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19942019

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Article
2019

Repurposing the electron transfer reactant phenazine methosulfate (Pms) for the apoptotic elimination of malignant melanoma cells through induction of lethal oxidative and mitochondriotoxic stress

Hua, A. B., Justiniano, R., Perer, J., Park, S. L., Li, H., Cabello, C. M. & Wondrak, G. T., May 2019, In : Cancers. 11, 5, 590.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
2018

Parkinson's disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function, and autophagy

Teves, J. M. Y., Bhargava, V., Kirwan, K. R., Corenblum, M. J., Justiniano, R., Wondrak, G. T., Anandhan, A., Flores, A. J., Schipper, D. A., Khalpey, Z., Sligh, J. E., Curiel-Lewandrowski, C., Sherman, S. J. & Madhavan, L., Jan 12 2018, In : Frontiers in Neuroscience. 11, JAN, 737.

Research output: Contribution to journalArticle

17 Scopus citations

Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

Blohm-Mangone, K., Burkett, N. B., Tahsin, S., Myrdal, P. B., Aodah, A., Ho, B., Janda, J., McComas, M., Saboda, K., Roe, D., Dong, Z., Bode, A. M., Petricoin, E. F., Calvert, V. S., Curiel, C. N., Alberts, D. S., Wondrak, G. T. & Dickinson, S. E., May 1 2018, In : Cancer Prevention Research. 11, 5, p. 265-277 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Dickinson, S. E. & Wondrak, G. T., Jan 1 2018, In : Current Medicinal Chemistry. 25, 40, p. 5487-5502 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

de la Vega, M. R., Zhang, D. D. & Wondrak, G. T., Mar 27 2018, In : Frontiers in Pharmacology. 9, MAR, 287.

Research output: Contribution to journalArticle

6 Scopus citations
2017

A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin

Justiniano, R., Perer, J., Hua, A., Fazel, M., Krajisnik, A., Cabello, C. M. & Wondrak, G. T., Nov 1 2017, In : Photochemistry and Photobiology. 93, 6, p. 1472-1482 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

The B6-vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis

Justiniano, R., Williams, J. D., Perer, J., Hua, A., Lesson, J., Park, S. L. & Wondrak, G. T., 2017, (Accepted/In press) In : Photochemistry and Photobiology.

Research output: Contribution to journalArticle

7 Scopus citations
2016

An essential role of NRF2 in diabetic wound healing

Long, M., De La Vega, M. R., Wen, Q., Bharara, M., Jiang, T., Zhang, R., Zhou, S., Wong, P. K., Wondrak, G. T., Zheng, H. & Zhang, D., Mar 1 2016, In : Diabetes. 65, 3, p. 780-793 14 p.

Research output: Contribution to journalArticle

67 Scopus citations

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo De La Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. GN. & Zhang, D., Jan 5 2016, In : Scientific Reports. 6, 18760.

Research output: Contribution to journalArticle

27 Scopus citations

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

Janda, J., Burkett, N. B., Blohm-Mangone, K., Huang, V., Curiel, C. N., Alberts, D. S., Petricoin, E. F., Calvert, V. S., Einspahr, J. G., Dong, Z., Bode, A. M., Wondrak, G. T. & Dickinson, S. E., Nov 1 2016, In : Photochemistry and Photobiology. 92, 6, p. 816-825 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Long, M., Tao, S., De La Vega, M. R., Jiang, T., Wen, Q., Park, S. L., Zhang, D. & Wondrak, G. T., May 1 2015, In : Cancer Prevention Research. 8, 5, p. 444-454 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Preface

Wondrak, G. T., Jan 1 2015, In : Unknown Journal.

Research output: Contribution to journalArticle

1 Scopus citations

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

Tao, S., Park, S. L., De La Vega, M. R., Zhang, D. & Wondrak, G. T., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 690-700 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells

Davis, A. L., Qiao, S., Lesson, J. L., De La Vega, M. R., Park, S. L., Seanez, C. M., Gokhale, V., Cabello, C. M. & Wondrak, G. T., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1623-1638 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

The tryptophan-derived endogenous aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole is a nanomolar UVA photosensitizer in epidermal keratinocytes

Park, S. L., Justiniano, R., Williams, J. D., Cabello, C. M., Qiao, S. & Wondrak, G. T., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 6, p. 1649-1658 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams, J. D., Bermudez, Y., Park, S. L., Stratton, S. P., Uchida, K., Hurst, C. A. & Wondrak, G. T., Mar 5 2014, In : Journal of Photochemistry and Photobiology B: Biology. 132, p. 56-65 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

Whitman, S. A., Long, M., Wondrak, G. T., Zheng, H. & Zhang, D. D., Oct 15 2013, In : Experimental Cell Research. 319, 17, p. 2673-2683 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells

Davis, A. L., Cabello, C. M., Qiao, S., Azimian, S. & Wondrak, G. T., Feb 1 2013, In : International journal of molecular sciences. 14, 2, p. 4185-4202 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo

Tao, S., Zheng, Y., Lau, A., Jaramillo, M. C., Chau, B. T., Lantz, R. C., Wong, P. K., Wondrak, G. T. & Zhang, D. D., Nov 11 2013, In : Antioxidants and Redox Signaling. 19, 14, p. 1647-1661 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- And chemotherapy-induced cell death

Qiao, S., Tao, S., Rojo De La Vega, M., Park, S. L., Vonderfecht, A. A., Jacobs, S. L., Zhang, D. D. & Wondrak, G. T., Dec 1 2013, In : Autophagy. 9, 12, p. 2087-2102 16 p.

Research output: Contribution to journalArticle

38 Scopus citations

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Tao, S., Justiniano, R., Zhang, D. D. & Wondrak, G. T., Oct 1 2013, In : Redox Biology. 1, 1, p. 532-541 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
21 Scopus citations
2012
31 Scopus citations

D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis

Qiao, S., Cabello, C. M., Lamore, S. D., Lesson, J. L. & Wondrak, G. T., Oct 1 2012, In : Apoptosis. 17, 10, p. 1079-1094 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

Cabello, C. M., Lamore, S. D., Bair, W. B., Qiao, S., Azimian, S., Lesson, J. L. & Wondrak, G. T., Aug 1 2012, In : Investigational New Drugs. 30, 4, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes

Qiao, S., Lamore, S. D., Cabello, C. M., Lesson, J. L., Muñoz-Rodriguez, J. L. & Wondrak, G. T., May 1 2012, In : Biochemical Pharmacology. 83, 9, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Vitamin B6: Beyond coenzyme functions

Wondrak, G. T. & Jacobson, E. L., Jan 1 2012, In : Sub-cellular biochemistry. 56, p. 291-300 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma

Cabello, C. M., Lamore, S. D., Bair, W. B., Davis, A. L., Azimian, S. M. & Wondrak, G. T., Mar 1 2011, In : Free Radical Research. 45, 3, p. 276-292 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D. & Zhang, D. D., Nov 1 2011, In : Diabetes. 60, 11, p. 3055-3066 12 p.

Research output: Contribution to journalArticle

297 Scopus citations

Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

Lamore, S. D. & Wondrak, G. T., Oct 1 2011, In : Biometals. 24, 5, p. 875-890 16 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

GLO1 overexpression in human malignant melanoma

Bair, W. B., Cabello, C. M., Uchida, K., Bause, A. S. & Wondrak, G. T., Apr 1 2010, In : Melanoma Research. 20, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts

Lamore, S. D., Qiao, S., Horn, D. & Wondrak, G. T., Nov 1 2010, In : Photochemistry and Photobiology. 86, 6, p. 1307-1317 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells

Papoutsis, A. J., Lamore, S. D., Wondrak, G. T., Selmin, O. I. & Romagnolo, D. F., Sep 1 2010, In : Journal of Nutrition. 140, 9, p. 1607-1614 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells

Wondrak, G. T., Villeneuve, N. F., Lamore, S. D., Bause, A. S., Jiang, T. & Zhang, D. D., May 1 2010, In : Molecules. 15, 5, p. 3338-3355 18 p.

Research output: Contribution to journalArticle

90 Scopus citations

The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells

Lamore, S. D., Azimian, S., Horn, D., Anglin, B. L., Uchida, K., Cabello, C. M. & Wondrak, G. T., Dec 2 2010, In : Journal of Photochemistry and Photobiology B: Biology. 101, 3, p. 251-264 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
38 Scopus citations
2009

Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1

Cabello, C. M., Bair, W. B., Bause, A. S. & Wondrak, G. T., Aug 15 2009, In : Biochemical Pharmacology. 78, 4, p. 344-354 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

More than skin deep: The human skin tissue equivalent as an advanced drug discovery tool

Bause, A. S., Lamore, S. D. & Wondrak, G. T., Dec 1 2009, In : Frontiers in Drug Design and Discovery. 4, 1, p. 135-161 27 p.

Research output: Contribution to journalArticle

3 Scopus citations

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

Cabello, C. M., Bair, W. B., Lamore, S. D., Ley, S., Bause, A. S., Azimian, S. & Wondrak, G. T., Jan 15 2009, In : Free Radical Biology and Medicine. 46, 2, p. 220-231 12 p.

Research output: Contribution to journalArticle

103 Scopus citations

The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A (p21) upregulation in human cancer cell lines

Cabello, C. M., Bair, W. B., Ley, S., Lamore, S. D., Azimian, S. & Wondrak, G. T., Apr 1 2009, In : Biochemical Pharmacology. 77, 7, p. 1125-1138 14 p.

Research output: Contribution to journalArticle

41 Scopus citations
2008

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

Wondrak, G. T., Cabello, C. M., Villeneuve, N. F., Zhang, S., Ley, S., Li, Y., Sun, Z. & Zhang, D. D., Aug 15 2008, In : Free Radical Biology and Medicine. 45, 4, p. 385-395 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X. J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., Wong, P. K. & Zhang, D. D., Jun 1 2008, In : Carcinogenesis. 29, 6, p. 1235-1243 9 p.

Research output: Contribution to journalArticle

467 Scopus citations

Reactivity-based drug discovery using vitamin B6-derived pharmacophores

Wondrak, G. T., Aug 29 2008, In : Mini-Reviews in Medicinal Chemistry. 8, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2007
49 Scopus citations
2006

Antimelanoma activity of apoptogenic carbonyl scavengers

Wondrak, G. T., Jacobson, M. K. & Jacobson, E. L., Feb 1 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 2, p. 805-814 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Endogenous UVA-photosensitizers: Mediators of skin photodamage and novel targets for skin photoprotection

Wondrak, G. T., Jacobson, M. K. & Jacobson, E. L., Feb 7 2006, In : Photochemical and Photobiological Sciences. 5, 2, p. 215-237 23 p.

Research output: Contribution to journalArticle

253 Scopus citations
2005

Identification of quenchers of photoexcited states as novel agents for skin photoprotection

Wondrak, G. T., Jacobson, M. K. & Jacobson, E. L., Feb 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 482-491 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

3-Hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells

Wondrak, G. T., Roberts, M. J., Jacobson, M. K. & Jacobson, E. L., Jul 16 2004, In : Journal of Biological Chemistry. 279, 29, p. 30009-30020 12 p.

Research output: Contribution to journalArticle

54 Scopus citations