• 11232 Citations
  • 49 h-Index
1981 …2021
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  • 5 Similar Profiles
NF-E2-Related Factor 2 Medicine & Life Sciences
Antioxidants Medicine & Life Sciences
Oxidative Stress Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Chemical activation Chemical Compounds
Antioxidant Response Elements Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences

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Projects 1981 2021

Arsenic, Nrf2 and Autophagy Dysfunction in Type II Diabetes

Zhang, D.

National Institutes of Health

7/15/166/30/20

Project: Research projectResearch Project

Autophagy
Arsenic
Type 2 Diabetes Mellitus
Lysosomes
Adipocytes

Nrf2, autophagy, and arsenic carcinogenesis

Zhang, D.

National Institutes of Health

7/1/166/30/21

Project: Research projectResearch Project

Autophagy
Arsenic
Carcinogenesis
Lysosomes
Reactive Oxygen Species
Arsenic
Autophagy
Arsenicals
Quality Control
Foot Diseases

Targeting colorectal carcinogenesis using a cinnamon-derived food factor

Zhang, D. & Wondrak, G. T.

National Institutes of Health

1/1/1312/31/14

Project: Research projectExploratory/Developmental Grants

Cinnamomum zeylanicum
NF-E2-Related Factor 2
Carcinogenesis
Food
Cinnamomum aromaticum
Phytochemicals
Antioxidant Response Elements
Ubiquitin-Protein Ligases
Neoplasms
Proteins

Research Output 1994 2018

A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells

Wang, S., Xiao, Y., Zhang, D. & Wong, P. K., Feb 1 2018, In : Biomaterials. 156, p. 56-64 9 p.

Research output: Contribution to journalArticle

Transcription
Monitoring
Nucleic Acid Probes
Proteins
Messenger RNA

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Wei, J., Yuan, Y., Chen, L., Xu, Y., Zhang, Y., Wang, Y., Yang, Y., Peek, C. B., Diebold, L., Yang, Y., Gao, B., Jin, C., Melo-Cardenas, J., Chandel, N. S., Zhang, D., Pan, H., Zhang, K., Wang, J., He, F. & Fang, D., Dec 1 2018, In : Nature communications. 9, 1, 3659.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
metabolism
Ligases
Ubiquitin
liver

Increased O-GlcNAcylation of SNAP29 drives arsenicinduced autophagic dysfunction

Dodson, M., Liu, P., Jiang, T., Ambrose, A. J., Luo, G., de la Vega, M. R., Cholanians, A. B., Wong, P. K., Chapman, E. & Zhang, D., Jun 1 2018, In : Molecular and Cellular Biology. 38, 11, e00595-17.

Research output: Contribution to journalArticle

Arsenic
SNARE Proteins
Autophagy
Lysosomes
Clustered Regularly Interspaced Short Palindromic Repeats

Kelch-like ECH-Associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2)

Tian, W., De La Vega, M. R., Schmidlin, C. J., Ooi, A. & Zhang, D., Jan 1 2018, In : Journal of Biological Chemistry. 293, 6, p. 2029-2040 12 p.

Research output: Contribution to journalArticle

GATA1 Transcription Factor
Proteins
Degradation
Bearings (structural)
Antioxidant Response Elements
1 Citations

Low-level arsenic causes proteotoxic stress and not oxidative stress

Dodson, M., de la Vega, M. R., Harder, B., Castro-Portuguez, R., Rodrigues, S. D., Wong, P. K., Chapman, E. & Zhang, D., Feb 15 2018, In : Toxicology and Applied Pharmacology. 341, p. 106-113 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Arsenic
Oxidative Stress
Autophagy
Pathology