., Cuevas, B. D., Johnson, G. L., Futscher, B. W. & Blancafort, P., Apr 26 2007, In : Oncogene. 26, 19, p. 2791-2798 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
2006

AP-2α and AP-2γ are transcriptional targets of p53 in human breast carcinoma cells

Li, H., Watts, G. S., Oshiro, M. M., Futscher, B. W. & Domann, F. E., Aug 31 2006, In : Oncogene. 25, 39, p. 5405-5415 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Comparisons of PCR-based genome amplification systems using CpG island microarrays

Pike, B. L., Groshen, S., Hsu, Y. H., Shai, R. M., Wang, X., Holtan, N., Futscher, B. W. & Hacia, J. G., Jun 1 2006, In : Human Mutation. 27, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epigenetic inactivation of the HOXA gene cluster in breast cancer

Novak, P., Jensen, T., Oshiro, M. M., Wozniak, R. J., Nouzova, M., Watts, G. S., Klimecki, W. T., Kim, C. & Futscher, B. W., Nov 15 2006, In : Cancer Research. 66, 22, p. 10664-10670 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Epigenetic regulation of maspin expression in human ovarian carcinoma cells

Rose, S. L., Fitzgerald, M. P., White, N. O., Hitchler, M. J., Futscher, B. W., De Geest, K. & Domann, F. E., Aug 1 2006, In : Gynecologic oncology. 102, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
Open Access
4 Scopus citations
2005

Epigenetic regulation of the cell type-specific gene 14-3-3σ

Oshiro, M. M., Futscher, B. W., Lisberg, A., Wozniak, R. J., Klimecki, W. T., Domann, F. E. & Cress, A. E., Sep 2005, In : Neoplasia. 7, 9, p. 799-808 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Epigenetic silencing of DSC3 is a common event in human breast cancer

Oshiro, M. M., Kim, C. J., Wozniak, R. J., Junk, D. J., Muñoz-Rodríguez, J. L., Burr, J. A., Fitzgerald, M., Pawar, S. C., Cress, A. E., Domann, F. E. & Futscher, B. W., Jun 16 2005, In : Breast Cancer Research. 7, 5, R669.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
2004

Aberrant methylation of the maspin promoter is an early event in human breast cancer

Futscher, B. W., O'Meara, M. M., Kim, C. J., Rennels, M. A., Lu, D., Gruman, L. M., Seftor, R. E. B., Hendrix, M. J. C. & Domann, F. E., Jul 1 2004, In : Neoplasia. 6, 4, p. 380-389 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Epigenomic changes during leukemia cell differentiation: Analysis of histone acetylation and cytosine methylation using CpG island microarrays

Nouzova, M., Holtan, N., Oshiro, M. M., Isett, R. B., Munoz-Rodriguez, J. L., List, A. F., Narro, M. L., Miller, S. J., Merchant, N. C. & Futscher, B. W., Dec 2004, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 968-981 14 p.

Research output: Contribution to journalArticle

68 Scopus citations