Evan M Hersh

  • 19267 Citations
  • 67 h-Index
1965 …2021

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2018

A Phase 2 Randomized, Double-Blind, Multicenter Trial of Imexon Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients with Metastatic Chemotherapy-naïve Pancreatic Adenocarcinoma

Cohen, S. J., Zalupski, M. M., Conkling, P., Nugent, F., Ma, W. W., Modiano, M., Pascual, R., Lee, F. C., Wong, L. & Hersh, E., Jan 1 2018, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 3, p. 230-235 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Long-Term Survival after Complete Surgical Resection and Adjuvant Immunotherapy for Distant Melanoma Metastases

MMAIT-IV Clinical Trial Group, Dec 1 2017, In : Annals of Surgical Oncology. 24, 13, p. 3991-4000 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma

Hersh, E. M., Del Vecchio, M., Brown, M. P., Kefford, R., Loquai, C., Testori, A., Bhatia, S., Gutzmer, R., Conry, R., Haydon, A., Robert, C., Ernst, S., Homsi, J., Grob, J. J., Kendra, K., Agarwala, S. S., Li, M., Clawson, A., Brachmann, C., Karnoub, M. & 3 others, Elias, I., Renschler, M. F. & Hauschild, A., Nov 2015, In : Annals of Oncology. 26, 11, p. 2267-2274 8 p., mdv324.

Research output: Contribution to journalArticle

28 Scopus citations
2011

A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma

Hersh, E. M., O'Day, S. J., Powderly, J., Khan, K. D., Pavlick, A. C., Cranmer, L. D., Samlowski, W. E., Nichol, G. M., Yellin, M. J. & Weber, J. S., Jun 1 2011, In : Investigational New Drugs. 29, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

215 Scopus citations
2010

A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma

Weber, J. S., Samlowski, W. E., Gonzalez, R., Ribas, A., Stephenson, J., O'Day, S., Sato, T., Dorr, R., Grenier, K. & Hersh, E., Aug 1 2010, In : Cancer. 116, 15, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

A phase 2 clinical trial of nab-Paclitaxel in previously treated and chemotherapy-naive patients with metastatic melanoma

Hersh, E. M., O'Day, S. J., Ribas, A., Samlowski, W. E., Gordon, M. S., Shechter, D. E., Clawson, A. A. & Gonzalez, R., Jan 1 2010, In : Cancer. 116, 1, p. 155-163 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

A phase i study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer

Cohen, S. J., Zalupski, M. M., Modiano, M. R., Conkling, P., Patt, Y. Z., Davis, P., Dorr, R. T., Boytim, M. L. & Hersh, E. M., Jul 1 2010, In : Cancer Chemotherapy And Pharmacology. 66, 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

A phase i trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer

Moulder, S., Dhillon, N., Ng, C., Hong, D., Wheler, J., Naing, A., Tse, S., La Paglia, A., Dorr, R., Hersh, E., Boytim, M. & Kurzrock, R., Oct 1 2010, In : Investigational New Drugs. 28, 5, p. 634-640 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma

Ribas, A., Camacho, L. H., Lee, S. M., Hersh, E. M., Brown, C. K., Richards, J. M., Rodriguez, M. J., Prieto, V. G., Glaspy, J. A., Oseguera, D. K., Hernandez, J., Villanueva, A., Chmielowski, B., Mitsky, P., Bercovici, N., Wasserman, E., Landais, D. & Ross, M. I., Sep 27 2010, In : Journal of Translational Medicine. 8, 89.

Research output: Contribution to journalArticle

31 Scopus citations

Serial monitoring of circulating tumor cells predicts outcome of induction biochemotherapy plus maintenance biotherapy for metastatic melanoma

Koyanagi, K., O'Day, S. J., Boasberg, P., Atkins, M. B., Wang, H. J., Gonzalez, R., Lewis, K., Thompson, J. A., Anderson, C. M., Lutzky, J., Amatruda, T. T., Hersh, E., Richards, J., Weber, J. S. & Hoon, D. S. B., Apr 15 2010, In : Clinical Cancer Research. 16, 8, p. 2402-2408 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Whole-brain radiation therapy in melanoma: an open question

Cranmer, L. D., Jeter, J. M., Morgan, S. S., Hersh, E. M. & Stea, B., Jan 2010, In : The Lancet Oncology. 11, 1, p. 13 1 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Phase II multicenter trial of maintenance biotherapy after induction concurrent biochemotherapy for patients with metastatic melanoma

O'Day, S. J., Atkins, M. B., Boasberg, P., Wang, H. J., Thompson, J. A., Anderson, C. M., Gonzalez, R., Lutzky, J., Amatruda, T., Hersh, E. M. & Weber, J. S., Dec 20 2009, In : Journal of Clinical Oncology. 27, 36, p. 6207-6212 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2008

Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 study group

McDermott, D. F., Sosman, J. A., Gonzalez, R., Hodi, F. S., Linette, G. P., Richards, J., Jakub, J. W., Beeram, M., Tarantolo, S., Agarwala, S., Frenette, G., Puzanov, I., Cranmer, L., Lewis, K., Kirkwood, J., White, J. M., Xia, C., Patel, K. & Hersh, E., Sep 22 2008, In : Journal of Clinical Oncology. 26, 13, p. 2178-2185 8 p.

Research output: Contribution to journalArticle

216 Scopus citations

Phase 1 trial of intranodal injection of a melan-A/MART-1 DNA plasmid vaccine in patients with stage IV melanoma

Weber, J., Boswell, W., Smith, J., Hersh, E., Snively, J., Diaz, M., Miles, S., Liu, X., Obrocea, M., Qiu, Z. & Bot, A., Feb 1 2008, In : Journal of Immunotherapy. 31, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Phase I/II study of ipilimumab for patients with metastatic melanoma

Weber, J. S., O'Day, S., Urba, W., Powderly, J., Nichol, G., Yellin, M., Snively, J. & Hersh, E., Dec 20 2008, In : Journal of Clinical Oncology. 26, 36, p. 5950-5956 7 p.

Research output: Contribution to journalArticle

319 Scopus citations
2007

Phase I trial of imexon in patients with advanced malignancy

Dragovich, T., Gordon, M., Mendelson, D., Wong, L., Modiano, M., Chow, H. H. S., Samulitis, B., O'Day, S., Grenier, K., Hersh, E. & Dorr, R., May 1 2007, In : Journal of Clinical Oncology. 25, 13, p. 1779-1784 6 p.

Research output: Contribution to journalArticle

42 Scopus citations
2006

Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The oblimersen melanoma study group

Bedikian, A. Y., Millward, M., Pehamberger, H., Conry, R., Gore, M., Trefzer, U., Pavlick, A. C., DeConti, R., Hersh, E. M., Hersey, P., Kirkwood, J. M. & Haluska, F. G., Oct 10 2006, In : Journal of Clinical Oncology. 24, 29, p. 4738-4745 8 p.

Research output: Contribution to journalArticle

504 Scopus citations

Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice

Pourpak, A., Meyers, R. O., Samulitis, B. K., Sherry Chow, H. H., Kepler, C. Y., Raymond, M. A., Hersh, E. & Dorr, R. T., Nov 1 2006, In : Anti-cancer drugs. 17, 10, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2005

A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors

Ebbinghaus, S., Rubin, E., Hersh, E., Cranmer, L. D., Bonate, P. L., Fram, R. J., Jekunen, A., Weitman, S. & Hammond, L. A., Nov 1 2005, In : Clinical Cancer Research. 11, 21, p. 7807-7816 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies

Nyman, D. W., Campbell, K. J., Hersh, E., Long, K., Richardson, K., Trieu, V., Desai, N., Hawkins, M. J. & Von Hoff, D. D., Dec 1 2005, In : Journal of Clinical Oncology. 23, 31, p. 7785-7793 9 p.

Research output: Contribution to journalArticle

221 Scopus citations
2004

A Phase II Trial of Vinorelbine Tartrate in Patients with Disseminated Malignant Melanoma and One Prior Systemic Therapy: A Southwest Oncology Group Study

Whitehead, R. P., Moon, J., McCachren, S. S., Hersh, E. M., Samlowski, W. E., Beck, J. T., Tchekmedyian, N. S. & Sondak, V. K., Apr 15 2004, In : Cancer. 100, 8, p. 1699-1704 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Generation of dendritic cell-tumor cell hybrids by electrofusion for clinical vaccine application

Trevor, K. T., Cover, C., Ruiz, Y. W., Akporiaye, E. T., Hersh, E. M., Landais, D., Taylor, R. R., King, A. D. & Walters, R. E., Aug 2004, In : Cancer Immunology, Immunotherapy. 53, 8, p. 705-714 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2003
3 Scopus citations
2002

Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast

Coronella, J. A., Spier, C., Welch, M., Trevor, K. T., Stopeck, A. T., Villar, H. & Hersh, E. M., Aug 15 2002, In : Journal of Immunology. 169, 4, p. 1829-1836 8 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma

Agarwala, S. S., Glaspy, J., O'Day, S. J., Mitchell, M., Gutheil, J., Whitman, E., Gonzalez, R., Hersh, E., Feun, L., Belt, R., Meyskens, F., Hellstrand, K., Wood, D., Kirkwood, J. M., Gehlsen, K. R. & Naredi, P., Jan 1 2002, In : Journal of Clinical Oncology. 20, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

145 Scopus citations
2001

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

Taylor, C. W., Dorr, R. T., Fanta, P., Hersh, E. M. & Salmon, S. E., Jul 31 2001, In : Cancer Chemotherapy And Pharmacology. 47, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Gene delivery using ultrasound contrast agents

Unger, E. C., Hersh, E., Vannan, M. & McCreery, T., Jan 1 2001, In : Echocardiography. 18, 4, p. 355-361 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Local drug and gene delivery through microbubbles

Unger, E. C., Hersh, E., Vannan, M., Matsunaga, T. O. & McCreery, T., Jan 1 2001, In : Progress in Cardiovascular Diseases. 44, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

239 Scopus citations

Phase II study of direct intralesional gene transfer of Allovectin-7, an HLA-B7/β2-microglobulin DNA-liposome complex, in patients with metastatic melanoma

Stopeck, A. T., Jones, A., Hersh, E. M., Thompson, J. A., Finucane, D. M., Gutheil, J. C. & Gonzalez, R., Jan 1 2001, In : Clinical Cancer Research. 7, 8, p. 2285-2291 7 p.

Research output: Contribution to journalArticle

109 Scopus citations

Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators

Dorr, R. T., Liddil, J. D., Sami, S. M., Remers, W., Hersh, E. M. & Alberts, D. S., Apr 17 2001, In : Anti-cancer drugs. 12, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2

Trevor, K. T., Hersh, E. M., Brailey, J., Balloul, J. M. & Acres, B., Nov 13 2001, In : Cancer Immunology, Immunotherapy. 50, 8, p. 397-407 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2000

Cationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft

Clark, P. R., Stopeck, A. T., Parker, S. E. & Hersh, E. M., Sep 15 2000, In : Cellular Immunology. 204, 2, p. 96-104 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Heat-inducible vectors for use in gene therapy

Gerner, E. W., Hersh, E. M., Pennington, M., Tsang, T. C., Harris, D., Vasanwala, F. & Brailey, J., Jan 1 2000, In : International Journal of Hyperthermia. 16, 2, p. 171-181 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma

Stopeck, A. T., Gessner, A., Miller, T. P., Hersh, E. M., Johnson, C. S., Cui, H., Frutiger, Y. & Grogan, T. M., Jan 1 2000, In : Clinical Cancer Research. 6, 10, p. 3904-3909 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Natural and induced human antibody response to cancer

Lake, D. F., Huynh, W. C. & Hersh, E. M., Jan 1 2000, In : Cancer Investigation. 18, 5, p. 480-489 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Studies of direct intratumoral gene transfer using cationic lipid- complexed plasmid DNA

Clark, P. R., Stopeck, A. T., Ferrari, M., Parker, S. E. & Hersh, E. M., Jan 1 2000, In : Cancer gene therapy. 7, 6, p. 853-860 8 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
1999

Cationic lipid-mediated gene transfer: Current concepts

Clark, P. R. & Hersh, E. M., Apr 1 1999, In : Current Opinion in Molecular Therapeutics. 1, 2, p. 158-176 19 p.

Research output: Contribution to journalArticle

76 Scopus citations

Immunotherapy of advanced malignancy by direct gene transfer of an interleukin-2 DNA/DMRIE/DOPE lipid complex: Phase I/II experience

Galanis, E., Hersh, E. M., Stopeck, A. T., Gonzalez, R., Burch, P., Spier, C., Akporiaye, E. T., Rinehart, J. J., Edmonson, J., Sobol, R. E., Forscher, C., Sondak, V. K., Lewis, B. D., Unger, E. C., O'Driscoll, M., Selk, L. & Rubin, J., Oct 1999, In : Journal of Clinical Oncology. 17, 10, p. 3313-3323 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Novel antitumor 2-cyanoaziridine-1-carboxamides

Iyengar, B. S., Dorr, R. T., Alberts, D. S., Hersh, E. M., Salmon, S. E. & Remers, W. A., Feb 24 1999, In : Journal of Medicinal Chemistry. 42, 3, p. 510-514 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phase II trial of biochemotherapy with interferon α, dacarbazine, cisplatin and tamoxifen in metastatic melanoma: A Southwest Oncology Group trial

Margolin, K. A., Liu, P. Y., Unger, J. M., Fletcher, W. S., Flaherty, L. E., Urba, W. J., Hersh, E. M., Hutchins, L. E., Sosman, J. A., Smith, J. W., Weiss, G. R. & Sondak, V. K., Jun 3 1999, In : Journal of Cancer Research and Clinical Oncology. 125, 5, p. 292-296 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells

Clark, P. R., Stopeck, A. T., Brailey, J. L., Wang, Q., McArthur, J., Finer, M. H. & Hersh, E. M., Jan 1 1999, In : Cancer gene therapy. 6, 5, p. 437-446 10 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia

Lopez, A. M., Wallace, L., Dorr, R. T., Koff, M., Hersh, E. M. & Alberts, D. S., Sep 2 1999, In : Cancer Chemotherapy And Pharmacology. 44, 4, p. 303-306 4 p.

Research output: Contribution to journalArticle

97 Scopus citations
1998

Transfection of primary tumor cells and tumor cell lines with plasmid DNA/lipid complexes

Stopeck, A. T., Hersh, E. M., Brailey, J. L., Clark, P. R., Norman, J. & Parker, S. E., Dec 1 1998, In : Cancer gene therapy. 5, 2, p. 119-126 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
1997

Advances in the biological therapy and gene therapy of malignant disease

Hersh, E. M. & Stopeck, A. T., Dec 1 1997, In : Clinical Cancer Research. 3, 12 II, p. 2623-2629 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Expression of an antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells

Park, J. A., Wang, E., Kurt, R. A., Schluter, S. F., Hersh, E. M. & Akporiaye, E. T., Dec 1 1997, In : Cancer gene therapy. 4, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Human gene therapy for melanoma: CT-guided interstitial injection

Waddill, W., Wright, W., Unger, E., Stopeck, A., Akporiaye, E., Harris, D., Grogan, T., Schluter, S., Hersh, E. & Stahl, S., Jul 1997, In : American Journal of Roentgenology. 169, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Human tumor models in the severe combined immune deficient (scid) mouse

Paine-Murrieta, G. D., Taylor, C. W., Curtis, R. A., Lopez, M. H. A., Dorr, R. T., Johnson, C. S., Funk, C. Y., Thompson, F. & Hersh, E. M., Jul 1 1997, In : Cancer Chemotherapy And Pharmacology. 40, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl] 5- methylisoxazole-4-carboxamide

Shawver, L. K., Schwartz, D. P., Mann, E., Chen, H., Tsai, J., Chu, L., Taylorson, L., Longhi, M., Meredith, S., Germain, L., Jacobs, J. S., Tang, C., Ullrich, A., Berens, M. E., Hersh, E., McMahon, G., Hirth, K. P. & Powell, T. J., Jul 1 1997, In : Clinical Cancer Research. 3, 7, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

129 Scopus citations

Mammalian expression vector with two multiple cloning sites for expression of two foreign genes

Tsang, T. C., Harris, D. T., Akporiaye, E. T., Chu, R. S., Brailey, J., Liu, F., Vasanwala, F. H., Schluter, S. F. & Hersh, E. M., Jan 28 1997, In : BioTechniques. 22, 1, 1 p.

Research output: Contribution to journalArticle

10 Scopus citations

Phase 1 trial of recombinant human interleukin-1β (rhIL-1β), carboplatin, and etoposide in patients with solid cancers: Southwest oncology group study 8940

Rinehart, J., Hersh, E., Issell, B., Triozzi, P., Buhles, W. & Neidhart, J., Jan 1 1997, In : Cancer Investigation. 15, 5, p. 403-410 8 p.

Research output: Contribution to journalArticle

30 Scopus citations