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  • 5 Similar Profiles
Drosophila Medicine & Life Sciences
Proteins Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
RNA Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences
Messenger RNA Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences

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Projects 2003 2020

RNA dysregulation in neurodegeneration

Zarnescu, D. C.

National Institutes of Health

9/1/155/31/20

Project: Research projectResearch Project

Amyotrophic Lateral Sclerosis
RNA
Protein Biosynthesis
Motor Neurons
Neurodegenerative Diseases

Deciphering RNA based mechanisms of neurodegeneration

Zarnescu, D. C.

National Institutes of Health

9/1/128/31/15

Project: Research projectExploratory/Developmental Grants

RNA
RNA-Binding Proteins
Drosophila
Motor Neurons
Mutation

Characterization of a novel Fragile X interacting gene

Zarnescu, D. C.

National Institutes of Health

8/1/037/31/06

Project: Research projectPostdoctoral Individual National Research Service Award

Genes
Proteins
Myosin Type V
Fragile X Syndrome
Intellectual Disability

Research Output 1998 2017

  • 1582 Citations
  • 18 h-Index
  • 30 Article
  • 1 Chapter
  • 1 Conference contribution
  • 1 Review article

Failure to deliver and translate—new insights into RNA dysregulation in ALS

Coyne, A. N., Zaepfel, B. L. & Zarnescu, D. C. Aug 17 2017 In : Frontiers in Cellular Neuroscience. 11, 243

Research output: Research - peer-reviewReview article

Amyotrophic Lateral Sclerosis
RNA
Mutation
RNA-Binding Proteins
RNA Transport

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Coyne, A. N., Lorenzini, I., Chou, C. C., Torvund, M., Rogers, R. S., Starr, A., Zaepfel, B. L., Levy, J., Johannesmeyer, J., Schwartz, J. C., Nishimune, H., Zinsmaier, K., Rossoll, W., Sattler, R. & Zarnescu, D. C. Oct 3 2017 In : Cell Reports. 21, 1, p. 110-125 16 p.

Research output: Research - peer-reviewArticle

Neurons
Defects
Synaptic Vesicles
Amyotrophic Lateral Sclerosis
Dynamins

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes

Coyne, A. N. & Zarnescu, D. C. Nov 1 2016 In : PLoS Genetics. 12, 11, e1006419

Research output: Research - peer-reviewArticle

19 Citations

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Coyne, A. N., Yamada, S. B., Siddegowda, B. B., Estes, P. S., Zaepfel, B. L., Johannesmeyer, J. S., Lockwood, D. B., Pham, L. T., Hart, M. P., Cassel, J. A., Freibaum, B., Boehringer, A. V., Paul Taylor, J., Reitz, A. B., Gitler, A. D. & Zarnescu, D. C. 2015 In : Human Molecular Genetics. 24, 24, p. 6886-6898 13 p.

Research output: Research - peer-reviewArticle

RNA
Proteins
Drosophila Fragile X mental retardation protein
Amyotrophic Lateral Sclerosis
Motor Neurons
2 Citations

PABPN1 suppresses TDP-43 toxicity in ALS disease models

Chou, C. C., Alexeeva, O. M., Yamada, S., Pribadi, A., Zhang, Y., Mo, B., Williams, K. R., Zarnescu, D. C. & Rossoll, W. Apr 9 2015 In : Human Molecular Genetics. 24, 18, p. 5154-5173 20 p., ddv238

Research output: Research - peer-reviewArticle

Poly(A)-Binding Protein II
Amyotrophic Lateral Sclerosis
DNA-Binding Proteins
Proteins
Nuclear Localization Signals