Evan M Hersh

  • 19132 Citations
  • 67 h-Index
1965 …2021
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Research Output 1965 2017

  • 19132 Citations
  • 67 h-Index
  • 490 Article
  • 48 Chapter
  • 3 Letter
  • 1 Conference contribution
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Article
1965
290 Citations (Scopus)

CAUSES OF DEATH IN ACUTE LEUKEMIA: A TEN-YEAR STUDY OF 414 PATIENTS FROM 1954-1963.

Hersh, E. M., BODEY, G. P., NIES, B. A. & FREIREICH, E. J., Jul 12 1965, In : Journal of the American Medical Association. 193, p. 105-109 5 p.

Research output: Contribution to journalArticle

Lymphoid Leukemia
Staphylococcal Infections
Myeloid Leukemia
Mycoses
Geriatrics
214 Citations (Scopus)

Impaired in vitro lymphocyte transformation in Hodgkin's disease.

Hersh, E. M. & Oppenheim, J. J., Nov 4 1965, In : New England Journal of Medicine. 273, 19, p. 1006-1012 7 p.

Research output: Contribution to journalArticle

Delayed Hypersensitivity
Lymphocyte Activation
Hodgkin Disease
Lymphocytes
In Vitro Techniques
47 Citations (Scopus)

Inhibition of the primary immune response in man by anti-metabolites.

Hersh, E. M., Carbone, P. P., Wong, V. G. & Freireich, E. J., Aug 1965, In : Cancer Research. 25, 7, p. 997-1001 5 p.

Research output: Contribution to journalArticle

Antimetabolites
6-Mercaptopurine
Uveitis
Vincristine
Immunosuppressive Agents
1966
99 Citations (Scopus)

Hepatotoxic effects of methotrexate.

Hersh, E. M., Wong, V. G., Henderson, E. S. & Freireich, E. J., Apr 1966, In : Cancer. 19, 4, p. 600-606 7 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Eye Diseases
Liver Function Tests
Transaminases
L-Lactate Dehydrogenase
54 Citations (Scopus)

Inhibition of the local inflammatory response in man by antimetabolites.

Hersh, E. M., Wong, V. G. & Freireich, E. J., Jan 1966, In : Blood. 27, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Antimetabolites
6-Mercaptopurine
Uveitis
Methotrexate
Leukemia
88 Citations (Scopus)

Pulmonary complications of acute leukemia.

Bodey, G. P., Powell, R. D., Hersh, E. M., Yeterian, A. & Freireich, E. J., Jun 1966, In : Cancer. 19, 6, p. 781-793 13 p.

Research output: Contribution to journalArticle

Photomicrography
Mucormycosis
Circulating Neoplastic Cells
Preschool Children
Pulmonary Edema
22 Citations (Scopus)

Treatment of a Presumed Case of Sympathetic Ophthalmia With Methotrexate

Wong, V. G., Hersh, E. M. & Mcmaster, P. R. B., 1966, In : Archives of Ophthalmology. 76, 1, p. 66-76 11 p.

Research output: Contribution to journalArticle

Blood Chemical Analysis
Kidney Function Tests
Sympathetic Ophthalmia
Cataract Extraction
Liver Function Tests
1967
79 Citations (Scopus)

Inhibition of in vitro lymphocyte transformation during chemotherapy in man.

Hersh, E. M. & Oppenheim, J. J., Jan 1967, In : Cancer Research. 27, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

Smallpox Vaccine
6-Mercaptopurine
Immune Tolerance
Hemolytic Anemia
Cytarabine
1968
166 Citations (Scopus)

Macrophage-lymphocyte interaction in the antigen-induced blastogenic response of human peripheral blood leukocytes.

Hersh, E. M. & Harris, J. E., Jun 1968, In : Journal of Immunology. 100, 6, p. 1184-1194 11 p.

Research output: Contribution to journalArticle

Antigen-Antibody Reactions
Tritium
Leukocyte Count
Lectins
Germ Cells
7 Citations (Scopus)

Recurrent Listeria monocytogenes meningitis in a patient with acute leukemia.

Bodey, G. P., Hersh, E. M. & Freireich, E. J., Apr 1968, In : Cancer. 21, 4, p. 619-622 4 p.

Research output: Contribution to journalArticle

Listeria Meningitis
Lymphoid Leukemia
6-Mercaptopurine
Diabetes Mellitus
Leukemia
10 Citations (Scopus)

The effect of 1-beta-D-arabinofuranosylcytosine on the immune response of mice to sheep red blood cells.

Harris, J. E. & Hersh, E. M., Dec 1968, In : Cancer Research. 28, 12, p. 2432-2436 5 p.

Research output: Contribution to journalArticle

Chemical Depression
Hemagglutination Tests
Cytarabine
Immunosuppressive Agents
Hemolysis
172 Citations (Scopus)

The transformation of column-purified lymphocytes with nonspecific and specific antigenic stimuli.

Oppenheim, J. J., Leventhal, B. G. & Hersh, E. M., Aug 1968, In : Journal of Immunology. 101, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Tritium
Staphylococcus
Phagocytosis
Lectins
Thymidine
1969
17 Citations (Scopus)

Blastogenic responses of lymphocytes from patients with untreated and treated lymphomas.

Hersh, E. M. & Irvin, W. S., Dec 1969, In : Lymphology. 2, 4, p. 150-160 11 p.

Research output: Contribution to journalArticle

Immunologic Deficiency Syndromes
Skin Tests
Hodgkin Disease
Mitosis
Lectins
1 Citation (Scopus)

Hodgkin's disease complicated by infection with Mycobacterium kansasii.

Harris, J., Alexanian, R., Hersh, E. M. & Leary, W., Aug 23 1969, In : Canadian Medical Association Journal. 101, 4, p. 231-234 4 p.

Research output: Contribution to journalArticle

Mycobacterium kansasii
Mycobacterium Infections
Delayed Hypersensitivity
Mycobacterium
Hodgkin Disease
14 Citations (Scopus)

Prevention of Rapid Immune Elimination of Anti-lymphocytic Globulin in Transplant Patients

Butler, W. T., Rossen, R. D., Hersh, E. M., Debakey, M. E., Diethrich, E. B., Brooks, D. K., Cooley, D. A., Nora, J. J., Leachman, R. D., Rochelle, D. G., Trentin, J. J., Judd, K. P., Beall, A. C., Jenkins, D. E., Morgen, R. O. & Knight, V., 1969, In : Nature. 224, 5222, p. 856-860 5 p.

Research output: Contribution to journalArticle

Globulins
Transplants
Horses
Antibody Formation
Allografts
1970
9 Citations (Scopus)

Antigen-specific immunity in recipients of leukocyte transfusions from immune donors.

Curtis, J. E., Hersh, E. M. & Freireich, E. J., Dec 1970, In : Cancer Research. 30, 12, p. 2921-2929 9 p.

Research output: Contribution to journalArticle

Maternally Acquired Immunity
Leukocyte Transfusion
Hemagglutination Tests
Antibody Specificity
Lymphocyte Activation
3 Citations (Scopus)

Human immune response to a xenogeneic nucleated cell

Harris, J. E., Hersh, E. M. & Huggins, S., 1970, In : Transplantation. 9, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

Lymphocyte Activation
Antibodies
Lymphocytes
Alligators and Crocodiles
Immunization
1 Citation (Scopus)

Immunologic considerations for future cardiac transplantation in man.

Butler, W. T., Rossen, R. D., Hersh, E. M., Beall, A. C., Morgen, R. D., Diethrich, E. B. & Debakey, M. E., Feb 1970, In : Laval medical. 41, 2, p. 155-160 6 p.

Research output: Contribution to journalArticle

Transplantation Immunology
Histocompatibility
Homologous Transplantation
Heart Transplantation
20 Citations (Scopus)

Immunosuppressive effects of L-asparaginase.

Ohno, R. & Hersh, E. M., Jun 1970, In : Cancer Research. 30, 6, p. 1605-1611 7 p.

Research output: Contribution to journalArticle

Adrenal Gland Neoplasms
Glutamates
Lymphoid Leukemia
Asparaginase
Hemocyanin
26 Citations (Scopus)

Influence of cell density on response of leukocytes and column-purified lymphocytes to mitogenic agents.

Hersh, E. M., Harris, J. E. & Rogers, E. A., May 1970, In : RES Journal of the Reticuloendothelial Society. 7, 5, p. 567-586 20 p.

Research output: Contribution to journalArticle

Chemical Stimulation
Contact Inhibition
Tritium
Lymphocyte Activation
Lectins
13 Citations (Scopus)

L-asparaginase: suppression of the immune response of mice to sheep red blood cells.

Ohno, R., Harris, J. E. & Hersh, E. M., Aug 1970, In : Clinical and Experimental Immunology. 7, 2, p. 221-227 7 p.

Research output: Contribution to journalArticle

Hemolytic Plaque Technique
Active Immunity
Asparaginase
Antibody-Producing Cells
Immunosuppressive Agents
28 Citations (Scopus)

Leukocytic mechanisms in inflammation.

Hersh, E. M. & Bodey, G. P., 1970, In : Annual Review of Medicine. 21, p. 105-132 28 p.

Research output: Contribution to journalArticle

Serum Globulins
Kinins
Blood Coagulation Factors
Blood vessels
Histamine
15 Citations (Scopus)

Lymphocyte activation: A rapid test to predict allograft rejection

Hersh, E. M., Butler, W. T., Rossen, R. D. & Morgen, R. O., 1970, In : Nature. 226, 5247, p. 757-758 2 p.

Research output: Contribution to journalArticle

Lymphocyte Activation
Allografts
Transplantation Immunology
Lymphocyte Count
Graft Rejection
1 Citation (Scopus)

The effect of the antitumor agent 1,1-diphenyl-2-propynyl cyclohexylcarbamate on the immune response of mice to sheep red blood cells.

Harris, J. E. & Hersh, E. M., Mar 1970, In : Cancer Research. 30, 3, p. 837-841 5 p.

Research output: Contribution to journalArticle

acetylenic carbamate
Hemolytic Plaque Technique
Cyclohexanes
Antigen-Antibody Reactions
Alkynes
76 Citations (Scopus)

The human primary immune response to keyhole limpet haemocyanin: interrelationships of delayed hypersensitivity, antibody response and in vitro blast transformation.

Curtis, J. E., Hersh, E. M., Harris, J. E., McBride, C. & Freireich, E. J., Apr 1970, In : Clinical and Experimental Immunology. 6, 4, p. 473-491 19 p.

Research output: Contribution to journalArticle

Nasopharyngeal Neoplasms
Synovial Sarcoma
Hemocyanin
Bronchogenic Carcinoma
Mollusca
45 Citations (Scopus)

The inhibition of lymphocyte blastogenesis by L-asparaginase.

Ohno, R. & Hersh, E. M., Feb 1970, In : Blood. 35, 2, p. 250-262 13 p.

Research output: Contribution to journalArticle

Streptodornase and Streptokinase
Streptolysins
Asparaginase
Tissue culture
Lymphocytes
1971
26 Citations (Scopus)

Antigen dose in the human immune response. Dose-response relationships in the human immune response to Keyhole limpet hemocyanin

Curtis, J. E., Hersh, E. M., Butler, W. T. & Rossen, R. D., 1971, In : The Journal of Laboratory and Clinical Medicine. 78, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

Antigens
Immunization
Lymphocytes
Hemagglutinins
Skin
12 Citations (Scopus)

Blastogenic responses of human lymphocytes to xenogeneic cells in vitro

Hersh, E. M., 1971, In : Transplantation. 12, 4, p. 287-293 7 p.

Research output: Contribution to journalArticle

Lymphocyte Activation
Lymphocytes
Cultured Cells
Cell Culture Techniques
Surface Antigens
150 Citations (Scopus)

Cells capable of colony formation in the peripheral blood of man

Mccredie, K. B., Hersh, E. M. & Freireich, E. J., 1971, In : Science. 171, 3968, p. 293-294 2 p.

Research output: Contribution to journalArticle

Leukapheresis
Agar
Blood Cells
Gels
Tissue Donors
180 Citations (Scopus)

Chemotherapy, immunocompetence, immunosuppression and prognosis in acute leukemia.

Hersh, E. M., Whitecar, J. P., McCredie, K. B., Bodey, G. P. & Freireich, E. J., Nov 1971, In : New England Journal of Medicine. 285, 22, p. 1211-1216 6 p.

Research output: Contribution to journalArticle

Immunologic Deficiency Syndromes
Spontaneous Remission
Thioguanine
Immunocompetence
6-Mercaptopurine
3 Citations (Scopus)

Effect of arabinosyl-6-mercaptopurine on the blastogenic responses in vitro of human lymphocytes to mitogenic agents

Hersh, E. M. & LePagb, G. A., 1971, In : Biochemical Pharmacology. 20, 9, p. 2459-2468 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Thymidine
Pharmaceutical Preparations
Lymphocyte Activation
Mitogens
19 Citations (Scopus)

Immune function in multiple myeloma: impaired responsiveness to keyhole limpet hemocyanin.

Harris, J., Alexanian, R., Hersh, E. M. & Migliore, P., Mar 6 1971, In : Canadian Medical Association Journal. 104, 5, p. 389-393 5 p.

Research output: Contribution to journalArticle

Hemocyanin
Plasmacytoma
Mollusca
Multiple Myeloma
Antibody Formation
27 Citations (Scopus)

Immunosuppression by l-asparaginase and related enzymes: A review

Hersh, E. M., 1971, In : Transplantation. 12, 5, p. 368-376 9 p.

Research output: Contribution to journalArticle

Asparaginase
Immunosuppression
glutamin-(asparagin-)ase
Immunosuppressive Agents
Amino Acids
29 Citations (Scopus)

Inhibition of immune responses by glutamine antagonism: effect of azotomycin on lymphocyte blastogenesis.

Hersh, E. M. & Brown, B. W., Jun 1971, In : Cancer Research. 31, 6, p. 834-840 7 p.

Research output: Contribution to journalArticle

Antineoplastic Antibiotics
Drug Synergism
Streptolysins
Asparaginase
Immunosuppressive Agents
38 Citations (Scopus)

In vitro studies of the human response to organ allografts: appearance and detection of circulating activation lymphocytes.

Hersh, E. M., Butler, W. T., Rossen, R. D., Morgan, R. O. & Suki, W., Aug 1971, In : Journal of Immunology. 107, 2, p. 571-578 8 p.

Research output: Contribution to journalArticle

Transplantation Immunology
Streptolysins
Antibody-Producing Cells
Tritium
Homologous Transplantation
26 Citations (Scopus)

L-Glutaminase: Suppression of lymphocyte blastogenic responses in vitro

Hersh, E. M., 1971, In : Science. 172, 3984, p. 736-738 3 p.

Research output: Contribution to journalArticle

Glutaminase
Lymphocytes
Asparagine
Phytohemagglutinins
Immunosuppressive Agents
10 Citations (Scopus)

Lymphocyte activation during allograft rejection.

Hersh, E. M., Butler, W. T., Rossen, R. D., Morgen, R. O. & Suki, W., Mar 1971, In : Transplantation Proceedings. 3, 1, p. 457-460 4 p.

Research output: Contribution to journalArticle

Transplantation Immunology
Homologous Transplantation
Graft Rejection
Heart Transplantation
Lymphocyte Activation
83 Citations (Scopus)

Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis.

Cheema, A. R. & Hersh, E. M., Oct 1971, In : Cancer. 28, 4, p. 851-855 5 p.

Research output: Contribution to journalArticle

Streptolysins
Spontaneous Remission
Lymphocyte Activation
Lectins
Acute Myeloid Leukemia
1972
49 Citations (Scopus)

Antigen solubilized from human leukemia: Lymphocyte stimulation

Gutterman, J. U., Mavligit, G., McCredie, K. B., Bodey, G. P., Freireich, E. J. & Hersh, E. M., 1972, In : Science. 177, 4054, p. 1114-1115 2 p.

Research output: Contribution to journalArticle

Lymphocyte Activation
Leukemia
Lymphocytes
Antigens
Tissue Donors
29 Citations (Scopus)

Cyclic nucleotide analogs as carcinostatic agents

LePage, G. A. & Hersh, E. M., Mar 10 1972, In : Biochemical and Biophysical Research Communications. 46, 5, p. 1918-1922 5 p.

Research output: Contribution to journalArticle

Lymphocytes
Cyclic Nucleotides
Tumors
Nucleotides
Vidarabine
28 Citations (Scopus)

Immune status of patients with multiple sclerosis: Analysis of primary and established immune responses in 24 patients

Davis, L. E., Hersh, E. M., Curtis, J. E., Lynch, R. E., Ziegler, D. K., Neumann, J. W. & Chin, T. D. Y., 1972, In : Neurology. 22, 9, p. 989 1 p.

Research output: Contribution to journalArticle

Delayed Hypersensitivity
Multiple Sclerosis
Antigens
Antibody Formation
Streptolysins
4 Citations (Scopus)

In vitro lymphocyte responses to malignant, benign neoplastic and normal tissue extracts.

Anderson, R. J., McBride, C. M. & Hersh, E. M., Jun 1972, In : Proceedings of the Society for Experimental Biology and Medicine. 140, 2, p. 465-470 6 p.

Research output: Contribution to journalArticle

Neoplasm Proteins
Streptolysins
Tissue Extracts
Tritium
Neoplasm Antigens
44 Citations (Scopus)

Leukapheresis therapy of chronic lymphocytic leukemia.

Curtis, J. E., Hersh, E. M. & Freireich, E. J., Feb 1972, In : Blood. 39, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

Histoplasmin
Streptodornase and Streptokinase
Lymphocytes
Tritium
Candida
35 Citations (Scopus)

Local tumor immunotherapy with in vitro activated autochithonous lymphocytes.

Cheema, A. R. & Hersh, E. M., Apr 1972, In : Cancer. 29, 4, p. 982-986 5 p.

Research output: Contribution to journalArticle

Spontaneous Neoplasm Regression
Chondrosarcoma
Lectins
Immunotherapy
Melanoma
35 Citations (Scopus)

Lymphocyte blastogenesis to human leukemia cells and their relationship to serum factors, immunocompetence, and prognosis.

Gutterman, J. U., Hersh, E. M., McCredie, K. B., Bodey, G. P., Rodriguez, V. & Freireich, E. J., Nov 1972, In : Cancer Research. 32, 11, p. 2524-2529 6 p.

Research output: Contribution to journalArticle

Neoplasm Transplantation
Spontaneous Remission
Lymphoid Leukemia
Immunocompetence
Homologous Transplantation
28 Citations (Scopus)

Lymphocyte blastogenic responses to cultured allogeneic tumor cells in vitro.

Anderson, R. J., McBride, C. M. & Hersh, E. M., May 1972, In : Cancer Research. 32, 5, p. 988-992 5 p.

Research output: Contribution to journalArticle

Streptodornase and Streptokinase
Streptolysins
Chemical Stimulation
Cultured Tumor Cells
Rhabdomyosarcoma
30 Citations (Scopus)

Multifaceted evaluation of human tumor immunity using a salt extracted colon carcinoma antigen.

Mavligit, G., Gutterman, J. U., McBride, C. M. & Hersh, E. M., Sep 1972, In : Proceedings of the Society for Experimental Biology and Medicine. 140, 4, p. 1240-1245 6 p.

Research output: Contribution to journalArticle

Lymphocytes
Lectins
Sodium Chloride
Tumors
Skin
25 Citations (Scopus)

The human secondary immune response to Keyhole limpet haemocyanin.

Curtis, J. E. & Hersh, E. M., Jan 1972, In : Clinical and Experimental Immunology. 10, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Secondary Immunization
Hemagglutination Tests
Hemocyanin
Tritium
Mollusca
1973
188 Citations (Scopus)

ACTIVE IMMUNOTHERAPY WITH B.C.G. FOR RECURRENT MALIGNANT MELANOMA

Gutterman, J. U., McBride, C., Freireich, E. J., Mavligit, G., Frei, E. & Hersh, E. M., Jun 2 1973, In : The Lancet. 301, 7814, p. 1208-1212 5 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Mycobacterium bovis
Melanoma
Immunotherapy
Delayed Hypersensitivity
17 Citations (Scopus)

Auto‐immunization with acute leukemia cells: Demonstration of increased lymphocyte responsiveness

Gutterman, J. U., Mavligit, G., McCredie, K. B., Freireich, E. J. & Hersh, E. M., 1973, In : International Journal of Cancer. 11, 3, p. 521-526 6 p.

Research output: Contribution to journalArticle

Leukemia
Lymphocytes
Immunization
Phytohemagglutinins
Serum