Evan M Hersh

  • 19105 Citations
  • 67 h-Index
1965 …2021
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Research Output 1965 2017

  • 19105 Citations
  • 67 h-Index
  • 490 Article
  • 48 Chapter
  • 3 Letter
  • 1 Conference contribution
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Article
1991
1 Citation (Scopus)

Ability of cell-sized beads bearing tumor cell membrane proteins to stimulate LAK cells to secrete interferon-γ and tumor necrosis factor-α1

Chong, A. S. F., Pinkard, J. K., Lam, K. S., Scuderi, P., Hersh, E. M. & Grimes, W. J., Apr 15 1991, In : Cellular Immunology. 134, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Interferons
Membrane Proteins
Tumor Necrosis Factor-alpha
Neoplasms
1579 Citations (Scopus)

A new type of synthetic peptide library for identifying ligand-binding activity

Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmierskit, W. M. & Knappt, R. J., Nov 7 1991, In : Nature. 354, 6348, p. 82-84 3 p.

Research output: Contribution to journalArticle

Peptide Library
Ligands
Libraries
Oligodeoxyribonucleotides
Cell Surface Receptors
31 Citations (Scopus)

A phase II trial of recombinant tumor necrosis factor in patients with adenocarcinoma of the pancreas: A southwest oncology group study

Brown, T. D., Goodman, P., Fleming, T., Macdonald, J. S., Hersh, E. M. & Braun, T. J., 1991, In : Journal of Immunotherapy. 10, 5, p. 376-378 3 p.

Research output: Contribution to journalArticle

Pancreas
Adenocarcinoma
Tumor Necrosis Factor-alpha
Hypertriglyceridemia
Anorexia
22 Citations (Scopus)

A Southwest Oncology Group Phase II trial of recombinant tumor necrosis factor in metastatic breast cancer

Budd, G. T., Green, S., Baker, L. H., Hersh, E. M., Weick, J. K. & Osborne, C. K., 1991, In : Cancer. 68, 8, p. 1694-1695 2 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Breast Neoplasms
Poisons
Growth Inhibitors
Chills
3 Citations (Scopus)

Current status of immunotherapy of patients with HIV-infection

Hersh, E. M., 1991, In : International Journal of Immunopharmacology. 13, SUPPL. 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Immunotherapy
HIV Infections
HIV
Thymus Hormones
Passive Immunization
84 Citations (Scopus)

Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS: A randomized, double-blind, placebo-controlled, multicenter study

Hersh, E. M., Brewton, G., Abrams, D., Bartlett, J., Galpin, J., Gill, P., Gorter, R., Gottlieb, M., Jonikas, J. J., Landesman, S., Levine, A., Marcel, A., Petersen, E. A., Whiteside, M., Zahradnik, J., Negron, C., Boutitie, F., Caraux, J., Dupuy, J. M. & Rachid Salmi, L., 1991, In : Journal of the American Medical Association. 265, 12, p. 1538-1544 7 p.

Research output: Contribution to journalArticle

Ditiocarb
Virus Diseases
Multicenter Studies
Acquired Immunodeficiency Syndrome
Placebos
1 Citation (Scopus)

Ditiocarb useful in HIV therapy.

Hersh, E. M., Brewton, G. & Abrams, D., May 22 1991, In : Nursing times. 87, 21, p. 10 1 p.

Research output: Contribution to journalArticle

Ditiocarb
Opportunistic Infections
HIV Infections
HIV-1
HIV
12 Citations (Scopus)

Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate

Hersh, E. M., Funk, C. Y., Ryschon, K. L., Petersen, E. A. & Mosier, D. E., 1991, In : AIDS Research and Human Retroviruses. 7, 6, p. 553-561 9 p.

Research output: Contribution to journalArticle

Ditiocarb
Retroviridae
Viruses
Hypergammaglobulinemia
Phytohemagglutinins
Lymphokine-Activated Killer Cells
Cisplatin
Interleukin-2
Melanoma
Clinical Trials
4 Citations (Scopus)

Gamma-irradiated peripheral blood mononuclear cells can express LAK activity

Chong, A. S. F., Hersh, E. M., Grimes, W. J. & Hersh, E. M., 1991, In : International Journal of Cell Cloning. 9, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

Feeder Cells
Mononuclear Leukocytes
Lymphokine-Activated Killer Cells
Cell Separation
Lymphokines
48 Citations (Scopus)

Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus

Montefiori, D. C., Zhou, J., Barnes, B., Lake, D., Hersh, E. M., Masuho, Y. & Lefkowitz, L. B., 1991, In : Virology. 182, 2, p. 635-643 9 p.

Research output: Contribution to journalArticle

Antibody Formation
HIV-1
HIV
Fluorescent Antibody Technique
Antigenic Variation

In Reply

for the Ditiocarb Study Group and Pasteur-Merieaux Serum et Vaccins, Aug 14 1991, In : Journal of the American Medical Association. 266, 6, p. 796 1 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

In vitro efficacy of anti-hiv immunotoxins targeted by various antibodies to the envelope protein

Pincus, S. H., Cole, R. L., Hersh, E. M., Lake, D., Masuho, Y., Durda, P. J. & Mcclure, J., Jun 15 1991, In : Journal of Immunology. 146, 12, p. 4315-4324 10 p.

Research output: Contribution to journalArticle

Immunotoxins
HIV
Antibodies
HIV Antibodies
Proteins
67 Citations (Scopus)

Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: A summary of the Southwest Oncology Group experience

Hersh, E. M., Metch, B. S., Muggia, F. M., Brown, T. D., Whitehead, R. P., Budd, G. T., Rinehart, J. J., Crawford, E. D., Bonnet, J. D. & Behrens, B. C., 1991, In : Journal of Immunotherapy. 10, 6, p. 426-431 6 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Urinary Bladder Neoplasms
Chills
Myalgia
Endometrial Neoplasms
39 Citations (Scopus)

Phase II study of intravenous bolus recombinant interleukin-2 in advanced malignant melanoma: Southwest Oncology Group Study

Whitehead, R. P., Kopecky, K. J., Samson, M. K., Costanzi, J. J., Natale, R. B., Feun, L. G., Hersh, E. M. & Rinehart, J. J., Sep 4 1991, In : Journal of the National Cancer Institute. 83, 17, p. 1250-1252 3 p.

Research output: Contribution to journalArticle

Recombinant proteins
Interleukin
Oncology
Melanoma
Human
18 Citations (Scopus)

Recognition of human immunodeficiency virus glycoproteins by natural anti-carbohydrate antibodies in human serum

Tomiyama, T., Lake, D., Masuho, Y. & Hersh, E. M., May 31 1991, In : Biochemical and Biophysical Research Communications. 177, 1, p. 279-285 7 p.

Research output: Contribution to journalArticle

Mannans
Viruses
Anti-Idiotypic Antibodies
Glycoproteins
Carbohydrates
1990
85 Citations (Scopus)

Antibodies to the primary immunodominant domain of human immunodeficiency virus type 1 (HIV-1) glycoprotein gp41 enhance HIV-1 infection in vitro

Robinson, W. E., Kawamura, T., Lake, D., Masuho, Y., Mitchell, W. M. & Hersh, E. M., 1990, In : Journal of Virology. 64, 11, p. 5301-5305 5 p.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Virus Diseases
Human immunodeficiency virus 1
HIV-1
glycoproteins
21 Citations (Scopus)

A phase II trial of recombinant tumor necrosis factor in patients with metastatic colorectal adenocarcinoma: A Southwest Oncology Group Study

Whitehead, R. P., Fleming, T., Macdonald, J. S., Goodman, P. J., Neefe, J., Braun, T. J., Swinnen, L. J. & Hersh, E. M., 1990, In : Journal of Biological Response Modifiers. 9, 6, p. 588-591 4 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Tumor Necrosis Factor-alpha
Nausea
Vomiting
Subclavian Vein
5 Citations (Scopus)
Ditiocarb
Retroviridae
HIV Infections
Animal Models
Clinical Trials
4 Citations (Scopus)
Ditiocarb
Immunologic Factors
Null Lymphocytes
Surface Antigens
Mitogens
75 Citations (Scopus)

Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 enhance HIV-1 infection in vitro

Robinson, W. E., Kawamura, T., Gorny, M. K., Lake, D., Xu, J. Y., Matsumoto, Y., Sugano, T., Masuho, Y., Mitchell, W. M., Hersh, E. M. & Zolla-Pazner, S., Apr 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 8, p. 3185-3189 5 p.

Research output: Contribution to journalArticle

Virus Diseases
HIV-1
Glycoproteins
Monoclonal Antibodies
Epitopes
8 Citations (Scopus)

Isolation and characterization of a human monoclonal antibody which reacts with breast and colorectal carcinoma

Goldstein, N. I., Nagle, R. B., Villar, H., Hersh, E. M. & Fisher, P. B., 1990, In : Anticancer Research. 10, 6, p. 1491-1500 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Monoclonal Antibodies
Breast Neoplasms
Epitopes
Glycoproteins
169 Citations (Scopus)

Pharmacokinetics of recombinant interleukin 2 in humans

Konrad, M. W., Hemstreet, G., Hersh, E. M., Mansell, P. W. A., Mertelsmann, R., Kolitz, J. E. & Bradley, E. C., Apr 1 1990, In : Cancer Research. 50, 7, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

Interleukin-2
Pharmacokinetics
Half-Life
Injections
Serum
10 Citations (Scopus)

Phenotypic analyses of lymphokine-activated killer cells that release interferon γ and tumor necrosis factor α

Chong, A. S. F., Ybarrondo, B., Grimes, W. J., Hersh, E. M. & Scuderi, P., Jul 1990, In : Cancer Immunology, Immunotherapy. 31, 4, p. 255-259 5 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
K562 Cells
Interferons
Tumor Necrosis Factor-alpha
Interleukin-2
56 Citations (Scopus)

Recombinant human interferon γ: Adverse effects in high-risk stage I and II cutaneous malignant melanoma

Meyskens, F. L., Kopecky, K., Samson, M., Hersh, E. M., Macdonald, J., Jaffe, H., Crowley, J. & Coltman, C., Jun 20 1990, In : Journal of the National Cancer Institute. 82, 12, p. 1071 1 p.

Research output: Contribution to journalArticle

Interferon-γ
Interferons
Melanoma
Human
Recombinant
1989
6 Citations (Scopus)

A hybridoma producing human monoclonal antibody specific for glycoprotein 120kDa of human immunodeficiency virus (HIV-1)

Lake, D., Sugano, T., Matsumoto, Y. I., Masuho, Y., Petersen, E. A., Feorino, P. & Hersh, E. M., 1989, In : Life Sciences. 45, 16

Research output: Contribution to journalArticle

Hybridomas
Viruses
HIV-1
Glycoproteins
Monoclonal Antibodies
18 Citations (Scopus)

A phase I trial of recombinant tumor necrosis factor (rTNF) administered by continuous intravenous infusion in patients with disseminated malignancy

Schwartz, J. E., Scuderi, P., Wiggins, C., Rudolph, A. & Hersh, E. M., Sep 1989, In : Biotherapy. 1, 3, p. 207-214 8 p.

Research output: Contribution to journalArticle

Intravenous Infusions
Tumor Necrosis Factor-alpha
Neoplasms
Thrombocytopenia
Hypotension
23 Citations (Scopus)

A pilot study of diethyldithiocarbamate in patients with acquired immune deficiency syndrome (AIDS) and the AIDS-related complex

Brewton, G. W., Hersh, E. M., Rios, A., Mansell, P. W. A., Hollinger, B. & Reuben, J. M., 1989, In : Life Sciences. 45, 26, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

Ditiocarb
Acquired Immunodeficiency Syndrome
Antifungal Agents
Toxicity
Hairy Leukoplakia
14 Citations (Scopus)
Ditiocarb
Virus Diseases
Viruses
Toxicity
HIV

Colony-stimulating factors. Clinical potential

Rifkin, R. M. & Hersh, E. M., 1989, In : Hospital Therapy. 14, 8, p. 44-54 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
9 Citations (Scopus)

Cytostatic and cytotoxic activity of lymphokine-activated killer cell supernatants

Hersh, E. M., Scuderi, P., Grimes, W. J., Chong, A., Brailey, J. L., Gschwind, C. R. & Salmon, S. E., Jan 1989, In : Cancer Immunology, Immunotherapy. 30, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Cytostatic Agents
Chromium
Neoplasms
Colonic Neoplasms
6 Citations (Scopus)

Increased peripheral blood leukocyte cytotoxic activity in cancer patients during the continuous intravenous administration of recombinant human tumor necrosis factor

Charnetsky, P. S., Greisman, R. A., Salmon, S. E., Hersh, E. M. & Scuderi, P., Jan 1989, In : Journal of Clinical Immunology. 9, 1, p. 34-38 5 p.

Research output: Contribution to journalArticle

Intravenous Administration
Leukocytes
Neoplasms
T-Lymphocytes
Intravenous Infusions
12 Citations (Scopus)

Phase I study of cancer therapy with recombinant interleukin-2 administered by intravenous bolus injection

Hersh, E. M., Lee Murray, J., Ki Hong, W., Rosenblum, M. G., Reuben, J. M., Weilbaecher, R., Sarwal, A. N., Bradley, E. C., Konrad, M. & Arnett, F. C., Sep 1989, In : Biotherapy. 1, 3, p. 215-226 12 p.

Research output: Contribution to journalArticle

Intravenous Injections
Interleukin-2
Arthritis
Fatigue
Neoplasms
23 Citations (Scopus)
Lymphokine-Activated Killer Cells
Interferons
Clone Cells
Tumor Necrosis Factor-alpha
Neoplasms
76 Citations (Scopus)

Tumor targets stimulate IL-2 activated killer cells to produce interferon-γ and tumor necrosis factor

Chong, A. S. F., Scuderi, P., Grimes, W. J. & Hersh, E. M., 1989, In : Journal of Immunology. 142, 6, p. 2133-2139 7 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Interferons
Interleukin-2
Tumor Necrosis Factor-alpha
Neoplasms
1988
18 Citations (Scopus)
Granulocyte-Macrophage Colony-Stimulating Factor
Bone
Granulocytes
Eructation
Bone Marrow
14 Citations (Scopus)

Blocking of lymphokine activated killer (LAK) cell mediated cytotoxicity by cell-sized beads bearing tumor cell proteins

Chong, A. S. F., Hersh, E. M. & Grimes, W. J., 1988, In : Journal of Immunology. 141, 12, p. 4418-4424 7 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Neoplasms
Proteins
Lymphokines
Membrane Proteins
15 Citations (Scopus)

Human monoclonal antibody against glycoproteins of human immunodeficiency virus

Sugano, T., Masuho, Y., Matsumoto, Y. I., Lake, D., Gschwind, C., Petersen, E. A. & Hersh, E. M., Sep 30 1988, In : Biochemical and Biophysical Research Communications. 155, 3, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Viruses
Glycoproteins
Monoclonal Antibodies
HIV
Lymphocytes

Immunological characteristics and potential approaches to immunotherapy of HIV infection.

Hersh, E. M., Petersen, E. A., Yocum, D. E., Gorman, S. R., Darragh, M. J., Gschwind, C. R., Brewton, G. W. & Reuben, J. A., 1988, In : Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer. 112, p. 17-26 10 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Ditiocarb
Mononuclear Leukocytes
Immunotherapy
HIV Infections
5 Citations (Scopus)
Virus Diseases
Lymphocyte Activation
Lymphoma
Acquired Immunodeficiency Syndrome
HIV
54 Citations (Scopus)

Multiple agent chemotherapy (POACH) in previously treated and untreated patients with chronic lymphocytic leukemia

Keating, M. J., Scouros, M., Murphy, S., Kantarjian, H., Hester, J., McCredie, K. B., Hersh, E. M. & Freireich, E. J., 1988, In : Leukemia. 2, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Drug Therapy
Survival
Cytarabine
Vincristine
40 Citations (Scopus)

Prospective randomized trial of high-dose cisplatin and fluorouracil infusion with or without sodium diethyldithiocarbamate in recurrent and/or metastatic squamous cell carcinoma of the head and neck

Paredes, J., Hong, W. K., Felder, T. B., Dimery, I. W., Choksi, A. J., Newman, R. A., Castellanos, A. M., Robbins, K. T., McCarthy, K., Atkinson, N., Kramer, A. M., Hersh, E. M. & Goepfert, H., 1988, In : Journal of Clinical Oncology. 6, 6, p. 955-962 8 p.

Research output: Contribution to journalArticle

Ditiocarb
Fluorouracil
Cisplatin
Poisons
Platinum

The AIDS epidemic: AIDS research in the life sciences

Hersh, E. M. & Petersen, E. A., 1988, In : Life Sciences. 42, 20

Research output: Contribution to journalArticle

HIV Seropositivity
Biological Science Disciplines
Brain Diseases
Disease Outbreaks
Acquired Immunodeficiency Syndrome
1987
4 Citations (Scopus)

A pilot clinical trial of the toxicity and immunorestorative effects of T cell reconstituting factor (SR 270258) in immunosuppressed cancer patients

Murray, J. L., Reuben, J. M., Smith, T. L., Gehan, E. A., Koretz, S. M. & Hersh, E. M., 1987, In : Journal of Biological Response Modifiers. 6, 1, p. 56-68 13 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
Clinical Trials
Neoplasms
Lymphocytes
Prealbumin
56 Citations (Scopus)

Clinical parameters related to optimal tumor localization of indium-111-labeled mouse antimelanoma monoclonal antibody ZME-018

Murray, J. L., Rosenblum, M. G., Lamki, L., Glenn, H. J., Krizan, Z., Hersh, E. M., Plager, C. E., Bartholomew, R. M., Unger, M. W. & Carlo, D. J., 1987, In : Journal of Nuclear Medicine. 28, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Indium
Monoclonal Antibodies
Neoplasms
Neoplasm Metastasis
Melanoma
7 Citations (Scopus)

Decreased 5′nucleotidase activity in suppressor (OKT8) T lymphocytes from homosexuals with AIDS-related complex: Nonassociation with enhanced deoxynucleoside toxicity

Murray, J. L., Bywaters, D. W., Reuben, J. M., Mansell, P. W. & Hersh, E. M., 1987, In : Clinical Immunology and Immunopathology. 42, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

AIDS-Related Complex
T-Lymphocytes
Purine-Nucleoside Phosphorylase
Adenosine Deaminase
Lymphocytes
66 Citations (Scopus)

Idiopathic production of interleukin-1 in acquired immune deficiency syndrome

Lepe-Zuniga, J. L., Mansell, P. W. A. & Hersh, E. M., 1987, In : Journal of Clinical Microbiology. 25, 9, p. 1695-1700 6 p.

Research output: Contribution to journalArticle

Interleukin-1
Acquired Immunodeficiency Syndrome
Human Herpesvirus 4
Endotoxins
HIV
12 Citations (Scopus)

Radioimmunoimaging in malignant melanoma patients with the use of indium-111-labeled antimelanoma monoclonal antibody (ZME-018) to high-molecular-weight antigen

Murray, J. L., Rosenblum, M. G., Lamki, L., Haynie, T. P., Glenn, H. J., Plager, C. E., Unger, M. W., Carlo, D. J. & Hersh, E. M., 1987, In : NCI Monographs. No. 3, p. 3-9 7 p.

Research output: Contribution to journalArticle

Radioimmunodetection
Neoplasm Antibodies
Indium
Radioisotopes
Radionuclide Imaging
41 Citations (Scopus)

Radioimmunological imaging of metastatic prostatic cancer with 111indium-labeled monoclonal antibody PAY 276

Babaian, R. J., Murray, J. L., Lamki, L. M., Haynie, T. P., Hersh, E. M., Rosenblum, M. G., Glenn, H. J., Unger, M. W., Carlo, D. J. & von Eschenbach, A. C., 1987, In : Journal of Urology. 137, 3, p. 439-443 5 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Monoclonal Antibodies
Acid Phosphatase
Neoplasm Metastasis
Urinalysis
10 Citations (Scopus)

Synergism between alpha-interferon and interleukin-2-activated killer cells: In vitro studies

Di Raimondo, F., LaPushin, R. & Hersh, E. M., 1987, In : Acta Haematologica. 78, SUPPL. 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

Lymphokine-Activated Killer Cells
Interferon-alpha
Interleukin-2
Neoplasms
In Vitro Techniques