• 3467 Citations
  • 31 h-Index
19942019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Repurposing the electron transfer reactant phenazine methosulfate (Pms) for the apoptotic elimination of malignant melanoma cells through induction of lethal oxidative and mitochondriotoxic stress

Hua, A. B., Justiniano, R., Perer, J., Park, S. L., Li, H., Cabello, C. M. & Wondrak, G. T., May 1 2019, In : Cancers. 11, 5, 590.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Parkinson's disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy

Teves, J. M. Y., Bhargava, V., Kirwan, K. R., Corenblum, M. J., Justiniano, R., Wondrak, G. T., Anandhan, A., Flores, A. J., Schipper, D. A., Khalpey, Z. I., Sligh, J. E., Curiel, C. N., Sherman, S. J. & Madhavan, L., Jan 12 2018, In : Frontiers in Neuroscience. 11, JAN, 737.

Research output: Contribution to journalArticle

17 Scopus citations

Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

Blohm-Mangone, K., Burkett, N. B., Tahsin, S., Myrdal, P. B., Aodah, A., Ho, B., Janda, J., McComas, M., Saboda, K., Roe, D., Dong, Z., Bode, A. M., Petricoin, E. F., Calvert, V. S., Curiel, C. N., Alberts, D. S., Wondrak, G. T. & Dickinson, S. E., May 1 2018, In : Cancer Prevention Research. 11, 5, p. 265-277 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Dickinson, S. E. & Wondrak, G. T., Jan 1 2018, In : Current Medicinal Chemistry. 25, 40, p. 5487-5502 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

de la Vega, M. R., Zhang, D. & Wondrak, G. T., Mar 27 2018, In : Frontiers in Pharmacology. 9, MAR, 287.

Research output: Contribution to journalArticle

6 Scopus citations
2017

A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin

Justiniano, R., Perer, J., Hua, A., Fazel, M., Krajisnik, A., Cabello, C. M. & Wondrak, G. T., Nov 1 2017, In : Photochemistry and Photobiology. 93, 6, p. 1472-1482 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting NRF2 for improved skin barrier function and photoprotection: Focus on the achiote-derived apocarotenoid bixin

de la Vega, M. R., Krajisnik, A., Zhang, D. & Wondrak, G. T., Dec 18 2017, In : Nutrients. 9, 12, 1371.

Research output: Contribution to journalReview article

15 Scopus citations

The B6-vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis

Justiniano, R., Williams, J. D., Perer, J., Hua, A., Lesson, J., Park, S. L. & Wondrak, G. T., 2017, (Accepted/In press) In : Photochemistry and Photobiology.

Research output: Contribution to journalArticle

5 Scopus citations
2016

An essential role of NRF2 in diabetic wound healing

Long, M., De La Vega, M. R., Wen, Q., Bharara, M., Jiang, T., Zhang, R., Zhou, S., Wong, P. K., Wondrak, G. T., Zheng, H. & Zhang, D., Mar 1 2016, In : Diabetes. 65, 3, p. 780-793 14 p.

Research output: Contribution to journalArticle

64 Scopus citations

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo De La Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. GN. & Zhang, D., Jan 5 2016, In : Scientific Reports. 6, 18760.

Research output: Contribution to journalArticle

26 Scopus citations

Preface

Wondrak, G. T., Jan 1 2016, Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing, p. v

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

Janda, J., Burkett, N. B., Blohm-Mangone, K., Huang, V., Curiel, C. N., Alberts, D. S., Petricoin, E. F., Calvert, V. S., Einspahr, J. G., Dong, Z., Bode, A. M., Wondrak, G. T. & Dickinson, S. E., Nov 1 2016, In : Photochemistry and Photobiology. 92, 6, p. 816-825 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

The aryl hydrocarbon receptor (AhR) as an environmental stress sensor and regulator of skin barrier function: Molecular mechanisms and therapeutic opportunities

Justiniano, R. & Wondrak, G. T., Jan 1 2016, Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing, p. 325-359 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2015

Introduction to cell stress responses in cancer: The big picture

Wondrak, G. T., Jan 1 2015, Stress Response Pathways in Cancer: From Molecular Targets to Novel Therapeutics. Springer Netherlands, p. 1-5 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities

Wondrak, G. T., Jan 1 2015, Stress Response Pathways in Cancer: From Molecular Targets to Novel Therapeutics. Springer Netherlands, p. 285-309 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Long, M., Tao, S., De La Vega, M. R., Jiang, T., Wen, Q., Park, S. L., Zhang, D. & Wondrak, G. T., May 1 2015, In : Cancer Prevention Research. 8, 5, p. 444-454 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Preface

Wondrak, G. T., Jan 1 2015, In : Unknown Journal.

Research output: Contribution to journalArticle

1 Scopus citations

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

Tao, S., Park, S. L., De La Vega, M. R., Zhang, D. & Wondrak, G. T., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 690-700 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells

Davis, A. L., Qiao, S., Lesson, J. L., De La Vega, M. R., Park, S. L., Seanez, C. M., Gokhale, V., Cabello, C. M. & Wondrak, G. T., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1623-1638 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

The tryptophan-derived endogenous aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole is a nanomolar UVA photosensitizer in epidermal keratinocytes

Park, S. L., Justiniano, R., Williams, J. D., Cabello, C. M., Qiao, S. & Wondrak, G. T., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 6, p. 1649-1658 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams, J. D., Bermudez, Y., Park, S. L., Stratton, S. P., Uchida, K., Hurst, C. A. & Wondrak, G. T., Mar 5 2014, In : Journal of Photochemistry and Photobiology B: Biology. 132, p. 56-65 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Sunscreen-Based skin protection against solar insult: Molecular mechanisms and opportunities

Wondrak, G. T., Jan 1 2014, Fundamentals of Cancer Prevention, Third Edition. Springer Berlin Heidelberg, p. 301-320 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
2013

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

Whitman, S. A., Long, M., Wondrak, G. T., Zheng, H. & Zhang, D. D., Oct 15 2013, In : Experimental Cell Research. 319, 17, p. 2673-2683 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells

Davis, A. L., Cabello, C. M., Qiao, S., Azimian, S. & Wondrak, G. T., Feb 1 2013, In : International journal of molecular sciences. 14, 2, p. 4185-4202 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo

Tao, S., Zheng, Y., Lau, A., Jaramillo, M. C., Chau, B. T., Lantz, R. C., Wong, P. K., Wondrak, G. T. & Zhang, D. D., Nov 11 2013, In : Antioxidants and Redox Signaling. 19, 14, p. 1647-1661 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- And chemotherapy-induced cell death

Qiao, S., Tao, S., Rojo De La Vega, M., Park, S. L., Vonderfecht, A. A., Jacobs, S. L., Zhang, D. D. & Wondrak, G. T., Dec 1 2013, In : Autophagy. 9, 12, p. 2087-2102 16 p.

Research output: Contribution to journalArticle

38 Scopus citations

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Tao, S., Justiniano, R., Zhang, D. D. & Wondrak, G. T., Oct 1 2013, In : Redox Biology. 1, 1, p. 532-541 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
20 Scopus citations
2012
31 Scopus citations

D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis

Qiao, S., Cabello, C. M., Lamore, S. D., Lesson, J. L. & Wondrak, G. T., Oct 1 2012, In : Apoptosis. 17, 10, p. 1079-1094 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

Cabello, C. M., Lamore, S. D., Bair, W. B., Qiao, S., Azimian, S., Lesson, J. L. & Wondrak, G. T., Aug 1 2012, In : Investigational New Drugs. 30, 4, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes

Qiao, S., Lamore, S. D., Cabello, C. M., Lesson, J. L., Muñoz-Rodriguez, J. L. & Wondrak, G. T., May 1 2012, In : Biochemical Pharmacology. 83, 9, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vitamin B6: Beyond coenzyme functions

Wondrak, G. T. & Jacobson, E. L., Jan 1 2012, In : Sub-cellular biochemistry. 56, p. 291-300 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma

Cabello, C. M., Lamore, S. D., Bair, W. B., Davis, A. L., Azimian, S. M. & Wondrak, G. T., Mar 1 2011, In : Free Radical Research. 45, 3, p. 276-292 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D. & Zhang, D. D., Nov 1 2011, In : Diabetes. 60, 11, p. 3055-3066 12 p.

Research output: Contribution to journalArticle

289 Scopus citations

Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

Lamore, S. D. & Wondrak, G. T., Oct 1 2011, In : Biometals. 24, 5, p. 875-890 16 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

GLO1 overexpression in human malignant melanoma

Bair, W. B., Cabello, C. M., Uchida, K., Bause, A. S. & Wondrak, G. T., Apr 1 2010, In : Melanoma Research. 20, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

HMGB1-Directed drug discovery targeting cutaneous inflammatory dysregulation

Lamore, S. D., Cabello, C. M. & Wondrak, G. T., Mar 1 2010, In : Current Drug Metabolism. 11, 3, p. 250-265 16 p.

Research output: Contribution to journalReview article

9 Scopus citations

Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts

Lamore, S. D., Qiao, S., Horn, D. & Wondrak, G. T., Nov 1 2010, In : Photochemistry and Photobiology. 86, 6, p. 1307-1317 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells

Papoutsis, A. J., Lamore, S. D., Wondrak, G. T., Selmin, O. I. & Romagnolo, D. F., Sep 1 2010, In : Journal of Nutrition. 140, 9, p. 1607-1614 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells

Wondrak, G. T., Villeneuve, N. F., Lamore, S. D., Bause, A. S., Jiang, T. & Zhang, D. D., May 1 2010, In : Molecules. 15, 5, p. 3338-3355 18 p.

Research output: Contribution to journalArticle

90 Scopus citations

The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells

Lamore, S. D., Azimian, S., Horn, D., Anglin, B. L., Uchida, K., Cabello, C. M. & Wondrak, G. T., Dec 2 2010, In : Journal of Photochemistry and Photobiology B: Biology. 101, 3, p. 251-264 14 p.

Research output: Contribution to journalArticle

25 Scopus citations
37 Scopus citations
2009

Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1

Cabello, C. M., Bair, W. B., Bause, A. S. & Wondrak, G. T., Aug 15 2009, In : Biochemical Pharmacology. 78, 4, p. 344-354 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

More than skin deep: The human skin tissue equivalent as an advanced drug discovery tool

Bause, A. S., Lamore, S. D. & Wondrak, G. T., Dec 1 2009, In : Frontiers in Drug Design and Discovery. 4, 1, p. 135-161 27 p.

Research output: Contribution to journalArticle

3 Scopus citations

Redox-directed cancer therapeutics: Molecular mechanisms and opportunities

Wondrak, G. T., Dec 1 2009, In : Antioxidants and Redox Signaling. 11, 12, p. 3013-3069 57 p.

Research output: Contribution to journalReview article

317 Scopus citations