Hsin-Jung Joyce Wu

  • 1972 Citations
  • 15 h-Index
20002019
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Research Output 2000 2019

  • 1972 Citations
  • 15 h-Index
  • 22 Article
  • 1 Review article
2019
1 Citation (Scopus)

Impact of gut microbiota on gut-distal autoimmunity: a focus on T cells

Sprouse, M. L., Bates, N. A., Felix, K. M. & Wu, H-J. J., Jan 1 2019, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

Autoimmunity
Dysbiosis
Regulatory T-Lymphocytes
T-Lymphocytes
Autoimmune Diseases
1 Citation (Scopus)

P2RX7 Deletion in T Cells Promotes Autoimmune Arthritis by Unleashing the Tfh Cell Response

Felix, K. M., Teng, F., Bates, N. A., Ma, H., Jaimez, I. A., Sleiman, K. C., Tran, N. L. & Wu, H-J. J., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Helper-Inducer T-Lymphocytes
Arthritis
T-Lymphocytes
Autoimmune Diseases
Bacteria
2018
2 Citations (Scopus)

Gut microbiota contributes to resistance against Pneumococcal Pneumonia in immunodeficient Ragl Mice

Felix, K. M., Jaimez, I. A., Nguyen, T. V. V., Ma, H., Raslan, W. A., Klinger, C. N., Doyle, K. & Wu, H-J. J., Apr 18 2018, In : Frontiers in cellular and infection microbiology. 8, APR, 118.

Research output: Contribution to journalArticle

Pneumococcal Pneumonia
Bacteria
Neutrophils
Lung
Pneumococcal Infections
2017
61 Citations (Scopus)

IgA-coated E. Coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation

Viladomiu, M., Kivolowitz, C., Abdulhamid, A., Dogan, B., Victorio, D., Castellanos, J. G., Woo, V., Teng, F., Tran, N. L., Sczesnak, A., Chai, C., Kim, M., Diehl, G. E., Ajami, N. J., Petrosino, J. F., Zhou, X. K., Schwartzman, S., Mandl, L. A., Abramowitz, M., Jacob, V. & 6 others, Bosworth, B., Steinlauf, A., Scherl, E. J., Wu, H-J. J., Simpson, K. W. & Longman, R. S., Feb 8 2017, In : Science Translational Medicine. 9, 376, eaaf9655.

Research output: Contribution to journalArticle

Th17 Cells
Crohn Disease
Immunoglobulin A
Escherichia coli
Inflammation
29 Citations (Scopus)

Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs

Bradley, C. P., Teng, F., Felix, K. M., Sano, T., Naskar, D., Block, K. E., Huang, H., Knox, K. S., Littman, D. R. & Wu, H-J. J., Nov 8 2017, In : Cell Host and Microbe. 22, 5, p. 697-704.e4

Research output: Contribution to journalArticle

Th17 Cells
Autoimmunity
Bacteria
Lung
T-Cell Antigen Receptor
9 Citations (Scopus)

Synthetic retinoid am80 ameliorates lung and arthritic autoimmune responses by inhibiting t follicular helper and th17 cell responses

Naskar, D., Teng, F., Felix, K. M., Bradley, C. P. & Wu, H-J. J., Mar 1 2017, In : Journal of Immunology. 198, 5, p. 1855-1864 10 p.

Research output: Contribution to journalArticle

Th17 Cells
Retinoids
Helper-Inducer T-Lymphocytes
Autoimmunity
Arthritis
7 Citations (Scopus)

The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis

Teng, F., Felix, K. M., Bradley, C. P., Naskar, D., Ma, H., Raslan, W. A. & Wu, H-J. J., Aug 15 2017, In : Arthritis Research and Therapy. 19, 1, 188.

Research output: Contribution to journalArticle

Th17 Cells
Arthritis
Helper-Inducer T-Lymphocytes
Rheumatoid Arthritis
Microbiota
2016
72 Citations (Scopus)

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells

Teng, F., Klinger, C. N., Felix, K. M., Bradley, C. P., Wu, E., Tran, N. L., Umesaki, Y. & Wu, H-J. J., Apr 19 2016, In : Immunity. 44, 4, p. 875-888 14 p.

Research output: Contribution to journalArticle

Peyer's Patches
Helper-Inducer T-Lymphocytes
Arthritis
Microbiota
Bacteria
7 Citations (Scopus)

Host–Microbiota interplay in mediating immune disorders

Felix, K. M., Tahsin, S. & Wu, H-J. J., Jan 1 2016, In : Annals of the New York Academy of Sciences. 1417, 1, p. 57-70 14 p.

Research output: Contribution to journalReview article

Immune System Diseases
Immune system
Health
Allergies
Pathogens
92 Citations (Scopus)

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H-J. J., Kasper, D. L., Benoist, C. & Mathis, D., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8141-E8150

Research output: Contribution to journalArticle

Th17 Cells
Bacteria
Intestines
Bifidobacterium
Probiotics
2012
222 Citations (Scopus)

The role of gut microbiota in immune homeostasis and autoimmunity

Wu, H-J. J. & Wu, E., Jan 2012, In : Gut Microbes. 3, 1

Research output: Contribution to journalArticle

Autoimmunity
Autoimmune Diseases
Immune System
Homeostasis
Self Tolerance

The role of gut microbiota in immune homeostasis and autoimmunity.

Wu, H. J. & Wu, E., Jan 2012, In : Gut Microbes. 3, 1, p. 4-14 11 p.

Research output: Contribution to journalArticle

Autoimmunity
Autoimmune Diseases
Immune System
Homeostasis
Self Tolerance
2011
261 Citations (Scopus)

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

Kriegel, M. A., Sefik, E., Hill, J. A., Wu, H-J. J., Benoist, C. & Mathis, D., Jul 12 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 28, p. 11548-11553 6 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Bacteria
Th17 Cells
Mucous Membrane
Autoimmunity
2010
873 Citations (Scopus)

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells

Wu, H-J. J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C. & Mathis, D., Jun 2010, In : Immunity. 32, 6, p. 815-827 13 p.

Research output: Contribution to journalArticle

Th17 Cells
Autoantibodies
Arthritis
Germinal Center
Bacteria
2009
34 Citations (Scopus)

CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function

Wu, H-J. J. & Bondada, S., Jan 2009, In : Journal of Clinical Immunology. 29, 1, p. 12-21 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Ligation
SH2 Domain-Containing Protein Tyrosine Phosphatases
Null Lymphocytes
src-Family Kinases
49 Citations (Scopus)

IL-17-producing T cells can augment autoantibody-induced arthritis

Jacobs, J. P., Wu, H-J. J., Benoist, C. & Mathis, D., Dec 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 51, p. 21789-21794 6 p.

Research output: Contribution to journalArticle

Interleukin-17
Autoantibodies
Arthritis
T-Lymphocytes
B-Lymphocytes
2007
68 Citations (Scopus)

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk

Wu, H-J. J., Sawaya, H., Binstadt, B., Brickelmaier, M., Blasius, A., Gorelik, L., Mahmood, U., Weissleder, R., Carulli, J., Benoist, C. & Mathis, D., Aug 6 2007, In : Journal of Experimental Medicine. 204, 8, p. 1911-1922 12 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Natural Killer Cells
Arthritis
Immune System
Neutrophil Infiltration
53 Citations (Scopus)

The K/BxN mouse model of inflammatory arthritis: theory and practice.

Monach, P., Hattori, K., Huang, H., Hyatt, E., Morse, J., Nguyen, L., Ortiz-Lopez, A., Wu, H-J. J., Mathis, D. & Benoist, C., 2007, In : Methods in molecular medicine. 136, p. 269-282 14 p.

Research output: Contribution to journalArticle

Glucose-6-Phosphate Isomerase
Arthritis
Autoantibodies
Serum
T-Cell Antigen Receptor
2002
26 Citations (Scopus)

Defective CD19-dependent signaling in B-1a and B-1b B lymphocyte subpopulations

Sen, G., Wu, H-J. J., Bikah, G., Venkataraman, C., Robertson, D. A., Snow, E. C. & Bondada, S., Sep 15 2002, In : Molecular Immunology. 39, 1-2, p. 57-68 12 p.

Research output: Contribution to journalArticle

Lymphocyte Subsets
B-Cell Antigen Receptors
B-Lymphocytes
src-Family Kinases
Tyrosine
14 Citations (Scopus)

Positive and negative roles of CD72 in B cell function

Wu, H-J. J. & Bondada, S., 2002, In : Immunologic Research. 25, 2, p. 155-166 12 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Plasma Cells
Ligation
Cell Differentiation
Ligands
21 Citations (Scopus)

Transcriptional regulation of the human polymeric Ig receptor gene: Analysis of basal promoter elements

Hempen, P. M., Phillips, K. M., Conway, P. S., Sandoval, K. H., Schneeman, T. A., Wu, H-J. J. & Kaetzel, C. S., Aug 15 2002, In : Journal of Immunology. 169, 4, p. 1912-1921 10 p.

Research output: Contribution to journalArticle

Polymeric Immunoglobulin Receptors
Immunoglobulin Genes
Genetic Promoter Regions
Cell Line
Upstream Stimulatory Factors
2001
30 Citations (Scopus)

Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation

Wu, H-J. J., Venkataraman, C., Estus, S., Dong, C., Davis, R. J., Flavell, R. A. & Bondada, S., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
B-Lymphocytes
Cell Proliferation
Extracellular Signal-Regulated MAP Kinases
Phosphotransferases
2000
40 Citations (Scopus)

Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

Bondada, S., Wu, H-J. J., Robertson, D. A. & Chelvarajan, R. L., Oct 15 2000, In : Vaccine. 19, 4-5, p. 557-565 9 p.

Research output: Contribution to journalArticle

T Independent Antigens
Polysaccharides
neonates
polysaccharides
Vaccines