Fayez K Ghishan

  • 6870 Citations
  • 44 h-Index
1978 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1978 2019

Filter
Article
2019
1 Citation (Scopus)

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Protein Isoforms
Neoplasms
Catenins
2 Citations (Scopus)

Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells

Figliuolo da Paz, V., Jamwal, D. R., Gurney, M., Midura-Kiela, M., Harrison, C. A., Cox, C., Wilson, J. M., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 2
Dendritic Cells
Down-Regulation
Phenotype
Colitis

Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis

Harrison, C. A., Laubitz, D., Midura-Kiela, M. T., Jamwal, D. R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jan 1 2019, In : Journal of Crohn's & colitis. 13, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Colitis
Sex Characteristics
Anti-Bacterial Agents
T-Lymphocytes
Adoptive Transfer
2018
1 Citation (Scopus)

Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice

Harrison, C. A., Laubitz, D., Ohland, C. L., Midura-Kiela, M. T., Patil, K., Besselsen, D. G., Jamwal, D. R., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jun 6 2018, (Accepted/In press) In : Mucosal Immunology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Dysbiosis
Microbiota
Colitis
Ecology
Bacteroidaceae
1 Citation (Scopus)

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 1 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Electrolytes
Genes
Gastrointestinal Tract
Antiporters
2017
8 Citations (Scopus)

Vitamins and Minerals in Inflammatory Bowel Disease

Ghishan, F. K. & Kiela, P. R., 2017, (Accepted/In press) In : Gastroenterology Clinics of North America.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Vitamins
Minerals
Avitaminosis
Vitamin A
2016
1 Citation (Scopus)

Expression of Cav1.3 calcium channel in the human and mouse colon: Posttranscriptional inhibition by IFNγ

Radhakrishnan, V. M., Gilpatrick, M. M., Parsa, N. A., Kiela, P. R. & Ghishan, F. K., Dec 8 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 1, p. G77-G84

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Colon
Colitis
Trinitrobenzenes
HCT116 Cells
8 Citations (Scopus)
Goblet Cells
HT29 Cells
Enterocytes
Mucins
Mucus
58 Citations (Scopus)

Physiology of intestinal absorption and secretion

Kiela, P. R. & Ghishan, F. K., Apr 1 2016, In : Best Practice and Research: Clinical Gastroenterology. 30, 2, p. 145-159 15 p.

Research output: Contribution to journalArticle

Intestinal Secretions
Intestinal Absorption
Food
Lipids
Oxalates
15 Citations (Scopus)

Reduced epithelial Na+/H+exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

Laubitz, D., Harrison, C. A., Midura-Kiela, M. T., Ramalingam, R., Larmonier, C. B., Chase, J. H., Caporaso, J. G., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Apr 1 2016, In : PLoS One. 11, 4, e0152044.

Research output: Contribution to journalArticle

Dysbiosis
T-cells
colitis
Colitis
intestinal microorganisms
15 Citations (Scopus)

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colitis
Somatostatin
Octreotide
seglitide
7 Citations (Scopus)

Transcriptional reprogramming and resistance to colonic mucosal injury in poly (ADP-ribose) polymerase 1 (PARP1) deficient mice

Larmonier, C. B., Shehab, K. W., Laubitz, D., Jamwal, D. R., Ghishan, F. K. & Kiela, P. R., Apr 22 2016, In : Journal of Biological Chemistry. 291, 17, p. 8918-8930 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Colitis
Wounds and Injuries
Adenosine Diphosphate Ribose
Dextran Sulfate
2015
16 Citations (Scopus)
Cardiopulmonary Bypass
Fatty Acid-Binding Proteins
Heart Diseases
Citrulline
Claudin-3
14 Citations (Scopus)

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

Leydig Cells
Testis
LH Receptors
Testosterone
Sodium-Hydrogen Antiporter
4 Citations (Scopus)

Experimental colitis is associated with transcriptional inhibition of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules

Radhakrishnan, V. M., Kojs, P., Ramalingam, R., Midura-Kiela, M. T., Angeli, P., Kiela, P. R. & Ghishan, F. K., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8964-8974 11 p.

Research output: Contribution to journalArticle

Distal Kidney Tubule
Colitis
Interferons
Minerals
Protein Isoforms
12 Citations (Scopus)

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

Dextran Sulfate
Goblet Cells
Paneth Cells
Colon
Intestinal Mucosa
10 Citations (Scopus)

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

Lacrimal Apparatus
Epithelial Cells
Conjunctiva
Tears
Cornea
11 Citations (Scopus)
Butyric Acid
Butyrates
Sodium
Genetic Promoter Regions
Epithelial Cells
42 Citations (Scopus)

The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention

Mcfadden, R. M. T., Larmonier, C. B., Shehab, K. W., Midura-Kiela, M., Ramalingam, R., Harrison, C. A., Besselsen, D. G., Chase, J. H., Caporaso, J. G., Jobin, C., Ghishan, F. K. & Kiela, P. R., Jul 25 2015, In : Inflammatory Bowel Diseases. 21, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

Curcumin
Microbiota
Colitis
Colonic Neoplasms
Interleukin-10
19 Citations (Scopus)

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

Larmonier, C. B., Shehab, K. W., Ghishan, F. K. & Kiela, P. R., 2015, In : BioMed Research International. 2015, 504638.

Research output: Contribution to journalArticle

T-cells
Microbiota
Inflammatory Bowel Diseases
T-Lymphocytes
Immune system
2014
284 Citations (Scopus)

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

Colitis
Mucus
Ulcerative Colitis
Colon
Bacteria
31 Citations (Scopus)

Epithelial transport in inflammatory bowel diseases

Ghishan, F. K. & Kiela, P. R., 2014, In : Inflammatory Bowel Diseases. 20, 6, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Food
Epithelium
Bacterial Antigens
Micronutrients
20 Citations (Scopus)

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)

Radhakrishnan, V. M., Kojs, P., Young, G., Ramalingam, R., Jagadish, B., Mash, E. A., Martinez, J. D., Ghishan, F. K. & Kiela, P. R., Jan 22 2014, In : PLoS One. 9, 1, e85796.

Research output: Contribution to journalArticle

Cortactin
Non-Receptor Type 1 Protein Tyrosine Phosphatase
protein-tyrosine-phosphatase
Curcumin
curcumin
2013
9 Citations (Scopus)

High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

Larmonier, C. B., McFadden, R. M. T., Hill, F. M., Schreiner, R., Ramalingam, R., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Jul 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 1

Research output: Contribution to journalArticle

Adoptive Transfer
Cholecalciferol
Colitis
Diet
T-Lymphocytes
23 Citations (Scopus)

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1

Research output: Contribution to journalArticle

Bacterial Adhesion
Knockout Mice
Dextran Sulfate
Colon
Salmonella typhimurium
16 Citations (Scopus)

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3

Research output: Contribution to journalArticle

Stomach
Adenoma
Stomach Ulcer
Sodium-Hydrogen Antiporter
Sodium Bicarbonate
19 Citations (Scopus)

Post-translational loss of renal trpv5 calcium channel expression, Ca 2+ wasting, and bone loss in experimental colitis

Radhakrishnan, V. M., Ramalingam, R., Larmonier, C. B., Thurston, R. D., Laubitz, D., Midura-Kiela, M. T., McFadden, R. M. T., Kuro-O, M., Kiela, P. R. & Ghishan, F. K., Sep 2013, In : Gastroenterology. 145, 3, p. 613-624 12 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Colitis
Calcium Channels
Kidney
Bone and Bones
40 Citations (Scopus)

Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice

Larmonier, C. B., Laubitz, D., Hill, F. M., Shehab, K. W., Lipinski, L., Midura-Kiela, M. T., McFadden, R. M. T., Ramalingam, R., Hassan, K. A., Golebiewski, M., Besselsen, D. G., Ghishan, F. K. & Kiela, P. R., Nov 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 10

Research output: Contribution to journalArticle

Colitis
Microbiota
Dysbiosis
Inflammation
Dextran Sulfate
1 Citation (Scopus)

The diagnostic role of magnetic resonance enterography in crohn's disease: An updated review of techniques, interpretation, and application

Arif-Tiwari, H., Kalb, B. T., Chundru, S., Costello, J., Sauer, C. G., Martin, D. R., Ghishan, F. K. & Goldschmid, S., Dec 2013, In : Applied Radiology. 42, 12, p. 5-15 11 p.

Research output: Contribution to journalArticle

Crohn Disease
Magnetic Resonance Spectroscopy
Young Adult
Chronic Disease
Tomography
2012
35 Citations (Scopus)

Curcumin inhibits interferon-γ signaling in colonic epithelial cells

Midura-Kiela, M. T., Radhakrishnan, V. M., Larmonier, C. B., Laubitz, D., Ghishan, F. K. & Kiela, P. R., Jan 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1

Research output: Contribution to journalArticle

Curcumin
Interferons
Epithelial Cells
Major Histocompatibility Complex
Inflammatory Bowel Diseases
61 Citations (Scopus)

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

Ramalingam, R., Larmonier, C. B., Thurston, R. D., Midura-Kiela, M. T., Zheng, S. G., Ghishan, F. K. & Kiel, P. R., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 3878-3893 16 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmunity
Dendritic Cells
Phenotype
Knockout Mice
29 Citations (Scopus)

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Xu, H., Zhang, B., Li, J., Wang, C., Chen, H. & Ghishan, F. K., Aug 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 3

Research output: Contribution to journalArticle

Mucins
Bicarbonates
Knockout Mice
Colon
Intestines
2 Citations (Scopus)

Metabolic bone disease in inflammatory bowel disease

Ghishan, F. K. & Kiela, P. R., Sep 2012, In : Practical Gastroenterology. 36, 9, p. 16-26 11 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Inflammatory Bowel Diseases
Bone and Bones
Bone Density
Dietary Calcium
15 Citations (Scopus)

Small intestinal ion transport

Ghishan, F. K. & Kiela, P. R., Mar 2012, In : Current Opinion in Gastroenterology. 28, 2, p. 130-134 5 p.

Research output: Contribution to journalArticle

Ion Transport
Sodium Chloride Symporters
Sodium Bicarbonate
Intestinal Absorption
Bicarbonates
2011
65 Citations (Scopus)
Inflammatory Bowel Diseases
Minerals
Bone and Bones
Inflammation Mediators
Metabolic Bone Diseases
10 Citations (Scopus)

From probiotics to therapeutics: Another step forward?

Ghishan, F. K. & Kiela, P. R., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2149-2152 4 p.

Research output: Contribution to journalArticle

Lactobacillus rhamnosus
Cytoprotection
Probiotics
Colitis
Clinical Trials
55 Citations (Scopus)

Modulation of neutrophil motility by curcumin: Implications for inflammatory bowel disease

Larmonier, C. B., Midura-Kiela, M. T., Ramalingam, R., Laubitz, D., Janikashvili, N., Larmonier, N., Ghishan, F. K. & Kiela, P. R., Feb 2011, In : Inflammatory Bowel Diseases. 17, 2, p. 503-515 13 p.

Research output: Contribution to journalArticle

Curcumin
Inflammatory Bowel Diseases
Neutrophils
Chemokine CXCL2
Chemotactic Factors
17 Citations (Scopus)

NHE2X3 DKO mice exhibit gender-specific NHE8 compensation

Xu, H., Li, J., Chen, R., Zhang, B., Wang, C., King, N., Chen, H. & Ghishan, F. K., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4

Research output: Contribution to journalArticle

Knockout Mice
Sodium-Hydrogen Antiporter
Caco-2 Cells
Intestinal Absorption
Puberty
18 Citations (Scopus)

NHE3 modulates the severity of colitis in IL-10-deficient mice

Larmonier, C. B., Laubitz, D., Thurston, R. D., Bucknam, A. L., Hill, F. M., Midura-Kiela, M., Ramalingam, R., Kiela, P. R. & Ghishan, F. K., Jun 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6

Research output: Contribution to journalArticle

Colitis
Interleukin-10
Knockout Mice
Inflammatory Bowel Diseases
Matrix Metalloproteinase 8
17 Citations (Scopus)

Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Wang, C., Xu, H., Chen, H., Li, J., Zhang, B., Tang, C. & Ghishan, F. K., Feb 2011, In : American Journal of Physiology - Cell Physiology. 300, 2

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
p38 Mitogen-Activated Protein Kinases
Somatostatin
Diarrhea
Octreotide
2010
18 Citations (Scopus)

Cooperative role of NF-κB and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts

Majewski, P. M., Thurston, R. D., Ramalingam, R., Kiela, P. R. & Ghishan, F. K., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34828-34838 11 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Osteoblasts
Bone
Down-Regulation
Genes
18 Citations (Scopus)

Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription

Xu, H., Zhang, B., Li, J., Chen, H., Tooley, J. & Ghishan, F. K., Jul 2010, In : American Journal of Physiology - Cell Physiology. 299, 1

Research output: Contribution to journalArticle

Epidermal Growth Factor
Caco-2 Cells
Sp3 Transcription Factor
Gene Expression
Messenger RNA
17 Citations (Scopus)
Glucocorticoids
Caco-2 Cells
Electrophoretic Mobility Shift Assay
Intestines
Transcription Factors
71 Citations (Scopus)

Tumor Necrosis Factor and Interferon-γ Down-regulate Klotho in Mice With Colitis

Thurston, R. D., Larmonier, C. B., Majewski, P. M., Ramalingam, R., Midura-Kiela, M., Laubitz, D., Vandewalle, A., Besselsen, D. G., Mühlbauer, M., Jobin, C., Kiela, P. R. & Ghishan, F. K., Apr 2010, In : Gastroenterology. 138, 4

Research output: Contribution to journalArticle

Colitis
Interferons
Down-Regulation
Tumor Necrosis Factor-alpha
Inflammatory Bowel Diseases
2009
18 Citations (Scopus)
STAT3 Transcription Factor
Genetic Promoter Regions
Transcriptional Activation
Cell Count
Madin Darby Canine Kidney Cells
37 Citations (Scopus)

Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury

Kiela, P. R., Laubitz, D., Larmonier, C. B., Midura-Kiela, M. T., Lipko, M. A., Janikashvili, N., Bai, A., Thurston, R. & Ghishan, F. K., Sep 2009, In : Gastroenterology. 137, 3

Research output: Contribution to journalArticle

Dextran Sulfate
Knockout Mice
Homeostasis
Wounds and Injuries
Interferons
23 Citations (Scopus)

Ion transport in the intestine

Kiela, P. R. & Ghishan, F. K., Mar 2009, In : Current Opinion in Gastroenterology. 25, 2, p. 87-91 5 p.

Research output: Contribution to journalArticle

Ion Transport
Intestinal Secretions
Intestines
Bicarbonates
Inflammation
46 Citations (Scopus)

Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis

Kiela, P. R. & Ghishan, F. K., Jan 2009, In : Laboratory Investigation. 89, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Homeostasis
Phosphates
Phosphate Transport Proteins
Kidney
22 Citations (Scopus)
Intestinal Absorption
Colitis
Tumor Necrosis Factor-alpha
Phosphates
Inflammatory Bowel Diseases
24 Citations (Scopus)

Tumor necrosis factor-α downregulates intestinal NHE8 expression by reducing basal promoter activity

Xu, H., Chen, H., Dong, J., Li, J., Chen, R., Uno, J. K. & Ghishan, F. K., Mar 2009, In : American Journal of Physiology - Cell Physiology. 296, 3

Research output: Contribution to journalArticle

Trinitrobenzenes
Down-Regulation
Tumor Necrosis Factor-alpha
Caco-2 Cells
Sulfonic Acids