Frank Porreca

  • 29446 Citations
  • 94 h-Index
1980 …2021
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Opioid Receptors Medicine & Life Sciences
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delta Opioid Receptor Medicine & Life Sciences
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Projects 1984 2021

Chronic Pain
Opioid Analgesics
Pain
Dopamine
Analgesics
kappa Opioid Receptor
Pain
mu Opioid Receptor
Opioid Analgesics
Analgesics
Reward
Pain
Brain
Nucleus Accumbens
Ventral Tegmental Area
Students
Vulnerable Populations
Nervous System Diseases
Research
Stroke

Research Output 1980 2018

3 Citations (Scopus)

Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer

Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., Kondo, T., Shinzato, T., Shimizu, T., Fukuchi, Y., Muto, A., Okano, H., Yamanaka, A., Tawfik, V. L., Kuzumaki, N., Navratilova, E., Porreca, F. & Narita, M., Jan 1 2018, In : Molecular Pain. 14

Research output: Contribution to journalArticle

Bone Neoplasms
Ventral Tegmental Area
Dopaminergic Neurons
Hyperalgesia
Nucleus Accumbens

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V. J. & Lee, Y. S., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

kappa Opioid Receptor
delta Opioid Receptor
mu Opioid Receptor
Opioid Receptors
hydrazine
1 Citations (Scopus)

Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain

Remeniuk, B., King, T., Sukhtankar, D., Nippert, A., Li, N., Li, F., Cheng, K., Rice, K. C. & Porreca, F., Apr 1 2018, In : Pain. 159, 4, p. 684-698 15 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Interleukin-6
Bone Remodeling
Pain
Neoplasms
1 Citations (Scopus)

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., Jan 1 2018, In : Molecular Pain. 14

Research output: Contribution to journalArticle

Microdialysis
Nucleus Accumbens
Mass Spectrometry
Pain
Neurotransmitter Agents
3 Citations (Scopus)

Kappa Opioid Receptor Distribution and Function in Primary Afferents

Snyder, L. M., Chiang, M. C., Loeza-Alcocer, E., Omori, Y., Hachisuka, J., Sheahan, T. D., Gale, J. R., Adelman, P. C., Sypek, E. I., Fulton, S. A., Friedman, R. L., Wright, M. C., Duque, M. G., Lee, Y. S., Hu, Z., Huang, H., Cai, X., Meerschaert, K. A., Nagarajan, V., Hirai, T. & 7 othersScherrer, G., Kaplan, D. H., Porreca, F., Davis, B. M., Gold, M. S., Koerber, H. R. & Ross, S. E., Sep 19 2018, In : Neuron. 99, 6, p. 1274-1288.e6

Research output: Contribution to journalArticle

kappa Opioid Receptor
Sensory Receptor Cells
Neurogenic Inflammation
Nociceptors
Mechanoreceptors