• 1785 Citations
  • 23 h-Index
19972019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1785 Citations
  • 23 h-Index
  • 50 Article
  • 2 Chapter
2019

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

Li, T., Li, Q., Wu, W., Li, Y., Hou, D. X., Xu, H., Zheng, B., Zeng, S., Shan, Y., Lu, X., Deng, F. & Qin, S., Nov 17 2018, In : Acta Biochimica et Biophysica Sinica. 51, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular Physiology of Gastrointestinal Function During Development

Xu, H. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 235-269 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 1 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

4 Scopus citations

Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei, X., Cai, L., Li, X., Xu, H., Geng, C. & Wang, C., May 1 2018, In : Korean Journal of Physiology and Pharmacology. 22, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

2016
9 Scopus citations

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

16 Scopus citations
2015

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

15 Scopus citations

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

16 Scopus citations

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

11 Scopus citations
12 Scopus citations
2014

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

310 Scopus citations

Somatostatin regulates tight junction proteins expression in colitis mice

Li, X. X., Wang, Q., Xu, H., Tao, L., Lu, J., Cai, L. & Wang, C., 2014, In : International Journal of Clinical and Experimental Pathology. 7, 5, p. 2153-2162 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1

Research output: Contribution to journalArticle

25 Scopus citations

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3

Research output: Contribution to journalArticle

18 Scopus citations

SPECT imaging of inflammatory response in ischemic-reperfused rat hearts using a 99mTc-labeled dual-domain cytokine ligand

Liu, Z., Barber, C., Wan, L., Liu, S., Hui, M. M., Furenlid, L. R., Xu, H. & Woolfenden, J. M., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2012

Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways

Liu, Z., Wyffels, L., Barber, C., Wan, L., Xu, H., Hui, M. M., Furenlid, L. R. & Woolfenden, J. M., Oct 2012, In : Nuclear Medicine and Biology. 39, 7, p. 905-915 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Xu, H., Zhang, B., Li, J., Wang, C., Chen, H. & Ghishan, F. K., Aug 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 3

Research output: Contribution to journalArticle

31 Scopus citations

Molecular Physiology of Gastrointestinal Function during Development

Xu, H., Collins, J. F. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 415-449 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2011

NHE2X3 DKO mice exhibit gender-specific NHE8 compensation

Xu, H., Li, J., Chen, R., Zhang, B., Wang, C., King, N., Chen, H. & Ghishan, F. K., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4

Research output: Contribution to journalArticle

17 Scopus citations

Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Wang, C., Xu, H., Chen, H., Li, J., Zhang, B., Tang, C. & Ghishan, F. K., Feb 2011, In : American Journal of Physiology - Cell Physiology. 300, 2

Research output: Contribution to journalArticle

17 Scopus citations
2010

Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription

Xu, H., Zhang, B., Li, J., Chen, H., Tooley, J. & Ghishan, F. K., Jul 2010, In : American Journal of Physiology - Cell Physiology. 299, 1

Research output: Contribution to journalArticle

19 Scopus citations
18 Scopus citations
2009
22 Scopus citations

Tumor necrosis factor-α downregulates intestinal NHE8 expression by reducing basal promoter activity

Xu, H., Chen, H., Dong, J., Li, J., Chen, R., Uno, J. K. & Ghishan, F. K., Mar 2009, In : American Journal of Physiology - Cell Physiology. 296, 3

Research output: Contribution to journalArticle

25 Scopus citations
2008
45 Scopus citations
2007

Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells

Hua, P., Xu, H., Uno, J. K., Lipko, M. A., Dong, J., Kiela, P. R. & Ghishan, F. K., Jul 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1

Research output: Contribution to journalArticle

9 Scopus citations
2006

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract

Kiela, P. R., Xu, H. & Ghishan, F. K., Nov 2006, In : Journal of Physiology and Pharmacology. 57, SUPPL. 7, p. 51-79 29 p.

Research output: Contribution to journalArticle

37 Scopus citations

Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells

Xu, L., Dixit, M. P., Nullmeyer, K. D., Xu, H., Kiela, P. R., Lynch, R. & Ghishan, F. K., Apr 2006, In : BBA - Biomembranes. 1758, 4, p. 519-526 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis

Uno, J. K., Kolek, O. I., Hines, E. R., Xu, H., Timmermann, B. N., Kiela, P. R. & Ghishan, F. K., Aug 2006, In : Gastroenterology. 131, 2, p. 497-509 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005
18 Scopus citations
70 Scopus citations
2004

Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2

Dixit, M. P., Xu, L., Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K., Jul 1 2004, In : BBA - Biomembranes. 1664, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
2003

Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen

Xu, H., Uno, J. K., Inouye, M., Xu, L., Drees, J. B., Collins, J. F. & Ghishan, F. K., Dec 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 285, 6 48-6

Research output: Contribution to journalArticle

59 Scopus citations

Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb

Xu, H., Inouye, M., Hines, E. R., Collins, J. F. & Ghishan, F. K., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

38 Scopus citations
2002
132 Scopus citations

Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes

Xu, H., Inouye, M., Missey, T., Collins, J. F. & Ghishan, F. K., Dec 23 2002, In : BBA - Biomembranes. 1567, SUPPL., p. 97-105 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2001

Epidermal growth factor regulation of rat NHE2 gene expression

Xu, H., Collins, J. F., Bai, L., Kiela, P. R., Lynch, R. & Ghishan, F. K., 2001, In : American Journal of Physiology - Cell Physiology. 281, 2 50-2

Research output: Contribution to journalArticle

33 Scopus citations

Molecular and Functional Analysis of a Novel Neuronal Vesicular Glutamate Transporter

Bai, L., Xu, H., Collins, J. F. & Ghishan, F. K., Sep 28 2001, In : Journal of Biological Chemistry. 276, 39, p. 36764-36769 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter

Bai, L., Collins, J. F., Xu, H., Xu, L. & Ghishan, F. K., Nov 11 2001, In : BBA - Gene Structure and Expression. 1522, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
53 Scopus citations

Transcriptional regulation of rat Na+/H+ exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor

Bai, L., Collins, J. F., Xu, H. & Ghisha, F. K., 2001, In : American Journal of Physiology - Cell Physiology. 280, 5 49-5

Research output: Contribution to journalArticle

15 Scopus citations
2000
32 Scopus citations

Expression of rat, renal NHE2 and NHE3 during postnatal developmental

Collins, J. F., Kiela, P. R., Xu, H. & Ghishan, F. K., Mar 15 2000, In : BBA - Biomembranes. 1464, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
1999
23 Scopus citations
14 Scopus citations
97 Scopus citations
1998

Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion disease

Michail, S., Collins, J. F., Xu, H., Kaufman, S., Vanderhoof, J. & Ghishan, F. K., Nov 1998, In : Journal of Pediatric Gastroenterology and Nutrition. 27, 5, p. 536-542 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
32 Scopus citations

Molecular cloning and characterization of the rat NHE-2 gene promoter

Muller, Y. L., Collins, J. F., Bai, L., Xu, H. & Ghishan, F. K., Nov 8 1998, In : BBA - Gene Structure and Expression. 1442, 2-3, p. 314-319 6 p.

Research output: Contribution to journalArticle

23 Scopus citations