• 4042 Citations
  • 36 h-Index
1977 …2021

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Article
2019

Coupling reactions between reduced intermediates of insensitive munitions compound analog 4-nitroanisole

Kadoya, W. M., Sierra Alvarez, M. R., Jagadish, B., Wong, S., Abrell, L. M., Mash, E. A. & Field, J. A., May 1 2019, In : Chemosphere. 222, p. 789-796 8 p.

Research output: Contribution to journalArticle

2018

Evidence of anaerobic coupling reactions between reduced intermediates of 4-nitroanisole

Kadoya, W. M., Sierra Alvarez, M. R., Wong, S., Abrell, L. M., Mash, E. A. & Field, J. A., Mar 1 2018, In : Chemosphere. 195, p. 372-380 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors

Raghunand, N., Scicinski, J., Guntle, G. P., Jagadish, B., Mash, E. A., Bruckheimer, E., Oronsky, B. & Korn, R. L., Jan 1 2017, In : Oncotarget. 8, 60, p. 102511-102520 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Solvent-free nitration of electron-rich arenes

Jagadish, B., Hurley, N. R. & Mash, E. A., Dec 17 2017, In : Synthetic Communications. 47, 24, p. 2395-2398 4 p.

Research output: Contribution to journalArticle

2016

Magnetic resonance imaging identifies differential response to pro-oxidant chemotherapy in a xenograft model

Landowski, T. H., Guntle, G. P., Zhao, D., Jagadish, B., Mash, E. A., Dorr, R. T. & Raghunand, N., Jun 1 2016, In : Translational Oncology. 9, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor

Elshan, N. G. R. D., Jayasundera, T., Weber, C. S., Lynch, R. M. & Mash, E. A., Apr 15 2015, In : Bioorganic and Medicinal Chemistry. 23, 8, p. 1841-1848 8 p.

Research output: Contribution to journalArticle

Linear scaffolds for multivalent targeting of melanocortin receptors

Dehigaspitiya, D. C., Anglin, B. L., Smith, K. R., Weber, C. S., Lynch, R. & Mash, E. A., 2015, In : Organic and Biomolecular Chemistry. 13, 47, p. 11507-11517 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and bioactivity of MSH4 oligomers prepared by an A<inf>2</inf> + B<inf>2</inf> strategy

Dehigaspitiya, D. C., Navath, S., Weber, C. S., Lynch, R. & Mash, E. A., Jul 3 2015, In : Tetrahedron Letters. 56, 23, p. 3060-3065 6 p., 45546.

Research output: Contribution to journalArticle

4 Scopus citations

Trigonal scaffolds for multivalent targeting of melanocortin receptors

Elshan, N. G. R. D., Jayasundera, T., Anglin, B. L., Weber, C. S., Lynch, R. M. & Mash, E. A., Feb 14 2015, In : Organic and Biomolecular Chemistry. 13, 6, p. 1778-1791 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Crystal engineering with 1,4-piperazine-2,5-diones

Mash, E. A., Oct 7 2014, In : CrystEngComm. 16, 37, p. 8620-8637 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

Improved synthesis of 10-(2-alkylamino-2-oxoethyl)-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid derivatives bearing acid-sensitive linkers

Jagadish, B., Ozumerzifon, T. J., Roberts, S. A., Hall, G. B., Mash, E. A. & Raghunand, N., Feb 1 2014, In : Synthetic Communications. 44, 3, p. 441-449 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)

Radhakrishnan, V. M., Kojs, P., Young, G., Ramalingam, R., Jagadish, B., Mash, E. A., Martinez, J. D., Ghishan, F. K. & Kiela, P. R., Jan 22 2014, In : PloS one. 9, 1, e85796.

Research output: Contribution to journalArticle

24 Scopus citations
6 Scopus citations

Synthesis of 13C and 15N labeled 2,4-dinitroanisole

Jagadish, B., Field, J. A., Chorover, J., Sierra-Alvarez, R., Abrell, L. & Mash, E. A., May 30 2014, In : Journal of Labelled Compounds and Radiopharmaceuticals. 57, 6, p. 434-436 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Martinez, G. V., Navath, S., Sewda, K., Rao, V., Foroutan, P., Alleti, R., Moberg, V. E., Ahad, A. M., Coppola, D., Lloyd, M. C., Gillies, R. J., Morse, D. L. & Mash, E. A., Apr 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 7, p. 2061-2064 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Substrate-dependent ligand inhibition of the human organic cation transporter OCT2

Belzer, M., Morales, M., Jagadish, B., Mash, E. A. & Wright, S. H., Aug 2013, In : Journal of Pharmacology and Experimental Therapeutics. 346, 2, p. 300-310 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors

Alleti, R., Vagner, J., Dehigaspitiya, D. C., Moberg, V. E., Elshan, N. G. R. D., Tafreshi, N. K., Brabez, N., Weber, C. S., Lynch, R. M., Hruby, V. J., Gillies, R. J., Morse, D. L. & Mash, E. A., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5029-5038 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Design, synthesis, and testing of a molecular truck for colonic delivery of 5-aminosalicylic acid

Navath, S., Rao, V., Woodford, R. M. T., Midura-Kiela, M. T., Ahad, A. M., Alleti, R., Kiela, P. R. & Mash, E. A., Sep 13 2012, In : ACS Medicinal Chemistry Letters. 3, 9, p. 710-714 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Heterobivalent ligands target cell-surface receptor combinations in vivo

Xu, L., Josan, J. S., Vagner, J., Caplan, M. R., Hruby, V. J., Mash, E. A., Lynch, R. M., Morse, D. L. & Gillies, R. J., Dec 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21295-21300 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Organic crystal engineering with 1,4-piperazine-2,5-diones. 8. Synthesis, crystal packing, and thermochemistry of piperazinediones derived from 2-amino-4,7-dialkoxyindan-2-carboxylic acids

Wells, K. E., Weatherhead, R. A., Murigi, F. N., Nichol, G. S., Carducci, M. D., Selby, H. D. & Mash, E. A., Oct 3 2012, In : Crystal Growth and Design. 12, 10, p. 5056-5068 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Redox-active magnetic resonance imaging contrast agents: Studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives

Jagadish, B., Guntle, G. P., Zhao, D., Gokhale, V., Ozumerzifon, T. J., Ahad, A. M., Mash, E. A. & Raghunand, N., Dec 13 2012, In : Journal of Medicinal Chemistry. 55, 23, p. 10378-10386 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Tumor xenograft response to redox-active therapies assessed by magnetic resonance imaging using a thiol-bearing DOTA complex of gadolinium

Guntle, G. P., Jagadish, B., Mash, E. A., Powis, G., Dorr, R. T. & Raghunand, N., Jun 2012, In : Translational Oncology. 5, 3, p. 190-199 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

A sucrose-derived scaffold for multimerization of bioactive peptides

Rao, V., Alleti, R., Xu, L., Tafreshi, N. K., Morse, D. L., Gillies, R. J. & Mash, E. A., Nov 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 21, p. 6474-6482 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cell-specific targeting by heterobivalent ligands

Josan, J. S., Handl, H. L., Sankaranarayanan, R., Xu, L., Lynch, R. M., Vagner, J., Mash, E. A., Hruby, V. J. & Gillies, R. J., Jul 20 2011, In : Bioconjugate Chemistry. 22, 7, p. 1270-1278 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Development of sulfonamide AKT PH domain inhibitors

Ahad, A. M., Zuohe, S., Du-Cuny, L., Moses, S. A., Zhou, L. L., Zhang, S., Powis, G., Meuillet, E. J. & Mash, E. A., Mar 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 6, p. 2046-2054 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

On the synthesis of 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10- tetraazacyclododecane

Jagadish, B., Brickert-Albrecht, G. L., Nichol, G. S., Mash, E. A. & Raghunand, N., Apr 27 2011, In : Tetrahedron Letters. 52, 17, p. 2058-2061 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Recent development of anticancer therapeutics targeting AKT

Morrow, J. K., Du-Cuny, L., Chen, L., Meuillet, E. J., Mash, E. A., Powis, G. & Zhang, S., Jan 11 2011, In : Recent Patents on Anti-Cancer Drug Discovery. 6, 1, p. 146-159 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

α-Tocopheryloxyacetic acid: A novel chemotherapeutic that stimulates the antitumor immune response

Hahn, T., Jagadish, B., Mash, E. A., Garrison, K. & Akporiaye, E. T., Jan 13 2011, In : Breast Cancer Research. 13, 1, R4.

Research output: Contribution to journalArticle

10 Scopus citations
2010

A solanesol-derived scaffold for multimerization of bioactive peptides

Alleti, R., Rao, V., Xu, L., Gillies, R. J. & Mash, E. A., Sep 3 2010, In : Journal of Organic Chemistry. 75, 17, p. 5895-5903 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7- triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging

Raghunand, N., Guntle, G. P., Gokhale, V., Nichol, G. S., Mash, E. A. & Jagadish, B., Sep 23 2010, In : Journal of Medicinal Chemistry. 53, 18, p. 6747-6757 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular pharmacology and antitumor activity of PHT-427, a novel akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor

Meuillet, E. J., Zuohe, S., Lemos, R., Ihle, N., Kingston, J., Watkins, R., Moses, S. A., Zhang, S., Du-Cuny, L., Herbst, R., Jacoby, J. J., Zhou, L. L., Ahad, A. M., Mash, E. A., Kirkpatrick, D. L. & Powis, G., Mar 1 2010, In : Molecular Cancer Therapeutics. 9, 3, p. 706-717 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors

Xu, L., Vagner, J., Alleti, R., Rao, V., Jagadish, B., Morse, D. L., Hruby, V. J., Gillies, R. J. & Mash, E. A., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2489-2492 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Murigi, F. N., Nichol, G. S. & Mash, E. A., Feb 19 2010, In : Journal of Organic Chemistry. 75, 4, p. 1293-1296 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

Du-Cuny, L., Song, Z., Moses, S., Powis, G., Mash, E. A., Meuillet, E. J. & Zhang, S., Oct 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 19, p. 6983-6992 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Conformational analysis of bridgehead-substituted bicyclo[m.m.m]alkanes and bicyclo[8.8.n]alkanes

Jones, I. W., Lynn, M. A. & Mash, E. A., Dec 12 2009, In : Tetrahedron. 65, 50, p. 10317-10322 6 p.

Research output: Contribution to journalArticle

Enhanced targeting with heterobivalent ligands

Xu, L., Vagner, J., Josan, J., Lynch, R. M., Morse, D. L., Baggett, B., Han, H., Mash, E. A., Hruby, V. J. & Gillies, R. J., Aug 1 2009, In : Molecular Cancer Therapeutics. 8, 8, p. 2356-2365 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT

Moses, S. A., Ali, M. A., Zuohe, S., Du-Cuny, L., Li, L. Z., Lemos, R., Ihle, N., Skillman, A. G., Zhang, S., Mash, E. A., Powis, G. & Meuillet, E. J., Jun 15 2009, In : Cancer Research. 69, 12, p. 5073-5081 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Synthesis of conformationally constrained diaminodicarboxylic acid derivatives

Weatherhead, R. A., Carducci, M. D. & Mash, E. A., Nov 20 2009, In : Journal of Organic Chemistry. 74, 22, p. 8773-8778 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008
1 Scopus citations

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Mahadevan, D., Powis, G., Mash, E. A., George, B., Gokhale, V. M., Zhang, S., Shakalya, K., Du-Cuny, L., Berggren, M., Ali, M. A., Jana, U., Ihle, N., Moses, S., Franklin, C., Narayan, S., Shirahatti, N. & Meuillet, E. J., Oct 22 2008, In : Molecular Cancer Therapeutics. 7, 9, p. 2621-2632 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Heterobivalent ligands crosslink multiple cell-surface receptors: The human melanocortin-4 and δ-opioid receptors

Vagner, J., Xu, L., Handl, H. L., Josan, J. S., Morse, D. L., Mash, E. A., Gillies, R. J. & Hruby, V. J., Feb 15 2008, In : Angewandte Chemie - International Edition. 47, 9, p. 1685-1688 4 p.

Research output: Contribution to journalArticle

60 Scopus citations
3 Scopus citations

Organic crystal engineering with 1,4-piperazine-2,5-diones. 7. Crystal packing of piperazinediones derived from 2-amino-7-nitro-4-methoxyindan-2- carboxylic acid

Ntirampebura, D., Jagadish, B., Nichol, G. S., Carducci, M. D., Dawson, A., Rajapakshe, A., Oliver, A. G., Clegg, W., Harrington, R. W., Layne, L., Margolis, J. I. & Mash, E. A., Sep 1 2008, In : Crystal Growth and Design. 8, 9, p. 3257-3270 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
2007

Design, synthesis, and validation of a branched flexible linker for bioactive peptides

Bowen, M. E., Monguchi, Y., Sankaranarayanan, R., Vagner, J., Begay, L. J., Xu, L., Jagadish, B., Hruby, V. J., Gillies, R. J. & Mash, E. A., Mar 2 2007, In : Journal of Organic Chemistry. 72, 5, p. 1675-1680 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Squalene-derived flexible linkers for bioactive peptides

Jagadish, B., Sankaranarayanan, R., Xu, L., Richards, R., Vagner, J., Hruby, V. J., Gillies, R. J. & Mash, E. A., Jun 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 12, p. 3310-3313 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis and evaluation of bivalent NDP-α-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R)

Handl, H. L., Sankaranarayanan, R., Josan, J. S., Vagner, J., Mash, E. A., Gillies, R. J. & Hruby, V. J., Jul 1 2007, In : Bioconjugate Chemistry. 18, 4, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2006

Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture

Eblin, K. E., Bowen, M. E., Cromey, D. W., Bredfeldt, T. G., Mash, E. A., Lau, S. S. & Gandolfi, A. J., Nov 15 2006, In : Toxicology and Applied Pharmacology. 217, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Deoxycholic acid induces intracellular signaling through membrane perturbations

Jean-Louis, S., Akare, S., Ali, M. A., Mash, E. A., Meuillet, E. & Martinez, J. D., May 26 2006, In : Journal of Biological Chemistry. 281, 21, p. 14948-14960 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Monomethylarsonous acid induces transformation of human bladder cells

Bredfeldt, T. G., Jagadish, B., Eblin, K. E., Mash, E. A. & Gandolfi, A. J., Oct 1 2006, In : Toxicology and Applied Pharmacology. 216, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

66 Scopus citations