• 5643 Citations
  • 43 h-Index
1978 …2020

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Article
1989

Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells.

Futscher, B. W., Micetich, K. C., Barnes, D. M., Fisher, R. I. & Erickson, L. C., 1989, In : Cancer communications. 1, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Transcription-terminating lesions induced by bifunctional alkylating agents in vitro

Pieper, R. O., Futscher, B. W. & Erickson, L. C., Jul 1 1989, In : Carcinogenesis. 10, 7, p. 1307-1314 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
1990

Changes in c-myc and c-fos Expression in a Human Tumor Cell Line following Exposure to Bifunctional Alkylating Agents

Erickson, L. C. & Futscher, B. W., Jan 1 1990, In : Cancer Research. 50, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gene amplification affecting o-alkylguanine-dna alkyltransferase activity is not detected in nitrosourea resistant or sensitive human cell lines

Vlahos, N. S., Futscher, B. W., Hora, N. K., Trent, J. M. & Erickson, L. C., Mar 1 1990, In : Carcinogenesis. 11, 3, p. 479-483 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Orcadian distribution of proteins in urine from healthy Young men

Kanabrocki, E. L., Kanabrocki, J. A., Sothern, R. B., Futscher, B., Lampo, S., Cournoyer, C., Rubnitz, M. E., Zieher, S. J., Greco, J., Bushneli, D. L., Tsai, T. H., Scheving, L. E. & Olwin, J. H., 1990, In : Chronobiology International. 7, 5-6, p. 433-443 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
1991

Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene

Pieper, R. O., Costello, J. F., Kroes, R. A., Futscher, B. W., Marathi, U. & Erickson, L. C., Jan 1 1991, In : Cancer communications. 3, 8, p. 241-253 13 p.

Research output: Contribution to journalArticle

58 Scopus citations
1992

Analysis of the Harvey ras gene in cisplatin-initiated mouse skin tumors by polymerase chain reaction and direct DNA sequencing

Nelson, M. A., Futscher, B. W., Loew, M. R. & Tim Bowden, G., Jul 31 1992, In : Cancer Letters. 65, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Collateral Sensitivity to Nitrosoureas in Multidrug-resistant Cells Selected with Verapamil

Futscher, B. W., Campbell, K. & Dalton, W. S., Sep 1992, In : Cancer Research. 52, 18, p. 5013-5017 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
112 Scopus citations

DNA–Damaging and Transcription‐Terminating Lesions Induced by AF64A In Vitro

Futscher, B. W., Pieper, R. O., Barnes, D. M., Hanin, I. & Erickson, L. C., Apr 1992, In : Journal of neurochemistry. 58, 4, p. 1504-1509 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Expression of ribosomal phosphoprotein po is induced by antitumor agents and increased in mer human tumor cell lines

Grabowski, D. T., Pieper, R. O., Futscher, B. W., Deutsch, W. A., Erickson, L. C. & Kelley, M. R., Feb 1 1992, In : Carcinogenesis. 13, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
30 Scopus citations

Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer

Micetich, K. C., Futscher, B., Koch, D., Fisher, R. I. & Erickson, L. C., Feb 19 1992, In : Journal of the National Cancer Institute. 84, 4, p. 256-261 6 p.

Research output: Contribution to journalArticle

54 Scopus citations
1993

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

List, A. F., Spier, C., Greer, J., Wolff, S., Hutter, J., Dorr, R., Salmon, S., Futscher, B., Baier, M. & Dalton, W., Jan 1 1993, In : Journal of Clinical Oncology. 11, 9, p. 1652-1660 9 p.

Research output: Contribution to journalArticle

293 Scopus citations

Quantitative polymerase chain-reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens

Futscher, B. W., Blake, L. L., Gerlach, J. H., Grogan, T. M. & Dalton, W. S., Sep 1993, In : Analytical Biochemistry. 213, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

70 Scopus citations
1994

Analysis of MRP mRNA in mitoxantrone-selected, multidrug-resistant human tumor cells

Futscher, B. W., Abbaszadegan, M. R., Domann, F. & Dalton, W. S., Apr 29 1994, In : Biochemical Pharmacology. 47, 9, p. 1601-1606 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Analysis of Multidrug Resistance-associated Protein (MRP) Messenger RNA in Normal and Malignant Hematopoietic Cells

Abbaszadegan, M. R., Futscher, B. W., Klimecki, W. T., List, A. & Dalton, W. S., Sep 1994, In : Cancer Research. 54, 17, p. 4676-4679 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Effects of ethanol and paraformaldehyde on RNA yield and quality

Klimecki, W. T., Futscher, B. W. & Dalton, W. S., Jan 1 1994, In : BioTechniques. 16, 6, p. 1021-1023 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells

Costello, J. F., Futscher, B. W., Tano, K., Graunke, D. M. & Pieper, R. O., Jun 24 1994, In : Journal of Biological Chemistry. 269, 25, p. 17228-17237 10 p.

Research output: Contribution to journalArticle

156 Scopus citations
Open Access
91 Scopus citations

P-glycoprotein expression and function in circulating blood cells from normal volunteers

Klimecki, W. T., Futscher, B. W., Grogan, T. M. & Dalton, W. S., May 1 1994, In : Blood. 83, 9, p. 2451-2458 8 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations
1995
2 Scopus citations
1996

Evidence for cytoplasmic P-glycoprotein location associated with increased multidrug resistance and resistance to chemosensitizers

Abbaszadegan, M. R., Cress, A. E., Futscher, B. W., Bellamy, W. T. & Dalton, W. S., Dec 1 1996, In : Cancer Research. 56, 23, p. 5435-5442 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene

Pieper, R. O., Patel, S., Ting, S. A., Futscher, B. W. & Costello, J. F., Jun 25 1996, In : Journal of Biological Chemistry. 271, 23, p. 13916-13924 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance

Futscher, B. W., Foley, N. E., Gleason-Guzman, M. C., Meltzer, P. S., Sullivan, D. M. & Dalton, W. S., May 16 1996, In : International Journal of Cancer. 66, 4, p. 520-525 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
1997

Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIα in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226

Wang, H., Jiang, Z. G., Wong, Y. W., Dalton, W. S., Futscher, B. W. & Chan, V. T. W., Aug 18 1997, In : Biochemical and Biophysical Research Communications. 237, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
Open Access
183 Scopus citations
1998

Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

Rice, J. C., Massey-Brown, K. S. & Futscher, B. W., Oct 8 1998, In : Oncogene. 17, 14, p. 1807-1812 6 p.

Research output: Contribution to journalArticle

Open Access
193 Scopus citations

Selective variegated methylation of the p15 CpG island in acute myeloid leukemia

Dodge, J. E., List, A. F. & Futscher, B. W., Nov 17 1998, In : International Journal of Cancer. 78, 5, p. 561-567 7 p.

Research output: Contribution to journalArticle

63 Scopus citations
1999

Developmental expression of N-acetyltransferases in C57BI/6 mice

Mitchell, M. K., Futscher, B. W. & McQueen, C. A., Feb 16 1999, In : Drug Metabolism and Disposition. 27, 2, p. 261-264 4 p.

Research output: Contribution to journalArticle

34 Scopus citations
2000

Epigenetic silencing of maspin gene expression in human breast cancers

Domann, F. E., Rice, J. C., Hendrix, M. J. C. & Futscher, B. W., Mar 15 2000, In : International Journal of Cancer. 85, 6, p. 805-810 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

Rice, J. C., Ozcelik, H., Maxeiner, P., Andrulis, I. & Futscher, B. W., Jan 1 2000, In : Carcinogenesis. 21, 9, p. 1761-1765 5 p.

Research output: Contribution to journalArticle

Open Access
178 Scopus citations
73 Scopus citations
2001

5-Azacytidine modulates the response of sensitive and multidrug-resistant K562 leukemic cells to cytostatic drugs

Efferth, T., Futscher, B. W. & Osieka, R., Jan 1 2001, In : Blood Cells, Molecules, and Diseases. 27, 3, p. 637-648 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

cDNA microarray analysis of multidrug resistance: Doxorubicin selection produces multiple defects in apoptosis signaling pathways

Watts, G. S., Futscher, B. W., Isett, R., Gleason-Guzman, M., Kunkel, M. W. & Salmon, S. E., Oct 30 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 2, p. 434-441 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Identification of a Novel Structural Variant of the α6 Integrin

Davis, T. L., Rabinovitz, I., Futscher, B. W., Schnölzer, M., Burger, F., Liu, Y., Kulesz-Martin, M. & Cress, A. E., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26099-26106 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen Zearalenone-induced cell-cycle progression in MCF-7 cells

Calaluce, R., Kunkel, M. W., Watts, G. S., Schmelz, M., Hao, J., Barrera, J., Gleason-Guzman, M., Isett, R., Fitchmun, M., Tim Bowden, G., Cress, A. E., Futscher, B. W. & Nagle, R. B., Mar 15 2001, In : Molecular Carcinogenesis. 30, 2, p. 88-98 11 p.

Research output: Contribution to journalArticle

98 Scopus citations
2002

Role for DNA methylation in the control of cell type-specific maspin expression

Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H. & Domann, F. E., Jun 2002, In : Nature Genetics. 31, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

364 Scopus citations
2003

Human Pancreatic Carcinoma Cells Activate Maspin Expression Through Loss of Epigenetic Control

Fitzgerald, M., Oshiro, M., Holtan, N., Krager, K., Cullen, J. J., Futscher, B. W. & Domann, F. E., Sep 1 2003, In : Neoplasia. 5, 5, p. 427-436 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

MnSOD Up-Regulates Maspin Tumor Suppressor Gene Expression in Human Breast and Prostate Cancer Cells

Duan, H., Zhang, H. J., Yang, J. Q., Oberley, L. W., Futscher, B. W. & Domann, F. E., Oct 2003, In : Antioxidants and Redox Signaling. 5, 5, p. 677-688 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression

Oshiro, M. M., Watts, G. S., Wozniak, R. J., Junk, D. J., Munoz-Rodriguez, J. L., Domann, F. E. & Futscher, B. W., Jun 5 2003, In : Oncogene. 22, 23, p. 3624-3634 11 p.

Research output: Contribution to journalArticle

77 Scopus citations
2004

Aberrant methylation of the maspin promoter is an early event in human breast cancer

Futscher, B. W., O'Meara, M. M., Kim, C. J., Rennels, M. A., Lu, D., Gruman, L. M., Seftor, R. E. B., Hendrix, M. J. C. & Domann, F. E., Jul 1 2004, In : Neoplasia. 6, 4, p. 380-389 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Epigenomic changes during leukemia cell differentiation: Analysis of histone acetylation and cytosine methylation using CpG island microarrays

Nouzova, M., Holtan, N., Oshiro, M. M., Isett, R. B., Munoz-Rodriguez, J. L., List, A. F., Narro, M. L., Miller, S. J., Merchant, N. C. & Futscher, B. W., Dec 2004, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 968-981 14 p.

Research output: Contribution to journalArticle

68 Scopus citations

The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells

Watts, G. S., Oshiro, M. M., Junk, D. J., Wozniak, R. J., Watterson, S. J., Domann, F. E. & Futscher, B. W., Jan 1 2004, In : Neoplasia. 6, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2005

Epigenetic regulation of the cell type-specific gene 14-3-3σ

Oshiro, M. M., Futscher, B. W., Lisberg, A., Wozniak, R. J., Klimecki, W. T., Domann, F. E. & Cress, A. E., Sep 2005, In : Neoplasia. 7, 9, p. 799-808 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Epigenetic silencing of DSC3 is a common event in human breast cancer

Oshiro, M. M., Kim, C. J., Wozniak, R. J., Junk, D. J., Muñoz-Rodríguez, J. L., Burr, J. A., Fitzgerald, M., Pawar, S. C., Cress, A. E., Domann, F. E. & Futscher, B. W., Jun 16 2005, In : Breast Cancer Research. 7, 5, R669.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
2006

AP-2α and AP-2γ are transcriptional targets of p53 in human breast carcinoma cells

Li, H., Watts, G. S., Oshiro, M. M., Futscher, B. W. & Domann, F. E., Aug 31 2006, In : Oncogene. 25, 39, p. 5405-5415 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Comparisons of PCR-based genome amplification systems using CpG island microarrays

Pike, B. L., Groshen, S., Hsu, Y. H., Shai, R. M., Wang, X., Holtan, N., Futscher, B. W. & Hacia, J. G., Jun 1 2006, In : Human Mutation. 27, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epigenetic inactivation of the HOXA gene cluster in breast cancer

Novak, P., Jensen, T., Oshiro, M. M., Wozniak, R. J., Nouzova, M., Watts, G. S., Klimecki, W. T., Kim, C. & Futscher, B. W., Nov 15 2006, In : Cancer Research. 66, 22, p. 10664-10670 7 p.

Research output: Contribution to journalArticle

90 Scopus citations