• 5993 Citations
  • 37 h-Index
1993 …2019

Research output per year

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Research Output

  • 5993 Citations
  • 37 h-Index
  • 113 Article
  • 6 Review article
  • 3 Chapter
2019

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4

Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C. & 5 others, Gütschow, M., Ragno, R., Gomes, P. A. C., Agrofoglio, L. A. & Muñoz-Torrero, D., Jan 1 2019, In : Molecules. 24, 1, p. 1-12 12 p.

Research output: Contribution to journalReview article

Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5

Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M. & 6 others, Kokotos, G., Siciliano, C., Capasso, R., Agrofoglio, L. A., Ragno, R. & Muñoz-Torrero, D., Jan 1 2019, In : Molecules. 24, 13, 2415.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

Velazquez, R., Meechoovet, B., Ow, A., Foley, C., Shaw, A., Smith, B., Oddo, S. ., Hulme, C. & Dunckley, T., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

2 Scopus citations
2018
5 Scopus citations

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2

Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., Jan 1 2018, In : Molecules. 23, 1, 65.

Research output: Contribution to journalReview article

1 Scopus citations

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3

Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., Jan 1 2018, In : Molecules. 23, 7, 1596.

Research output: Contribution to journalReview article

Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Zhang, J., Hu, Y., Foley, C., Wang, Y., Musharrafieh, R., Xu, S., Zhang, Y., Ma, C., Hulme, C. & Wang, J., Dec 1 2018, In : Scientific Reports. 8, 1, 4653.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes

Muñoz-Torrero, D., Mangoni, A. A., Guillou, C., Collina, S., Eynde, J. J. V., Rautio, J., Keseru, G. M., Hulme, C., Chibale, K., Luque, F. J., Karaman, R., Gütschow, M., Liu, H. & Ragno, R., May 1 2017, In : Molecules. 22, 5, 743.

Research output: Contribution to journalReview article

2 Scopus citations

Copper(i) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2° α-ketoamides and α-ketotetrazoles

Collet, J. W., Foley, C., Shaw, A. Y., Orru, R. V. A., Ruijter, E. & Hulme, C., 2017, In : Organic and Biomolecular Chemistry. 15, 29, p. 6132-6135 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dyrk1 inhibition improves Alzheimer's disease-like pathology

Branca, C., Shaw, D. M., Belfiore, R., Gokhale, V., Shaw, A. Y., Foley, C., Smith, B., Hulme, C., Dunckley, T., Meechoovet, B., Caccamo, A. & Oddo, S. ., Oct 1 2017, In : Aging Cell. 16, 5, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
7 Scopus citations

Reaction of 3-amino-1,2,4-triazole with diethyl phosphite and triethyl orthoformate: Acid-base properties and antiosteoporotic activities of the products

Miszczyk, P., Wieczorek, D., Gałeȩzowska, J., Dziuk, B., Wietrzyk, J., Chmielewska, E., Muñoz-Torrero, D., Lavilla, R. & Hulme, C., Feb 1 2017, In : Molecules. 22, 2, 254.

Research output: Contribution to journalArticle

3 Scopus citations

Synthesis of fluorescent heterocycles: Via a Knoevenagel/[4 + 1]-cycloaddition cascade using acetyl cyanide

Martinez-Ariza, G., Mehari, B. T., Pinho, L. A. G., Foley, C., Day, K., Jewett, J. C. & Hulme, C., 2017, In : Organic and Biomolecular Chemistry. 15, 29, p. 6076-6079 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines

Martinez-Ariza, G., McConnell, N. & Hulme, C., Apr 15 2016, In : Organic Letters. 18, 8, p. 1864-1867 4 p.

Research output: Contribution to journalArticle

18 Scopus citations
20 Scopus citations
2015

(Z)-Stereoselective Synthesis of Mono- and Bis-heterocyclic Benzimidazol-2-ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction

Xu, Z., Martinez-Ariza, G., Cappelli, A. P., Roberts, S. A. & Hulme, C., Sep 18 2015, In : Journal of Organic Chemistry. 80, 18, p. 9007-9015 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Acetyl cyanide as a cyanide source in a tandem catalyst-free modified Groebke-Blackburn-Bienaymé [4+1]-cycloaddition-Strecker cascade

Martinez-Ariza, G., Nunez-Rios, J., Lee, Y. S. & Hulme, C., Feb 18 2015, In : Tetrahedron Letters. 56, 8, p. 1038-1040 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Medda, F., Martinez-Ariza, G. & Hulme, C., Sep 16 2015, In : Tetrahedron Letters. 56, 38, p. 5295-5298 4 p., 46572.

Research output: Contribution to journalArticle

13 Scopus citations

Computational study of organo-cesium complexes and the possibility of lanthanide/actinide ions substitution

Rabanal-León, W. A., Martinez-Ariza, G., Roberts, S. A., Hulme, C. & Arratia-Pérez, R., Nov 16 2015, In : Chemical Physics Letters. 641, p. 181-186 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Recent advances in allosteric androgen receptor inhibitors for the potential treatment of castration-resistant prostate cancer

Martinez-Ariza, G. & Hulme, C., Jan 1 2015, In : Pharmaceutical patent analyst. 4, 5, p. 387-402 16 p.

Research output: Contribution to journalReview article

3 Scopus citations

Recent Advances in Multicomponent Reaction Chemistry: Applications in Small Molecule Drug Discovery

Hulme, C., Ayaz, M., Martinez-Ariza, G., Medda, F. & Shaw, A., Oct 23 2015, Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell, p. 145-187 43 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Scopus citations

The Synthesis of Stable, Complex Organocesium Tetramic Acids through the Ugi Reaction and Cesium-Carbonate-Promoted Cascades

Martinez-Ariza, G., Ayaz, M., Roberts, S. A., Rabanal-Leõn, W. A., Arratia-Pérez, R. & Hulme, C., Sep 1 2015, In : Angewandte Chemie - International Edition. 54, 40, p. 11672-11676 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Zeta inhibitory peptide disrupts electrostatic interactions that maintain atypical protein Kinase C in its active conformation on the scaffold p62

Tsai, L. C. L., Xie, L., Dore, K., Xie, L., Del Rio, J. C., King, C. C., Martinez-Ariza, G., Hulme, C., Malinow, R., Bourne, P. E. & Newton, A. C., Sep 4 2015, In : Journal of Biological Chemistry. 290, 36, p. 21845-21856 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

A robust protocol for the synthesis of quinoxalines and 5 H -benzo[ e ][1,4]diazepines via the acidless Ugi reaction

Ayaz, M., Martinez-Ariza, G. & Hulme, C., 2014, In : Synlett. 25, 12, p. 1680-1684 5 p., 8037.

Research output: Contribution to journalArticle

13 Scopus citations

Expeditious routes to polycyclic molecular frameworks via one-pot, two-step Ugi ring-closing sequences

Xu, Z., De Moliner, F., Cappelli, A. P., Ayaz, M. & Hulme, C., Jan 2014, In : Synlett. 25, 2, p. 225-228 4 p., ST-2013-D0922-L.

Research output: Contribution to journalArticle

9 Scopus citations

Exploiting the divalent nature of isonitriles: A novel Pictet-Spengler amidination process

Medda, F. & Hulme, C., May 28 2014, In : Tetrahedron Letters. 55, 22, p. 3328-3331 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines

Bell, C. E., Shaw, A. Y., De Moliner, F. & Hulme, C., Jan 7 2014, In : Tetrahedron. 70, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Novel succinct routes to quinoxalines and 2-benzimidazolylquinoxalines via the Ugi reaction

Ayaz, M., Xu, Z. & Hulme, C., Jun 4 2014, In : Tetrahedron Letters. 55, 23, p. 3406-3409 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells

Chen, Y. H., Lu, P. J., Hulme, C. & Shaw, A. Y., Jan 2014, In : Journal of Heterocyclic Chemistry. 51, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions

Martinez-Ariza, G., Ayaz, M., Medda, F. & Hulme, C., Jun 6 2014, In : Journal of Organic Chemistry. 79, 11, p. 5153-5162 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

Kusne, Y., Carrera-Silva, E. A., Perry, A. S., Rushing, E. J., Mandell, E. K., Dietrich, J. D., Errasti, A. E., Gibbs, D., Berens, M. E., Loftus, J. C., Hulme, C., Yang, W., Lu, Z., Aldape, K., Sanai, N., Rothlin, C. V. & Ghosh, S., Aug 12 2014, In : Science Signaling. 7, 338, ra75.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Aldol reactions in multicomponent reaction based domino pathways: A multipurpose enabling tool in heterocyclic chemistry

Xu, Z., De Moliner, F., Cappelli, A. P. & Hulme, C., 2013, In : Organic Letters. 15, 11, p. 2738-2741 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles

Martinez-Ariza, G., Ayaz, M. & Hulme, C., Dec 4 2013, In : Tetrahedron Letters. 54, 49, p. 6719-6721 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

A tandem [3+2] cycloaddition-elimination cascade reaction to generate pyrrolo-[3,4-c]pyrrole-1,3-diones

Martinez-Ariza, G., Dietrich, J., De Moliner, F. & Hulme, C., 2013, In : Synlett. 24, 14, p. 1801-1804 4 p., ST-2013-D0356-L.

Research output: Contribution to journalArticle

8 Scopus citations

Beyond secretases: Kinase inhibitors for the treatment of Alzheimer's disease

Medda, F., Smith, B., Gokhale, V., Shaw, A. Y., Dunckley, T. & Hulme, C., 2013, In : Annual Reports in Medicinal Chemistry. 48, p. 57-71 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
35 Scopus citations

Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade

Gunawan, S. & Hulme, C., Aug 14 2013, In : Tetrahedron Letters. 54, 33, p. 4467-4470 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

One-pot two-step synthesis of quinoxalinones and diazepinones via a tandem oxidative amidation-deprotection-cyclization sequence

Shaw, A. Y., Denning, C. R. & Hulme, C., 2013, In : Synthesis. 45, 4, p. 459-462 4 p., SS-2012-M0793-OP.

Research output: Contribution to journalArticle

18 Scopus citations

Structure-activity relationship study of growth inhibitory 2-styrylchromones against carcinoma cells

Lin, C., Lu, P. J., Yang, C. N., Hulme, C. & Shaw, A. Y., May 2013, In : Medicinal Chemistry Research. 22, 5, p. 2385-2394 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

Medda, F., Sells, E., Chang, H. H., Dietrich, J., Chappeta, S., Smith, B., Gokhale, V., Meuillet, E. & Hulme, C., Jan 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 2, p. 528-531 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Hsu, M. Y., Dietrich, J., Hulme, C. & Shaw, A. Y., 2013, In : Synthetic Communications. 43, 11, p. 1538-1542 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of kojic acid-derived copper-chelating apoptosis inducing agents

Chen, Y. H., Lu, P. J., Hulme, C. & Shaw, A. Y., Feb 2013, In : Medicinal Chemistry Research. 22, 2, p. 995-1003 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

2,4-Diphenyl-6-trifluoromethyl-2,3-dihydro-1H,5H-pyrrolo-[3,4-c]pyrrole-1, 3-dione

Roberts, S. A., Martinez-Ariza, G., Dietrich, J. & Hulme, C., Feb 2012, In : Acta Crystallographica Section E: Structure Reports Online. 68, 2

Research output: Contribution to journalArticle

21 Scopus citations

Applications of Isocyanides in IMCRs for the Rapid Generation of Molecular Diversity

Ayaz, M., De Moliner, F., Dietrich, J. & Hulme, C., Aug 23 2012, Isocyanide Chemistry: Applications in Synthesis and Material Science. Wiley-VCH, p. 335-384 50 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes

Xu, Z., Shaw, A. Y., Nichol, G. S., Cappelli, A. P. & Hulme, C., Aug 2012, In : Molecular Diversity. 16, 3, p. 607-612 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families

De Moliner, F. & Hulme, C., Oct 24 2012, In : Tetrahedron Letters. 53, 43, p. 5787-5790 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Gunawan, S., Petit, J. & Hulme, C., Mar 12 2012, In : ACS Combinatorial Science. 14, 3, p. 160-163 4 p.

Research output: Contribution to journalArticle

37 Scopus citations