Evan C Unger

  • 6827 Citations
  • 44 h-Index
1985 …2019
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Research Output 1985 2019

  • 6827 Citations
  • 44 h-Index
  • 133 Article
  • 6 Conference contribution
  • 3 Chapter
  • 2 Review article
2019
2 Citations (Scopus)

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Graham, K., Moon-Massat, P. F. & Unger, E. C., Oct 1 2019, In : Shock. 52, 1S, p. 50-54 5 p.

Research output: Contribution to journalReview article

Hemorrhagic Shock
Emulsions
Resuscitation
Oxygen
Fluorocarbons
1 Citation (Scopus)

Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction

Liu, Z., Barber, C., Gupta, A., Wan, L., Won, Y. W., Furenlid, L. R., Chen, Q., Desai, A., Zhao, M., Bull, D. A., Unger, E. C. & Martin, D. R., Jan 1 2019, In : Nuclear Medicine and Biology.

Research output: Contribution to journalArticle

Fluorocarbons
Emulsions
Myocardial Infarction
Oxygen
Reperfusion

In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Jayaraman, M. S., Graham, K. & Unger, E. C., Dec 4 2019, In : Artificial Cells, Nanomedicine and Biotechnology. 47, 1, p. 783-789 7 p.

Research output: Contribution to journalArticle

Open Access
Emulsions
Oxygen
Solubility
Gases
perfluoropentane
2018
3 Citations (Scopus)

Endothelial vascular cell adhesion molecule 1 is a marker for high-risk carotid plaques and target for ultrasound molecular imaging

Weinkauf, C. C., Concha-Moore, K., Lindner, J. R., Marinelli, E. R., Hadinger, K. P., Bhattacharjee, S., Berman, S. S., Goshima, K., Leon, L. R., Matsunaga, T. O. & Unger, E. C., Jan 1 2018, (Accepted/In press) In : Journal of Vascular Surgery.

Research output: Contribution to journalArticle

Molecular Imaging
Vascular Cell Adhesion Molecule-1
Ultrasonography
Carotid Endarterectomy
Class E Scavenger Receptors
10 Citations (Scopus)

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

Graham, K. & Unger, E. C., Jan 1 2018, In : International Journal of Nanomedicine. 13, p. 6049-6058 10 p.

Research output: Contribution to journalReview article

Oncology
Chemotherapy
Radiotherapy
Immunotherapy
Tumors
4 Citations (Scopus)

Ultrasound Molecular Imaging of Atherosclerosis Using Small-Peptide Targeting Ligands Against Endothelial Markers of Inflammation and Oxidative Stress

Moccetti, F., Weinkauf, C. C., Davidson, B. P., Belcik, J. T., Marinelli, E. R., Unger, E. C. & Lindner, J. R., Jan 1 2018, (Accepted/In press) In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

arteriosclerosis
Molecular Imaging
Vascular Cell Adhesion Molecule-1
von Willebrand Factor
markers
2015
9 Citations (Scopus)

Radiosensitization of Hs-766T pancreatic tumor xenografts in mice dosed with dodecafluoropentane nano-emulsion-preliminary findings

Johnson, J. L. H., Leos, R. A., Baker, A. F. & Unger, E. C., Feb 1 2015, In : Journal of Biomedical Nanotechnology. 11, 2, p. 274-281 8 p.

Research output: Contribution to journalArticle

Emulsions
Heterografts
Tumors
Radiation
Neoplasms
2014
95 Citations (Scopus)

Cardiovascular drug delivery with ultrasound and microbubbles

Unger, E. C., Porter, T., Lindner, J. & Grayburn, P., Jun 15 2014, In : Advanced Drug Delivery Reviews. 72, p. 110-126 17 p.

Research output: Contribution to journalArticle

Cardiovascular Agents
Microbubbles
Stroke
Clinical Trials
Genes
2 Citations (Scopus)
Emulsions
Adenosine Triphosphate
Myocardial Infarction
Troponin I
perfluoropentane
13 Citations (Scopus)

Sonothrombolysis in acute stroke and myocardial infarction: A systematic review

Roos, S. S., Juffermans, L. M. L., Slikkerveer, J., Unger, E. C., Porter, T. R. & Kampa, O., Jan 1 2014, In : IJC Heart and Vessels. 4, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Stroke
Myocardial Infarction
Microbubbles
Fibrinolytic Agents
Tissue Plasminogen Activator
2013
17 Citations (Scopus)

Diagnostic Ultrasound Induced Inertial Cavitation to Non-Invasively Restore Coronary and Microvascular Flow in Acute Myocardial Infarction

Xie, F., Gao, S., Wu, J., Lof, J., Radio, S., Vignon, F., Shi, W., Powers, J., Unger, E. C., Everbach, E. C., Liu, J. & Porter, T. R., Jul 29 2013, In : PLoS One. 8, 7, e69780.

Research output: Contribution to journalArticle

myocardial infarction
Cavitation
Ultrasonography
Ultrasonics
Myocardial Infarction
2012
4 Citations (Scopus)

Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA

Rodriguez, B. L., Li, X., Kiguchi, K., Digiovanni, J., Unger, E. C. & Cui, Z., Apr 2012, In : Nanomedicine. 7, 4, p. 475-491 17 p.

Research output: Contribution to journalArticle

RNA Replicase
RNA
plasmid
Epidermal Growth Factor Receptor
tumor
20 Citations (Scopus)

Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model

Culp, W. C., Woods, S. D., Skinner, R. D., Brown, A. T., Lowery, J. D., Johnson, J. L. H., Unger, E. C., Hennings, L. J., Borrelli, M. J. & Roberson, P. K., Jan 2012, In : Journal of Vascular and Interventional Radiology. 23, 1, p. 116-121 6 p.

Research output: Contribution to journalArticle

Emulsions
Stroke
Rabbits
Weights and Measures
Control Groups
2011
35 Citations (Scopus)

Coronary and microvascular thrombolysis with guided diagnostic ultrasound and microbubbles in acute ST segment elevation myocardial infarction

Xie, F., Slikkerveer, J., Gao, S., Lof, J., Kamp, O., Unger, E. C., Radio, S., Matsunaga, T. O. & Porter, T. R., Dec 2011, In : Journal of the American Society of Echocardiography. 24, 12, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

Microbubbles
Ultrasonography
Swine
Transducers
Coronary Thrombosis
14 Citations (Scopus)

Diagnostic and therapeutic imaging for cancer: Therapeutic considerations and future directions

Roach, M., Alberini, J. L., Pecking, A. P., Testori, A., Verrecchia, F., Soteldo, J., Ganswindt, U., Joyal, J. L., Babich, J. W., Witte, R. S., Unger, E. C. & Gottlieb, R., May 1 2011, In : Journal of Surgical Oncology. 103, 6, p. 587-601 15 p.

Research output: Contribution to journalArticle

Precision Medicine
Diagnostic Imaging
Health Care Costs
Ultrasonography
Lymph Nodes
2010

Lipid coated microbubbles and nanodroplets as tools for biomedical nanotechnology

Unger, E. C. & Matsunaga, T. O., Sep 1 2010, Handbook of Materials for Nanomedicine. Pan Stanford Publishing Pte. Ltd., p. 749-786 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanotechnology
Lipids
Ultrasonics
Imaging techniques
Medicine
Randomized Controlled Trials
Liver
Neoplasms
Radiology
DNA Damage
2009
37 Citations (Scopus)
Emulsions
Oxygen
Water
perflubron
perfluoropentane
171 Citations (Scopus)

Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial

Molina, C. A., Barreto, A. D., Tsivgoulis, G., Sierzenski, P., Malkoff, M. D., Rubiera, M., Gonzales, N., Mikulik, R., Pate, G., Ostrem, J., Singleton, W., Manvelian, G., Unger, E. C., Grotta, J. C., Schellinger, P. D. & Alexandrov, A. V., Jul 2009, In : Annals of Neurology. 66, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Clinical Trials
Cerebral Hemorrhage
perflutren
Blood Pressure
2007
1 Citation (Scopus)
Genetic Therapy
Coronary Disease
Magnetic Resonance Imaging
Left Ventricular Function
Vascular Endothelial Growth Factor A
2006

Lipid-Coated Perfluorocarbon Structures as Parenteral Therapeutic Agents

Unger, E. C., Matsunaga, T. O. & Zutshi, R., Jun 14 2006, Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples. John Wiley & Sons, Inc., p. 170-196 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorocarbons
Lipids
Therapeutics
3 Citations (Scopus)

Lipid-coated submicron-sized particles as drug carriers

Unger, E. C., Zutshi, R., Matsunaga, T. O. & Ramaswami, R., Jan 1 2006, Nanoparticulates as Drug Carriers. Imperial College Press, p. 225-254 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Carriers
Lipids

Nanobubble-enhanced sonothrombolysis: From benchtop to bedside

Unger, E. C., May 8 2006, AIP Conference Proceedings. Vol. 829. p. 21-23 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

dissolving
drugs
22 Citations (Scopus)

Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles

Tsutsui, J. M., Xie, F., Johanning, J., Lof, J., Cory, B., He, A., Thomas, L., Matsunaga, T. O., Unger, E. C. & Porter, T. R., Sep 2006, In : Journal of Ultrasound in Medicine. 25, 9, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Microbubbles
occlusion
Ultrasonography
Thrombosis
intervals

Ultrasound-mediated therapies using receptor-targeted nanodroplets

Schumann, P., Labell, R., Penrose, K., Kerschen, A., Unger, E. C., Matsunaga, T. O. & Zutshi, R., May 8 2006, AIP Conference Proceedings. Vol. 829. p. 525-527 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

therapy
tumors
encapsulating
vessels
drugs
2005
102 Citations (Scopus)

Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis

Xie, F., Tsutsui, J. M., Lof, J., Unger, E. C., Johanning, J., Culp, W. C., Matsunaga, T. O. & Porter, T. R., Jul 2005, In : Ultrasound in Medicine and Biology. 31, 7, p. 979-985 7 p.

Research output: Contribution to journalArticle

thrombosis
Microbubbles
lipids
Thrombosis
Lipids
2 Citations (Scopus)

Sonothrombolysis with phospholipid-coated perfluoropropane microbubbles

Unger, E. C., Matsunaga, T. O., Zutshi, R., Labell, R., Porter, T. R., Lof, J., Xie, F., Ferrara, K., Dayton, P. & Bloch, S., Mar 28 2005, AIP Conference Proceedings. Vol. 754. p. 58-61 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

therapy
cavitation flow
ablation
delivery
drugs
2004
8 Citations (Scopus)

DNA delivery to cells in culture using ultrasound.

McCreery, T. P., Sweitzer, R. H. & Unger, E. C., 2004, In : Methods in molecular biology (Clifton, N.J.). 245, p. 287-292 6 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
NIH 3T3 Cells
Chloramphenicol O-Acetyltransferase
HeLa Cells
Ultrasonics
17 Citations (Scopus)

DNA delivery to cells in vivo by ultrasound.

McCreery, T. P., Sweitzer, R. H., Unger, E. C. & Sullivan, S., 2004, In : Methods in molecular biology (Clifton, N.J.). 245, p. 293-298 6 p.

Research output: Contribution to journalArticle

Cultured Tumor Cells
Gene Transfer Techniques
Chloramphenicol O-Acetyltransferase
Interleukin-12
Ultrasonics
436 Citations (Scopus)

Therapeutic applications of lipid-coated microbubbles

Unger, E. C., Porter, T., Culp, W., Labell, R., Matsunaga, T. O. & Zutshi, R., May 7 2004, In : Advanced Drug Delivery Reviews. 56, 9, p. 1291-1314 24 p.

Research output: Contribution to journalArticle

Microbubbles
Lipids
Fluorocarbons
Therapeutics
Diagnostic Imaging
2003
35 Citations (Scopus)

How Can Superparamagnetic Iron Oxides Be Used to Monitor Disease and Treatment?

Unger, E. C., Dec 2003, In : Radiology. 229, 3, p. 615-616 2 p.

Research output: Contribution to journalArticle

Cell Biology
Research Personnel
Technology
Therapeutics
ferric oxide
14 Citations (Scopus)

Microbubbles in molecular imaging and therapy

Unger, E. C., Matsunaga, T. O., Schumann, P. A. & Zutshi, R., Apr 2003, In : MedicaMundi. 47, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

Microbubbles
Molecular Imaging
Blood Vessels
Thrombosis
Ligands
160 Citations (Scopus)

MR imaging of arrhythmogenic right ventricular cardiomyopathy: Morphologic findings and interobserver reliability

Bluemke, D. A., Krupinski, E. A., Ovitt, T., Gear, K., Unger, E. C., Axel, L., Boxt, L. M., Casolo, G., Ferrari, V. A., Funaki, B., Globits, S., Higgins, C. B., Julsrud, P., Lipton, M., Mawson, J., Nygren, A., Pennell, D. J., Stillman, A., White, R. D., Wichter, T. & 1 others, Marcus, F., 2003, In : Cardiology. 99, 3, p. 153-162 10 p.

Research output: Contribution to journalArticle

Arrhythmogenic Right Ventricular Dysplasia
Heart Ventricles
Magnetic Resonance Imaging
Advisory Committees
Fats
111 Citations (Scopus)

Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors

Williams, J., Lansdown, R., Sweitzer, R., Romanowski, M., LaBell, R., Ramaswami, R. & Unger, E. C., Aug 28 2003, In : Journal of Controlled Release. 91, 1-2, p. 167-172 6 p.

Research output: Contribution to journalArticle

irinotecan
Topoisomerase Inhibitors
Infusion Pumps
Nanoparticles
Camptotheca
2002
4 Citations (Scopus)

Biomedical implications of a thrombus-specific US contrast agent

Unger, E. C., Matsunaga, T. O., McCreery, T. P. & Sweitzer, R. H., 2002, In : Academic Radiology. 9, SUPPL. 1

Research output: Contribution to journalArticle

Animal Disease Models
Platelet Aggregation
Contrast Media
Phospholipids
Thrombosis
179 Citations (Scopus)

Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi

Schumann, P. A., Christiansen, J. P., Quigley, R. M., McCreery, T. P., Sweitzer, R. H., Unger, E. C., Lindner, J. R. & Matsunaga, T. O., Nov 1 2002, In : Investigative Radiology. 37, 11, p. 587-593 7 p.

Research output: Contribution to journalArticle

Microbubbles
Platelet Glycoprotein GPIIb-IIIa Complex
Thrombosis
Blood Platelets
Fluorocarbons
243 Citations (Scopus)

Therapeutic applications of microbubbles

Unger, E. C., Matsunaga, T. O., McCreery, T., Schumann, P., Sweitzer, R. & Quigley, R., 2002, In : European Journal of Radiology. 42, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Microbubbles
Therapeutics
Drug Delivery Systems
Pharmaceutical Preparations
Contrast Media
99 Citations (Scopus)

Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA

Vannan, M., McCreery, T., Li, P., Han, Z., Unger, E. C., Kuersten, B., Nabel, E. & Rajagopalan, S., Mar 2002, In : Journal of the American Society of Echocardiography. 15, 3, p. 214-218 5 p.

Research output: Contribution to journalArticle

Microbubbles
Intravenous Administration
Transfection
Canidae
Myocardium
2001
139 Citations (Scopus)

Gene delivery using ultrasound contrast agents

Unger, E. C., Hersh, E. M., Vannan, M. & McCreery, T., 2001, In : Echocardiography. 18, 4, p. 355-361 7 p.

Research output: Contribution to journalArticle

Microbubbles
Contrast Media
Genes
Genetic Therapy
DNA
237 Citations (Scopus)

Local drug and gene delivery through microbubbles

Unger, E. C., Hersh, E. M., Vannan, M., Matsunaga, T. O. & McCreery, T., 2001, In : Progress in Cardiovascular Diseases. 44, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

Microbubbles
Pharmaceutical Preparations
Genes
Contrast Media
Genetic Therapy
288 Citations (Scopus)

Science, medicine, and the future: Microbubble contrast agents: A new era in ultrasound

Blomley, M. J. K., Cooke, J. C., Unger, E. C., Monaghan, M. J. & Cosgrove, D. O., May 19 2001, In : BMJ (Clinical research ed.). 322, 7296, p. 1222-1225 4 p.

Research output: Contribution to journalArticle

Microbubbles
Vesico-Ureteral Reflux
Drug Delivery Systems
Liver Neoplasms
Microspheres
2000
113 Citations (Scopus)

Advances in imaging of lymph flow disorders

Witte, C. L., Witte, M. H., Unger, E. C., Williams, W. H., Bernas, M. J., McNeill, G. C. & Stazzone, A. M., Nov 2000, In : Radiographics. 20, 6, p. 1697-1719 23 p.

Research output: Contribution to journalArticle

Lymph
Magnetic Resonance Imaging
Lymphangiectasis
Lymphatic Endothelium
Tomography
39 Citations (Scopus)

The use of a thrombus-specific ultrasound contrast agent to detect thrombus in arteriovenous fistulae

Unger, E. C., Metzger, P., Krupinski, E. A., Baker, M., Hulett, R., Gabaeff, D., Mills, J. L., Ihnat, D. & McCreery, T., 2000, In : Investigative Radiology. 35, 1, p. 86-89 4 p.

Research output: Contribution to journalArticle

Arteriovenous Fistula
Contrast Media
Thrombosis
Transplants
Ultrasonics
144 Citations (Scopus)

Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration

Anwer, K., Kao, G., Proctor, B., Anscombe, I., Florack, V., Earls, R., Wilson, E., McCreery, T., Unger, E. C., Rolland, A. & Sullivan, S. M., 2000, In : Gene Therapy. 7, 21, p. 1833-1839 7 p.

Research output: Contribution to journalArticle

Lipids
Plasmids
Genes
Neoplasms
Interleukin-12
1999
72 Citations (Scopus)

Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombus-targeting ultrasonographic contrast agent (MRX-408A1): In vivo experimental echocardiographic studies

Takeuchi, M., Ogunyankin, K., Pandian, N. G., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., Unger, E. C., Avelar, E., Sheahan, M. & Connolly, R., 1999, In : Journal of the American Society of Echocardiography. 12, 12, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

Atrial Appendage
Contrast Media
Thrombosis
Dogs
Inferior Vena Cava
19 Citations (Scopus)

Gadolinium-containing copolymeric chelates - A new potential MR contrast agent

Unger, E. C., Shen, D., Wu, G., Stewart, L., Matsunaga, T. O. & Trouard, T. T., Aug 1999, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 8, 3, p. 154-162 9 p.

Research output: Contribution to journalArticle

Gadolinium
Contrast Media
Pentetic Acid
Magnetic Resonance Spectroscopy
Gadolinium DTPA
91 Citations (Scopus)

Immunotherapy of advanced malignancy by direct gene transfer of an interleukin-2 DNA/DMRIE/DOPE lipid complex: Phase I/II experience

Galanis, E., Hersh, E. M., Stopeck, A. T., Gonzalez, R., Burch, P., Perry, C. S., Akporiaye, E. T., Rinehart, J. J., Edmonson, J., Sobol, R. E., Forscher, C., Sondak, V. K., Lewis, B. D., Unger, E. C., O'Driscoll, M., Selk, L. & Rubin, J., Oct 1999, In : Journal of Clinical Oncology. 17, 10, p. 3313-3323 11 p.

Research output: Contribution to journalArticle

Ethanolamine
Immunotherapy
Interleukin-2
Lipids
DNA
1998
25 Citations (Scopus)

Accuracy of CT biopsy: Laser guidance versus conventional freehand techniques

Pereles, F. S., Baker, M., Baldwin, R., Krupinski, E. A. & Unger, E. C., 1998, In : Academic Radiology. 5, 11 SUPPL. 3, p. 766-770 5 p.

Research output: Contribution to journalArticle

Lasers
Biopsy
Analysis of Variance
Needles
Hand
237 Citations (Scopus)

Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent

Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E. & Wu, Y., Dec 1998, In : Investigative Radiology. 33, 12, p. 886-892 7 p.

Research output: Contribution to journalArticle

Paclitaxel
Contrast Media
Therapeutics
Pharmaceutical Preparations
Soybean Oil
108 Citations (Scopus)

Binding and lysing of blood clots using MRX-408

Wu, Y., Unger, E. C., McCreery, T. P., Sweitzer, R. H., Shen, D., Wu, G. & Vielhauer, M. D., Dec 1998, In : Investigative Radiology. 33, 12, p. 880-885 6 p.

Research output: Contribution to journalArticle

Thrombosis
Microbubbles
Contrast Media
Ultrasonography
Platelet Glycoprotein GPIIb-IIIa Complex