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Hendrikus "Henk" Granzier

  • 15186 Citations
  • 67 h-Index
1983 …2020
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Fingerprint Dive into the research topics where Hendrikus "Henk" Granzier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Connectin Medicine & Life Sciences
Sarcomeres Medicine & Life Sciences
Muscles Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Nemaline Myopathies Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences
Muscle Chemical Compounds
Myocardium Medicine & Life Sciences

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Projects 1995 2018

Titin in Skeletal Muscle Health and Disease

Granzier, H. ".

Project: Research project

Role of the giant protein titin in cardiac health and disease

Granzier, H. ".

Project: Research project

Myofilament-based mechanisms of diastolic dysfunction in HFpEF

Granzier, H. ". & Lewinter, M.

National Institutes of Health

9/1/14 → 6/30/18

Project: Research project

Myofibrils
Connectin
Heart Failure
Troponin I
Phosphorylation

Titin-based adaptations of cardiac function

Granzier, H. ".

National Institutes of Health

3/1/13 → 1/31/17

Project: Research project

Connectin
Protein Isoforms
Starlings
Hypertrophy
Extracellular Matrix

Role of the Giant Protein Titin in Skeletal Muscle Structure and Function

Granzier, H. ".

National Institutes of Health

4/1/11 → 2/29/16

Project: Research project

Connectin
Skeletal Muscle
Muscles
Proteins
Hypertrophy

Research Output 1983 2020

Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: Effects on muscle structure and function

Li, F., Kolb, J., Crudele, J., Hourani, Z., Smith, J. E., Chamberlain, J. S. & Granzier, H., Jan 28 2020, In : Skeletal Muscle. 10, 1, 2.

Research output: Contribution to journal › Article

Open Access
Muscles
Nemaline Myopathies
nebulin
Sarcomeres
Intramuscular Injections

In vivo characterization of skeletal muscle function in nebulin-deficient mice

Gineste, C., Ogier, A. C., Varlet, I., Hourani, Z., Bernard, M., Granzier, H., Bendahan, D. & Gondin, J., Mar 1 2020, In : Muscle and Nerve. 61, 3, p. 416-424 9 p.

Research output: Contribution to journal › Article

Skeletal Muscle
Knockout Mice
Muscles
Myosin Heavy Chains
Muscle Weakness
3 Citations (Scopus)

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Meurs, K. M., Friedenberg, S. G., Kolb, J., Saripalli, C., Tonino, P., Woodruff, K., Olby, N. J., Keene, B. W., Adin, D. B., Yost, O. L., DeFrancesco, T. C., Lahmers, S., Tou, S., Shelton, G. D. & Granzier, H. H., Jan 1 2019, In : Human Genetics.

Research output: Contribution to journal › Article

Connectin
Sudden Cardiac Death
Dogs
Dilated Cardiomyopathy
Genetic Heterogeneity
2 Citations (Scopus)

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Radke, M. H., Polack, C., Methawasin, M., Fink, C., Granzier, H. H. & Gotthardt, M., Apr 9 2019, In : Circulation. 139, 15, p. 1813-1827 15 p.

Research output: Contribution to journal › Article

Connectin
Phenotype
Sarcomeres
Striated Muscle
Dilated Cardiomyopathy
3 Citations (Scopus)

Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy

Li, F., Barton, E. R. & Granzier, H. H., May 15 2019, In : Human molecular genetics. 28, 10, p. 1709-1725 17 p.

Research output: Contribution to journal › Article

Nemaline Myopathies
Muscular Diseases
Insulin-Like Growth Factor I
Muscles
Serine