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Daniela C Zarnescu

  • 1923 Citations
  • 20 h-Index
19982020
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  • 8 Similar Profiles
Drosophila Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences
Fragile X Mental Retardation Protein Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Proteins Medicine & Life Sciences
Spectrin Medicine & Life Sciences

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Projects 2003 2020

RNA dysregulation in neurodegeneration

Zarnescu, D. C.

National Institutes of Health

9/1/15 → 5/31/20

Project: Research project

Amyotrophic Lateral Sclerosis
RNA
Protein Biosynthesis
Motor Neurons
Neurodegenerative Diseases

Deciphering RNA based mechanisms of neurodegeneration

Zarnescu, D. C.

National Institutes of Health

9/1/12 → 8/31/15

Project: Research project

RNA
RNA-Binding Proteins
Drosophila
Motor Neurons
Fragile X Syndrome

Characterization of a novel Fragile X interacting gene

Zarnescu, D. C.

National Institutes of Health

8/1/03 → 7/31/06

Project: Research project

Myosin Type V
Fragile X Syndrome
Intellectual Disability
Drosophila
Genes

Research Output 1998 2019

  • 1923 Citations
  • 20 h-Index
  • 37 Article
  • 2 Chapter
  • 1 Conference contribution
  • 1 Review article

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Manzo, E., Lorenzini, I., Barrameda, D., O'Conner, A. G., Barrows, J. M., Starr, A., Kovalik, T., Rabichow, B. E., Lehmkuhl, E. M., Shreiner, D. D., Joardar, A., Liévens, J. C., Bowser, R., Sattler, R. & Zarnescu, D. C., Jun 10 2019, In : eLife. 8

Research output: Contribution to journal › Article

Open Access
Amyotrophic Lateral Sclerosis
Motor Neurons
Glycolysis
Neurons
TDP-43 Proteinopathies
1 Citation (Scopus)

Dynamic duo – FMRP and TDP-43: Regulating common targets, causing different diseases

Ferro, D., Yao, S. & Zarnescu, D. C., Jan 1 2018, (Accepted/In press) In : Brain Research.

Research output: Contribution to journal › Article

Fragile X Mental Retardation Protein
RNA-Binding Proteins
RNA Sequence Analysis
Neuronal Plasticity
DNA-Binding Proteins
5 Citations (Scopus)

Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1

Chu, M., Novak, S. M., Cover, C., Wang, A. A., Chinyere, I. R., Juneman, E. B., Zarnescu, D. C., Wong, P. K. & Gregorio, C., Feb 6 2018, In : Circulation. 137, 6, p. 605-618 14 p.

Research output: Contribution to journal › Article

RNA-Binding Proteins
Gap Junctions
Up-Regulation
Dilated Cardiomyopathy
Heart Diseases
3 Citations (Scopus)

Lost in translation: Evidence for protein synthesis deficits in ALS/FTD and related neurodegenerative diseases

Lehmkuhl, E. M. & Zarnescu, D. C., Jan 1 2018, Advances in Neurobiology. Springer New York LLC, p. 283-301 19 p. (Advances in Neurobiology; vol. 20).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Neurodegenerative diseases
Protein Biosynthesis
Neurodegenerative Diseases
RNA
Enzyme inhibition
2 Citations (Scopus)

Medium-chain fatty acids, beta-hydroxybutyric acid and genetic modulation of the carnitine shuttle are protective in a drosophila model of ALS based on TDP-43

Manzo, E., O’Conner, A. G., Barrows, J. M., Shreiner, D. D., Birchak, G. J. & Zarnescu, D. C., May 31 2018, In : Frontiers in Molecular Neuroscience. 11, 182.

Research output: Contribution to journal › Article

3-Hydroxybutyric Acid
Carnitine
Drosophila
Fatty Acids
Lipid Metabolism