Hendrikus "Henk" Granzier

  • 13557 Citations
  • 64 h-Index
1983 …2018
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Research Output 1983 2018

  • 13557 Citations
  • 64 h-Index
  • 215 Article
  • 2 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2018
5 Citations

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Jeong, M. Y., Lin, Y. H., Wennersten, S. A., Demos-Davies, K. M., Cavasin, M. A., Mahaffey, J. H., Monzani, V., Saripalli, C., Mascagni, P., Reece, T. B., Ambardekar, A. V., Granzier, H. L., Dinarello, C. A. & McKinsey, T. A., Feb 7 2018, In : Science Translational Medicine. 10, 427, eaao0144

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Myofibrils
Left Ventricular Dysfunction
Treatment Failure
1 Citations

Positive end-expiratory pressure ventilation induces longitudinal atrophy in diaphragm fibers

Lindqvist, J., Van Den Berg, M., Van Der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., De Waard, M., Girbes, A., Spoelstra-De Man, A., Shi, Z. H., Van Den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., Aug 15 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 14 p.

Research output: Contribution to journalArticle

Positive-Pressure Respiration
Diaphragm
Atrophy
Connectin
Critical Illness

Thick-Filament Extensibility in Intact Skeletal Muscle

Ma, W., Gong, H., Kiss, B., Lee, E. J., Granzier, H. & Irving, T., Jan 1 2018, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

Myosins
Skeletal Muscle
Periodicity
Connectin
Calcium
1 Citations

Titin-based mechanosensing modulates muscle hypertrophy

van der Pijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H. & Ottenheijm, C., Jan 1 2018, (Accepted/In press) In : Journal of Cachexia, Sarcopenia and Muscle.

Research output: Contribution to journalArticle

Connectin
Hypertrophy
Muscles
Denervation
Diaphragm
2017
10 Citations

219th ENMC International Workshop Titinopathies International database of titin mutations and phenotypes, Heemskerk, The Netherlands, 29 April–1 May 2016

Titinopathy Database Consortium, Apr 1 2017, In : Neuromuscular Disorders. 27, 4, p. 396-407 12 p.

Research output: Contribution to journalArticle

1 Citations

Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction

Slater, R. E., Strom, J. G. & Granzier, H., Jul 1 2017, In : Journal of Molecular and Cellular Cardiology. 108, p. 24-33 10 p.

Research output: Contribution to journalArticle

Connectin
Exercise
ivabradine
Heart Rate
Phosphorylation
1 Citations

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

Joureau, B., de Winter, J. M., Stam, K., Granzier, H. & Ottenheijm, C. A. C., Jan 1 2017, In : Neuromuscular Disorders. 27, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Muscle Weakness
Diaphragm
Skeletal Muscle
Muscles
4 Citations

The giant protein titin regulates the length of the striated muscle thick filament

Tonino, P., Kiss, B., Strom, J., Methawasin, M., Smith, J. E., Kolb, J., Labeit, S. & Granzier, H., Dec 1 2017, In : Nature Communications. 8, 1, 1041

Research output: Contribution to journalArticle

Connectin
skeletal muscle
Striated Muscle
muscles
Muscle
2016
6 Citations

Alternative splicing of titin restores diastolic function in an HFpEF-like genetic murine model (Ttn ΔIAjxn)

Bull, M., Methawasin, M., Strom, J., Nair, P., Hutchinson, K. & Granzier, H., Sep 2 2016, In : Circulation Research. 119, 6, p. 764-772 9 p.

Research output: Contribution to journalArticle

Connectin
Genetic Models
Alternative Splicing
Heart Failure
Protein Isoforms
5 Citations

Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy

Evans, J. M., Cox, M. L., Huska, J., Li, F., Gaitero, L., Guo, L. T., Casal, M. L., Granzier, H. L., Shelton, G. D. & Clark, L. A., May 23 2016, (Accepted/In press) In : Mammalian Genome. p. 1-8 8 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Exome
Nonsense Codon
Dogs
Muscular Diseases
19 Citations

Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure with Preserved Ejection Fraction

Methawasin, M., Strom, J. G., Slater, R. E., Fernandez, V., Saripalli, C. & Granzier, H., Oct 11 2016, In : Circulation. 134, 15, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

Connectin
Compliance
Heart Failure
Desoxycorticosterone
Constriction
2 Citations

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: The cardiomyopathy-linked mutation T2580I

Bogomolovas, J., Fleming, J. R., Anderson, B. R., Williams, R., Lange, S., Simon, B., Khan, M. M., Rudolf, R., Franke, B., Bullard, B., Rigden, D. J., Granzier, H., Labeit, S. & Mayans, O., Sep 1 2016, In : Open Biology. 6, 9, 160114

Research output: Contribution to journalArticle

Connectin
Polymorphism
Cardiomyopathies
Single Nucleotide Polymorphism
Nucleotides
1 Citations

Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice

Pulcastro, H. C., Awinda, P. O., Methawasin, M., Granzier, H., Dong, W. & Tanner, B. C. W., Jul 29 2016, In : Frontiers in Physiology. 7, JUL, 322

Research output: Contribution to journalArticle

Connectin
Sarcomeres
Compliance
Myocardium
Myosins
11 Citations

Mutation-specific effects on thin filament length in thin filament myopathy

Winter, J. M. D. , Joureau, B. , Lee, E. J. , Kiss, B. , Yuen, M. , Gupta, V. A. , Pappas, C. T. , Gregorio, C. C. , Stienen, G. J. M. , Edvardson, S. , Wallgren-Pettersson, C. , Lehtokari, V. L. , Pelin, K. , Malfatti, E. , Romero, N. B. , Engelen, B. G. V. , Voermans, N. C. , Donkervoort, S. , Bönnemann, C. G. , Clarke, N. F. & 3 others Beggs, A. H., Granzier, H. & Ottenheijm, C. A. C., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Muscular Diseases
Sarcomeres
Mutation
Muscles
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
7 Citations

Reduced passive force in skeletal muscles lacking protein arginylation

Leite, F. S., Minozzo, F. C., Kalganov, A., Cornachione, A. S., Cheng, Y. S., Leu, N. A., Han, X., Saripalli, C., Yates, J. R., Granzier, H., Kashina, A. S. & Rassier, D. E., Jan 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 2, p. C127-C135

Research output: Contribution to journalArticle

Connectin
Muscle Proteins
arginyltransferase
Skeletal Muscle
Myofibrils
11 Citations

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Hinze, F., Dieterich, C., Radke, M. H., Granzier, H. & Gotthardt, M., Dec 1 2016, In : Journal of Molecular Medicine. 94, 12, p. 1349-1358 10 p.

Research output: Contribution to journalArticle

Connectin
Atrophy
Protein Isoforms
Hypertrophy
Diastole
7 Citations

Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats

Kovács, Á., Fülöp, G., Kovács, A., Csípő, T., Bódi, B., Priksz, D., Juhász, B., Beke, L., Hendrik, Z., Méhes, G., Granzier, H. L., Édes, I., Fagyas, M., Papp, Z., Barta, J. & Tóth, A., Jun 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 11, p. H1671-H1682

Research output: Contribution to journalArticle

Connectin
Renin
Body Weight
Blood Pressure
Cardiac Myocytes
3 Citations

Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice

Birch, C. L., Behunin, S. M., Lopez-Pier, M. A., Danilo, C., Lipovka, Y., Saripalli, C., Granzier, H. & Konhilas, J. P., Jul 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H125-H136

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Sex Characteristics
Familial Hypertrophic Cardiomyopathy
Costs and Cost Analysis
Sarcomeres
7 Citations

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

Kolb, J., Li, F., Methawasin, M., Adler, M., Escobar, Y. N., Nedrud, J., Pappas, C. T., Harris, S. P. & Granzier, H., Aug 1 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 286-294 9 p.

Research output: Contribution to journalArticle

Connectin
Sarcomeres
Tropomodulin
Heart Atria
Muscle Cells
2015
10 Citations

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

de Winter, J. M., Joureau, B., Sequeira, V., Clarke, N. F., van der Velden, J., Stienen, G. J. M., Granzier, H., Beggs, A. H. & Ottenheijm, C. A. C., Apr 28 2015, (Accepted/In press) In : Skeletal Muscle. p. 1-10 10 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Muscles
Mutation
Slow-Twitch Muscle Fibers
Troponin C
15 Citations

Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling

Hutchinson, K. R., Saripalli, C., Chung, C. S. & Granzier, H., Feb 1 2015, In : Journal of Molecular and Cellular Cardiology. 79, p. 104-114 11 p.

Research output: Contribution to journalArticle

Connectin
Protein Isoforms
Fistula
Blood Pressure
Left Ventricular Dysfunction
26 Citations

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Pappas, C. T., Mayfield, R. M., Henderson, C., Jamilpour, N., Cover, C., Hernandez, Z., Hutchinson, K. R., Chu, M., Nam, K. H., Valdez, J. M., Wong, P. K., Granzier, H. L. & Gregorio, C. C., Nov 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13573-13578 6 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Actin Cytoskeleton
Ventricular Dysfunction
Microfilament Proteins
Striated Muscle
149 Citations

Myocardial stiffness in patients with heart failure and a preserved ejection fraction contributions of collagen and titin

Zile, M. R., Baicu, C. F., Ikonomidis, J. S., Stroud, R. E., Nietert, P. J., Bradshaw, A. D., Slater, R., Palmer, B. M., Van Buren, P., Meyer, M., Redfield, M. M., Bull, D. A., Granzier, H. L. & LeWinter, M. M., 2015, In : Circulation. 131, 14, p. 1247-1259 13 p.

Research output: Contribution to journalArticle

Connectin
Collagen
Heart Failure
Hypertension
Phosphorylation
3 Citations

Myosin light chain phosphorylation to the rescue

Granzier, H. L. & De Tombe, P. P., Jul 28 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. 9148-9149 2 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Hypertrophic Cardiomyopathy
Phosphorylation
11 Citations

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: Novel insights in nemaline myopathy

Li, F., Buck, D., De Winter, J., Kolb, J., Meng, H., Birch, C., Slater, R., Escobar, Y. N., Smith, J. E., Yang, L., Konhilas, J., Lawlor, M. W., Ottenheijm, C. & Granzier, H. L., Apr 9 2015, In : Human Molecular Genetics. 24, 18, p. 5219-5233 15 p., ddv243

Research output: Contribution to journalArticle

Nemaline Myopathies
Sarcomeres
Muscles
Muscle Weakness
nebulin
10 Citations

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

Perkin, J., Slater, R., Del Favero, G., Lanzicher, T., Hidalgo, C., Anderson, B., Smith, J. E., Sbaizero, O., Labeit, S. & Granzier, H., Dec 15 2015, In : Biophysical Journal. 109, 12, p. 2592-2601 10 p.

Research output: Contribution to journalArticle

Connectin
Mitogen-Activated Protein Kinase 1
Myocardium
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Calcium-Calmodulin-Dependent Protein Kinase Type 2
2 Citations
Connectin
Sarcomeres
Myocardium
21 Citations

Role of titin missense variants in dilated cardiomyopathy

Begay, R. L., Graw, S., Sinagra, G., Merlo, M., Slavov, D., Gowan, K., Jones, K. L., Barbati, G., Spezzacatene, A., Brun, F., Di Lenarda, A., Smith, J. E., Granzier, H. L., Mestroni, L. & Taylor, M., Nov 1 2015, In : Journal of the American Heart Association. 4, 11, e002645

Research output: Contribution to journalArticle

Connectin
Dilated Cardiomyopathy
Genes
Sarcomeres
Heterozygote
2014
41 Citations

Cardiac titin and heart disease

Lewinter, M. M. & Granzier, H. L., 2014, In : Journal of Cardiovascular Pharmacology. 63, 3, p. 207-212 6 p.

Research output: Contribution to journalArticle

Connectin
Heart Diseases
Dilated Cardiomyopathy
Mutation
Protein Isoforms
24 Citations

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Granzier, H. L., Hutchinson, K. R., Tonino, P., Methawasin, M., Li, F. W., Slater, R. E., Bull, M. M., Saripalli, C., Pappas, C. T., Gregorio, C. C. & Smith, J. E., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14589-14594 6 p.

Research output: Contribution to journalArticle

Connectin
Microscopy
Lighting
Sarcomeres
Elasticity
2 Citations

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Elhamine, F., Radke, M. H., Pfitzer, G., Granzier, H., Gotthardt, M. & Stehle, R., 2014, In : Journal of Cell Science. 127, 17, p. 3666-3674 9 p.

Research output: Contribution to journalArticle

Connectin
Myofibrils
Knockout Mice
Sarcomeres
Myocardial Contraction
15 Citations
Connectin
Striated Muscle
Muscle
Stiffness
Exercise
55 Citations

Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole

Methawasin, M., Hutchinson, K. R., Lee, E. J., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C. & Granzier, H., 2014, In : Circulation. 129, 19, p. 1924-1936 13 p.

Research output: Contribution to journalArticle

Connectin
Starlings
Diastole
Compliance
Cardiac Myocytes
23 Citations

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

Rain, S., Goncalves Bos, D. S., Handoko, M. L., Westerhof, N., Stienen, G., Ottenheijm, C., Goebel, M., Dorfmüller, P., Guignabert, C., Humbert, M., Bogaard, H. J., Dos Remedios, C., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., Van der Velden, J. & De Man, F. S., 2014, In : Journal of the American Heart Association. 3, 3, 000716

Research output: Contribution to journalArticle

Pulmonary Hypertension
Cardiac Myocytes
Connectin
Phosphorylation
Right Ventricular Dysfunction
16 Citations

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

Buck, D., Smith, J. E., Chung, C. S., Ono, Y., Sorimachi, H., Labeit, S. & Granzier, H. L., Feb 2014, In : Journal of General Physiology. 143, 2, p. 215-230 16 p.

Research output: Contribution to journalArticle

Connectin
Muscular Diseases
Skeletal Muscle
Protein Isoforms
Immunoglobulin Domains
18 Citations

Tissue triage and freezing for models of skeletal muscle disease

Meng, H., Janssen, P. M. L., Grange, R. W., Yang, L., Beggs, A. H., Swanson, L. C., Cossette, S. A., Frase, A., Childers, M. K., Granzier, H., Gussoni, E. & Lawlor, M. W., 2014, In : Journal of visualized experiments : JoVE. 89

Research output: Contribution to journalArticle

Triage
Freezing
Muscle
Skeletal Muscle
Tissue
2013
12 Citations

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

Lee, E. J., Nedrud, J., Schemmel, P., Gotthardt, M., Irving, T. C. & Granzier, H. L., Jul 1 2013, In : Archives of Biochemistry and Biophysics. 535, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

Connectin
Myofibrils
Sarcomeres
Phosphorylation
Myocardium
23 Citations

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Ottenheijm, C. A. C., Buck, D., De Winter, J. M., Ferrara, C., Piroddi, N., Tesi, C., Jasper, J. R., Malik, F. I., Meng, H., Stienen, G. J. M., Beggs, A. H., Labeit, S., Poggesi, C., Lawlor, M. W. & Granzier, H., Jun 2013, In : Brain. 136, 6, p. 1718-1731 14 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Muscle Weakness
Exons
Genes
Muscles
11 Citations

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

Lee, E. J., de Winter, J. M., Buck, D., Jasper, J. R., Malik, F. I., Labeit, S., Ottenheijm, C. A. & Granzier, H., Feb 20 2013, In : PLoS One. 8, 2, e55861

Research output: Contribution to journalArticle

troponins
Troponin
Muscle Weakness
Muscle
skeletal muscle
64 Citations

Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction

Reil, J. C., Hohl, M., Reil, G. H., Granzier, H. L., Kratz, M. T., Kazakov, A., Fries, P., Müller, A., Lenski, M., Custodis, F., Gräber, S., Fröhlig, G., Steendijk, P., Neuberger, H. R. & Böhm, M., Sep 21 2013, In : European Heart Journal. 34, 36, p. 2839-2849 11 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Heart Failure
Heart Rate
ivabradine
Fibrosis
12 Citations

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype

Gineste, C., De Winter, J. M., Kohl, C., Witt, C. C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P. J., Stienen, G. J. M., Granzier, H., Labeit, S., Ottenheijm, C. A. C., Bendahan, D. & Gondin, J., Apr 2013, In : Neuromuscular Disorders. 23, 4, p. 357-369 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Skeletal Muscle
Phenotype
Energy Metabolism
Nemaline Myopathies
82 Citations

Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy

Ceyhan-Birsoy, O., Agrawal, P. B., Hidalgo, C., Schmitz-Abe, K., Dechene, E. T., Swanson, L. C., Soemedi, R., Vasli, N., Iannaccone, S. T., Shieh, P. B., Shur, N., Dennison, J. M., Lawlor, M. W., Laporte, J., Markianos, K., Fairbrother, W. G., Granzier, H. & Beggs, A. H., Oct 1 2013, In : Neurology. 81, 14, p. 1205-1214 10 p.

Research output: Contribution to journalArticle

Congenital Structural Myopathies
Connectin
Mutation
Genes
Exome
116 Citations

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

Rain, S. , Handoko, M. L. , Trip, P. , Gan, C. T. J. , Westerhof, N. , Stienen, G. J. , Paulus, W. J. , Ottenheijm, C. A. C. , Marcus, J. T. , Dorfmüller, P. , Guignabert, C. , Humbert, M. , Macdonald, P. , Dos Remedios, C. , Postmus, P. E. , Saripalli, C. , Hidalgo, C. G. , Granzier, H. L. , Vonk-Noordegraaf, A. , Van Der Velden, J. & 1 others De Man, F. S., Oct 29 2013, In : Circulation. 128, 18, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Connectin
Sarcomeres
Cardiac Myocytes
Protein Isoforms
14 Citations

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

Lassche, S., Stienen, G. J. M., Irving, T. C., Van Der Maarel, S. M., Voermans, N. C., Padberg, G. W., Granzier, H., Van Engelen, B. G. M. & Ottenheijm, C. A. C., Feb 19 2013, In : Neurology. 80, 8, p. 733-737 5 p.

Research output: Contribution to journalArticle

Facioscapulohumeral Muscular Dystrophy
Muscle Weakness
Connectin
Sarcomeres
Myofibrils
45 Citations

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction

Chung, C. S., Hutchinson, K. R., Methawasin, M., Saripalli, C., Smith, J. E., Hidalgo, C. G., Luo, X., Labeit, S., Guo, C. & Granzier, H. L., Jul 2 2013, In : Circulation. 128, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

Connectin
Immunoglobulins
Extracellular Matrix
Phospho-Specific Antibodies
Exercise Tolerance
14 Citations

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism

Anderson, B. R., Bogomolovas, J., Labeit, S. & Granzier, H., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5303-5315 13 p.

Research output: Contribution to journalArticle

Connectin
Immunoglobulins
Heart Diseases
Spectroscopy
Cardiomyopathies
37 Citations

The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements

Hidalgo, C. G., Chung, C. S., Saripalli, C., Methawasin, M., Hutchinson, K. R., Tsaprailis, G., Labeit, S., Mattiazzi, A. & Granzier, H. L., Jan 2013, In : Journal of Molecular and Cellular Cardiology. 54, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

Connectin
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Reperfusion
Mass Spectrometry
47 Citations

Titin is a major human disease gene

Lewinter, M. M. & Granzier, H. L., 2013, In : Circulation. 127, 8, p. 938-944 7 p.

Research output: Contribution to journalArticle

Connectin
Muscle Proteins
Protein Kinases
Heart Diseases
Signal Transduction
24 Citations

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

de Winter, J. M., Buck, D., Hidalgo, C., Jasper, J. R., Malik, F. I., Clarke, N. F., Stienen, G. J. M., Lawlor, M. W., Beggs, A. H., Ottenheijm, C. A. C. & Granzier, H., 2013, In : Journal of Medical Genetics. 50, 6, p. 383-392 10 p.

Research output: Contribution to journalArticle

Nemaline Myopathies
Troponin
Muscles
Mutation
Contractile Proteins
44 Citations

Tuning the molecular giant titin through phosphorylation: Role in health and disease

Hidalgo, C. & Granzier, H., Jul 2013, In : Trends in Cardiovascular Medicine. 23, 5, p. 165-171 7 p.

Research output: Contribution to journalArticle

Connectin
Phosphorylation
Health
Heart Failure
Sarcomeres