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Eli Chapman

  • 1963 Citations
  • 24 h-Index
19952019
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Chaperonins Medicine & Life Sciences
Biological Products Medicine & Life Sciences
Sulfotransferases Chemical Compounds
tyrosine-ester sulfotransferase Medicine & Life Sciences
Proteins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Autophagy Medicine & Life Sciences

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Projects 2004 2018

Stress response, p97, and Nrf2 in arsenic-mediated toxicity

Chapman, E. & Zhang, D.

National Institutes of Health

2/1/14 → 10/31/18

Project: Research project

Arsenic
Autophagy
Arsenicals
Quality Control
Foot Diseases

Using chemical genetics to explore GroEL function

Chapman, E.

National Institutes of Health

2/1/04 → 1/31/07

Project: Research project

Chaperonins
Peptides
Escherichia coli
Inclusion Bodies
Protein Folding

Research Output 1995 2019

A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78

Ambrose, A. J., Zerio, C. J., Sivinski, J., Schmidlin, C. J., Shi, T., Ross, A. B., Widrick, K. J., Johnson, S. M., Zhang, D. & Chapman, E., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1689-1693 5 p.

Research output: Contribution to journal › Article

Hexachlorophene
HSP70 Heat-Shock Proteins
Assays
Throughput
Substrates

An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol

Shi, T., Kithsiri Wijeratne, E. M., Solano, C., Ambrose, A. J., Ross, A. B., Norwood, C., Orido, C. K., Grigoryan, T., Tillotson, J., Kang, M., Luo, G., Keegan, B. M., Hu, W., Blagg, B. S. J., Zhang, D., Gunatilaka, L. & Chapman, E., Jul 30 2019, In : Biochemistry. 58, 30, p. 3225-3231 7 p.

Research output: Contribution to journal › Article

Nitrogen Compounds
hydrazine
Protein Isoforms
Nitrogen
Non-Receptor Type 1 Protein Tyrosine Phosphatase

A One-Step, Atom Economical Synthesis of Thieno[2,3-d]pyrimidin-4-amine Derivatives by a Four-Component Reaction

Shi, T., Zerio, C. J., Sivinski, J., Ambrose, A. J., Moore, K. T., Buckley, T., Kaneko, L., Zhang, M., Zhang, D. & Chapman, E., Jun 2 2019, In : European Journal of Organic Chemistry. 2019, 20, p. 3269-3272 4 p.

Research output: Contribution to journal › Article

Ketones
Amines
amines
Phosphotransferases
Derivatives

Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)

Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K. & Zhang, D., Mar 1 2019, In : Cancer Research. 79, 5, 1 p.

Research output: Contribution to journal › Comment/debate

Western Blotting
Research
Neoplasms
Emotions

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB)inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Washburn, A., Abdeen, S., Ovechkina, Y., Ray, A. M., Stevens, M., Chitre, S., Sivinski, J., Park, Y., Johnson, J., Hoang, Q. Q., Chapman, E., Parish, T. & Johnson, S. M., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journal › Article

Polypharmacology
Chaperonins
Mycobacterium Infections
Protein Tyrosine Phosphatases
Mycobacterium tuberculosis