Heddwen L Brooks

  • 2187 Citations
  • 26 h-Index
20002019

Research output per year

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Research Output

  • 2187 Citations
  • 26 h-Index
  • 45 Article
  • 4 Review article
  • 1 Chapter
  • 1 Conference contribution
2019

Menopause and foxp3 treg cell depletion eliminate female protection against t cell-mediated angiotensin ii hypertension

Pollow, D. P., Uhlorn, J. A., Sylvester, M. A., Romero-Aleshire, M. J., Uhrlaub, J. L., Lindsey, M. L., Nikolich-Zugich, J. & Brooks, H. L., Aug 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 2, p. H415-H423

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of postmenopausal hypertension

Pollow, D. P., Uhlorn, J., Husband, N. & Brooks, H. L., Jan 1 2019, Sex Differences in Cardiovascular Physiology and Pathophysiology. Elsevier, p. 105-118 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sex-Specific Mechanisms in Inflammation and Hypertension

Sylvester, M. A. & Brooks, H. L., Jul 1 2019, In : Current Hypertension Reports. 21, 7, 53.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Classification of primary cilia in microscopy images using convolutional neural random forests

Ram, S., Majdi, M. S., Rodriguez, J. J., Gao, Y. & Brooks, H. L., Sep 21 2018, 2018 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 89-92 4 p. 8470320. (Proceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation; vol. 2018-April).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Guidelines for authors and reviewers on antibody use in physiology studies

Brooks, H. L. & Lindsey, M. L., Apr 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 4, p. H724-H732

Research output: Contribution to journalReview article

29 Scopus citations

N-acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses

Small, D. M., Sanchez, W. Y., Roy, S. F., Morais, C., Brooks, H. L., Coombes, J. S., Johnson, D. W. & Gobe, G. C., Jan 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F956-F968

Research output: Contribution to journalArticle

3 Scopus citations

Renoprotective impact of estrogen receptor-α and its splice variants in female mice with type 1 diabetes

Irsik, D. L., Romero-Aleshire, M. J., Chavez, E. M., Fallet, R. W., Brooks, H. L., Carmines, P. K. & Lane, P. H., Sep 1 2018, In : American Journal of Physiology - Renal Physiology. 315, 3, p. F512-F520

Research output: Contribution to journalArticle

2 Scopus citations
2017

Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus

Poulsen, S. B., Kristensen, T. B., Brooks, H. L., Kohan, D. E., Rieg, T. & Fenton, R. A., Apr 6 2017, In : JCI Insight. 2, 7, p. e91042

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Early retinal neuronal dysfunction in diabetic mice: Reduced light-evoked inhibition increases rod pathway signaling

Moore-Dotson, J. M., Beckman, J. J., Mazade, R. E., Hoon, M., Bernstein, A. S., Romero-Aleshire, M. J., Brooks, H. L. & Eggers, E. D., Mar 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 3, p. 1418-1430 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome

Brooks, H. L., Pollow, D. P. & Hoyer, P. B., Jul 1 2016, In : Physiology. 31, 4, p. 250-257 8 p.

Research output: Contribution to journalReview article

19 Scopus citations
2015
13 Scopus citations

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

Goldberg, E. L., Romero-Aleshire, M. J., Renkema, K. R., Ventevogel, M. S., Chew, W. M., Uhrlaub, J. L., Smithey, M. J., Limesand, K. H., Sempowski, G. D., Brooks, H. L. & Nikolich-Žugich, J., Feb 1 2015, In : Aging Cell. 14, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2014

A method to study the impact of chemically-induced ovarian failure on exercise capacity and cardiac adaptation in mice

Chen, H., Perez, J. N., Constantopoulos, E., McKee, L., Regan, J., Hoyer, P. B., Brooks, H. L. & Konhilas, J., 2014, In : Journal of Visualized Experiments. 86

Research output: Contribution to journalArticle

4 Scopus citations

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

Kusne, Y., Goldberg, E. L., Parker, S. S., Hapak, S. M., Maskaykina, I. Y., Chew, W. M., Limesand, K. H., Brooks, H. L., Price, T. J., Sanai, N., Nikolich-Zugich, J. & Ghosh, S., Feb 2014, In : Age. 36, 1, p. 199-212 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Sex differences in T-lymphocyte tissue infiltration and development of Angiotensin II Hypertension

Pollow, D. P., Uhrlaub, J., Romero-Aleshire, M. J., Sandberg, K., Nikolich-Zugich, J., Brooks, H. L. & Hay, M., Aug 2014, In : Hypertension. 64, 2, p. 384-390 7 p.

Research output: Contribution to journalArticle

75 Scopus citations
2013

Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells

Gao, Y., Romero-Aleshire, M. J., Cai, Q., Price, T. J. & Brooks, H. L., Oct 15 2013, In : American Journal of Physiology - Renal Physiology. 305, 8, p. F1201-F1208

Research output: Contribution to journalArticle

13 Scopus citations
2011

Midkine, a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause

Diamond-Stanic, M. K., Romero-Aleshire, M. J., Hoyer, P. B., Greer, K., Hoying, J. B. & Brooks, H. L., Jan 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 1, p. F139-F146

Research output: Contribution to journalArticle

11 Scopus citations
11 Scopus citations
2010

Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect

Cai, Q., Nelson, S. K., McReynolds, M. R., Diamond-Stanic, M. K., Elliott, D. & Brooks, H. L., Oct 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 4, p. F712-F719

Research output: Contribution to journalArticle

14 Scopus citations
2009
42 Scopus citations

Steroidogenic capacity of residual ovarian tissue in 4-vinylcyclohexene diepoxide- treated mice

Rivera, Z., Christian, P. J., Marion, S. L., Brooks, H. L. & Hoyer, P. B., Feb 1 2009, In : Biology of reproduction. 80, 2, p. 328-336 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats

Fernandez, S. M., Keating, A. F., Christian, P. J., Sen, N., Hoying, J. B., Brooks, H. L. & Hoyer, P. B., Aug 1 2008, In : Biology of reproduction. 79, 2, p. 318-327 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2007

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct

Carmosino, M., Brooks, H. L., Cai, Q., Davis, L. S., Opalenik, S., Hao, C. & Breyer, M. D., Jan 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 1, p. F351-F360

Research output: Contribution to journalArticle

38 Scopus citations

Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause

Keck, M., Romero-Aleshire, M. J., Cai, Q., Hoyer, P. B. & Brooks, H. L., Jul 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 1, p. F193-F199

Research output: Contribution to journalArticle

39 Scopus citations

Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: Contribution of hyperglycaemia and matrix metalloproteinases

Hawkins, B. T., Lundeen, T. F., Norwood, K. M., Brooks, H. L. & Egleton, R. D., Jan 1 2007, In : Diabetologia. 50, 1, p. 202-211 10 p.

Research output: Contribution to journalArticle

189 Scopus citations

Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic

Pysher, M. D., Sollome, J. J., Regan, S., Cardinal, T. R., Hoying, J. B., Brooks, H. L. & Vaillancourt, R. R., Oct 1 2007, In : Toxicology and Applied Pharmacology. 224, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia

Kim, D., Wang, M., Cai, Q., Brooks, H. & Dressler, G. R., May 1 2007, In : Journal of the American Society of Nephrology. 18, 5, p. 1458-1465 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes

Chakraborty, A., Brooks, H., Zhang, P., Smith, W., McReynolds, M. R., Hoying, J. B., Bick, R., Truong, L., Poindexter, B., Lan, H., Elbjeirami, W. & Sheikh-Hamad, D., Feb 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 2, p. F895-F904

Research output: Contribution to journalArticle

44 Scopus citations

Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice

Cai, Q., McReynolds, M. R., Keck, M., Greer, K. A., Hoying, J. B. & Brooks, H. L., Dec 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 6, p. F1858-F1864

Research output: Contribution to journalArticle

19 Scopus citations
2006

CARMA: A platform for analyzing microarray datasets that incorporate replicate measures

Greer, K. A., McReynolds, M. R., Brooks, H. L. & Hoying, J. B., Mar 17 2006, In : BMC bioinformatics. 7, 149.

Research output: Contribution to journalArticle

16 Scopus citations
11 Scopus citations

Effects of water restriction on gene expression in mouse renal medulla: Identification of 3βHSD4 as a collecting duct protein

Cai, Q., Keck, M., McReynolds, M. R., Klein, J. D., Greer, K., Sharma, K., Hoying, J. B., Sands, J. M. & Brooks, H. L., Jun 30 2006, In : American Journal of Physiology - Renal Physiology. 291, 1, p. F218-F224

Research output: Contribution to journalArticle

11 Scopus citations
2005

Altered expression of selected genes in kidney of rats with lithium-induced NDI

Rojek, A., Nielsen, J., Brooks, H. L., Gong, H., Kim, Y. H., Kwon, T. H., Frøkiær, J. & Nielsen, S., Jun 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 6 57-6, p. F1276-F1289

Research output: Contribution to journalArticle

44 Scopus citations

Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice

Morris, R. G., Uchida, S., Brooks, H., Knepper, M. A. & Chou, C. L., Jul 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 1 58-1, p. F194-F199

Research output: Contribution to journalArticle

16 Scopus citations

Developmental expression of glucokinase in rat hypothalamus

Sutherland, V. L., McReynolds, M., Tompkins, L. S., Brooks, H. L. & Lynch, R. M., Feb 8 2005, In : Developmental Brain Research. 154, 2, p. 255-258 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance

Cai, Q., Dmitrieva, N. I., Ferraris, J. D., Brooks, H. L., Van Balkom, B. W. M. & Burg, M., Jan 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 2, p. 503-508 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Renal medullary gene expression in aquaporin-1 null mice

McReynolds, M. R., Taylor-Garcia, K. M., Greer, K. A., Hoying, J. B. & Brooks, H. L., Feb 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 2 57-2, p. F315-F321

Research output: Contribution to journalArticle

29 Scopus citations
2003

cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion

Brooks, H. L., Ageloff, S., Kwon, T. H., Brandt, W., Terris, J. M., Seth, A., Michea, L., Nielsen, S., Fenton, R. & Knepper, M. A., Jan 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 1 53-1, p. F218-F228

Research output: Contribution to journalArticle

70 Scopus citations

Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats

Zhang, Z., Ferraris, J. D., Brooks, H. L., Brisc, I. & Burg, M. B., Oct 1 2003, In : American Journal of Physiology - Renal Physiology. 285, 4 54-4, p. F688-F693

Research output: Contribution to journalArticle

46 Scopus citations

Long-term regulation of ENaC expression in kidney by angiotensin II

Beutler, K. T., Masilamani, S., Turban, S., Nielsen, J., Brooks, H. L., Ageloff, S., Fenton, R. A., Packer, R. K. & Knepper, M. A., May 1 2003, In : Hypertension. 41, 5, p. 1143-1150 8 p.

Research output: Contribution to journalArticle

126 Scopus citations
2002

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene

Takahashi, N., Brooks, H. L., Wade, J. B., Liu, W., Kondo, Y., Ito, S., Knepper, M. A. & Smithies, O., Mar 11 2002, In : Journal of the American Society of Nephrology. 13, 3, p. 604-610 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeted proteomic profiling of renal Na+ transporter and channel abundances in angiotensin II type 1a receptor knockout mice

Brooks, H. L., Allred, A. J., Beutler, K. T., Coffman, T. M. & Knepper, M. A., Mar 4 2002, In : Hypertension. 39, 2 II, p. 470-473 4 p.

Research output: Contribution to journalArticle

69 Scopus citations

Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction

Masilamani, S., Wang, X., Kim, G. H., Brooks, H., Nielsen, J., Nielsen, S., Nakamura, K., Stokes, J. B. & Knepper, M. A., Oct 1 2002, In : American Journal of Physiology - Renal Physiology. 283, 4 52-4, p. F648-F657

Research output: Contribution to journalArticle

106 Scopus citations
2001

Immunocytochemical and immunoelectron microscopic localization of α-, β-, and γ-ENaC in rat kidney

Hager, H., Kwon, T. H., Vinnikova, A. K., Masilamani, S., Brooks, H. L., Frøkiaer, J., Knepper, M. A. & Nielsen, S., Jul 4 2001, In : American Journal of Physiology - Renal Physiology. 280, 6 49-6, p. F1093-F1106

Research output: Contribution to journalArticle

149 Scopus citations

Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics

Brooks, H. L., Sorensen, A. M., Terris, J., Schultheis, P. J., Lorenz, J. N., Shull, G. E. & Knepper, M. A., Feb 1 2001, In : Journal of Physiology. 530, 3, p. 359-366 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney

Knepper, M. A. & Brooks, H. L., Sep 5 2001, In : Current Opinion in Nephrology and Hypertension. 10, 5, p. 655-659 5 p.

Research output: Contribution to journalReview article

42 Scopus citations

The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon

Wang, X. Y., Masilamani, S., Nielsen, J., Kwon, T. H., Brooks, H. L., Nielsen, S. & Knepper, M. A., Jan 1 2001, In : Journal of Clinical Investigation. 108, 2, p. 215-222 8 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
2000

Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

Ho, H. T. B., Chung, S. K., Law, J. W. S., Ko, B. C. B., Tam, S. C. F., Brooks, H. L., Knepper, M. A. & Chung, S. S. M., Aug 21 2000, In : Molecular and cellular biology. 20, 16, p. 5840-5846 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Cloned human aquaporin-1 is a cyclic GMP-gated ion channel

Anthony, T. L., Brooks, H. L., Boassa, D., Leonov, S., Yanochko, G. M., Regan, J. W. & Yool, A. J., Jan 1 2000, In : Molecular pharmacology. 57, 3, p. 576-588 13 p.

Research output: Contribution to journalArticle

120 Scopus citations

Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop E pore region

Brooks, H. L., Regan, J. W. & Yool, A. J., May 22 2000, In : Molecular pharmacology. 57, 5, p. 1021-1026 6 p.

Research output: Contribution to journalArticle

113 Scopus citations