Frank Porreca

  • 30172 Citations
  • 96 h-Index
1980 …2021
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  • 9 Similar Profiles
Opioid Receptors Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Morphine Medicine & Life Sciences
Pain Medicine & Life Sciences
Neuralgia Medicine & Life Sciences
Hyperalgesia Medicine & Life Sciences
delta Opioid Receptor Medicine & Life Sciences
D-Penicillamine (2,5)-Enkephalin Medicine & Life Sciences

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Projects 1984 2021

Chronic Pain
Opioid Analgesics
Pain
Dopamine
Analgesics
kappa Opioid Receptor
Pain
mu Opioid Receptor
Opioid Analgesics
Analgesics
Reward
Pain
Brain
Nucleus Accumbens
Ventral Tegmental Area

Research Output 1980 2019

Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140)

Guerrero, M., Urbano, M., Kim, E. K., Gamo, A. M., Riley, S., Abgaryan, L., Leaf, N., Van Orden, L. J., Brown, S. J., Xie, J. Y., Porreca, F., Cameron, M. D., Rosen, H. & Roberts, E., Feb 28 2019, In : Journal of Medicinal Chemistry. 62, 4, p. 1761-1780 20 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Pyrans
Dynorphins
Clinical Trials, Phase I

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Khanna, R., Patwardhan, A. M., Yang, X., Li, W., Cai, S., Ji, Y., Chew, L. A., Dorame, A., Bellampalli, S. S., Schmoll, R. W., Gordon, J., Moutal, A., Vanderah, T. W., Porreca, F. & Ibrahim, M. M., Jan 1 2019, In : Journal of Pain.

Research output: Contribution to journalArticle

Hyperalgesia
Light
Pain
Wounds and Injuries
Color

Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

Jassar, H., Nascimento, T. D., Kaciroti, N., DosSantos, M. F., Danciu, T., Koeppe, R. A., Smith, Y. R., Bigal, M. E., Porreca, F., Casey, K. L., Zubieta, J. K. & DaSilva, A. F., Jan 1 2019, In : NeuroImage: Clinical. 23, 101905.

Research output: Contribution to journalArticle

Open Access
Limbic System
Migraine Disorders
Synaptic Transmission
Opioid Analgesics
Opioid Receptors
2 Citations (Scopus)

Inhibition of experimental visceral pain in rodents by cebranopadol

Schiene, K., Schröder, W., Linz, K., Frosch, S., Tzschentke, T. M., Christoph, T., Xie, J. Y. & Porreca, F., Jun 1 2019, In : Behavioural Pharmacology. 30, 4, p. 320-326 7 p.

Research output: Contribution to journalArticle

Visceral Pain
Rodentia
Hyperalgesia
Colitis
Confidence Intervals
3 Citations (Scopus)

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

Navratilova, E., Ji, G., Phelps, C., Qu, C., Hein, M., Yakhnitsa, V., Neugebauer, V. & Porreca, F., Apr 1 2019, In : Pain. 160, 4, p. 824-832 9 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Neuralgia
Spinal Nerves
Chronic Pain
Opioid Analgesics