No photo of Hendrikus "Henk" Granzier

View Scopus Profile

Hendrikus "Henk" Granzier

  • 14752 Citations
  • 66 h-Index
1983 …2019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Dive into the research topics where Hendrikus "Henk" Granzier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Connectin Medicine & Life Sciences
Sarcomeres Medicine & Life Sciences
Muscles Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences
Muscle Chemical Compounds
Myocardium Medicine & Life Sciences
Nemaline Myopathies Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1995 2018

Role of the giant protein titin in cardiac health and disease

Granzier, H. ".

Project: Research project

Titin in Skeletal Muscle Health and Disease

Granzier, H. ".

Project: Research project

Myofilament-based mechanisms of diastolic dysfunction in HFpEF

Granzier, H. ". & Lewinter, M.

National Institutes of Health

9/1/14 → 6/30/18

Project: Research project

Myofibrils
Connectin
Heart Failure
Troponin I
Phosphorylation

Titin-based adaptations of cardiac function

Granzier, H. ".

National Institutes of Health

3/1/13 → 1/31/17

Project: Research project

Connectin
Protein Isoforms
Starlings
Hypertrophy
Extracellular Matrix

Role of the Giant Protein Titin in Skeletal Muscle Structure and Function

Granzier, H. ".

National Institutes of Health

4/1/11 → 2/29/16

Project: Research project

Connectin
Skeletal Muscle
Muscles
Proteins
Hypertrophy

Research Output 1983 2019

3 Citations (Scopus)

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Meurs, K. M., Friedenberg, S. G., Kolb, J., Saripalli, C., Tonino, P., Woodruff, K., Olby, N. J., Keene, B. W., Adin, D. B., Yost, O. L., DeFrancesco, T. C., Lahmers, S., Tou, S., Shelton, G. D. & Granzier, H. H., Jan 1 2019, In : Human Genetics.

Research output: Contribution to journal › Article

Connectin
Sudden Cardiac Death
Dogs
Dilated Cardiomyopathy
Genetic Heterogeneity
2 Citations (Scopus)

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Radke, M. H., Polack, C., Methawasin, M., Fink, C., Granzier, H. H. & Gotthardt, M., Apr 9 2019, In : Circulation. 139, 15, p. 1813-1827 15 p.

Research output: Contribution to journal › Article

Connectin
Phenotype
Sarcomeres
Striated Muscle
Dilated Cardiomyopathy
1 Citation (Scopus)

Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy

Li, F., Barton, E. R. & Granzier, H. H., May 15 2019, In : Human molecular genetics. 28, 10, p. 1709-1725 17 p.

Research output: Contribution to journal › Article

Nemaline Myopathies
Muscular Diseases
Insulin-Like Growth Factor I
Muscles
Serine
1 Citation (Scopus)

Diaphragm contractile weakness due to reduced mechanical loading: role of titin

van der Pijl, R. J., Granzier, H. H. & Ottenheijm, C. A. C., Aug 1 2019, In : American journal of physiology. Cell physiology. 317, 2, p. C167-C176

Research output: Contribution to journal › Article

Connectin
Diaphragm
Sarcomeres
Muscle Proteins
Muscles

Fine mapping titin's C-zone: Matching cardiac myosin-binding protein C stripes with titin's super-repeats

Tonino, P., Kiss, B., Gohlke, J., Smith, J. E. & Granzier, H. H., Aug 1 2019, In : Journal of Molecular and Cellular Cardiology. 133, p. 47-56 10 p.

Research output: Contribution to journal › Article

Open Access
Cardiac Myosins
Connectin
myosin-binding protein C
Sarcomeres
Immunoelectron Microscopy