Frank Porreca

  • 28547 Citations
  • 93 h-Index
1980 …2021
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Projects 1984 2021

Cortical opioid dysfunction in chronic pain

Porreca, F.

National Institutes of Health


Project: Research projectResearch Project

Chronic Pain
Opioid Analgesics

Long-Acting Peripherally-Restricted Peptidic Kappa Opioid Receptor Agonists for Pain

Porreca, F.

National Institutes of Health


Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase I

kappa Opioid Receptor
mu Opioid Receptor
Opioid Analgesics

Brain reward circuits and relief of ongoing pain

Porreca, F.

National Institutes of Health


Project: Research projectResearch Project

Nucleus Accumbens
Ventral Tegmental Area

High School Student NeuroResearch Program (HSNRP)

Witte, M. H. & Porreca, F.

National Institutes of Health


Project: Research projectEducation Projects

Vulnerable Populations
Nervous System Diseases

Research Output 1980 2018

1 Citations

Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia

Godfrey, L., Iannitelli, A., Garrett, N. L., Moger, J., Imbert, I., King, T., Porreca, F., Soundararajan, R., Lalatsa, A., Schätzlein, A. G. & Uchegbu, I. F., Jan 28 2018, In : Journal of Controlled Release. 270, p. 135-144 10 p.

Research output: Contribution to journalArticle

2 Citations

Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla

Hitomi, S., Kross, K., Kurose, M., Porreca, F. & Meng, I. D., Apr 1 2017, In : Cephalalgia. 37, 5, p. 407-417 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-fos
2 Citations

Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine

Rice, F. L., Xie, J. Y., Albrecht, P. J., Acker, E., Bourgeois, J., Navratilova, E., Dodick, D. W. & Porreca, F., Dec 1 2017, In : Cephalalgia. 37, 14, p. 1350-1372 23 p.

Research output: Contribution to journalArticle

Unmyelinated Nerve Fibers
Macaca mulatta
Migraine Disorders
Adrenergic Receptors
4 Citations

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Moutal, A., Yang, X., Li, W., Gilbraith, K. B., Luo, S., Cai, S., François-Moutal, L., Chew, L. A., Yeon, S. K., Bellampalli, S. S., Qu, C., Xie, J. Y., Ibrahim, M. M., Khanna, M., Park, K. D., Porreca, F. & Khanna, R., Jan 1 2017, In : Pain. 158, 12, p. 2301-2319 19 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Neurofibromatosis 1 Genes
Neurofibromatosis 1
Neurofibromin 1
9 Citations

Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention

Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., Lavigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., Navratilova, E., Dodick, D., Rosen, H., Roberts, E. & Porreca, F., Jul 1 2017, In : Cephalalgia. 37, 8, p. 780-794 15 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Narcotic Antagonists
Migraine Disorders
Secondary Headache Disorders