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Cyclization Chemical Compounds
Scaffolds Chemical Compounds
Cyanides Medicine & Life Sciences
Microwaves Medicine & Life Sciences
Azides Medicine & Life Sciences
Libraries Medicine & Life Sciences
Lactams Chemical Compounds
Condensation Chemical Compounds

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Projects 2009 2014

Expeditious, biologically driven Pilot Libraries for File Enhancement

Hulme, C.

National Institutes of Health


Project: Research projectBiotechnology Resource Grants

Pharmaceutical Chemistry
Drug Design
Research Personnel

The Southwest Comprehensive Center for Drug Discovery and Development

Hulme, C., Mousses, S., Berens, M. E. & Meurice, N.

National Institutes of Health


Project: Research projectHigh Impact Research and Research Infrastructure Programs

Drug Discovery
Pharmaceutical Chemistry
Molecular Probes

Research Output 1993 2018

  • 5297 Citations
  • 35 h-Index
  • 112 Article
  • 3 Chapter
  • 2 Review article
Transformer substations
Affinity chromatography

Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Zhang, J., Hu, Y., Foley, C., Wang, Y., Musharrafieh, R., Xu, S., Zhang, Y., Ma, C., Hulme, C. & Wang, J. Dec 1 2018 In : Scientific Reports. 8, 1, 4653

Research output: Contribution to journalArticle

Drug Resistance
Human Influenza
Antiviral Agents

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes

Muñoz-Torrero, D., Mangoni, A. A., Guillou, C., Collina, S., Eynde, J. J. V., Rautio, J., Keseru, G. M., Hulme, C., Chibale, K., Luque, F. J., Karaman, R., Gütschow, M., Liu, H. & Ragno, R. May 1 2017 In : Molecules. 22, 5, 743

Research output: Contribution to journalReview article

Slip forming
2 Citations

Copper(i) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2° α-ketoamides and α-ketotetrazoles

Collet, J. W., Foley, C., Shaw, A. Y., Orru, R. V. A., Ruijter, E. & Hulme, C. 2017 In : Organic and Biomolecular Chemistry. 15, 29, p. 6132-6135 4 p.

Research output: Contribution to journalArticle

Reaction products
1 Citations

Dyrk1 inhibition improves Alzheimer's disease-like pathology

Branca, C., Shaw, D. M., Belfiore, R., Gokhale, V., Shaw, A. Y., Foley, C., Smith, B., Hulme, C., Dunckley, T., Meechoovet, B., Caccamo, A. & Oddo, S. Oct 1 2017 In : Aging Cell. 16, 5, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid beta-Protein Precursor