Hendrikus "Henk" Granzier

  • 15702 Citations
  • 68 h-Index
1983 …2020

Research output per year

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Research Output

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Review article
2020

Research Priorities for Heart Failure with Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary

Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., Granzier, H., Hummel, S. L., Kass, D. A., Redfield, M. M., Sam, F., Wang, T. J., Desvigne-Nickens, P. & Adhikari, B. B., Mar 24 2020, In : Circulation. p. 1001-1026 26 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Titin mutations and muscle disease

Kellermayer, D., Smith, J. E. & Granzier, H. H., Jan 1 2019, In : Pflugers Archiv European Journal of Physiology.

Research output: Contribution to journalReview article

5 Scopus citations
2017

Novex-3, the tiny titin of muscle

Kellermayer, D., Smith, J. E. & Granzier, H. H., Jun 1 2017, In : Biophysical Reviews. 9, 3, p. 201-206 6 p.

Research output: Contribution to journalReview article

5 Scopus citations

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease

dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H. H., Bezzina, C., van Dijk, S., De Man, F., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. & van der Velden, J., Aug 1 2017, In : Biophysical Reviews. 9, 4, p. 431-441 11 p.

Research output: Contribution to journalReview article

8 Scopus citations
2016

A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies

Gigli, M., Begay, R. L., Morea, G., Graw, S. L., Sinagra, G., Taylor, M. R. G., Granzier, H. & Mestroni, L., Jul 21 2016, In : Frontiers in Cardiovascular Medicine. 3, 21.

Research output: Contribution to journalReview article

Open Access
40 Scopus citations
2014

Cardiac titin and heart disease

Lewinter, M. M. & Granzier, H. L., Mar 2014, In : Journal of Cardiovascular Pharmacology. 63, 3, p. 207-212 6 p.

Research output: Contribution to journalReview article

64 Scopus citations
2013

Tuning the molecular giant titin through phosphorylation: Role in health and disease

Hidalgo, C. & Granzier, H., Jul 1 2013, In : Trends in Cardiovascular Medicine. 23, 5, p. 165-171 7 p.

Research output: Contribution to journalReview article

63 Scopus citations
2012

The sarcomeric protein nebulin: Another multifunctio giant in charge of muscle strength optimization

Ottenheijm, C. A. C., Granzier, H. & Labeit, S., Sep 20 2012, In : Frontiers in Physiology. 3 FEB, Article 37.

Research output: Contribution to journalReview article

20 Scopus citations

Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

Anderson, B. R. & Granzier, H. L., Oct 1 2012, In : Progress in Biophysics and Molecular Biology. 110, 2-3, p. 204-217 14 p.

Research output: Contribution to journalReview article

47 Scopus citations

Transforming growth factor beta signaling in adult cardiovascular diseases and repair

Doetschman, T., Barnett, J. V., Runyan, R. B., Camenisch, T. D., Heimark, R. L., Granzier, H. L., Conway, S. J. & Azhar, M., Jan 1 2012, In : Cell and Tissue Research. 347, 1, p. 203-223 21 p.

Research output: Contribution to journalReview article

56 Scopus citations
2011

Nebulin, a major player in muscle health and disease

Labeit, S., Ottenheijm, C. A. C. & Granzier, H., Mar 1 2011, In : FASEB Journal. 25, 3, p. 822-829 8 p.

Research output: Contribution to journalReview article

53 Scopus citations

Titin-based mechanosensing and signaling: Role in diaphragm atrophy during unloading?

Ottenheijm, C. A. C., Van Hees, H. W. H., Heunks, L. M. A. & Granzier, H., Feb 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 300, 2, p. L161-L166

Research output: Contribution to journalReview article

20 Scopus citations
2010

Cardiac titin: A multifunctional giant

Lewinter, M. M. & Granzier, H., May 18 2010, In : Circulation. 121, 19, p. 2137-2145 9 p.

Research output: Contribution to journalReview article

135 Scopus citations

Lifting the nebula: Novel insights into skeletal muscle contractility

Ottenheijm, C. A. C. & Granzier, H., Oct 1 2010, In : Physiology. 25, 5, p. 304-310 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

New insights into the structural roles of nebulin in skeletal muscle

Granzier, H. & Ottenheijm, C. A. C., Jul 20 2010, In : Journal of Biomedicine and Biotechnology. 2010, 968139.

Research output: Contribution to journalReview article

21 Scopus citations
2008

Physiological functions of the giant elastic protein titin in mammalian striated muscle

Fukuda, N., Granzier, H. L., Ishiwata, S. & Kurihara, S., Jun 1 2008, In : Journal of Physiological Sciences. 58, 3, p. 151-159 9 p.

Research output: Contribution to journalReview article

68 Scopus citations
2007

Cardiac titin: Structure, functions and role in disease

LeWinter, M. M., Wu, Y., Labeit, S. & Granzier, H., Jan 1 2007, In : Clinica Chimica Acta. 375, 1-2, p. 1-9 9 p.

Research output: Contribution to journalReview article

81 Scopus citations

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle

Granzier, H., Radke, M., Royal, J., Wu, Y., Irving, T. C., Gotthardt, M. & Labeit, S., Aug 1 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 2, p. R557-R567

Research output: Contribution to journalReview article

24 Scopus citations

Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells

Granzier, H. & Labeit, S., Dec 1 2007, In : Muscle and Nerve. 36, 6, p. 740-755 16 p.

Research output: Contribution to journalReview article

87 Scopus citations
2006

The giant muscle protein titin is an adjustable molecular spring

Granzier, H. L. & Labeit, S., Apr 1 2006, In : Exercise and Sport Sciences Reviews. 34, 2, p. 50-53 4 p.

Research output: Contribution to journalReview article

48 Scopus citations
2005

Titin: Physiological function and role in cardiomyopathy and failure

Granzier, H. L., Wu, Y., Siegfried, L. & LeWinter, M., Sep 1 2005, In : Heart Failure Reviews. 10, 3, p. 211-223 13 p.

Research output: Contribution to journalReview article

59 Scopus citations

Titin and its associated proteins: The third myofilament system of the sarcomere

Granzier, H. L. & Labeit, S., Oct 21 2005, In : Advances in Protein Chemistry. 71, p. 89-119 31 p.

Research output: Contribution to journalReview article

59 Scopus citations
2004

Role of the giant elastic protein titin in the Frank-Starling mechanism of the heart

Fukuda, N. & Granzier, H., Apr 1 2004, In : Current Vascular Pharmacology. 2, 2, p. 135-139 5 p.

Research output: Contribution to journalReview article

40 Scopus citations

The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

Granzier, H. L. & Labeit, S., Feb 20 2004, In : Circulation research. 94, 3, p. 284-295 12 p.

Research output: Contribution to journalReview article

384 Scopus citations

The sensitive giant: The role of titin-based stretch sensing complexes in the heart

Miller, M. K., Granzier, H., Ehler, E. & Gregorio, C. C., Mar 1 2004, In : Trends in Cell Biology. 14, 3, p. 119-126 8 p.

Research output: Contribution to journalReview article

87 Scopus citations
2002

Titin as a modular spring: Emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Granzier, H., Labeit, D., Wu, Y. & Labeit, S., Dec 1 2002, In : Journal of Muscle Research and Cell Motility. 23, 5-6, p. 457-471 15 p.

Research output: Contribution to journalReview article

18 Scopus citations
2001

The complete gene sequence of titin, expression of an unusual ≈700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

Bang, M. L., Centner, T., Fornoff, F., Geach, A. J., Gotthardt, M., McNabb, M., Witt, C. C., Labeit, D., Gregorio, C. C., Granzier, H. & Labeit, S., Nov 23 2001, In : Circulation research. 89, 11, p. 1065-1072 8 p.

Research output: Contribution to journalReview article

Open Access
422 Scopus citations