Research Output 1983 2017

  • 12436 Citations
  • 61 h-Index
  • 211 Article
  • 2 Review article
  • 1 Letter
Filter
Article
2017
1 Citations

219th ENMC International Workshop Titinopathies International database of titin mutations and phenotypes, Heemskerk, The Netherlands, 29 April–1 May 2016

Hackman, P. , Udd, B. , Bönnemann, C. G. , Ferreiro, A. , Udd, B. , Hackman, P. , Ferreiro, A. , Bonnemann, C. , Beggs, A. , Gautel, M. , Davis, M. , Evangelista, T. , Savarese, M. , Glumac, J. N. , Laporte, J. , Smith, J. E. , Richard, I. , Granzier, H. , Schneider, R. , Jungbluth, H. & 3 others Foye, S., Frase, A. R. & Titinopathy Database Consortium Apr 1 2017 In : Neuromuscular Disorders. 27, 4, p. 396-407 12 p.

Research output: Research - peer-reviewArticle

1 Citations

Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction

Slater, R. E., Strom, J. G. & Granzier, H. Jul 1 2017 In : Journal of Molecular and Cellular Cardiology. 108, p. 24-33 10 p.

Research output: Research - peer-reviewArticle

Exercise
Connectin
Heart Rate
Phosphorylation
Heart Failure
1 Citations

Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy

Joureau, B., de Winter, J. M., Stam, K., Granzier, H. & Ottenheijm, C. A. C. Jan 1 2017 In : Neuromuscular Disorders. 27, 1, p. 83-89 7 p.

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Muscle Weakness
Diaphragm
Skeletal Muscle
nebulin

The giant protein titin regulates the length of the striated muscle thick filament

Tonino, P., Kiss, B., Strom, J., Methawasin, M., Smith, J. E., Kolb, J., Labeit, S. & Granzier, H. Dec 1 2017 In : Nature Communications. 8, 1, 1041

Research output: Research - peer-reviewArticle

Connectin
Striated Muscle
Muscles
Proteins
skeletal muscle
2016
4 Citations

Alternative splicing of titin restores diastolic function in an HFpEF-like genetic murine model (Ttn ΔIAjxn)

Bull, M., Methawasin, M., Strom, J., Nair, P., Hutchinson, K. & Granzier, H. Sep 2 2016 In : Circulation Research. 119, 6, p. 764-772 9 p.

Research output: Research - peer-reviewArticle

Connectin
Genetic Models
Alternative Splicing
Heart Failure
RNA-Binding Motifs
3 Citations

Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy

Evans, J. M., Cox, M. L., Huska, J., Li, F., Gaitero, L., Guo, L. T., Casal, M. L., Granzier, H. L., Shelton, G. D. & Clark, L. A. May 23 2016 (Accepted/In press) In : Mammalian Genome. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Exome
Nonsense Codon
Dogs
nebulin
11 Citations

Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure with Preserved Ejection Fraction

Methawasin, M., Strom, J. G., Slater, R. E., Fernandez, V., Saripalli, C. & Granzier, H. Oct 11 2016 In : Circulation. 134, 15, p. 1085-1099 15 p.

Research output: Research - peer-reviewArticle

Connectin
Compliance
Heart Failure
RNA-Binding Motifs
Constriction
1 Citations

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: The cardiomyopathy-linked mutation T2580I

Bogomolovas, J., Fleming, J. R., Anderson, B. R., Williams, R., Lange, S., Simon, B., Khan, M. M., Rudolf, R., Franke, B., Bullard, B., Rigden, D. J., Granzier, H., Labeit, S. & Mayans, O. Sep 1 2016 In : Open Biology. 6, 9, 160114

Research output: Research - peer-reviewArticle

Connectin
Cardiomyopathies
Single Nucleotide Polymorphism
Mutation
Nucleotides
1 Citations

Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice

Pulcastro, H. C., Awinda, P. O., Methawasin, M., Granzier, H., Dong, W. & Tanner, B. C. W. Jul 29 2016 In : Frontiers in Physiology. 7, JUL, 322

Research output: Research - peer-reviewArticle

Connectin
Sarcomeres
Compliance
Myocardium
Myosins
5 Citations

Mutation-specific effects on thin filament length in thin filament myopathy

Winter, J. M. D. , Joureau, B. , Lee, E. J. , Kiss, B. , Yuen, M. , Gupta, V. A. , Pappas, C. T. , Gregorio, C. C. , Stienen, G. J. M. , Edvardson, S. , Wallgren-Pettersson, C. , Lehtokari, V. L. , Pelin, K. , Malfatti, E. , Romero, N. B. , Engelen, B. G. V. , Voermans, N. C. , Donkervoort, S. , Bönnemann, C. G. , Clarke, N. F. & 3 others Beggs, A. H., Granzier, H. & Ottenheijm, C. A. C. 2016 (Accepted/In press) In : Annals of Neurology.

Research output: Research - peer-reviewArticle

Muscular Diseases
Mutation
Sarcomeres
Muscles
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
6 Citations

Reduced passive force in skeletal muscles lacking protein arginylation

Leite, F. S., Minozzo, F. C., Kalganov, A., Cornachione, A. S., Cheng, Y. S., Leu, N. A., Han, X., Saripalli, C., Yates, J. R., Granzier, H., Kashina, A. S. & Rassier, D. E. Jan 15 2016 In : American Journal of Physiology - Cell Physiology. 310, 2, p. C127-C135

Research output: Research - peer-reviewArticle

Connectin
Muscle Proteins
Skeletal Muscle
Proteins
Myofibrils
3 Citations

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Hinze, F., Dieterich, C., Radke, M. H., Granzier, H. & Gotthardt, M. Dec 1 2016 In : Journal of Molecular Medicine. 94, 12, p. 1349-1358 10 p.

Research output: Research - peer-reviewArticle

Connectin
Atrophy
Therapeutics
Protein Isoforms
Hypertrophy
7 Citations

Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats

Kovács, Á., Fülöp, G., Kovács, A., Csípő, T., Bódi, B., Priksz, D., Juhász, B., Beke, L., Hendrik, Z., Méhes, G., Granzier, H. L., Édes, I., Fagyas, M., Papp, Z., Barta, J. & Tóth, A. Jun 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 11, p. H1671-H1682

Research output: Research - peer-reviewArticle

Connectin
Renin
Body Weight
Blood Pressure
Weights and Measures
1 Citations

Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice

Birch, C. L., Behunin, S. M., Lopez-Pier, M. A., Danilo, C., Lipovka, Y., Saripalli, C., Granzier, H. & Konhilas, J. P. Jul 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H125-H136

Research output: Research - peer-reviewArticle

Hypertrophic Cardiomyopathy
Sex Characteristics
Costs and Cost Analysis
Familial Hypertrophic Cardiomyopathy
Sarcomeres
3 Citations

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

Kolb, J., Li, F., Methawasin, M., Adler, M., Escobar, Y. N., Nedrud, J., Pappas, C. T., Harris, S. P. & Granzier, H. Aug 1 2016 In : Journal of Molecular and Cellular Cardiology. 97, p. 286-294 9 p.

Research output: Research - peer-reviewArticle

Connectin
Sarcomeres
nebulin
Tropomodulin
Heart Atria
2015
7 Citations

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

de Winter, J. M., Joureau, B., Sequeira, V., Clarke, N. F., van der Velden, J., Stienen, G. J. M., Granzier, H., Beggs, A. H. & Ottenheijm, C. A. C. Apr 28 2015 (Accepted/In press) In : Skeletal Muscle. p. 1-10 10 p.

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Muscles
Mutation
Genes
simendan
12 Citations

Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling

Hutchinson, K. R., Saripalli, C., Chung, C. S. & Granzier, H. Feb 1 2015 In : Journal of Molecular and Cellular Cardiology. 79, p. 104-114 11 p.

Research output: Research - peer-reviewArticle

Connectin
Protein Isoforms
Fistula
Blood Pressure
Proteins
18 Citations

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Pappas, C. T., Mayfield, R. M., Henderson, C., Jamilpour, N., Cover, C., Hernandez, Z., Hutchinson, K. R., Chu, M., Nam, K. H., Valdez, J. M., Wong, P. K., Granzier, H. L. & Gregorio, C. C. Nov 3 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13573-13578 6 p.

Research output: Research - peer-reviewArticle

Dilated Cardiomyopathy
Actin Cytoskeleton
Ventricular Dysfunction
Microfilament Proteins
Striated Muscle
105 Citations

Myocardial stiffness in patients with heart failure and a preserved ejection fraction contributions of collagen and titin

Zile, M. R., Baicu, C. F., Ikonomidis, J. S., Stroud, R. E., Nietert, P. J., Bradshaw, A. D., Slater, R., Palmer, B. M., Van Buren, P., Meyer, M., Redfield, M. M., Bull, D. A., Granzier, H. L. & LeWinter, M. M. 2015 In : Circulation. 131, 14, p. 1247-1259 13 p.

Research output: Research - peer-reviewArticle

Connectin
Collagen
Heart Failure
Hypertension
Phosphorylation
3 Citations

Myosin light chain phosphorylation to the rescue

Granzier, H. L. & De Tombe, P. P. Jul 28 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. 9148-9149 2 p.

Research output: Research - peer-reviewArticle

5 Citations

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: Novel insights in nemaline myopathy

Li, F., Buck, D., De Winter, J., Kolb, J., Meng, H., Birch, C., Slater, R., Escobar, Y. N., Smith, J. E., Yang, L., Konhilas, J., Lawlor, M. W., Ottenheijm, C. & Granzier, H. L. Apr 9 2015 In : Human Molecular Genetics. 24, 18, p. 5219-5233 15 p., ddv243

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Sarcomeres
Muscles
nebulin
Muscle Weakness
6 Citations

Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force

Perkin, J., Slater, R., Del Favero, G., Lanzicher, T., Hidalgo, C., Anderson, B., Smith, J. E., Sbaizero, O., Labeit, S. & Granzier, H. Dec 15 2015 In : Biophysical Journal. 109, 12, p. 2592-2601 10 p.

Research output: Research - peer-reviewArticle

Connectin
Mitogen-Activated Protein Kinase 1
Myocardium
Single Molecule Imaging
Calcium-Calmodulin-Dependent Protein Kinase Kinase
1 Citations
14 Citations

Role of titin missense variants in dilated cardiomyopathy

Begay, R. L., Graw, S., Sinagra, G., Merlo, M., Slavov, D., Gowan, K., Jones, K. L., Barbati, G., Spezzacatene, A., Brun, F., Di Lenarda, A., Smith, J. E., Granzier, H. L., Mestroni, L. & Taylor, M. Nov 1 2015 In : Journal of the American Heart Association. 4, 11, e002645

Research output: Research - peer-reviewArticle

Connectin
Dilated Cardiomyopathy
Genes
Sarcomeres
Heterozygote
2014
28 Citations

Cardiac titin and heart disease

Lewinter, M. M. & Granzier, H. L. 2014 In : Journal of Cardiovascular Pharmacology. 63, 3, p. 207-212 6 p.

Research output: Research - peer-reviewArticle

Connectin
Heart Diseases
Mutation
Dilated Cardiomyopathy
Protein Isoforms
9 Citations

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Granzier, H. L., Hutchinson, K. R., Tonino, P., Methawasin, M., Li, F. W., Slater, R. E., Bull, M. M., Saripalli, C., Pappas, C. T., Gregorio, C. C. & Smith, J. E. Oct 7 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14589-14594 6 p.

Research output: Research - peer-reviewArticle

Connectin
Microscopy
Lighting
Sarcomeres
Elasticity
1 Citations

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Elhamine, F., Radke, M. H., Pfitzer, G., Granzier, H., Gotthardt, M. & Stehle, R. 2014 In : Journal of Cell Science. 127, 17, p. 3666-3674 9 p.

Research output: Research - peer-reviewArticle

Connectin
Myofibrils
Knockout Mice
Sarcomeres
Myocardial Contraction
12 Citations
Connectin
Striated Muscle
Exercise
Muscle
Stiffness
35 Citations

Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole

Methawasin, M., Hutchinson, K. R., Lee, E. J., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C. & Granzier, H. 2014 In : Circulation. 129, 19, p. 1924-1936 13 p.

Research output: Research - peer-reviewArticle

Connectin
Starlings
Diastole
Compliance
Cardiac Myocytes
15 Citations

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

Rain, S., Goncalves Bos, D. S., Handoko, M. L., Westerhof, N., Stienen, G., Ottenheijm, C., Goebel, M., Dorfmüller, P., Guignabert, C., Humbert, M., Bogaard, H. J., Dos Remedios, C., Saripalli, C., Hidalgo, C. G., Granzier, H. L., Vonk-Noordegraaf, A., Van der Velden, J. & De Man, F. S. 2014 In : Journal of the American Heart Association. 3, 3, 000716

Research output: Research - peer-reviewArticle

Pulmonary Hypertension
Cardiac Myocytes
Proteins
Phosphorylation
Connectin
14 Citations

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

Buck, D., Smith, J. E., Chung, C. S., Ono, Y., Sorimachi, H., Labeit, S. & Granzier, H. L. Feb 2014 In : Journal of General Physiology. 143, 2, p. 215-230 16 p.

Research output: Research - peer-reviewArticle

Connectin
Muscular Diseases
Skeletal Muscle
Immunoglobulin Domains
Protein Isoforms
10 Citations

Tissue triage and freezing for models of skeletal muscle disease

Meng, H., Janssen, P. M. L., Grange, R. W., Yang, L., Beggs, A. H., Swanson, L. C., Cossette, S. A., Frase, A., Childers, M. K., Granzier, H., Gussoni, E. & Lawlor, M. W. 2014 In : Journal of visualized experiments : JoVE. 89

Research output: Research - peer-reviewArticle

Triage
Freezing
Skeletal Muscle
Muscle
Tissue
2013
11 Citations

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

Lee, E. J., Nedrud, J., Schemmel, P., Gotthardt, M., Irving, T. C. & Granzier, H. L. Jul 1 2013 In : Archives of Biochemistry and Biophysics. 535, 1, p. 76-83 8 p.

Research output: Research - peer-reviewArticle

Connectin
Myofibrils
Myocardium
Calcium
Chemical activation
19 Citations

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Ottenheijm, C. A. C., Buck, D., De Winter, J. M., Ferrara, C., Piroddi, N., Tesi, C., Jasper, J. R., Malik, F. I., Meng, H., Stienen, G. J. M., Beggs, A. H., Labeit, S., Poggesi, C., Lawlor, M. W. & Granzier, H. Jun 2013 In : Brain. 136, 6, p. 1718-1731 14 p.

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Muscle Weakness
Exons
Genes
nebulin
7 Citations

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

Lee, E. J., de Winter, J. M., Buck, D., Jasper, J. R., Malik, F. I., Labeit, S., Ottenheijm, C. A. & Granzier, H. Feb 20 2013 In : PLoS One. 8, 2, e55861

Research output: Research - peer-reviewArticle

Troponin
Muscle Weakness
Skeletal Muscle
Calcium
nebulin
50 Citations

Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction

Reil, J. C., Hohl, M., Reil, G. H., Granzier, H. L., Kratz, M. T., Kazakov, A., Fries, P., Müller, A., Lenski, M., Custodis, F., Gräber, S., Fröhlig, G., Steendijk, P., Neuberger, H. R. & Böhm, M. Sep 21 2013 In : European Heart Journal. 34, 36, p. 2839-2849 11 p.

Research output: Research - peer-reviewArticle

Vascular Stiffness
Heart Failure
Heart Rate
Fibrosis
Therapeutics
11 Citations

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype

Gineste, C., De Winter, J. M., Kohl, C., Witt, C. C., Giannesini, B., Brohm, K., Le Fur, Y., Gretz, N., Vilmen, C., Pecchi, E., Jubeau, M., Cozzone, P. J., Stienen, G. J. M., Granzier, H., Labeit, S., Ottenheijm, C. A. C., Bendahan, D. & Gondin, J. Apr 2013 In : Neuromuscular Disorders. 23, 4, p. 357-369 13 p.

Research output: Research - peer-reviewArticle

Knockout Mice
Skeletal Muscle
Phenotype
nebulin
In Vitro Techniques
59 Citations

Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy

Ceyhan-Birsoy, O., Agrawal, P. B., Hidalgo, C., Schmitz-Abe, K., Dechene, E. T., Swanson, L. C., Soemedi, R., Vasli, N., Iannaccone, S. T., Shieh, P. B., Shur, N., Dennison, J. M., Lawlor, M. W., Laporte, J., Markianos, K., Fairbrother, W. G., Granzier, H. & Beggs, A. H. Oct 1 2013 In : Neurology. 81, 14, p. 1205-1214 10 p.

Research output: Research - peer-reviewArticle

Congenital Structural Myopathies
Connectin
Mutation
Genes
Gene
90 Citations

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

Rain, S. , Handoko, M. L. , Trip, P. , Gan, C. T. J. , Westerhof, N. , Stienen, G. J. , Paulus, W. J. , Ottenheijm, C. A. C. , Marcus, J. T. , Dorfmüller, P. , Guignabert, C. , Humbert, M. , Macdonald, P. , Dos Remedios, C. , Postmus, P. E. , Saripalli, C. , Hidalgo, C. G. , Granzier, H. L. , Vonk-Noordegraaf, A. , Van Der Velden, J. & 1 others De Man, F. S. Oct 29 2013 In : Circulation. 128, 18, p. 2016-2025 10 p.

Research output: Research - peer-reviewArticle

Pulmonary Hypertension
Connectin
Sarcomeres
Cardiac Myocytes
Protein Isoforms
12 Citations

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

Lassche, S., Stienen, G. J. M., Irving, T. C., Van Der Maarel, S. M., Voermans, N. C., Padberg, G. W., Granzier, H., Van Engelen, B. G. M. & Ottenheijm, C. A. C. Feb 19 2013 In : Neurology. 80, 8, p. 733-737 5 p.

Research output: Research - peer-reviewArticle

Facioscapulohumeral Muscular Dystrophy
Muscle Weakness
Fiber
Length
Muscles
39 Citations

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction

Chung, C. S., Hutchinson, K. R., Methawasin, M., Saripalli, C., Smith, J. E., Hidalgo, C. G., Luo, X., Labeit, S., Guo, C. & Granzier, H. L. Jul 2 2013 In : Circulation. 128, 1, p. 19-28 10 p.

Research output: Research - peer-reviewArticle

Connectin
Immunoglobulins
Extracellular Matrix
Phospho-Specific Antibodies
Exercise Tolerance
14 Citations

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism

Anderson, B. R., Bogomolovas, J., Labeit, S. & Granzier, H. Feb 22 2013 In : Journal of Biological Chemistry. 288, 8, p. 5303-5315 13 p.

Research output: Research - peer-reviewArticle

Connectin
Heart Diseases
Mutation
Single Molecule Imaging
Immunoglobulin Domains
33 Citations

The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements

Hidalgo, C. G., Chung, C. S., Saripalli, C., Methawasin, M., Hutchinson, K. R., Tsaprailis, G., Labeit, S., Mattiazzi, A. & Granzier, H. L. Jan 2013 In : Journal of Molecular and Cellular Cardiology. 54, 1, p. 90-97 8 p.

Research output: Research - peer-reviewArticle

Connectin
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Reperfusion
Mass Spectrometry
38 Citations

Titin is a major human disease gene

Lewinter, M. M. & Granzier, H. L. 2013 In : Circulation. 127, 8, p. 938-944 7 p.

Research output: Research - peer-reviewArticle

17 Citations

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

de Winter, J. M., Buck, D., Hidalgo, C., Jasper, J. R., Malik, F. I., Clarke, N. F., Stienen, G. J. M., Lawlor, M. W., Beggs, A. H., Ottenheijm, C. A. C. & Granzier, H. 2013 In : Journal of Medical Genetics. 50, 6, p. 383-392 10 p.

Research output: Research - peer-reviewArticle

Nemaline Myopathies
Troponin
Muscles
Mutation
nebulin
34 Citations

Tuning the molecular giant titin through phosphorylation: Role in health and disease

Hidalgo, C. & Granzier, H. Jul 2013 In : Trends in Cardiovascular Medicine. 23, 5, p. 165-171 7 p.

Research output: Research - peer-reviewArticle

Connectin
Phosphorylation
Health
Heart Failure
Sarcomeres
2012
2 Citations

Advances in muscle physiology and pathophysiology 2011

Kontrogianni-Konstantopoulos, A., Benian, G. & Granzier, H. 2012 In : Journal of Biomedicine and Biotechnology. 2012, 930836

Research output: Research - peer-reviewArticle

41 Citations

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics

Raskin, A., Lange, S., Banares, K., Lyon, R. C., Zieseniss, A., Lee, L. K., Yamazaki, K. G., Granzier, H. L., Gregorio, C. C., McCulloch, A. D., Omens, J. H. & Sheikh, F. Aug 24 2012 In : Journal of Biological Chemistry. 287, 35, p. 29273-29284 12 p.

Research output: Research - peer-reviewArticle

LIM Domain Proteins
Connectin
Mitogen-Activated Protein Kinase 1
Mechanics
Phosphorylation
11 Citations

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Wu, Y., Luczak, E. D., Lee, E. J., Hidalgo, C., Yang, J., Gao, Z., Li, J., H.T. Wehrens, X., Granzier, H. & Anderson, M. E. Sep 2012 In : Journal of Molecular and Cellular Cardiology. 53, 3, p. 429-436 8 p.

Research output: Research - peer-reviewArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
phospholamban
Heart Ventricles
Pressure
Myofibrils
72 Citations

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

Sheikh, F., Ouyang, K., Campbell, S. G., Lyon, R. C., Chuang, J., Fitzsimons, D., Tangney, J., Hidalgo, C. G., Chung, C. S., Cheng, H., Dalton, N. D., Gu, Y., Kasahara, H., Ghassemian, M., Omens, J. H., Peterson, K. L., Granzier, H. L., Moss, R. L., McCulloch, A. D. & Chen, J. Apr 2 2012 In : Journal of Clinical Investigation. 122, 4, p. 1209-1221 13 p.

Research output: Research - peer-reviewArticle

Myosins
Heart Diseases
Myocardium
Muscle Contraction
Actins