• 5453 Citations
  • 43 h-Index
1978 …2021
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Research Output 1989 2018

  • 5453 Citations
  • 43 h-Index
  • 92 Article
  • 2 Chapter
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Article
2018
4 Citations (Scopus)

A suite of DNA methylation markers that can detect most common human cancers

Vrba, L. & Futscher, B. W., Feb 1 2018, (Accepted/In press) In : Epigenetics. p. 1-12 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Genetic Markers
Neoplasms
Area Under Curve
Untranslated RNA
8 Citations (Scopus)

Epigenetic silencing of lncRNA MORT in 16 TCGA cancer types

Vrba, L. & Futscher, B. W., Jan 1 2018, In : F1000Research. 7, 211.

Research output: Contribution to journalArticle

Long Noncoding RNA
Atlases
Epigenomics
Genes
Genome
2017
4 Citations (Scopus)
Epigenomics
Breast Neoplasms
Neoplasms
Carcinogenesis
Long Noncoding RNA
2016
16 Citations (Scopus)

Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression

Black, S. A., Nelson, A. C., Gurule, N. J., Futscher, B. W. & Lyons, T. R., Sep 29 2016, In : Oncogene. 35, 39, p. 5170-5178 9 p.

Research output: Contribution to journalArticle

Semaphorins
Breast Neoplasms
Lymphangiogenesis
Carcinoma, Intraductal, Noninfiltrating
Neoplasm Metastasis
2015
12 Citations (Scopus)

Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells

Lee, J. K., Garbe, J. C., Vrba, L., Miyano, M., Futscher, B. W., Stampfer, M. R. & LaBarge, M. A., Mar 11 2015, In : Frontiers in Cell and Developmental Biology. 3, MAR, 13.

Research output: Contribution to journalArticle

Open Access
Breast
Epithelial Cells
Keratin-19
Cell Line
Cell Aging
12 Citations (Scopus)

A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

Vrba, L., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., 2015, In : Epigenetics. 10, 11, p. 1074-1083 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Mortality
Neoplasms
Atlases
decitabine
1 Citation (Scopus)

Characterization of a novel radiation-induced sarcoma cell line

Lang, J., Zhu, W., Nokes, B., Sheth, G., Novak, P., Fuchs, L., Watts, G. S., Futscher, B. W., Mineyev, N., Ring, A., Lebeau, L., Nagle, R. B. & Cranmer, L. D., May 1 2015, In : Journal of Surgical Oncology. 111, 6, p. 669-682 14 p.

Research output: Contribution to journalArticle

Sarcoma
Radiation
Cell Line
Neoplasms
SCID Mice
16 Citations (Scopus)

Differentially expressed MicroRNAs in postpartum breast cancer in Hispanic women

Muñoz-Rodríguez, J. L., Vrba, L., Futscher, B. W., Hu, C., Komenaka, I. K., Meza-Montenegro, M. M., Gutierrez-Millan, L. E., Daneri-Navarro, A., Thompson, P. A. & Martinez, M. E., Apr 13 2015, In : PLoS One. 10, 4, e0124340.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
Hispanic Americans
breast neoplasms
Postpartum Period
2014
21 Citations (Scopus)

Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease

Clarke, J. D., Novak, P., Lake, A. D., Shipkova, P., Aranibar, N., Robertson, D., Severson, P. L., Reily, M. D., Futscher, B. W., Lehman-Mckeeman, L. D. & Cherrington, N. J., Feb 2014, In : Digestive Diseases and Sciences. 59, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Genes
Metabolomics
Down-Regulation
Non-alcoholic Fatty Liver Disease
15 Citations (Scopus)

Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells

Severson, P. L., Vrba, L., Stampfer, M. R. & Futscher, B. W., Dec 1 2014, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 775-776, p. 48-54 7 p.

Research output: Contribution to journalArticle

Exome
Benzo(a)pyrene
Breast
Epithelial Cells
Mutation
36 Citations (Scopus)

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

Vorrink, S. U., Severson, P. L., Kulak, M. V., Futscher, B. W. & Domann, F. E., Feb 1 2014, In : Toxicology and Applied Pharmacology. 274, 3, p. 408-416 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Polychlorinated Biphenyls
Liver
Skin
32 Citations (Scopus)

Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations

Garbe, J. C., Vrba, L., Sputova, K., Fuchs, L., Novak, P., Brothman, A. R., Jackson, M., Chin, K., La Barge, M. A., Watts, G. S., Futscher, B. W. & Stampfer, M. R., Nov 1 2014, In : Cell Cycle. 13, 21, p. 3423-3435 13 p.

Research output: Contribution to journalArticle

Breast
Epithelial Cells
Telomerase
Telomere Shortening
Carcinoma
2013
23 Citations (Scopus)

Arsenic exposure induces the warburg effect in cultured human cells

Zhao, F., Severson, P., Pacheco, S., Futscher, B. W. & Klimecki, W., Aug 5 2013, In : Toxicology and Applied Pharmacology. 271, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Arsenic
Glycolysis
Cultured Cells
Cells
Cell Line
24 Citations (Scopus)

Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation

Severson, P. L., Tokar, E. J., Vrba, L., Waalkes, M. P. & Futscher, B. W., Oct 2013, In : Epigenetics. 8, 10, p. 1080-1088 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Genes
Gene Silencing
Epigenomics
Down-Regulation
6 Citations (Scopus)

In vitro assessment of the inflammatory breast cancer cell line SUM 149: Discovery of 2 single nucleotidepolymorphisms in the Rnase L gene

Nokes, B. T., Cunliffe, H. E., LaFleur, B., Mount, D. W., Livingston, R. B., Futscher, B. W. & Lang, J. E., 2013, In : Journal of Cancer. 4, 2, p. 104-116 13 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Cell Line
Ribonucleases
Genes
Breast Neoplasms
8 Citations (Scopus)

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes

Cyr, A. R., Brown, K. E., McCormick, M. L., Coleman, M. C., Case, A. J., Watts, G. S., Futscher, B. W., Spitz, D. R. & Domann, F. E., 2013, In : Redox Biology. 1, 1, p. 172-177 6 p.

Research output: Contribution to journalArticle

Liver
Superoxide Dismutase
Hepatocytes
Maintenance
Mitochondrial DNA
82 Citations (Scopus)

miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast Cancer

Vrba, L., Muñoz-Rodríguez, J. L., Stampfer, M. R. & Futscher, B. W., Jan 16 2013, In : PLoS One. 8, 1, e54398.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
MicroRNAs
microRNA
breast neoplasms
2012
20 Citations (Scopus)

Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation

Severson, P. L., Tokar, E. J., Vrba, L., Waalkes, M. P. & Futscher, B. W., Nov 2012, In : Epigenetics. 7, 11, p. 1238-1248 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Arsenicals
Histones
Lysine
15 Citations (Scopus)

Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity

Novak, P., Stampfer, M. R., Munoz-Rodriguez, J. L., Garbe, J. C., Ehrich, M., Futscher, B. W. & Jensen, T. J., Dec 20 2012, In : PLoS One. 7, 12, e52299.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
breasts
Breast
cells
36 Citations (Scopus)

Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis

Teoh-Fitzgerald, M. L. T., Fitzgerald, M. P., Jensen, T. J., Futscher, B. W. & Domann, F. E., Jan 2012, In : Molecular Cancer Research. 10, 1, p. 40-51 12 p.

Research output: Contribution to journalArticle

Epigenomics
Superoxide Dismutase
Lung Neoplasms
Homeostasis
Phenotype
2011
56 Citations (Scopus)

Arsenic toxicology: Translating between experimental models and human pathology

States, J. C., Barchowsky, A., Cartwright, I. L., Reichard, J. F., Futscher, B. W. & Lantz, R. C., Oct 2011, In : Environmental Health Perspectives. 119, 10, p. 1356-1363 8 p.

Research output: Contribution to journalArticle

Arsenic
Toxicology
Theoretical Models
Pathology
Epigenomics
62 Citations (Scopus)

Epigenetic regulation of normal human mammary cell type-specific miRNAs

Vrba, L., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., Dec 2011, In : Genome Research. 21, 12, p. 2026-2037 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Epigenomics
Breast
DNA Methylation
Epigenetic Repression
19 Citations (Scopus)

Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer

Radhakrishnan, V. M., Jensen, T. J., Cui, H., Futscher, B. W. & Martinez, J. D., Oct 2011, In : Genes Chromosomes and Cancer. 50, 10, p. 830-836 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
14-3-3 Proteins
Genes
Neoplasms
Lung
2010
42 Citations (Scopus)

Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure

Wnek, S. M., Jensen, T. J., Severson, P. L., Futscher, B. W. & Gandolfi, A. J., Apr 7 2010, In : Toxicological Sciences. 116, 1, p. 44-57 14 p.

Research output: Contribution to journalArticle

Urinary Bladder
Cells
Cell Line
DNA Methylation
Arsenicals
219 Citations (Scopus)

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

Vrba, L., Jensen, T. J., Garbe, J. C., Heimark, R. L., Cress, A. E., Dickinson, S. E., Stampfer, M. R. & Futscher, B. W., Jan 13 2010, In : PLoS One. 5, 1, e8697.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Cells
CpG Islands
Neoplasms
2009
38 Citations (Scopus)
Arsenicals
DNA Methylation
Tumors
Genes
Cells
68 Citations (Scopus)

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

Jensen, T. J., Wozniak, R. J., Eblin, K. E., Wnek, S. M., Gandolfi, A. J. & Futscher, B. W., Feb 15 2009, In : Toxicology and Applied Pharmacology. 235, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Arsenicals
Epigenomics
Transcriptional Activation
Chemical activation
Urinary Bladder Neoplasms
20 Citations (Scopus)

Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling

Eblin, K. E., Jensen, T. J., Wnek, S. M., Buffington, S. E., Futscher, B. W. & Gandolfi, A. J., Jan 8 2009, In : Toxicology. 255, 1-2, p. 107-114 8 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Chemical activation
Up-Regulation
Antioxidants
monomethylarsonous acid
86 Citations (Scopus)

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization

Novak, P., Jensen, T. J., Garbe, J. C., Stampfer, M. R. & Futscher, B. W., Jun 15 2009, In : Cancer Research. 69, 12, p. 5251-5258 8 p.

Research output: Contribution to journalArticle

DNA Methylation
Breast
Epithelial Cells
Telomere
Epigenomics
2008
95 Citations (Scopus)

Agglomerative epigenetic aberrations are a common event in human breast cancer

Novak, P., Jensen, T., Oshiro, M. M., Watts, G. S., Kim, C. J. & Futscher, B. W., Oct 15 2008, In : Cancer Research. 68, 20, p. 8616-8625 10 p.

Research output: Contribution to journalArticle

Epigenomics
Breast Neoplasms
DNA Methylation
Multigene Family
Genomic Segmental Duplications
44 Citations (Scopus)

Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells

Junk, D. J., Vrba, L., Watts, G. S., Oshiro, M. M., Martinez, J. D. & Futscher, B. W., May 2008, In : Neoplasia. 10, 5, p. 450-461 12 p.

Research output: Contribution to journalArticle

Breast
Epithelial Cells
Carcinogenesis
Phenotype
Choristoma
89 Citations (Scopus)

Epigenetic remodeling during arsenical-induced malignant transformation

Jensen, T. J., Novak, P., Eblin, K. E., Gandolfi, A. J. & Futscher, B. W., 2008, In : Carcinogenesis. 29, 8, p. 1500-1508 9 p.

Research output: Contribution to journalArticle

Arsenicals
Epigenomics
Carcinogenesis
Arsenic
Acetylation
31 Citations (Scopus)

p53 induces distinct epigenetic states at its direct target promoters

Vrba, L., Junk, D. J., Novak, P. & Futscher, B. W., Oct 15 2008, In : BMC Genomics. 9, 486.

Research output: Contribution to journalArticle

Acetylation
Epigenomics
Histones
DNA
Histone Code
22 Citations (Scopus)

The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies

Eblin, K. E., Hau, A. M., Jensen, T. J., Futscher, B. W. & Gandolfi, A. J., Aug 19 2008, In : Toxicology. 250, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Signal transduction
Arsenicals
Reactive Oxygen Species
Signal Transduction
Urinary Bladder
2007
133 Citations (Scopus)
decitabine
Desmocollins
Tumor Suppressor Genes
Histones
Methylation
31 Citations (Scopus)

Optimal search-based gene subset selection for gene array cancer classification

Li, J., Su, H., Chen, H. & Futscher, B. W., Jul 2007, In : IEEE Transactions on Information Technology in Biomedicine. 11, 4, p. 398-405 8 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Genes
Taboo
Tabu search
65 Citations (Scopus)

Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors

Beltran, A., Parikh, S., Liu, Y., Cuevas, B. D., Johnson, G. L., Futscher, B. W. & Blancafort, P., Apr 26 2007, In : Oncogene. 26, 19, p. 2791-2798 8 p.

Research output: Contribution to journalArticle

Serine Proteinase Inhibitors
Tumor Suppressor Genes
Breast
Transcription Factors
Neoplasms
2006
22 Citations (Scopus)

AP-2α and AP-2γ are transcriptional targets of p53 in human breast carcinoma cells

Li, H., Watts, G. S., Oshiro, M. M., Futscher, B. W. & Domann, F. E., Aug 31 2006, In : Oncogene. 25, 39, p. 5405-5415 11 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Breast Neoplasms
Chromatin
GC Rich Sequence
Chromatin Immunoprecipitation
2 Citations (Scopus)

Comparisons of PCR-based genome amplification systems using CpG island microarrays

Pike, B. L., Groshen, S., Hsu, Y. H., Shai, R. M., Wang, X., Holtan, N., Futscher, B. W. & Hacia, J. G., Jun 2006, In : Human Mutation. 27, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

CpG Islands
Genome
DNA-Directed DNA Polymerase
Polymerase Chain Reaction
Gene Library
88 Citations (Scopus)

Epigenetic inactivation of the HOXA gene cluster in breast cancer

Novak, P., Jensen, T., Oshiro, M. M., Wozniak, R. J., Nouzova, M., Watts, G. S., Klimecki, W., Kim, C. & Futscher, B. W., Nov 15 2006, In : Cancer Research. 66, 22, p. 10664-10670 7 p.

Research output: Contribution to journalArticle

Multigene Family
Epigenomics
Breast Neoplasms
DNA Methylation
Histone Code
47 Citations (Scopus)

Epigenetic regulation of maspin expression in human ovarian carcinoma cells

Rose, S. L., Fitzgerald, M. P., White, N. O., Hitchler, M. J., Futscher, B. W., De Geest, K. & Domann, F. E., Aug 2006, In : Gynecologic Oncology. 102, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

Epigenomics
Carcinoma
decitabine
Ovarian Neoplasms
Chromatin
4 Citations (Scopus)
Pharmacogenetics
Polyamines
DNA Methylation
Colon
Adenocarcinoma
2005
22 Citations (Scopus)

Epigenetic regulation of the cell type-specific gene 14-3-3σ

Oshiro, M. M., Futscher, B. W., Lisberg, A., Wozniak, R. J., Klimecki, W., Domann, F. E. & Cress, A. E., Sep 2005, In : Neoplasia. 7, 9, p. 799-808 10 p.

Research output: Contribution to journalArticle

Epigenomics
Histones
Genes
CpG Islands
p53 Genes
81 Citations (Scopus)

Epigenetic silencing of DSC3 is a common event in human breast cancer.

Oshiro, M. M., Kim, C. J., Wozniak, R. J., Junk, D. J., Muñoz-Rodríguez, J. L., Burr, J. A., Fitzgerald, M., Pawar, S. C., Cress, A. E., Domann, F. E. & Futscher, B. W., 2005, In : Breast Cancer Research. 7, 5

Research output: Contribution to journalArticle

Desmocollins
Epigenomics
Breast Neoplasms
Ductal Carcinoma
Chromatin
2004
56 Citations (Scopus)

Aberrant methylation of the maspin promoter is an early event in human breast cancer

Futscher, B. W., O'Meara, M. M., Kim, C. J., Rennels, M. A., Lu, D., Gruman, L. M., Seftor, R. E. B., Hendrix, M. J. C. & Domann, F. E., Jul 2004, In : Neoplasia. 6, 4, p. 380-389 10 p.

Research output: Contribution to journalArticle

Methylation
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
SERPIN-B5
Mammaplasty
65 Citations (Scopus)

Epigenomic changes during leukemia cell differentiation: Analysis of histone acetylation and cytosine methylation using CpG island microarrays

Nouzova, M., Holtan, N., Oshiro, M. M., Isett, R. B., Munoz-Rodriguez, J. L., List, A. F., Narro, M. L., Miller, S. J., Merchant, N. C. & Futscher, B. W., Dec 2004, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 968-981 14 p.

Research output: Contribution to journalArticle

CpG Islands
Cytosine
Acetylation
Tretinoin
Epigenomics
35 Citations (Scopus)

The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells

Watts, G. S., Oshiro, M. M., Junk, D. J., Wozniak, R. J., Watterson, S. J., Domann, F. E. & Futscher, B. W., May 2004, In : Neoplasia. 6, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Acetyltransferases
p53 Genes
Breast Neoplasms
Tumor Cell Line
Doxorubicin
2003
8 Citations (Scopus)

Editorial: Maspin as a molecular target for cancer therapy

Domann, F. E. & Futscher, B. W., Mar 1 2003, In : Journal of Urology. 169, 3, p. 1162-1164 3 p.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
SERPIN-B5
42 Citations (Scopus)

Human Pancreatic Carcinoma Cells Activate Maspin Expression Through Loss of Epigenetic Control

Fitzgerald, M., Oshiro, M., Holtan, N., Krager, K., Cullen, J. J., Futscher, B. W. & Domann, F. E., Sep 2003, In : Neoplasia. 5, 5, p. 427-436 10 p.

Research output: Contribution to journalArticle

Epigenomics
Histones
Pancreas
decitabine
Pancreatic Carcinoma
33 Citations (Scopus)

MnSOD Up-Regulates Maspin Tumor Suppressor Gene Expression in Human Breast and Prostate Cancer Cells

Duan, H., Zhang, H. J., Yang, J. Q., Oberley, L. W., Futscher, B. W. & Domann, F. E., Oct 2003, In : Antioxidants and Redox Signaling. 5, 5, p. 677-688 12 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Gene expression
Superoxide Dismutase
Tumors
Prostatic Neoplasms