Evan M Hersh

  • 19105 Citations
  • 67 h-Index
1965 …2021
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Research Output 1965 2017

  • 19105 Citations
  • 67 h-Index
  • 490 Article
  • 48 Chapter
  • 3 Letter
  • 1 Conference contribution
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Article
1997
55 Citations (Scopus)

Expression of an antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells

Park, J. A., Wang, E., Kurt, R. A., Schluter, S. F., Hersh, E. M. & Akporiaye, E. T., 1997, In : Cancer Gene Therapy. 4, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Transgenes
Breast Neoplasms
Neoplasms
Cytokines
1 Citation (Scopus)

Foundations of clinical cancer research: perspective for the 21st century.

Hersh, E. M., Dec 1997, In : Clinical Cancer Research. 3, 12 Pt 2, p. 2551-2553 3 p.

Research output: Contribution to journalArticle

20th Century History
Antineoplastic Combined Chemotherapy Protocols
Medical Oncology
Leukemia
Research
26 Citations (Scopus)

Human gene therapy for melanoma: CT-guided interstitial injection

Waddill, W., Wright, W., Unger, E. C., Stopeck, A. T., Akporiaye, E., Harris, D. T., Grogan, T., Schluter, S., Hersh, E. M. & Stahl, S., Jul 1997, In : American Journal of Roentgenology. 169, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

Genetic Therapy
Melanoma
HLA-B7 Antigen
Injections
Neoplasms
60 Citations (Scopus)

Human tumor models in the severe combined immune deficient (scid) mouse

Paine-Murrieta, G. D., Taylor, C. W., Curtis, R. A., Lopez, M. H. A., Dorr, R. T., Johnson, C. S., Funk, C. Y., Thompson, F. & Hersh, E. M., 1997, In : Cancer Chemotherapy and Pharmacology. 40, 3, p. 209-214 6 p.

Research output: Contribution to journalArticle

Tumors
Carmustine
Melanoma
Cyclophosphamide
Growth
129 Citations (Scopus)

Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl] 5- methylisoxazole-4-carboxamide

Shawver, L. K., Schwartz, D. P., Mann, E., Chen, H., Tsai, J., Chu, L., Taylorson, L., Longhi, M., Meredith, S., Germain, L., Jacobs, J. S., Tang, C., Ullrich, A., Berens, M. E., Hersh, E. M., McMahon, G., Hirth, K. P. & Powell, T. J., Jul 1997, In : Clinical Cancer Research. 3, 7, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

leflunomide
Platelet-Derived Growth Factor
Platelet-Derived Growth Factor Receptors
Signal Transduction
Growth
10 Citations (Scopus)

Mammalian expression vector with two multiple cloning sites for expression of two foreign genes

Tsang, T. C., Harris, D. T., Akporiaye, E. T., Chu, R. S., Brailey, J., Liu, F., Vasanwala, F. H., Schluter, S. F. & Hersh, E. M., 1997, In : BioTechniques. 22, 1, p. 68 1 p.

Research output: Contribution to journalArticle

Avian Sarcoma Viruses
Genetic Vectors
Cloning
Molecular Cloning
Cytomegalovirus
29 Citations (Scopus)

Phase 1 trial of recombinant human interleukin-1β (rhIL-1β), carboplatin, and etoposide in patients with solid cancers: Southwest oncology group study 8940

Rinehart, J., Hersh, E. M., Issell, B., Triozzi, P., Buhles, W. & Neidhart, J., 1997, In : Cancer Investigation. 15, 5, p. 403-410 8 p.

Research output: Contribution to journalArticle

Carboplatin
Etoposide
Interleukin-1
Neoplasms
Drug Therapy
134 Citations (Scopus)

Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma

Stopeck, A. T., Hersh, E. M., Akporiaye, E. T., Harris, D. T., Grogan, T., Unger, E. C., Warneke, J. A., Schluter, S. F. & Stahl, S., Jan 1997, In : Journal of Clinical Oncology. 15, 1, p. 341-349 9 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Histocompatibility Antigens
Melanoma
Genes
Plasmids
1 Citation (Scopus)

Recent advances in the treatment of malignant melanoma with gene therapy

Hersh, E. M. & Stopeck, A. T., 1997, In : Molecular Medicine. 3, 10, p. 636-651 16 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Cancer Vaccines
Genetic Therapy
Melanoma
Clinical Trials
1996
7 Citations (Scopus)

Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection

Wallace, M. R., Moss, R. B., Beecham, H. J., Grace, C. J., Hersh, E. M., Peterson, E., Murphy, R., Shepp, D. H., Siegal, F. P., Turner, J. L., Safrin, S., Carlo, D. J. & Levine, A. M., 1996, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 12, 4, p. 358-362 5 p.

Research output: Contribution to journalArticle

Virus Diseases
Biomarkers
HIV
HIV-1
HIV Envelope Protein gp120
21 Citations (Scopus)

Interferon γ(IFNγ) gene transfer of an EMT6 tumor that is poorly responsive to IFNγ stimulation: Increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC

Panelli, M. C., Wang, E., Shen, S., Schluter, S. F., Bernstein, R. M., Hersh, E. M., Stopeck, A. T., Gangavalli, R., Barber, J., Jolly, D. & Akporiaye, E. T., 1996, In : Cancer Immunology, Immunotherapy. 42, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Interferons
Genes
Neoplasms
MHC class II transactivator protein
Immunity
22 Citations (Scopus)

Liposomal amikacin: Improved treatment of Mycobacterium avium complex infection in the beige mouse model

Petersen, E. A., Grayson, J. B., Hersh, E. M., Dorr, R. T., Chiang, S. M., Oka, M. & Proffitt, R. T., 1996, In : Journal of Antimicrobial Chemotherapy. 38, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

Mycobacterium avium Complex
Amikacin
Infection
Mycobacterium avium
Therapeutics
8 Citations (Scopus)

Simple method for adapting DNA fragments and PCR products to all of the commonly used restriction sites

Tsang, T. C., Harris, D. T., Akporiaye, E. T., Schluter, S. F., Bowden, G. T. & Hersh, E. M., Jan 1996, In : BioTechniques. 20, 1, p. 51-52 2 p.

Research output: Contribution to journalArticle

Bacteriophage lambda
Genetic Techniques
Genetic Vectors
Restriction Mapping
Recombinant DNA
1995
30 Citations (Scopus)

A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes

Zhang, H., Lake, D. F., Barbuto, J. A. M., Bernstein, R. M., Grimes, W. J. & Hersh, E. M., 1995, In : Cancer Research. 55, 16, p. 3584-3591 8 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Single-Chain Antibodies
B-Lymphocytes
Melanoma
Polymerase Chain Reaction
8 Citations (Scopus)

Antibodies to tumor necrosis factor: a component of B cell immune responses with a role in tumor/host interaction

Barbuto, J. A. M., Grimes, W. J. & Hersh, E. M., Jan 1995, In : Cancer Immunology, Immunotherapy. 40, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Tumor Necrosis Factor-alpha
Antibodies
Neoplasms
Antibody Formation
2 Citations (Scopus)

Comparison of 4- and 24-hour intravenous infusion schedules for granulocyte-macrophage colony-stimulating factor

Wong, L., Taylor, C. W., Radwanski, E., Hersh, E. M. & Salmon, S. E., 1995, In : Journal of Immunotherapy. 18, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Intravenous Infusions
Appointments and Schedules
Pharmacokinetics
Pain
4 Citations (Scopus)

Phase i trial of recombinant interleukin 3 before and after Carboplatin/Etoposide chemotherapy in patients with solid tumors: A southwest oncology group study

Rinehart, J., Margolin, K. A., Triozzi, P., Hersh, E. M., Campion, M., Resta, D. & Levitt, D., 1995, In : Clinical Cancer Research. 1, 10, p. 1139-1144 6 p.

Research output: Contribution to journalArticle

Interleukin-3
Carboplatin
Etoposide
Bone Marrow
Drug Therapy
17 Citations (Scopus)

Preclinical pharmacokinetics and antitumor activity of imexon

Dorr, R. T., Liddil, J. D., Klein, M. K. & Hersh, E. M., Jun 1995, In : Investigational New Drugs. 13, 2, p. 113-116 4 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Pharmaceutical Preparations
Dogs
Leukemia L1210
Neoplasms
84 Citations (Scopus)

Randomized trial of adjuvant human interferon gamma versus observation in high-risk cutaneous melanoma: A southwest oncology group study

Meyskens, F. L., Kopecky, K. J., Taylor, C. W., Noyes, R. D., Tuthill, R. J., Hersh, E. M., Feun, L. G., Doroshow, J. H., Flaherty, L. E. & Sondak, V. K., Nov 15 1995, In : Journal of the National Cancer Institute. 87, 22, p. 1710-1711 2 p.

Research output: Contribution to journalArticle

Neoplasm Staging
Skin Neoplasms
Adjuvant Chemotherapy
Survival Analysis
Antineoplastic Agents

Response

Salmon, S. E. & Hersh, E. M., Jun 21 1995, In : Journal of the National Cancer Institute. 87, 12, p. 936 1 p.

Research output: Contribution to journalArticle

1994
42 Citations (Scopus)

Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes

Punt, C. J. A., Barbuto, J. A. M., Zhang, H., Grimes, W. J., Hatch, K. D. & Hersh, E. M., Jul 1994, In : Cancer Immunology, Immunotherapy. 38, 4, p. 225-232 8 p.

Research output: Contribution to journalArticle

Neoplasm Antibodies
Anti-Idiotypic Antibodies
B-Lymphocytes
Neoplasms
Feeder Cells
14 Citations (Scopus)

Construction and Serological Characterization of a Recombinant Human Single Chain T-Cell Receptor

Lake, D. F., Bernstein, R. M., Hersh, E. M., Kaymaz, H., Schluter, S. F. & Marchalonis, J. J., Jun 30 1994, In : Biochemical and Biophysical Research Communications. 201, 3, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Immune Sera
Assays
T-Cell Receptor Genes
Jurkat Cells
2 Citations (Scopus)

GM-CSF, carboplatin, doxorubicin: a phase I study

Poplin, E. A., Alberts, D. S., Rinehart, J. J., Smith, H. O., Neidhart, J. A. & Hersh, E. M., Jul 1994, In : Cancer Chemotherapy and Pharmacology. 33, 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

Carboplatin
Granulocyte-Macrophage Colony-Stimulating Factor
Doxorubicin
Chemotherapy
Drug Therapy
14 Citations (Scopus)

Molecular cloning, expression and mutagenesis of an anti-insulin single chain Fv (scFv)

Lake, D. F., Lam, K. S., Peng, L. & Hersh, E. M., 1994, In : Molecular Immunology. 31, 11, p. 845-856 12 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Molecular Cloning
Mutagenesis
Insulin
Light
21 Citations (Scopus)

Peptide sequences binding to MHC class I proteins

Smith, M. H., Lam, K. S., Hersh, E. M., Lebl, M. & Grimes, W. J., 1994, In : Molecular Immunology. 31, 18, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Peptides
HLA-A2 Antigen
Proteins
B7 Antigens
19 Citations (Scopus)

Phase I study of immunotherapy of malignant melanoma by direct gene transfer

Hersh, E. M., Akporiayc, E., Harris, D. T., Stopeck, A. T., Unger, E. C. & Warneke, J. A., Nov 1994, In : Human Gene Therapy. 5, 11, p. 1371-1384 14 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Intralesional Injections
Gene Transfer Techniques
Genetic Vectors
Recombinant DNA
25 Citations (Scopus)

Sensitivity of multiple myeloma to imexon in the human tumor cloning assay

Salmon, S. E. & Hersh, E. M., Feb 2 1994, In : Journal of the National Cancer Institute. 86, 3, p. 228-230 3 p.

Research output: Contribution to journalArticle

Hexanones
Tumor Stem Cell Assay
Drug Administration Schedule
Cultured Tumor Cells
Immunologic Factors
1993
29 Citations (Scopus)

An in vivo model of human multidrug-resistant multiple myeloma in SCID mice

Bellamy, W. T., Odeleye, A., Finley, P., Huizenga, B., Dalton, W. S., Weinstein, R. S., Hersh, E. M. & Grogan, T. M., Mar 1993, In : American Journal of Pathology. 142, 3, p. 691-698 8 p.

Research output: Contribution to journalArticle

SCID Mice
Multiple Myeloma
P-Glycoprotein
Heterografts
Doxorubicin
3 Citations (Scopus)

Dose response and timing effects in the therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate

Hersh, E. M., Funk, C. Y., Petersen, E. A., Ryschon, K. L. & Mosier, D. E., 1993, In : International Journal of Immunopharmacology. 15, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

Ditiocarb
Retroviridae
Murine Acquired Immunodeficiency Syndrome
Viruses
Hypergammaglobulinemia
5 Citations (Scopus)

Phase II study of vindesine and dacarbazine with or without non-specific stimulation of the immune system in patients with metastatic melanoma

Verschraegen, C. F., Legha, S. S., Hersh, E. M., Plager, C., Papadopoulos, N. & Burgess, M. A., 1993, In : European Journal of Cancer. 29, 5, p. 708-711 4 p.

Research output: Contribution to journalArticle

Vindesine
Dacarbazine
Immune System
Melanoma
Methanol
2 Citations (Scopus)

Preparation of large peptide libraries with one peptide per bead and their use for the discovery of peptides that bind to acceptors.

Hruby, V. J., Lam, K. S., Lebl, M., Kazmierski, W., Hersh, E. M. & Salmon, S. E., 1993, In : NIDA research monograph. 134, p. 75-83 9 p.

Research output: Contribution to journalArticle

Factual Databases
Peptide Library
Cell Surface Receptors
Peptides
Consensus Sequence
10 Citations (Scopus)

Suppression of human lymphoma development in the severe combined immune- deficient mouse by imexon therapy

Hersh, E. M., Grogan, T. M., Funk, C. Y. & Taylor, C. W., 1993, In : Journal of Immunotherapy. 13, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

Human Development
Lymphoma
Human Herpesvirus 4
Therapeutics
Blood Cells
64 Citations (Scopus)

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Lam, K. S., Hruby, V. J., Lebl, M., Knapp, R. J., Kazmierski, W. M., Hersh, E. M. & Salmon, S. E., 1993, In : Bioorganic and Medicinal Chemistry Letters. 3, 3, p. 419-424 6 p.

Research output: Contribution to journalArticle

Peptide Library
Ligands
Peptides
Libraries
Molecules
7 Citations (Scopus)

The use of transformed T cell lines for clonal expansion of human B cells from peripheral blood, spleen, and tumor-infiltrating lymphocytes

Barbuto, J. A. M., Verastegui, E. L. & Hersh, E. M., 1993, In : Hybridoma. 12, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Transformed Cell Line
B-Lymphocytes
Spleen
T-Lymphocytes
33 Citations (Scopus)

Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation

Moran, M. J., Andris, J. S., Matsumato, Y. I., Capra, J. D. & Hersh, E. M., 1993, In : Molecular Immunology. 30, 16, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
HIV
Mutation
Genes
Immunoglobulin G
1992
33 Citations (Scopus)

Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro

Hersh, E. M., Gschwind, C. R., Taylor, C. W., Dorr, R. T., Taetle, R. & Salmon, S. E., Aug 19 1992, In : Journal of the National Cancer Institute. 84, 16, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Tumors
Tumor
Cells
Line
9 Citations (Scopus)

A phase I trial of fluorouracil, leucovorin, and recombinant interferon α-2b in patients with advanced malignancy

Taylor, C. W., Modiano, M. R., Woodson, M. E., Marcus, S. G., Alberts, D. S. & Hersh, E. M., 1992, In : Seminars in Oncology. 19, 2 SUPPL. 3, p. 185-190 6 p.

Research output: Contribution to journalArticle

Leucovorin
Fluorouracil
Interferons
Colonic Neoplasms
Pancreatic Neoplasms
11 Citations (Scopus)

A Southwest Oncology Group Phase I study of the sequential combination of recombinant interferon-γ and recombinant interleukin-2 in patients with cancer

Taylor, C. W., Chase, E. M., Whitehead, R. P., Rinehart, J. J., Neidhart, J. A., Gonzalez, R., Bunn, P. A. & Hersh, E. M., 1992, In : Journal of Immunotherapy. 11, 3, p. 176-183 8 p.

Research output: Contribution to journalArticle

Interferons
Interleukin-2
Maximum Tolerated Dose
Neoplasms
Chills

Chemosensitivity of human melanoma to cisplatin and heat at pharmacokinetic doses achievable by isolated hyperthermic perfusion

Leon, S. P. L., Xu, M. J., Alberts, D. S., Wang, T. F., Peng, Y. M., Hersh, E. M., Taylor, C. W., Fanta, P. & Salmon, S. E., 1992, In : Regional Cancer Treatment. 4, 5-6, p. 216-219 4 p.

Research output: Contribution to journalArticle

Cisplatin
Melanoma
Pharmacokinetics
Perfusion
Hot Temperature
6 Citations (Scopus)

Erratum: A new type of synthetic peptide library for identifying ligand-binding activity (Nature (1991) 354 (82-84))

Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmeierski, W. M. & Knapp, R. J., 1992, In : Nature. 360, 6406, p. 768 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Erratum: A new type of synthetic peptide library for identifying ligand-binding activity (Nature (1991) 354 (82-84))

Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmeierski, W. M. & Knapp, R. J., 1992, In : Nature. 358, 6385, p. 434 1 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Expression of type IV collagenase correlates with the invasion of human lymphoblastoid cell lines and pathogenesis in SCID mice

Hendrix, M. J. C., Seftor, E. A., Grogan, T. M., Seftor, R. E. B., Hersh, E. M., Boyse, E. A., Liotta, L. A., Stetler-Stevenson, W. & Ray, C. G., 1992, In : Molecular and Cellular Probes. 6, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

SCID Mice
Collagenases
Human Herpesvirus 4
Cell Line
Aptitude
15 Citations (Scopus)

Generation and characterization of a human monoclonal antibody that neutralizes diverse HIV-1 isolates in vitro

Lake, D. F., Kawamura, T., Tomiyama, T., Robinson, W. E., Matsumoto, Y. I., Masuho, Y. & Hersh, E. M., Jan 1992, In : AIDS. 6, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

HIV-1
Monoclonal Antibodies
HIV
In Vitro Techniques
Radioimmunoprecipitation Assay
11 Citations (Scopus)

Growth and dissemination of human malignant melanoma cells in mice with severe combined immune deficiency

Taylor, C. W., Grogan, T. M., Lopez, M. H. A., Leong, S. P. L., Odeleye, A., Feo-Zuppardi, F. J. & Hersh, E. M., 1992, In : Laboratory Investigation. 67, 1, p. 130-137 8 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Melanoma
Growth
Neoplasms
Intraperitoneal Injections
8 Citations (Scopus)

High incidence of coagulopathy in phase II studies of recombinant tumor necrosis factor in advanced pancreatic and gastric cancers

Muggia, F. M., Brown, T. D., Goodman, P. J., Macdonald, J. S., Hersh, E. M., Fleming, T. R. & Leichman, L., 1992, In : Anti-Cancer Drugs. 3, 3, p. 211-217 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Stomach Neoplasms
Tumor Necrosis Factor-alpha
Incidence
Chills
2 Citations (Scopus)
Immunologic Deficiency Syndromes
Immunologic Adjuvants
Opportunistic Infections
Nucleic Acids
Cytokines
7 Citations (Scopus)

Interferon-γ induced by administration of recombinant interleukin-2 to patients with cancer: Kinetics, dose dependence, and correlation with physiological and therapeutic response

Konrad, M. W., DeWitt, S. K., Bradley, E. C., Goodman, G., Groves, E. C., Hersh, E. M., Krigel, R. L. & Rudolph, A., 1992, In : Journal of Immunotherapy. 12, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

Interferons
Interleukin-2
Neoplasms
Therapeutics
Serum
40 Citations (Scopus)

Long-term engraftment of fresh human myeloma cells in SCID mice

Feo-Zuppardi, F. J., Taylor, C. W., Iwato, K., Lopez, M. H. A., Grogan, T. M., Odeleye, A., Hersh, E. M. & Salmon, S. E., Dec 1 1992, In : Blood. 80, 11, p. 2843-2850 8 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Grafts
Immunoglobulins
Bone
Cells
17 Citations (Scopus)

Phase I study of low-dose cyclophosphamide and recombinant interleukin-2 for the treatment of advanced cancer

Verdi, C. J., Taylor, C. W., Croghan, M. K., Dalke, P., Meyskens, F. L. & Hersh, E. M., 1992, In : Journal of Immunotherapy. 11, 4, p. 286-291 6 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Interleukin-2
Neoplasms
Therapeutics
Renal Cell Carcinoma
10 Citations (Scopus)
Immunologic Factors
Retroviridae
Inbred C57BL Mouse
Murine Acquired Immunodeficiency Syndrome
Viruses