• 2068 Citations
  • 21 h-Index
19982020

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Article
2019

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Manzo, E., Lorenzini, I., Barrameda, D., O'Conner, A. G., Barrows, J. M., Starr, A., Kovalik, T., Rabichow, B. E., Lehmkuhl, E. M., Shreiner, D. D., Joardar, A., Liévens, J. C., Bowser, R., Sattler, R. & Zarnescu, D. C., Jun 10 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

François-Moutal, L., Felemban, R., Scott, D. D., Sayegh, M. R., Miranda, V. G., Perez-Miller, S., Khanna, R., Gokhale, V., Zarnescu, D. C. & Khanna, M., Sep 20 2019, In : ACS Chemical Biology. 14, 9, p. 2006-2013 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Dynamic duo – FMRP and TDP-43: Regulating common targets, causing different diseases

Ferro, D., Yao, S. & Zarnescu, D. C., Jan 1 2018, (Accepted/In press) In : Brain Research.

Research output: Contribution to journalArticle

2 Scopus citations

Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1

Chu, M., Novak, S. M., Cover, C., Wang, A. A., Chinyere, I. R., Juneman, E. B., Zarnescu, D. C., Wong, P. K. & Gregorio, C., Feb 6 2018, In : Circulation. 137, 6, p. 605-618 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Medium-chain fatty acids, beta-hydroxybutyric acid and genetic modulation of the carnitine shuttle are protective in a drosophila model of ALS based on TDP-43

Manzo, E., O’Conner, A. G., Barrows, J. M., Shreiner, D. D., Birchak, G. J. & Zarnescu, D. C., May 31 2018, In : Frontiers in Molecular Neuroscience. 11, 182.

Research output: Contribution to journalArticle

5 Scopus citations

MiR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila

Daniel, S. G., Russ, A. D., Guthridge, K. M., Raina, A. I., Estes, P. S., Parsons, L. M., Richardson, H. E., Schroeder, J. A. & Zarnescu, D. C., Jan 1 2018, In : Biology Open. 7, 1, bio027391.

Research output: Contribution to journalArticle

4 Scopus citations

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

Chou, C. C., Zhang, Y., Umoh, M. E., Vaughan, S. W., Lorenzini, I., Liu, F., Sayegh, M., Donlin-Asp, P. G., Chen, Y. H., Duong, D. M., Seyfried, N. T., Powers, M. A., Kukar, T., Hales, C. M., Gearing, M., Cairns, N. J., Boylan, K. B., Dickson, D. W., Rademakers, R., Zhang, Y. J. & 5 others, Petrucelli, L., Sattler, R., Zarnescu, D. C., Glass, J. D. & Rossoll, W., Feb 1 2018, In : Nature Neuroscience. 21, 2, p. 228-239 12 p.

Research output: Contribution to journalArticle

94 Scopus citations
2017

Endocytosis regulates TDP-43 toxicity and turnover

Liu, G., Coyne, A. N., Pei, F., Vaughan, S., Chaung, M., Zarnescu, D. C. & Buchan, J. R., Dec 1 2017, In : Nature communications. 8, 1, 2092.

Research output: Contribution to journalArticle

17 Scopus citations

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Coyne, A. N., Lorenzini, I., Chou, C. C., Torvund, M., Rogers, R. S., Starr, A., Zaepfel, B. L., Levy, J., Johannesmeyer, J., Schwartz, J. C., Nishimune, H., Zinsmaier, K., Rossoll, W., Sattler, R. & Zarnescu, D. C., Oct 3 2017, In : Cell Reports. 21, 1, p. 110-125 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes

Coyne, A. N. & Zarnescu, D. C., Nov 1 2016, In : PLoS Genetics. 12, 11, e1006419.

Research output: Contribution to journalArticle

2015

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Coyne, A. N., Yamada, S. B., Siddegowda, B. B., Estes, P. S., Zaepfel, B. L., Johannesmeyer, J. S., Lockwood, D. B., Pham, L. T., Hart, M. P., Cassel, J. A., Freibaum, B., Boehringer, A. V., Paul Taylor, J., Reitz, A. B., Gitler, A. D. & Zarnescu, D. C., 2015, In : Human Molecular Genetics. 24, 24, p. 6886-6898 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

PABPN1 suppresses TDP-43 toxicity in ALS disease models

Chou, C. C., Alexeeva, O. M., Yamada, S., Pribadi, A., Zhang, Y., Mo, B., Williams, K. R., Zarnescu, D. C. & Rossoll, W., Apr 9 2015, In : Human Molecular Genetics. 24, 18, p. 5154-5173 20 p., ddv238.

Research output: Contribution to journalArticle

8 Scopus citations

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43

Joardar, A., Menzl, J., Podolsky, T. C., Manzo, E., Estes, P. S., Ashford, S. & Zarnescu, D. C., 2015, In : Human Molecular Genetics. 24, 6, p. 1741-1754 14 p., ddu587.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of heart rate in drosophila via fragile X mental retardation protein

Novak, S. M., Joardar, A., Gregorio, C. & Zarnescu, D. C., Nov 1 2015, In : PLoS One. 10, 11, e0142836.

Research output: Contribution to journalArticle

4 Scopus citations
2014

FUTSCH/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis

Coyne, A. N., Siddegowda, B. B., Estes, P. S., Johannesmeyer, J., Kovalik, T., Daniel, S. G., Pearson, A., Bowser, R. & Zarnescu, D. C., Nov 26 2014, In : Journal of Neuroscience. 34, 48, p. 15962-15974 13 p.

Research output: Contribution to journalArticle

69 Scopus citations
2013

Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

Estes, P. S., Daniel, S. G., Mccallum, A. P., Boehringer, A. V., Sukhina, A. S., Zwick, R. A. & Zarnescu, D. C., May 1 2013, In : DMM Disease Models and Mechanisms. 6, 3, p. 721-733 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain

Callan, M. A., Clements, N., Ahrendt, N. & Zarnescu, D. C., Jun 26 2012, In : Brain Research. 1462, p. 151-161 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hugl1 and Hugl2 in Mammary Epithelial Cells: Polarity, Proliferation, and Differentiation

Russ, A., Louderbough, J. M. V., Zarnescu, D. & Schroeder, J. A., Oct 23 2012, In : PloS one. 7, 10, e47734.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle

Whitman, S. A., Cover, C., Yu, L., Nelson, D. L., Zarnescu, D. C. & Gregorio, C. C., Jul 22 2011, In : Circulation research. 109, 3, p. 262-271 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS

Estes, P. S., Boehringer, A., Zwick, R., Tang, J. E., Grigsby, B. & Zarnescu, D. C., Jun 1 2011, In : Human molecular genetics. 20, 12, p. 2308-2321 14 p.

Research output: Contribution to journalArticle

82 Scopus citations
2010

Fragile X protein controls neural stem cell proliferation in the Drosophila brain

Callan, M. A., Cabernard, C., Heck, J., Luois, S., Doe, C. Q. & Zarnescu, D. C., Aug 1 2010, In : Human molecular genetics. 19, 15, p. 3068-3079 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

The cell adhesion molecule Roughest depends on ßHeavy-spectrin during eye morphogenesis in Drosophila

Lee, H. G., Zarnescu, D., MacIver, B. & Thomas, G. H., Jan 15 2010, In : Journal of Cell Science. 123, 2, p. 277-285 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Drosophila Fragile X Protein controls cellular proliferation by regulating cbl levels in the ovary

Epstein, A. M., Bauer, C. R., Ho, A., Bosco, G. & Zarnescu, D. C., Jun 1 2009, In : Developmental biology. 330, 1, p. 83-92 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genetic modifiers of dFMR1 encode RNA granule components in Drosophila

Cziko, A. M. J., McCann, C. T., Howlett, I. C., Barbee, S. A., Duncan, R. P., Luedemann, R., Zarnescu, D., Zinsmaier, K. E., Parker, R. R. & Ramaswami, M., Aug 1 2009, In : Genetics. 182, 4, p. 1051-1060 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2008

Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons

Estes, P. S., O'Shea, M., Clasen, S. & Zarnescu, D. C., Oct 1 2008, In : Molecular and Cellular Neuroscience. 39, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks

Bauer, C. R., Epstein, A. M., Sweeney, S. J., Zarnescu, D. C. & Bosco, G., Nov 25 2008, In : BMC Systems Biology. 2, 101.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

Chang, S., Bray, S. M., Li, Z., Zarnescu, D. C., He, C., Jin, P. & Warren, S. T., Apr 2008, In : Nature chemical biology. 4, 4, p. 256-263 8 p.

Research output: Contribution to journalArticle

203 Scopus citations
2005

Fragile X protein functions with Lgl and the PAR complex in flies and mice

Zarnescu, D. C., Jin, P., Betschinger, J., Nakamoto, M., Wang, Y., Dockendorff, T. C., Feng, Y., Jongens, T. A., Sisson, J. C., Knoblich, J. A., Warren, S. T. & Moses, K., Jan 1 2005, In : Developmental Cell. 8, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2004

Biochemical and genetic interaction between the fragile X mental retardation protein 3nd the microRNA pathway

Jin, P., Zarnescu, D. C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T. A., Nelson, D. L., Moses, K. & Warren, S. T., Feb 1 2004, In : Nature neuroscience. 7, 2, p. 113-117 5 p.

Research output: Contribution to journalArticle

477 Scopus citations
2003

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila

Jin, P., Zarnescu, D. C., Zhang, F., Pearson, C. E., Lucchesi, J. C., Moses, K. & Warren, S. T., Aug 28 2003, In : Neuron. 39, 5, p. 739-747 9 p.

Research output: Contribution to journalArticle

272 Scopus citations
2002

Crumbs interacts with moesin and βHeavy-spectrin in the apical membrane skeleton of Drosophila

Médina, E., Williams, J., Klipfell, E., Zarnescu, D., Thomas, G. & Bivic, A. L., Sep 2 2002, In : Journal of Cell Biology. 158, 5, p. 941-951 11 p.

Research output: Contribution to journalArticle

135 Scopus citations
1999

Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila

Zarnescu, D. C. & Thomas, G. H., Sep 22 1999, In : Journal of Cell Biology. 146, 5, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

77 Scopus citations
1998

Drosophila β(Heavy)-spectrin is essential for development and contributes to specific cell fates in the eye

Thomas, G. H., Zarnescu, D. C., Juedes, A. E., Bales, M. A., Londergan, A., Korte, C. C. & Kiehart, D. P., Jan 1 1998, In : Development. 125, 11, p. 2125-2134 10 p.

Research output: Contribution to journalArticle

59 Scopus citations