Research Output 1999 2018

  • 2215 Citations
  • 12 h-Index
  • 23 Article
  • 1 Chapter
2018

Study quiescence heterogeneity by coupling single-cell measurements and computer modeling

Kwon, J. S., Wang, X. & Yao, G. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1686, p. 287-299 13 p. (Methods in Molecular Biology; vol. 1686)

Research output: ResearchChapter

Gene Regulatory Networks
Computer Simulation
2017

Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

Kwon, J. S., Everetts, N. J., Wang, X., Wang, W., Della Croce, K., Xing, J. & Yao, G. Sep 26 2017 In : Cell Reports. 20, 13, p. 3223-3235 13 p.

Research output: Research - peer-reviewArticle

Switches
Retinoblastoma
Chemical activation
Growth
Network components
4 Citations

Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum

Dai, J., Miller, M. A., Everetts, N. J., Wang, X., Li, P., Li, Y., Xu, J. H. & Yao, G. 2017 In : Oncotarget. 8, 8, p. 13770-13781 12 p.

Research output: Research - peer-reviewArticle

Reishi
Neoplasms
Therapeutics
ergosterol-5,8-peroxide
Neoplastic Stem Cells
1 Citations

Exit from quiescence displays a memory of cell growth and division

Wang, X., Fujimaki, K., Mitchell, G. C., Kwon, J. S., Della Croce, K., Langsdorf, C., Zhang, H. H. & Yao, G. Dec 1 2017 In : Nature Communications. 8, 1, 321

Research output: Research - peer-reviewArticle

Cell growth
Data storage equipment
division
cells
Cell Division
2 Citations

Expression level is a key determinant of E2F1-mediated cell fate

Shats, I., Deng, M., Davidovich, A., Zhang, C., Kwon, J. S., Manandhar, D., Gordân, R., Yao, G. & You, L. Apr 1 2017 In : Cell Death and Differentiation. 24, 4, p. 626-637 12 p.

Research output: Research - peer-reviewArticle

Neoplasms
Apoptosis
Phenotype
Population
G2 Phase Cell Cycle Checkpoints
2016
2 Citations

Antitumor effects and mechanisms of Ganoderma extracts and spores oil

Chen, C., Li, P., Li, Y., Yao, G. & Xu, J. H. Nov 1 2016 In : Oncology Letters. 12, 5, p. 3571-3578 8 p.

Research output: Research - peer-reviewArticle

Ganoderma
Spores
Oils
Type II DNA Topoisomerase
Type I DNA Topoisomerase
2015
4 Citations

Ovarian serous carcinogenesis from tubal secretory cells

Zhang, W., Wei, L., Li, L., Yang, B., Kong, B., Yao, G. & Zheng, W. Nov 1 2015 In : Histology and Histopathology. 30, 11, p. 1295-1302 8 p.

Research output: Research - peer-reviewArticle

Ovarian Neoplasms
Carcinogenesis
Fallopian Tubes
Pathologic Processes
Cause of Death
2014
3 Citations

IMP3 signatures of fallopian tube: A risk for pelvic serous cancers

Wang, Y., Wang, Y., Li, D., Li, L., Zhang, W., Yao, G., Jiang, Z. & Zheng, W. Jul 12 2014 In : Journal of Hematology and Oncology. 7, 1, 49

Research output: Research - peer-reviewArticle

Pelvic Neoplasms
Fallopian Tubes
Carcinoma
Carcinogenesis
Mucous Membrane
2 Citations

Linear population allocation by bistable switches in response to transient stimulation

Srimani, J. K., Yao, G., Neu, J., Tanouchi, Y., Lee, T. J. & You, L. Aug 20 2014 In : PLoS One. 9, 8, e105408

Research output: Research - peer-reviewArticle

Switches
Population
duration
Computer simulation
cells
18 Citations

Modelling mammalian cellular quiescence

Yao, G. 2014 In : Interface Focus. 4, 3

Research output: Research - peer-reviewArticle

Switches
Mammals
Lymphocytes
Cell proliferation
Fibroblasts

Systematic reverse engineering of network topologies: A case study of resettable bistable cellular responses

Mondal, D., Dougherty, E., Mukhopadhyay, A., Carbo, A., Yao, G. & Xing, J. Aug 29 2014 In : PLoS One. 9, 8, e105833

Research output: Research - peer-reviewArticle

topology
engineering
case studies
Reverse engineering
Topology
2011
57 Citations

Origin of bistability underlying mammalian cell cycle entry

Yao, G., Tan, C., West, M., Nevins, J. R. & You, L. 2011 In : Molecular Systems Biology. 7, 485

Research output: Research - peer-reviewArticle

Bistability
Cell Cycle
Gene Regulatory Networks
Cell Cycle Checkpoints
Homeostasis
1 Citations

Using noisy gene expression mediated by engineered adenovirus to probe signaling dynamics in mammalian cells

Wong, J. V., Yao, G., Nevins, J. R. & You, L. 2011 In : Methods in Enzymology. 497, p. 221-237 17 p.

Research output: Research - peer-reviewArticle

Cell Physiological Phenomena
Adenoviridae
Cell Biology
Cell Survival
Pharmacology
30 Citations

Viral-Mediated Noisy Gene Expression Reveals Biphasic E2f1 Response to MYC

Wong, J. V., Yao, G., Nevins, J. R. & You, L. Feb 4 2011 In : Molecular Cell. 41, 3, p. 275-285 11 p.

Research output: Research - peer-reviewArticle

Gene Expression
Serum
Gene Expression Regulation
MicroRNAs
Noise
2010
25 Citations

Stochastic E2F activation and Reconciliation of phenomenological Cell-Cycle Models

Lee, T. J., Yao, G., Bennett, D. C., Nevins, J. R. & You, L. Sep 2010 In : PLoS Biology. 8, 9, e1000488

Research output: Research - peer-reviewArticle

Chemical activation
Cells
Cell Cycle
Growth
cell cycle
2009
110 Citations

Anchorage-independent cell growth signature identifies tumors with metastatic potential

Mori, S., Chang, J. T., Andrechek, E. R., Matsumura, N., Baba, T., Yao, G., Kim, J. W., Gatza, M., Murphy, S. & Nevins, J. R. Aug 6 2009 In : Oncogene. 28, 31, p. 2796-2805 10 p.

Research output: Research - peer-reviewArticle

Growth
Neoplasms
Phenotype
In Vitro Techniques
Oligonucleotide Array Sequence Analysis
2008
184 Citations

A bistable Rb-E2F switch underlies the restriction point

Yao, G., Lee, T. J., Mori, S., Nevins, J. R. & You, L. 2008 In : Nature Cell Biology. 10, 4, p. 476-482 7 p.

Research output: Research - peer-reviewArticle

Serum
Cell Cycle
Homeostasis
Growth
Neoplasms
29 Citations

Sensing and integration of Erk and PI3K signals by Myc

Lee, T., Yao, G., Nevins, J. & You, L. Feb 2008 In : PLoS Computational Biology. 4, 2

Research output: Research - peer-reviewArticle

phosphatidylinositol 3-kinase
mitogen-activated protein kinase
proteins
Phosphatidylinositol 3-Kinase
Extracellular Signal-Regulated MAP Kinases
38 Citations

Utilization of pathway signatures to reveal distinct types of B lymphoma in the Eμ-myc model and human diffuse large B-cell lymphoma

Mori, S., Rempel, R. E., Chang, J. T., Yao, G., Lagoo, A. S., Potti, A., Bild, A. & Nevins, J. R. Oct 15 2008 In : Cancer Research. 68, 20, p. 8525-8534 10 p.

Research output: Research - peer-reviewArticle

Lymphoma, Large B-Cell, Diffuse
Lymphoma
Gene Expression
Neoplasms
Burkitt Lymphoma
2006
1319 Citations

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Bild, A. H., Yao, G., Chang, J. T., Wang, Q., Potti, A., Chasse, D., Joshi, M. B., Harpole, D., Lancaster, J. M., Berchuck, A., Olson, J. A., Marks, J. R., Dressman, H. K., West, M. & Nevins, J. R. Jan 19 2006 In : Nature. 439, 7074, p. 353-357 5 p.

Research output: Research - peer-reviewArticle

Neoplasms
Therapeutics
Transcriptome
Neoplasm Genes
Therapeutic Uses
2005

DIG - A system for gene annotation and functional discovery

DeLong, M., Yao, G., Wang, Q., Dobra, A., Black, E. P., Chang, J. T., Bild, A., West, M., Nevins, J. R. & Dressman, H. Jul 1 2005 In : Bioinformatics. 21, 13, p. 2957-2959 3 p.

Research output: Research - peer-reviewArticle

Genomics
Annotation
Gene
Molecular Sequence Annotation
Genes
2004
19 Citations

Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor

Yao, G., Craven, M., Drinkwater, N. & Bradfield, C. A. 2004 In : PLoS Biology. 2, 3

Research output: Research - peer-reviewArticle

Aryl Hydrocarbon Receptors
Vertebrates
Yeasts
hydrocarbons
vertebrates
221 Citations

Sparse graphical models for exploring gene expression data

Dobra, A., Hans, C., Jones, B., Nevins, J. R., Yao, G. & West, M. Jul 2004 In : Journal of Multivariate Analysis. 90, 1 SPEC. ISS., p. 196-212 17 p.

Research output: Research - peer-reviewArticle

Graphical Models
Gene Expression Data
Pathway
Graphical models
Gene expression
1999
146 Citations

Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways: Demonstration of competition and compensation

Chan, W. K., Yao, G., Gu, Y. Z. & Bradfield, C. A. Apr 23 1999 In : Journal of Biological Chemistry. 274, 17, p. 12115-12123 9 p.

Research output: Research - peer-reviewArticle

Aryl Hydrocarbon Receptors
Demonstrations
Compensation and Redress
Hypoxia
Dioxins