Evan M Hersh

  • 19346 Citations
  • 67 h-Index
1965 …2018

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1997

Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma

Stopeck, A. T., Hersh, E. M., Akporiaye, E. T., Harris, D. T., Grogan, T., Unger, E., Warneke, J., Schluter, S. F. & Stahl, S., Jan 1997, In : Journal of Clinical Oncology. 15, 1, p. 341-349 9 p.

Research output: Contribution to journalArticle

135 Scopus citations
1996

Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection

Wallace, M. R., Moss, R. B., Beecham, H. J., Grace, C. J., Hersh, E. M., Peterson, E., Murphy, R., Shepp, D. H., Siegal, F. P., Turner, J. L., Safrin, S., Carlo, D. J. & Levine, A. M., Jan 1 1996, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 12, 4, p. 358-362 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interferon γ(IFNγ) gene transfer of an EMT6 tumor that is poorly responsive to IFNγ stimulation: Increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC

Panelli, M. C., Wang, E., Shen, S., Schluter, S. F., Bernstein, R. M., Hersh, E. M., Stopeck, A., Gangavalli, R., Barber, J., Jolly, D. & Akporiaye, E. T., Jan 1 1996, In : Cancer Immunology, Immunotherapy. 42, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Liposomal amikacin: Improved treatment of Mycobacterium avium complex infection in the beige mouse model

Petersen, E. A., Grayson, J. B., Hersh, E. M., Dorr, R. T., Chiang, S. M., Oka, M. & Proffitt, R. T., 1996, In : Journal of Antimicrobial Chemotherapy. 38, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Simple method for adapting DNA fragments and PCR products to all of the commonly used restriction sites

Tsang, T. C., Harris, D. T., Akporiaye, E. T., Schluter, S. F., Bowden, G. T. & Hersh, E. M., Jan 1 1996, In : BioTechniques. 20, 1, p. 51-52 2 p.

Research output: Contribution to journalArticle

8 Scopus citations
1995

A Human Monoclonal Antimelanoma Single-Chain Fv Antibody Derived from Tumor-infiltrating Lymphocytes

Zhang, H., Lake, D. F., Barbuto, J. A. M., Bernstein, R. M., Grimes, W. J. & Hersh, E. M., Aug 1 1995, In : Cancer Research. 55, 16, p. 3584-3591 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Antibodies to tumor necrosis factor: a component of B cell immune responses with a role in tumor/host interaction

Barbuto, J. A. M., Grimes, W. J. & Hersh, E. M., Jan 1 1995, In : Cancer Immunology Immunotherapy. 40, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Comparison of 4− and 24-hour intravenous infusion schedules for granulocyte-macrophage colony-stimulating factor

Wong, L., Taylor, C. W., Radwanski, E., Hersh, E. M. & Salmon, S. E., Jul 1995, In : Journal of Immunotherapy. 18, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phase I Trial of Recombinant Interleukin 3 before and after Carboplatin/Etoposide Chemotherapy in Patients with Solid Tumors: A Southwest Oncology Group Study

Rinehart, J., Margolin, K. A., Triozzi, P., Hersh, E., Campion, M., Resta, D. & Levitt, D., Oct 1 1995, In : Clinical Cancer Research. 1, 10, p. 1139-1144 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Preclinical pharmacokinetics and antitumor activity of imexon

Dorr, R. T., Liddil, J. D., Klein, M. K. & Hersh, E. M., Jun 1 1995, In : Investigational New Drugs. 13, 2, p. 113-116 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
1994

Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes

Punt, C. J. A., Barbuto, J. A. M., Zhang, H., Grimes, W. J., Hatch, K. D. & Hersh, E. M., Jul 1 1994, In : Cancer Immunology Immunotherapy. 38, 4, p. 225-232 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Construction and serological characterization of a recombinant human single chain T-cell receptor

Lake, D. F., Bernstein, R. M., Hersh, E. M., Kaymaz, H., Schluter, S. F. & Marchalonis, J. J., Jun 30 1994, In : Biochemical and Biophysical Research Communications. 201, 3, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

GM-CSF, carboplatin, doxorubicin: a phase I study

Poplin, E. A., Alberts, D. S., Rinehart, J. J., Smith, H. O., Neidhart, J. A. & Hersh, E. M., Jul 1 1994, In : Cancer Chemotherapy And Pharmacology. 33, 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular cloning, expression and mutagenesis of an anti-insulin single chain Fv (scFv)

Lake, D. F., Lam, K. S., Peng, L. & Hersh, E. M., Aug 1994, In : Molecular Immunology. 31, 11, p. 845-856 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Peptide sequences binding to MHC class I proteins

Smith, M. H., Lam, K. S., Hersh, E. M., Lebl, M. & Grimes, W. J., Dec 1994, In : Molecular Immunology. 31, 18, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Phase I Study of Immunotherapy of Malignant Melanoma by Direct Gene Transfer

Hersh, E. M., Akporiaye, E., Harris, D., Stopeck, A. T., Unger, E. C., Warneke, J. A. & Kradjian, S. A., Nov 1 1994, In : Human Gene Therapy. 5, 11, p. 1371-1384 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sensitivity of multiple myeloma to imexon in the human tumor cloning assay

Salmon, S. E. & Hersh, E. M., Feb 2 1994, In : Journal of the National Cancer Institute. 86, 3, p. 228-230 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
1993

An in vivo model of human multidrug-resistant multiple myeloma in SCID mice

Bellamy, W. T., Odeleye, A., Finley, P., Huizenga, B., Dalton, W. S., Weinstein, R. S., Hersh, E. M. & Grogan, T. M., Dec 1 1993, In : American Journal of Pathology. 142, 3, p. 691-698 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dose response and timing effects in the therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate

Hersh, E. M., Funk, C. Y., Petersen, E. A., Ryschon, K. L. & Mosier, D. E., Feb 1993, In : International Journal of Immunopharmacology. 15, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phase II study of vindesine and dacarbazine with or without non-specific stimulation of the immune system in patients with metastatic melanoma

Verschraegen, C. F., Legha, S. S., Hersh, E. M., Plager, C., Papadopoulos, N. & Burgess, M. A., 1993, In : European Journal of Cancer. 29, 5, p. 708-711 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Suppression of human lymphoma development in the severe combined immune-deficient mouse by imexon therapy

Hersh, E. M., Grogan, T. M., Funk, C. Y. & Taylor, C. W., Feb 1993, In : Journal of Immunotherapy. 13, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Lam, K. S., Hruby, V. J., Lebl, M., Knapp, R. J., Kazmierski, W. M., Hersh, E. M. & Salmon, S. E., Mar 1993, In : Bioorganic and Medicinal Chemistry Letters. 3, 3, p. 419-424 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

The use of transformed T cell lines for clonal expansion of human B cells from peripheral blood, spleen, and tumor-infiltrating lymphocytes

Barbuto, J. A. M., Verastegui, E. L. & Hersh, E. M., Jan 1 1993, In : Hybridoma. 12, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation

Moran, M. J., Andris, J. S., Matsumato, Y. I., Capra, J. D. & Hersh, E. M., Nov 1993, In : Molecular Immunology. 30, 16, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
1992

Antiproliferative and antitumor activity of the 2-cyanoaziridine compound imexon on tumor cell lines and fresh tumor cells in vitro

Hersh, E. M., Gschwind, C. R., Taylor, C. W., Dorr, R. T., Taetle, R. & Salmon, S. E., Aug 19 1992, In : Journal of the National Cancer Institute. 84, 16, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

A phase I trial of fluorouracil, leucovorin, and recombinant interferon α-2b in patients with advanced malignancy

Taylor, C. W., Modiano, M. R., Woodson, M. E., Marcus, S. G., Alberts, D. S. & Hersh, E. M., Apr 1992, In : Seminars in Oncology. 19, 2 SUPPL. 3, p. 185-190 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

A southwest oncology group phase i study of the sequential combination of recombinant interferon-γ and recombinant interleukin-2 in patients with cancer

W. Taylor, C., Chase, E. M., Whitehead, R. P., Rinehart, J. J., Rinerhart, J. J., Neidhart, J. A., Gonzalez, R., Bunn, P. A. & Hersh, E. M., Apr 1992, In : Journal of Immunotherapy. 11, 3, p. 176-183 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Chemosensitivity of human melanoma to cisplatin and heat at pharmacokinetic doses achievable by isolated hyperthermic perfusion

Leon, S. P. L., Xu, M. J., Alberts, D. S., Wang, T. F., Peng, Y. M., Hersh, E. M., Taylor, C. W., Fanta, P. & Salmon, S. E., Dec 1 1992, In : Regional Cancer Treatment. 4, 5-6, p. 216-219 4 p.

Research output: Contribution to journalArticle

Expression of type IV collagenase correlates with the invasion of human lymphoblastoid cell lines and pathogenesis in SCID mice

Hendrix, M. J. C., Seftor, E. A., Grogan, T. M., Seftor, R. E. B., Hersh, E. M., Boyse, E. A., Liotta, L. A., Stetler-Stevenson, W. & Ray, C. G., Feb 1992, In : Molecular and Cellular Probes. 6, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Generation and characterization of a human monoclonal antibody that neutralizes diverse HIV-1 isolates in vitro

Lake, D. F., Kawamura, T., Tomiyama, T., Robinson, W. E., Matsumoto, Y. I., Masuho, Y. & Hersh, E. M., Jan 1992, In : AIDS. 6, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Growth and dissemination of human malignant melanoma cells in mice with severe combined immune deficiency

Taylor, C. W., Grogan, T. M., Lopez, M. H. A., Leong, S. P. L., Odeleye, A., Feo-Zuppardi, F. J. & Hersh, E. M., Jan 1 1992, In : Laboratory Investigation. 67, 1, p. 130-137 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

High incidence of coagulopathy in phase II studies of recombinant tumor necrosis factor in advanced pancreatic and gastric cancers

Muggia, F. M., Brown, T. D., Goodman, P. J., Macdonald, J. S., Hersh, E. M., Fleming, T. R. & Leichman, L., Jan 1 1992, In : Anti-cancer drugs. 3, 3, p. 211-217 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Immunomodulatory drugs or relevance to the management of microbial infections

Hersh, E. M., Jan 1 1992, In : Advances in experimental medicine and biology. 319, p. 1-11 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Interferon-γ induced by administration of recombinant interleukin-2 to patients with cancer: Kinetics, dose dependence, and correlation with physiological and therapeutic response

Konrad, M. W., DeWitt, S. K., Bradley, E. C., Goodman, G., Groves, E. C., Hersh, E. M. & Krigel, R. L., Jul 1992, In : Journal of Immunotherapy. 12, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Long-term engraftment of fresh human myeloma cells in SCID mice

Feo-Zuppardi, F. J., Taylor, C. W., Iwato, K., Lopez, M. H. A., Grogan, T. M., Odeleye, A., Hersh, E. M. & Salmon, S. E., 1992, In : Blood. 80, 11, p. 2843-2850 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Phase I study of low-dose cyclophosphamide and recombinant interleukin-2 for the treatment of advanced cancer

Verdi, C. J., Taylor, C. W., Croghan, M. K., Dalke, P., Meyskens, F. L. & Hersh, E. M., May 1992, In : Journal of Immunotherapy. 11, 4, p. 286-291 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
10 Scopus citations
1991

Ability of cell-sized beads bearing tumor cell membrane proteins to stimulate LAK cells to secrete interferon-γ and tumor necrosis factor-α1

Chong, A. S. F., Pinkard, J. K., Lam, K. S., Scuderi, P., Hersh, E. M. & Grimes, W. J., Apr 15 1991, In : Cellular Immunology. 134, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

A new type of synthetic peptide library for identifying ligand-binding activity

Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmierskit, W. M. & Knappt, R. J., Nov 7 1991, In : Nature. 354, 6348, p. 82-84 3 p.

Research output: Contribution to journalArticle

1602 Scopus citations

A phase II trial of recombinant tumor necrosis factor in patients with adenocarcinoma of the pancreas: A southwest oncology group study

Brown, T. D., Goodman, P., Fleming, T., Macdonald, J. S., Hersh, E. M. & Braun, T. J., Oct 1991, In : Journal of Immunotherapy. 10, 5, p. 376-378 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

A Southwest Oncology Group phase II trial of recombinant tumor necrosis factor in metastatic breast cancer

Budd, G. T., Green, S., Baker, L. H., Hersh, E. P., Weick, J. K. & Kent Osborne, C., Oct 15 1991, In : Cancer. 68, 8, p. 1694-1695 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Current status of immunotherapy of patients with HIV-infection

Hersh, E. M., 1991, In : International Journal of Immunopharmacology. 13, SUPPL. 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ditiocarb Sodium (Diethyldithiocarbamate) Therapy in Patients With Symptomatic HIV Infection and AIDS: A Randomized, Double-blind, Placebo-Controlled, Multicenter Study

Hersh, E. M., Brewton, G., Abrams, D., Bartlett, J., Galpin, J., Gill, P., Gorter, R., Gottlieb, M., Jonikas, J. J., Landesman, S., Levine, A., Marcel, A., Petersen, E. A., Whiteside, M., Zahradnik, J., Negron, C., Boutitie, F., Caraux, J., Dupuy, J. M. & Salmi, L. R., Mar 27 1991, In : JAMA: The Journal of the American Medical Association. 265, 12, p. 1538-1544 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Ditiocarb useful in HIV therapy.

Hersh, E. M., Brewton, G. & Abrams, D., May 22 1991, In : Nursing times. 87, 21, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effective Therapy of the LP-BM5 Murine Retrovirus-Induced Lymphoproliferative Immunodeficiency Disease with Diethyldithiocarbamate

Hersh, E. M., Funk, C. Y., Ryschon, K. L., Petersen, E. A. & Mosier, D. E., Jun 1991, In : AIDS Research and Human Retroviruses. 7, 6, p. 553-561 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of cisplatin on interleukin-2-induced lymphokine-activated killer cell generation and cytotoxicity against malignant melanoma cells

Taylor, C. W., Gore, B. H. & Hersh, E. M., Jan 1 1991, In : Regional Cancer Treatment. 4, 3, p. 103-109 7 p.

Research output: Contribution to journalArticle

Gamma‐Irradiated peripheral blood mononuclear cells can express LAK activity

Chong, A. S. F., Hersh, E. M., Grimes, W. J. & Bier, D. E., 1991, In : The International Journal of Cell Cloning. 9, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus

Montefiori, D. C., Zhou, J., Barnes, B., Lake, D., Hersh, E. M., Masuho, Y. & Lefkowitz, L. B., Jun 1991, In : Virology. 182, 2, p. 635-643 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

In Reply

for the Ditiocarb Study Group and Pasteur-Merieaux Serum et Vaccins, Aug 14 1991, In : Journal of the American Medical Association. 266, 6, p. 796 1 p.

Research output: Contribution to journalArticle

In vitro efficacy of anti-hiv immunotoxins targeted by various antibodies to the envelope protein

Pincus, S. H., Cole, R. L., Hersh, E. M., Lake, D., Masuho, Y., Durda, P. J. & Mcclure, J., Jun 15 1991, In : Journal of Immunology. 146, 12, p. 4315-4324 10 p.

Research output: Contribution to journalArticle

38 Scopus citations