Evan C Unger

  • 6986 Citations
  • 45 h-Index
1985 …2019

Research output per year

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Research Output

2019

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Graham, K., Moon-Massat, P. F. & Unger, E. C., Oct 1 2019, In : Shock. 52, 1S, p. 50-54 5 p.

Research output: Contribution to journalReview article

2 Scopus citations

Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction

Liu, Z., Barber, C., Gupta, A., Wan, L., Won, Y. W., Furenlid, L. R., Chen, Q., Desai, A. A., Zhao, M., Bull, D. A., Unger, E. C. & Martin, D. R., Mar 2019, In : Nuclear Medicine and Biology. 70, p. 67-77 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Jayaraman, M. S., Graham, K. & Unger, E. C., Dec 4 2019, In : Artificial Cells, Nanomedicine and Biotechnology. 47, 1, p. 783-789 7 p.

Research output: Contribution to journalArticle

Open Access
2018

Endothelial vascular cell adhesion molecule 1 is a marker for high-risk carotid plaques and target for ultrasound molecular imaging

Weinkauf, C. C., Concha-Moore, K., Lindner, J. R., Marinelli, E. R., Hadinger, K. P., Bhattacharjee, S., Berman, S. S., Goshima, K., Leon, L. R., Matsunaga, T. O. & Unger, E., Dec 2018, In : Journal of vascular surgery. 68, 6, p. 105S-113S

Research output: Contribution to journalArticle

4 Scopus citations

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

Graham, K. & Unger, E., 2018, In : International journal of nanomedicine. 13, p. 6049-6058 10 p.

Research output: Contribution to journalReview article

36 Scopus citations

Ultrasound Molecular Imaging of Atherosclerosis Using Small-Peptide Targeting Ligands Against Endothelial Markers of Inflammation and Oxidative Stress

Moccetti, F., Weinkauf, C. C., Davidson, B. P., Belcik, J. T., Marinelli, E. R., Unger, E. & Lindner, J. R., Jun 2018, In : Ultrasound in Medicine and Biology. 44, 6, p. 1155-1163 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Radiosensitization of Hs-766T pancreatic tumor xenografts in mice dosed with dodecafluoropentane nano-emulsion-preliminary findings

Johnson, J. L. H., Leos, R. A., Baker, A. F. & Unger, E. C., Feb 1 2015, In : Journal of Biomedical Nanotechnology. 11, 2, p. 274-281 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Cardiovascular drug delivery with ultrasound and microbubbles

Unger, E., Porter, T., Lindner, J. & Grayburn, P., Jun 15 2014, In : Advanced Drug Delivery Reviews. 72, p. 110-126 17 p.

Research output: Contribution to journalReview article

113 Scopus citations
3 Scopus citations

Sonothrombolysis in acute stroke and myocardial infarction: A systematic review

Roos, S. S., Juffermans, L. M. L., Slikkerveer, J., Unger, E. C., Porter, T. R. & Kampa, O., Jan 1 2014, In : IJC Heart and Vessels. 4, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Diagnostic Ultrasound Induced Inertial Cavitation to Non-Invasively Restore Coronary and Microvascular Flow in Acute Myocardial Infarction

Xie, F., Gao, S., Wu, J., Lof, J., Radio, S., Vignon, F., Shi, W., Powers, J., Unger, E., Everbach, E. C., Liu, J. & Porter, T. R., Jul 29 2013, In : PloS one. 8, 7, e69780.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA

Rodriguez, B. L., Li, X., Kiguchi, K., Digiovanni, J., Unger, E. C. & Cui, Z., Apr 1 2012, In : Nanomedicine. 7, 4, p. 475-491 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model

Culp, W. C., Woods, S. D., Skinner, R. D., Brown, A. T., Lowery, J. D., Johnson, J. L. H., Unger, E. C., Hennings, L. J., Borrelli, M. J. & Roberson, P. K., Jan 1 2012, In : Journal of Vascular and Interventional Radiology. 23, 1, p. 116-121 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Coronary and microvascular thrombolysis with guided diagnostic ultrasound and microbubbles in acute ST segment elevation myocardial infarction

Xie, F., Slikkerveer, J., Gao, S., Lof, J., Kamp, O., Unger, E., Radio, S., Matsunaga, T. & Porter, T. R., Dec 1 2011, In : Journal of the American Society of Echocardiography. 24, 12, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Diagnostic and therapeutic imaging for cancer: Therapeutic considerations and future directions

Roach, M., Alberini, J. L., Pecking, A. P., Testori, A., Verrecchia, F., Soteldo, J., Ganswindt, U., Joyal, J. L., Babich, J. W., Witte, R. S., Unger, E. & Gottlieb, R., May 1 2011, In : Journal of Surgical Oncology. 103, 6, p. 587-601 15 p.

Research output: Contribution to journalReview article

16 Scopus citations
2010

Lipid coated microbubbles and nanodroplets as tools for biomedical nanotechnology

Unger, E. & Matsunaga, T. O., Sep 1 2010, Handbook of Materials for Nanomedicine. Pan Stanford Publishing Pte. Ltd., p. 749-786 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2009
38 Scopus citations

Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial

Molina, C. A., Barreto, A. D., Tsivgoulis, G., Sierzenski, P., Malkoff, M. D., Rubiera, M., Gonzales, N., Mikulik, R., Pate, G., Ostrem, J., Singleton, W., Manvelian, G., Unger, E. C., Grotta, J. C., Schellinger, P. D. & Alexandrov, A. V., Jul 1 2009, In : Annals of Neurology. 66, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

175 Scopus citations
2007
1 Scopus citations
2006

Lipid-Coated Perfluorocarbon Structures as Parenteral Therapeutic Agents

Unger, E. C., Matsunaga, T. O. & Zutshi, R., Jun 14 2006, Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples. John Wiley & Sons, Inc., p. 170-196 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lipid-coated submicron-sized particles as drug carriers

Unger, E. C., Zutshi, R., Matsunaga, T. O. & Ramaswami, R., Jan 1 2006, Nanoparticulates as Drug Carriers. Imperial College Press, p. 225-254 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Nanobubble-enhanced sonothrombolysis: From benchtop to bedside

Unger, E. C., May 8 2006, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. p. 21-23 3 p. (AIP Conference Proceedings; vol. 829).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles

Tsutsui, J. M., Xie, F., Johanning, J., Lof, J., Cory, B., He, A., Thomas, L., Matsunaga, T., Unger, E. & Porter, T. R., Sep 2006, In : Journal of Ultrasound in Medicine. 25, 9, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ultrasound-mediated therapies using receptor-targeted nanodroplets

Schumann, P., Labell, R., Penrose, K., Kerschen, A., Unger, E., Matsunaga, T. & Zutshi, R., May 8 2006, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. p. 525-527 3 p. (AIP Conference Proceedings; vol. 829).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2005

Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis

Xie, F., Tsutsui, J. M., Lof, J., Unger, E. C., Johanning, J., Culp, W. C., Matsunaga, T. & Porter, T. R., Jul 1 2005, In : Ultrasound in Medicine and Biology. 31, 7, p. 979-985 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Sonothrombolysis with phospholipid-coated perfluoropropane microbubbles

Unger, E., Matsunaga, T. O., Zutshi, R., Labell, R., Porter, T. R., Lof, J., Xie, F., Ferrara, K., Dayton, P. & Bloch, S., Mar 28 2005, 4th International Symposium on Therapeutic Ultrasound. p. 58-61 4 p. (AIP Conference Proceedings; vol. 754).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations
2004

DNA delivery to cells in culture using ultrasound.

McCreery, T. P., Sweitzer, R. H. & Unger, E. C., 2004, In : Methods in molecular biology (Clifton, N.J.). 245, p. 287-292 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

DNA delivery to cells in vivo by ultrasound.

McCreery, T. P., Sweitzer, R. H., Unger, E. C. & Sullivan, S., 2004, In : Methods in molecular biology (Clifton, N.J.). 245, p. 293-298 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Therapeutic applications of lipid-coated microbubbles

Unger, E. C., Porter, T., Culp, W., Labell, R., Matsunaga, T. & Zutshi, R., May 7 2004, In : Advanced Drug Delivery Reviews. 56, 9, p. 1291-1314 24 p.

Research output: Contribution to journalArticle

450 Scopus citations
2003

How Can Superparamagnetic Iron Oxides Be Used to Monitor Disease and Treatment?

Unger, E. C., Dec 1 2003, In : Radiology. 229, 3, p. 615-616 2 p.

Research output: Contribution to journalShort survey

35 Scopus citations

Microbubbles in molecular imaging and therapy

Unger, E., Matsunaga, T. O., Schumann, P. A. & Zutshi, R., Apr 1 2003, In : MedicaMundi. 47, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

MR imaging of arrhythmogenic right ventricular cardiomyopathy: Morphologic findings and interobserver reliability

Bluemke, D. A., Krupinski, E. A., Ovitt, T., Gear, K., Unger, E., Axel, L., Boxt, L. M., Casolo, G., Ferrari, V. A., Funaki, B., Globits, S., Higgins, C. B., Julsrud, P., Lipton, M., Mawson, J., Nygren, A., Pennell, D. J., Stillman, A., White, R. D., Wichter, T. & 1 others, Marcus, F., Jun 30 2003, In : Cardiology. 99, 3, p. 153-162 10 p.

Research output: Contribution to journalArticle

162 Scopus citations

Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors

Williams, J., Lansdown, R., Sweitzer, R., Romanowski, M., LaBell, R., Ramaswami, R. & Unger, E., Aug 28 2003, In : Journal of Controlled Release. 91, 1-2, p. 167-172 6 p.

Research output: Contribution to journalArticle

113 Scopus citations
2002

Biomedical implications of a thrombus-specific US contrast agent

Unger, E. C., Matsunaga, T. O., McCreery, T. P. & Sweitzer, R. H., Jan 1 2002, In : Academic radiology. 9, SUPPL. 1, p. S56-S57

Research output: Contribution to journalArticle

4 Scopus citations

Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi

Schumann, P. A., Christiansen, J. P., Quigley, R. M., McCreery, T. P., Sweitzer, R. H., Unger, E. C., Lindner, J. R. & Matsunaga, T. O., Nov 1 2002, In : Investigative Radiology. 37, 11, p. 587-593 7 p.

Research output: Contribution to journalArticle

182 Scopus citations

Therapeutic applications of microbubbles

Unger, E. C., Matsunaga, T. O., McCreery, T., Schumann, P., Sweitzer, R. & Quigley, R., Apr 23 2002, In : European Journal of Radiology. 42, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

243 Scopus citations

Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA

Vannan, M., McCreery, T., Li, P., Han, Z., Unger, E., Kuersten, B., Nabel, E. & Rajagopalan, S., Mar 2002, In : Journal of the American Society of Echocardiography. 15, 3, p. 214-218 5 p.

Research output: Contribution to journalArticle

99 Scopus citations
2001

Gene delivery using ultrasound contrast agents

Unger, E. C., Hersh, E., Vannan, M. & McCreery, T., Jan 1 2001, In : Echocardiography. 18, 4, p. 355-361 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Local drug and gene delivery through microbubbles

Unger, E. C., Hersh, E., Vannan, M., Matsunaga, T. O. & McCreery, T., Jan 1 2001, In : Progress in Cardiovascular Diseases. 44, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

244 Scopus citations

Science, medicine, and the future: Microbubble contrast agents: A new era in ultrasound

Blomley, M. J. K., Cooke, J. C., Unger, E. C., Monaghan, M. J. & Cosgrove, D. O., May 19 2001, In : British Medical Journal. 322, 7296, p. 1222-1225 4 p.

Research output: Contribution to journalReview article

300 Scopus citations
2000

Advances in imaging of lymph flow disorders

Witte, C. L., Witte, M. H., Unger, E. C., Williams, W. H., Bernas, M. J., McNeill, G. C. & Stazzone, A. M., Jan 1 2000, In : Radiographics. 20, 6, p. 1697-1719 23 p.

Research output: Contribution to journalArticle

121 Scopus citations

The use of a thrombus-specific ultrasound contrast agent to detect thrombus in arteriovenous fistulae

Unger, E., Metzger, P., Krupinski, E., Baker, M., Hulett, R., Gabaeff, D., Mills, J., Ihnat, D. & McCreery, T., Jan 18 2000, In : Investigative Radiology. 35, 1, p. 86-89 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration

Anwer, K., Kao, G., Proctor, B., Anscombe, I., Florack, V., Earls, R., Wilson, E., McCreery, T., Unger, E., Rolland, A. & Sullivan, S. M., Jan 1 2000, In : Gene Therapy. 7, 21, p. 1833-1839 7 p.

Research output: Contribution to journalArticle

Open Access
144 Scopus citations
1999

Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombus-targeting ultrasonographic contrast agent (MRX-408A1): In vivo experimental echocardiographic studies

Takeuchi, M., Ogunyankin, K., Pandian, N. G., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., Unger, E. C., Avelar, E., Sheahan, M. & Connolly, R., Jan 1 1999, In : Journal of the American Society of Echocardiography. 12, 12, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Gadolinium-containing copolymeric chelates - A new potential MR contrast agent

Unger, E. C., Shen, D., Wu, G., Stewart, L., Matsunaga, T. O. & Trouard, T. P., Aug 1 1999, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 8, 3, p. 154-162 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Immunotherapy of advanced malignancy by direct gene transfer of an interleukin-2 DNA/DMRIE/DOPE lipid complex: Phase I/II experience

Galanis, E., Hersh, E. M., Stopeck, A. T., Gonzalez, R., Burch, P., Spier, C., Akporiaye, E. T., Rinehart, J. J., Edmonson, J., Sobol, R. E., Forscher, C., Sondak, V. K., Lewis, B. D., Unger, E. C., O'Driscoll, M., Selk, L. & Rubin, J., Oct 1999, In : Journal of Clinical Oncology. 17, 10, p. 3313-3323 11 p.

Research output: Contribution to journalArticle

92 Scopus citations
1998

Accuracy of CT biopsy: Laser guidance versus conventional freehand techniques

Pereles, F. S., Baker, M., Baldwin, R., Krupinski, E. & Unger, E. C., Jan 1 1998, In : Academic radiology. 5, 11 SUPPL. 3, p. 766-770 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent

Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E. & Wu, Y., Dec 1 1998, In : Investigative Radiology. 33, 12, p. 886-892 7 p.

Research output: Contribution to journalArticle

241 Scopus citations

Binding and lysing of blood clots using MRX-408

Wu, Y., Unger, E. C., McCreery, T. P., Sweitzer, R. H., Shen, D., Wu, G. & Vielhauer, M. D., Dec 1 1998, In : Investigative Radiology. 33, 12, p. 880-885 6 p.

Research output: Contribution to journalArticle

108 Scopus citations