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19942019
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Research Output 1994 2019

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Article
2019
1 Citation (Scopus)

Repurposing the electron transfer reactant phenazine methosulfate (Pms) for the apoptotic elimination of malignant melanoma cells through induction of lethal oxidative and mitochondriotoxic stress

Hua, A. B., Justiniano, R., Perer, J., Park, S. L., Li, H., Cabello, C. M. & Wondrak, G. T., May 1 2019, In : Cancers. 11, 5, 590.

Research output: Contribution to journalArticle

Open Access
Methylphenazonium Methosulfate
Melanoma
Oxidative Stress
Electrons
Oxidation-Reduction
Skin Neoplasms
Skin
HMGB1 Protein
Merkel Cell Carcinoma
Environmental Exposure
2018
15 Citations (Scopus)

Parkinson's disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy

Teves, J. M. Y., Bhargava, V., Kirwan, K. R., Corenblum, M. J., Justiniano, R., Wondrak, G. T., Anandhan, A., Flores, A. J., Schipper, D. A., Khalpey, Z. I., Sligh, J. E., Curiel, C. N., Sherman, S. J. & Madhavan, L., Jan 12 2018, In : Frontiers in Neuroscience. 11, JAN, 737.

Research output: Contribution to journalArticle

Autophagy
Oxidation-Reduction
Parkinson Disease
Homeostasis
Fibroblasts
6 Citations (Scopus)

Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

Blohm-Mangone, K., Burkett, N. B., Tahsin, S., Myrdal, P. B., Aodah, A., Ho, B., Janda, J., McComas, M., Saboda, K., Roe, D., Dong, Z., Bode, A. M., Petricoin, E. F., Calvert, V. S., Curiel, C. N., Alberts, D. S., Wondrak, G. T. & Dickinson, S. E., May 1 2018, In : Cancer Prevention Research. 11, 5, p. 265-277 13 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Carcinogenesis
Pharmacology
Skin
Skin Neoplasms
1 Citation (Scopus)
Solar System
Midwestern United States
Odds Ratio
Confidence Intervals
Tanning
5 Citations (Scopus)

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Dickinson, S. E. & Wondrak, G. T., Jan 1 2018, In : Current Medicinal Chemistry. 25, 40, p. 5487-5502 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Skin
Carcinogenesis
Skin Neoplasms
Pharmacology
5 Citations (Scopus)

Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

de la Vega, M. R., Zhang, D. & Wondrak, G. T., Mar 27 2018, In : Frontiers in Pharmacology. 9, MAR, 287.

Research output: Contribution to journalArticle

Hair
Skin
Ficusin
NF-E2 Transcription Factor
Bixaceae
2017
1 Citation (Scopus)

A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin

Justiniano, R., Perer, J., Hua, A., Fazel, M., Krajisnik, A., Cabello, C. M. & Wondrak, G. T., Nov 1 2017, In : Photochemistry and Photobiology. 93, 6, p. 1472-1482 11 p.

Research output: Contribution to journalArticle

Ionophores
progressions
mice
Zinc
Skin
5 Citations (Scopus)

The B6-vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis

Justiniano, R., Williams, J. D., Perer, J., Hua, A., Lesson, J., Park, S. L. & Wondrak, G. T., 2017, (Accepted/In press) In : Photochemistry and Photobiology.

Research output: Contribution to journalArticle

Pyridoxal
epidermis
Keratinocytes
Epidermis
DNA Damage
2016
62 Citations (Scopus)

An essential role of NRF2 in diabetic wound healing

Long, M., De La Vega, M. R., Wen, Q., Bharara, M., Jiang, T., Zhang, R., Zhou, S., Wong, P. K., Wondrak, G. T., Zheng, H. & Zhang, D., Mar 1 2016, In : Diabetes. 65, 3, p. 780-793 14 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Wound Healing
Skin Ulcer
Matrix Metalloproteinase 9
Transforming Growth Factors
26 Citations (Scopus)

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo De La Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. GN. & Zhang, D., Jan 5 2016, In : Scientific Reports. 6, 18760.

Research output: Contribution to journalArticle

Lung Injury
Ventilation
Artificial Respiration
Ventilator-Induced Lung Injury
Lung
10 Citations (Scopus)

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

Janda, J., Burkett, N. B., Blohm-Mangone, K., Huang, V., Curiel, C. N., Alberts, D. S., Petricoin, E. F., Calvert, V. S., Einspahr, J. G., Dong, Z., Bode, A. M., Wondrak, G. T. & Dickinson, S. E., Nov 1 2016, In : Photochemistry and Photobiology. 92, 6, p. 816-825 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Transcription Factor AP-1
Keratinocytes
mice
Skin
2015
23 Citations (Scopus)

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Long, M., Tao, S., De La Vega, M. R., Jiang, T., Wen, Q., Park, S. L., Zhang, D. & Wondrak, G. T., May 1 2015, In : Cancer Prevention Research. 8, 5, p. 444-454 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Azoxymethane
Cinnamomum zeylanicum
Dextran Sulfate
Colon
1 Citation (Scopus)

Preface

Wondrak, G. T., Jan 1 2015, In : Unknown Journal.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

Tao, S., Park, S. L., De La Vega, M. R., Zhang, D. & Wondrak, G. T., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 690-700 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Skin
Chemical activation
Food additives
Food Additives
12 Citations (Scopus)

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells

Davis, A. L., Qiao, S., Lesson, J. L., De La Vega, M. R., Park, S. L., Seanez, C. M., Gokhale, V., Cabello, C. M. & Wondrak, G. T., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1623-1638 16 p.

Research output: Contribution to journalArticle

Noxae
Heat-Shock Response
Melanoma
Apoptosis
Cell death
35 Citations (Scopus)

The tryptophan-derived endogenous aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole is a nanomolar UVA photosensitizer in epidermal keratinocytes

Park, S. L., Justiniano, R., Williams, J. D., Cabello, C. M., Qiao, S. & Wondrak, G. T., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 6, p. 1649-1658 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Oxidative stress
Photosensitizing Agents
Keratinocytes
Tryptophan
2014
20 Citations (Scopus)

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams, J. D., Bermudez, Y., Park, S. L., Stratton, S. P., Uchida, K., Hurst, C. A. & Wondrak, G. T., Mar 5 2014, In : Journal of Photochemistry and Photobiology B: Biology. 132, p. 56-65 10 p.

Research output: Contribution to journalArticle

Skin Neoplasms
Malondialdehyde
Epitopes
lysine
cancer
2013
23 Citations (Scopus)

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

Whitman, S. A., Long, M., Wondrak, G. T., Zheng, H. & Zhang, D., Oct 15 2013, In : Experimental Cell Research. 319, 17, p. 2673-2683 11 p.

Research output: Contribution to journalArticle

Muscular Atrophy
Streptozocin
Atrophy
Skeletal Muscle
Myosins
9 Citations (Scopus)

Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells

Davis, A. L., Cabello, C. M., Qiao, S., Azimian, S. & Wondrak, G. T., Feb 2013, In : International Journal of Molecular Sciences. 14, 2, p. 4185-4202 18 p.

Research output: Contribution to journalArticle

Heat-Shock Response
gene expression
Methylene Blue
methylene blue
Gene expression
63 Citations (Scopus)

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo

Tao, S., Zheng, Y., Lau, A., Jaramillo, M. C., Chau, B. T., Lantz, R. C., Wong, P. K., Wondrak, G. T. & Zhang, D., 2013, In : Antioxidants and Redox Signaling. 19, 14, p. 1647-1661 15 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Pneumonia
Antioxidants
Environmental Exposure
Medicinal Plants
38 Citations (Scopus)

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- And chemotherapy-induced cell death

Qiao, S., Tao, S., Rojo De La Vega, M., Park, S. L., Vonderfecht, A. A., Jacobs, S. L., Zhang, D. & Wondrak, G. T., Dec 2013, In : Autophagy. 9, 12, p. 2087-2102 16 p.

Research output: Contribution to journalArticle

Amodiaquine
Antimalarials
Starvation
Melanoma
Cell Death
53 Citations (Scopus)

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Tao, S., Justiniano, R., Zhang, D. & Wondrak, G. T., Oct 2013, In : Redox Biology. 1, 1, p. 532-541 10 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Skin
Chemical activation
Fibroblasts
Glutathione
19 Citations (Scopus)
Cathepsin L
Cathepsin B
fibroblasts
Cathepsins
deactivation
2012
30 Citations (Scopus)
Cathepsin B
fibroblasts
Fibroblasts
deactivation
Skin
17 Citations (Scopus)

D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis

Qiao, S., Cabello, C. M., Lamore, S. D., Lesson, J. L. & Wondrak, G. T., Oct 2012, In : Apoptosis. 17, 10, p. 1079-1094 16 p.

Research output: Contribution to journalArticle

Noxae
Unfolded Protein Response
Penicillamine
Melanoma
Oxidative stress
42 Citations (Scopus)

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

Cabello, C. M., Lamore, S. D., Bair, W. B., Qiao, S., Azimian, S., Lesson, J. L. & Wondrak, G. T., Aug 2012, In : Investigational New Drugs. 30, 4, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

dihydroartemisinin
Melanocytes
Antimalarials
Oxidation-Reduction
Melanoma
27 Citations (Scopus)

Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes

Qiao, S., Lamore, S. D., Cabello, C. M., Lesson, J. L., Muñoz-Rodriguez, J. L. & Wondrak, G. T., May 1 2012, In : Biochemical Pharmacology. 83, 9, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Thiostrepton
Melanocytes
Melanoma
Oxidative Stress
Gene expression
17 Citations (Scopus)

Vitamin B6: Beyond coenzyme functions

Wondrak, G. T. & Jacobson, E. L., 2012, In : Sub-Cellular Biochemistry. 56, p. 291-300 10 p.

Research output: Contribution to journalArticle

Vitamin B 6
Coenzymes
Metals
Neurodegenerative diseases
Tissue
2011
12 Citations (Scopus)

DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma

Cabello, C. M., Lamore, S. D., Bair, W. B., Davis, A. L., Azimian, S. M. & Wondrak, G. T., Mar 2011, In : Free Radical Research. 45, 3, p. 276-292 17 p.

Research output: Contribution to journalArticle

2,6-Dichloroindophenol
Oxidation-Reduction
Genotype
Breast Neoplasms
Oxidative stress
285 Citations (Scopus)

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D. & Zhang, D., Nov 2011, In : Diabetes. 60, 11, p. 3055-3066 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Streptozocin
Mesangial Cells
Kidney
Transforming Growth Factors
22 Citations (Scopus)

Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

Lamore, S. D. & Wondrak, G. T., Oct 2011, In : BioMetals. 24, 5, p. 875-890 16 p.

Research output: Contribution to journalArticle

epidermis (animal)
Gene expression
Epidermis
Zinc
stress response
2010
51 Citations (Scopus)

GLO1 overexpression in human malignant melanoma

Bair, W. B., Cabello, C. M., Uchida, K., Bause, A. S. & Wondrak, G. T., Apr 2010, In : Melanoma Research. 20, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
Melanoma
Lactoylglutathione Lyase
Up-Regulation
Proteins
9 Citations (Scopus)

HMGB1-Directed drug discovery targeting cutaneous inflammatory dysregulation

Lamore, S. D., Cabello, C. M. & Wondrak, G. T., Mar 2010, In : Current Drug Metabolism. 11, 3, p. 250-265 16 p.

Research output: Contribution to journalArticle

Pathology
Drug Discovery
Drug Delivery Systems
Skin
Modulation
24 Citations (Scopus)

Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts

Lamore, S. D., Qiao, S., Horn, D. & Wondrak, G. T., Nov 2010, In : Photochemistry and Photobiology. 86, 6, p. 1307-1317 11 p.

Research output: Contribution to journalArticle

Cathepsin B
fibroblasts
Fibroblasts
Proteomics
Two-Dimensional Difference Gel Electrophoresis
84 Citations (Scopus)

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells

Papoutsis, A. J., Lamore, S. D., Wondrak, G. T., Selmin, O. & Romagnolo, D., Sep 2010, In : Journal of Nutrition. 140, 9, p. 1607-1614 8 p.

Research output: Contribution to journalArticle

Aromatic Hydrocarbons
Epigenomics
Breast Neoplasms
DNA Breaks
Methyltransferases
89 Citations (Scopus)

The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells

Wondrak, G. T., Villeneuve, N. F., Lamore, S. D., Bause, A. S., Jiang, T. & Zhang, D., May 2010, In : Molecules. 15, 5, p. 3338-3355 18 p.

Research output: Contribution to journalArticle

Cinnamomum zeylanicum
antioxidants
aldehydes
HCT116 Cells
Colorectal Neoplasms
25 Citations (Scopus)

The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells

Lamore, S. D., Azimian, S., Horn, D., Anglin, B. L., Uchida, K., Cabello, C. M. & Wondrak, G. T., Dec 2 2010, In : Journal of Photochemistry and Photobiology B: Biology. 101, 3, p. 251-264 14 p.

Research output: Contribution to journalArticle

lysine
Malondialdehyde
Lysine
Skin
cells
37 Citations (Scopus)
Heat-Shock Response
Poly(ADP-ribose) Polymerases
DNA Damage
Skin
DNA
2009
30 Citations (Scopus)

Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1

Cabello, C. M., Bair, W. B., Bause, A. S. & Wondrak, G. T., Aug 15 2009, In : Biochemical Pharmacology. 78, 4, p. 344-354 11 p.

Research output: Contribution to journalArticle

2,6-Dichloroindophenol
Oxidation-Reduction
Cells
Cytotoxicity
Melanoma
3 Citations (Scopus)

More than skin deep: The human skin tissue equivalent as an advanced drug discovery tool

Bause, A. S., Lamore, S. D. & Wondrak, G. T., 2009, In : Frontiers in Drug Design and Discovery. 4, 1, p. 135-161 27 p.

Research output: Contribution to journalArticle

Drug Discovery
Skin
Pharmaceutical Preparations
Skin Pigmentation
Skin Care
316 Citations (Scopus)

Redox-directed cancer therapeutics: Molecular mechanisms and opportunities

Wondrak, G. T., Dec 1 2009, In : Antioxidants and Redox Signaling. 11, 12, p. 3013-3069 57 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Neoplasms
Therapeutics
Tumor Suppressor Genes
Oncogenes
101 Citations (Scopus)

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

Cabello, C. M., Bair, W. B., Lamore, S. D., Ley, S., Bause, A. S., Azimian, S. & Wondrak, G. T., Jan 15 2009, In : Free Radical Biology and Medicine. 46, 2, p. 220-231 12 p.

Research output: Contribution to journalArticle

Cinnamomum zeylanicum
Cell proliferation
Tumors
Melanoma
Cell Proliferation
39 Citations (Scopus)

The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A (p21) upregulation in human cancer cell lines

Cabello, C. M., Bair, W. B., Ley, S., Lamore, S. D., Azimian, S. & Wondrak, G. T., Apr 1 2009, In : Biochemical Pharmacology. 77, 7, p. 1125-1138 14 p.

Research output: Contribution to journalArticle

DNA Damage
Cytokinins
Up-Regulation
Adenosine Triphosphate
Cells
2008
69 Citations (Scopus)

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

Wondrak, G. T., Cabello, C. M., Villeneuve, N. F., Zhang, S., Ley, S., Li, Y., Sun, Z. & Zhang, D., Aug 15 2008, In : Free Radical Biology and Medicine. 45, 4, p. 385-395 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Skin
Oxidative Stress
Keratinocytes
Up-Regulation
456 Citations (Scopus)

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X. J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W. ., Wondrak, G. T., Wong, P. K. & Zhang, D., Jun 2008, In : Carcinogenesis. 29, 6, p. 1235-1243 9 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Pharmaceutical Preparations
Neoplasms
Transcription Factors
Antioxidant Response Elements
3 Citations (Scopus)

Reactivity-based drug discovery using vitamin B6-derived pharmacophores

Wondrak, G. T., 2008, In : Mini-Reviews in Medicinal Chemistry. 8, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

Vitamin B 6
Schiff Bases
Pathology
Drug Discovery
Metals
2007
93 Citations (Scopus)

Experimental therapeutics: Targeting the redox Achilles heel of cancer

Cabello, C. M., Bair, W. B. & Wondrak, G. T., Dec 12 2007, In : Current Opinion in Investigational Drugs. 8, 12, p. 1022-1037 16 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Reactive Oxygen Species
Neoplasms
Therapeutics
Antioxidants
35 Citations (Scopus)

Let the sun shine in: Mechanisms and potential for therapeutics in skin photodamage

Wondrak, G. T., May 2007, In : Current Opinion in Investigational Drugs. 8, 5, p. 390-400 11 p.

Research output: Contribution to journalArticle

Solar System
Skin
Oxidative Stress
Therapeutics
Heat-Shock Response
47 Citations (Scopus)
Cytotoxicity
Oxidation-Reduction
Lead compounds
Cells
Apoptosis