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Porifera Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Ligands Chemical Compounds
Mortierella Medicine & Life Sciences
Growth Medicine & Life Sciences
Assays Chemical Compounds
Military Personnel Medicine & Life Sciences

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Research Output 1993 2017

  • 903 Citations
  • 17 h-Index
  • 42 Article
  • 1 Review article

Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities

Xi, J. B., Fang, Y. F., Frett, B., Zhu, M. L., Zhu, T., Kong, Y. N., Guan, F. J., Zhao, Y., Zhang, X. W., Li, H. Y., Ma, M. L. & Hu, W. Jan 27 2017 In : European Journal of Medicinal Chemistry. 126, p. 1083-1106 24 p.

Research output: Research - peer-reviewArticle

In Vitro Techniques

Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

Wang, J., Cheng, P., Pavlyukov, M. S., Yu, H., Zhang, Z., Kim, S. H., Minata, M., Mohyeldin, A., Xie, W., Chen, D., Goidts, V., Frett, B., Hu, W., Li, H., Shin, Y. J., Lee, Y., Nam, D. H., Kornblum, H. I., Wang, M. & Nakano, I. Aug 1 2017 In : Journal of Clinical Investigation. 127, 8, p. 3075-3089 15 p.

Research output: Research - peer-reviewArticle

NIMA-Related Kinases
Enhancer of Zeste Homolog 2 Protein
histone methyltransferase

The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer

De Falco, V., Carlomagno, F., Li, H. Y. & Santoro, M. 2017 (Accepted/In press) In : Best Practice and Research: Clinical Endocrinology and Metabolism.

Research output: Research - peer-reviewArticle

Thyroid Neoplasms
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-ret
2 Citations

Biliary elimination of pemetrexed is dependent on Mrp2 in rats: Potential mechanism of variable response in nonalcoholic steatohepatitis

Dzierlenga, A. L., Clarke, J. D., Klein, D. M., Anumol, T., Snyder, S. A., Li, H. & Cherrington, N. J. Aug 1 2016 In : Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 246-253 8 p.

Research output: Research - peer-reviewArticle

Non-alcoholic Fatty Liver Disease
Hepatobiliary Elimination
multidrug resistance-associated protein 2
6 Citations

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

Frett, B., McConnell, N., Smith, C. C., Wang, Y., Shah, N. P. & Li, H. Y. Apr 13 2015 In : European Journal of Medicinal Chemistry. 94, p. 123-131 9 p.

Research output: Research - peer-reviewArticle

Drug Discovery
Molecular Weight
Molecular weight