Fayez K Ghishan

  • 6870 Citations
  • 44 h-Index
1978 …2019
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Research Output 1978 2019

2019
1 Citation (Scopus)

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Protein Isoforms
Neoplasms
Catenins
2 Citations (Scopus)

Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells

Figliuolo da Paz, V., Jamwal, D. R., Gurney, M., Midura-Kiela, M., Harrison, C. A., Cox, C., Wilson, J. M., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 2
Dendritic Cells
Down-Regulation
Phenotype
Colitis

Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis

Harrison, C. A., Laubitz, D., Midura-Kiela, M. T., Jamwal, D. R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Journal of Crohn's & colitis. 13, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Colitis
Sex Characteristics
Anti-Bacterial Agents
T-Lymphocytes
Adoptive Transfer
2018
1 Citation (Scopus)

Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice

Harrison, C. A., Laubitz, D., Ohland, C. L., Midura-Kiela, M. T., Patil, K., Besselsen, D. G., Jamwal, D. R., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jun 6 2018, (Accepted/In press) In : Mucosal Immunology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Dysbiosis
Microbiota
Colitis
Ecology
Bacteroidaceae
1 Citation (Scopus)

Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium

Kiela, P. R. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1405-1449 45 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intestinal Absorption
Membranes
Plasma Membrane Calcium-Transporting ATPases
Sodium-Phosphate Cotransporter Proteins
Transient Receptor Potential Channels
1 Citation (Scopus)

Molecular Physiology of Gastrointestinal Function During Development

Xu, H. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 235-269 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Weaning
Food
Large Intestine
Small Intestine
Intestines

Na+/H+ Exchange in Mammalian Digestive Tract

Kiela, P. R. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1273-1316 44 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium-Hydrogen Antiporter
Gastrointestinal Tract
Protein Isoforms
Digestive System Physiological Phenomena
Physiological Phenomena

Pathophysiology of Diarrhea and Its Clinical Implications

Sheikh, I. A., Ammoury, R. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1669-1687 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diarrhea
Ion Transport
Fluids and Secretions
Water-Electrolyte Balance
Enterocytes
1 Citation (Scopus)

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 1 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Electrolytes
Genes
Gastrointestinal Tract
Antiporters
2017
14 Citations (Scopus)

Pathophysiology of Intestinal Na+/H+ Exchange

Gurney, M. A., Laubitz, D., Ghishan, F. K. & Kiela, P. R., Jan 1 2017, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 3, 1, p. 27-40 14 p.

Research output: Contribution to journalReview article

Sodium-Hydrogen Antiporter
Food
Intrinsic Factor
Bile Acids and Salts
Cell Size
8 Citations (Scopus)

Vitamins and Minerals in Inflammatory Bowel Disease

Ghishan, F. K. & Kiela, P. R., 2017, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Vitamins
Minerals
Avitaminosis
Vitamin A
2016
1 Citation (Scopus)

Expression of Cav1.3 calcium channel in the human and mouse colon: Posttranscriptional inhibition by IFNγ

Radhakrishnan, V. M., Gilpatrick, M. M., Parsa, N. A., Kiela, P. R. & Ghishan, F. K., Dec 8 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 1, p. G77-G84

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colon
Colitis
Trinitrobenzenes
HCT116 Cells
8 Citations (Scopus)
Goblet Cells
HT29 Cells
Enterocytes
Mucins
Mucus
3 Citations (Scopus)

Phosphorus: Basic Nutritional Aspects

Kiela, P. R., Radhakrishnan, V. M. & Ghishan, F. K., Sep 29 2016, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., p. 413-427 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphorus
Phosphates
Homeostasis
Maintenance
Hyperphosphatemia
58 Citations (Scopus)

Physiology of intestinal absorption and secretion

Kiela, P. R. & Ghishan, F. K., Apr 1 2016, In : Best Practice and Research: Clinical Gastroenterology. 30, 2, p. 145-159 15 p.

Research output: Contribution to journalArticle

Intestinal Secretions
Intestinal Absorption
Food
Lipids
Oxalates
15 Citations (Scopus)

Reduced epithelial Na+/H+exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

Laubitz, D., Harrison, C. A., Midura-Kiela, M. T., Ramalingam, R., Larmonier, C. B., Chase, J. H., Caporaso, J. G., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Apr 1 2016, In : PLoS One. 11, 4, e0152044.

Research output: Contribution to journalArticle

Dysbiosis
T-cells
colitis
Colitis
intestinal microorganisms

Sodium: Basic Nutritional Aspects

Laubitz, D., Ghishan, F. K. & Kiela, P. R., Sep 29 2016, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., p. 489-501 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sodium
Salts
Dietary Sodium
Membrane Transport Proteins
Micronutrients
15 Citations (Scopus)

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colitis
Somatostatin
Octreotide
seglitide
7 Citations (Scopus)

Transcriptional reprogramming and resistance to colonic mucosal injury in poly (ADP-ribose) polymerase 1 (PARP1) deficient mice

Larmonier, C. B., Shehab, K. W., Laubitz, D., Jamwal, D. R., Ghishan, F. K. & Kiela, P. R., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 8918-8930 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Colitis
Wounds and Injuries
Adenosine Diphosphate Ribose
Dextran Sulfate
2015
16 Citations (Scopus)
Cardiopulmonary Bypass
Fatty Acid-Binding Proteins
Heart Diseases
Citrulline
Claudin-3
14 Citations (Scopus)

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

Leydig Cells
Testis
LH Receptors
Testosterone
Sodium-Hydrogen Antiporter
4 Citations (Scopus)

Experimental colitis is associated with transcriptional inhibition of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules

Radhakrishnan, V. M., Kojs, P., Ramalingam, R., Midura-Kiela, M. T., Angeli, P., Kiela, P. R. & Ghishan, F. K., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8964-8974 11 p.

Research output: Contribution to journalArticle

Distal Kidney Tubule
Colitis
Interferons
Minerals
Protein Isoforms
12 Citations (Scopus)

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

Dextran Sulfate
Goblet Cells
Paneth Cells
Colon
Intestinal Mucosa
10 Citations (Scopus)

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

Lacrimal Apparatus
Epithelial Cells
Conjunctiva
Tears
Cornea
11 Citations (Scopus)
Butyric Acid
Butyrates
Sodium
Genetic Promoter Regions
Epithelial Cells
42 Citations (Scopus)

The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention

Mcfadden, R. M. T., Larmonier, C. B., Shehab, K. W., Midura-Kiela, M., Ramalingam, R., Harrison, C. A., Besselsen, D. G., Chase, J. H., Caporaso, J. G., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jul 25 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

Curcumin
Microbiota
Colitis
Colonic Neoplasms
Interleukin-10
19 Citations (Scopus)

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

Larmonier, C. B., Shehab, K. W., Ghishan, F. K. & Kiela, P. R., 2015, In : BioMed Research International. 2015, 504638.

Research output: Contribution to journalArticle

T-cells
Microbiota
Inflammatory Bowel Diseases
T-Lymphocytes
Immune system
2014
284 Citations (Scopus)

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

Colitis
Mucus
Ulcerative Colitis
Colon
Bacteria
31 Citations (Scopus)

Epithelial transport in inflammatory bowel diseases

Ghishan, F. K. & Kiela, P. R., 2014, In : Inflammatory Bowel Diseases. 20, 6, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Food
Epithelium
Bacterial Antigens
Micronutrients
20 Citations (Scopus)

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)

Radhakrishnan, V. M., Kojs, P., Young, G., Ramalingam, R., Jagadish, B., Mash, E. A., Martinez, J. D., Ghishan, F. K. & Kiela, P. R., Jan 22 2014, In : PLoS One. 9, 1, e85796.

Research output: Contribution to journalArticle

Cortactin
Non-Receptor Type 1 Protein Tyrosine Phosphatase
protein-tyrosine-phosphatase
Curcumin
curcumin
2013
9 Citations (Scopus)

High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

Larmonier, C. B., McFadden, R. M. T., Hill, F. M., Schreiner, R., Ramalingam, R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jul 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 1

Research output: Contribution to journalArticle

Adoptive Transfer
Cholecalciferol
Colitis
Diet
T-Lymphocytes
23 Citations (Scopus)

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1

Research output: Contribution to journalArticle

Bacterial Adhesion
Knockout Mice
Dextran Sulfate
Colon
Salmonella typhimurium
16 Citations (Scopus)

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3

Research output: Contribution to journalArticle

Stomach
Adenoma
Stomach Ulcer
Sodium-Hydrogen Antiporter
Sodium Bicarbonate
19 Citations (Scopus)

Post-translational loss of renal trpv5 calcium channel expression, Ca 2+ wasting, and bone loss in experimental colitis

Radhakrishnan, V. M., Ramalingam, R., Larmonier, C. B., Thurston, R. D., Laubitz, D., Midura-Kiela, M. T., McFadden, R. M. T., Kuro-O, M., Kiela, P. R. & Ghishan, F. K., Sep 2013, In : Gastroenterology. 145, 3, p. 613-624 12 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Colitis
Calcium Channels
Kidney
Bone and Bones
40 Citations (Scopus)

Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice

Larmonier, C. B., Laubitz, D., Hill, F. M., Shehab, K. W., Lipinski, L., Midura-Kiela, M. T., McFadden, R. M. T., Ramalingam, R., Hassan, K. A., Golebiewski, M., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Nov 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 10

Research output: Contribution to journalArticle

Colitis
Microbiota
Dysbiosis
Inflammation
Dextran Sulfate
1 Citation (Scopus)

The diagnostic role of magnetic resonance enterography in crohn's disease: An updated review of techniques, interpretation, and application

Arif-Tiwari, H., Kalb, B. T., Chundru, S., Costello, J., Sauer, C. G., Martin, D. R., Ghishan, F. K. & Goldschmid, S., Dec 2013, In : Applied Radiology. 42, 12, p. 5-15 11 p.

Research output: Contribution to journalArticle

Crohn Disease
Magnetic Resonance Spectroscopy
Young Adult
Chronic Disease
Tomography
2012
35 Citations (Scopus)

Curcumin inhibits interferon-γ signaling in colonic epithelial cells

Midura-Kiela, M. T., Radhakrishnan, V. M., Larmonier, C. B., Laubitz, D., Ghishan, F. K. & Kiela, P. R., Jan 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1

Research output: Contribution to journalArticle

Curcumin
Interferons
Epithelial Cells
Major Histocompatibility Complex
Inflammatory Bowel Diseases
61 Citations (Scopus)

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

Ramalingam, R., Larmonier, C. B., Thurston, R. D., Midura-Kiela, M. T., Zheng, S. G., Ghishan, F. K. & Kiel, P. R., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 3878-3893 16 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmunity
Dendritic Cells
Phenotype
Knockout Mice
29 Citations (Scopus)

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Xu, H., Zhang, B., Li, J., Wang, C., Chen, H. & Ghishan, F. K., Aug 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 3

Research output: Contribution to journalArticle

Mucins
Bicarbonates
Knockout Mice
Colon
Intestines
2 Citations (Scopus)

Inborn Errors of Metabolism that Lead to Permanent Liver Injury

Ghishan, F. K., 2012, Zakim and Boyer's Hepatology. Elsevier Inc., p. 1155-1201 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inborn Errors Metabolism
Liver
Wounds and Injuries
2 Citations (Scopus)

Metabolic bone disease in inflammatory bowel disease

Ghishan, F. K. & Kiela, P. R., Sep 2012, In : Practical Gastroenterology. 36, 9, p. 16-26 11 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Inflammatory Bowel Diseases
Bone and Bones
Bone Density
Dietary Calcium
4 Citations (Scopus)

Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium

Kiela, P. R., Collins, J. F. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 2. p. 1877-1919 43 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

calcium magnesium phosphate
3 Citations (Scopus)

Molecular Physiology of Gastrointestinal Function during Development

Xu, H., Collins, J. F. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 415-449 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Physiology
5 Citations (Scopus)

Na+/H+ Exchange in Mammalian Digestive Tract

Kiela, P. R. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 2. p. 1781-1818 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Pathophysiology of Diarrhea and its Clinical Implications

Ammoury, R. F. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 2. p. 2183-2197 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Physiology of the Gastrointestinal Tract

Johnson, L., Ghishan, F. K., Kaunitz, J., Merchant, J., Said, H. & Wood, J., 2012, Elsevier Inc.

Research output: Book/ReportBook

Physiology
Gastrointestinal Tract
Lactose Intolerance
Hemorrhoids
Food Hypersensitivity
15 Citations (Scopus)

Small intestinal ion transport

Ghishan, F. K. & Kiela, P. R., Mar 2012, In : Current Opinion in Gastroenterology. 28, 2, p. 130-134 5 p.

Research output: Contribution to journalArticle

Ion Transport
Sodium Chloride Symporters
Sodium Bicarbonate
Intestinal Absorption
Bicarbonates
2011

Abnormalities of Hepatic Protein Metabolism

Hassan, H. H. & Ghishan, F. K., 2011, Pediatric Gastrointestinal and Liver Disease. Elsevier Inc., p. 786-794 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liver
Proteins
65 Citations (Scopus)
Inflammatory Bowel Diseases
Minerals
Bone and Bones
Inflammation Mediators
Metabolic Bone Diseases
10 Citations (Scopus)

From probiotics to therapeutics: Another step forward?

Ghishan, F. K. & Kiela, P. R., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2149-2152 4 p.

Research output: Contribution to journalArticle

Lactobacillus rhamnosus
Cytoprotection
Probiotics
Colitis
Clinical Trials