• 1695 Citations
  • 22 h-Index
19972019
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Research Output 1997 2019

  • 1695 Citations
  • 22 h-Index
  • 50 Article
  • 2 Chapter
2019
1 Citation (Scopus)

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Protein Isoforms
Neoplasms
Catenins
2018

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

Li, T., Li, Q., Wu, W., Li, Y., Hou, D. X., Xu, H., Zheng, B., Zeng, S., Shan, Y., Lu, X., Deng, F. & Qin, S., Nov 17 2018, In : Acta Biochimica et Biophysica Sinica. 51, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Antioxidant Response Elements
Seed
Seeds
Skin
1 Citation (Scopus)

Molecular Physiology of Gastrointestinal Function During Development

Xu, H. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 235-269 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Weaning
Food
Large Intestine
Small Intestine
Intestines
1 Citation (Scopus)

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 1 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Electrolytes
Genes
Gastrointestinal Tract
Antiporters

Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei, X., Cai, L., Li, X., Xu, H., Geng, C. & Wang, C., May 1 2018, In : Korean Journal of Physiology and Pharmacology. 22, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Colitis
Somatostatin
Diarrhea
Protein Isoforms
2016
8 Citations (Scopus)
Goblet Cells
HT29 Cells
Enterocytes
Mucins
Mucus
15 Citations (Scopus)

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colitis
Somatostatin
Octreotide
seglitide
2015
14 Citations (Scopus)

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

Leydig Cells
Testis
LH Receptors
Testosterone
Sodium-Hydrogen Antiporter
12 Citations (Scopus)

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

Dextran Sulfate
Goblet Cells
Paneth Cells
Colon
Intestinal Mucosa
10 Citations (Scopus)

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

Lacrimal Apparatus
Epithelial Cells
Conjunctiva
Tears
Cornea
11 Citations (Scopus)
Butyric Acid
Butyrates
Sodium
Genetic Promoter Regions
Epithelial Cells
2014
273 Citations (Scopus)

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

Colitis
Mucus
Ulcerative Colitis
Colon
Bacteria
20 Citations (Scopus)

Somatostatin regulates tight junction proteins expression in colitis mice

Li, X. X., Wang, Q., Xu, H., Tao, L., Lu, J., Cai, L. & Wang, C., 2014, In : International Journal of Clinical and Experimental Pathology. 7, 5, p. 2153-2162 10 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Claudin-3
Colitis
Somatostatin
Citrobacter rodentium
2013
23 Citations (Scopus)

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1

Research output: Contribution to journalArticle

Bacterial Adhesion
Knockout Mice
Dextran Sulfate
Colon
Salmonella typhimurium
16 Citations (Scopus)

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3

Research output: Contribution to journalArticle

Stomach
Adenoma
Stomach Ulcer
Sodium-Hydrogen Antiporter
Sodium Bicarbonate
4 Citations (Scopus)

SPECT imaging of inflammatory response in ischemic-reperfused rat hearts using a 99mTc-labeled dual-domain cytokine ligand

Liu, Z., Barber, C., Wan, L., Liu, S., Hui, M. M., Furenlid, L. R., Xu, H. & Woolfenden, J. M., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Interleukin 1 Receptor Antagonist Protein
Single-Photon Emission-Computed Tomography
Cytokines
Ligands
2012
10 Citations (Scopus)

Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways

Liu, Z., Wyffels, L., Barber, C., Wan, L., Xu, H., Hui, M. M., Furenlid, L. R. & Woolfenden, J. M., Oct 2012, In : Nuclear Medicine and Biology. 39, 7, p. 905-915 11 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Interleukin 1 Receptor Antagonist Protein
Interleukin-1
Cytokines
Ear
29 Citations (Scopus)

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Xu, H., Zhang, B., Li, J., Wang, C., Chen, H. & Ghishan, F. K., Aug 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 3

Research output: Contribution to journalArticle

Mucins
Bicarbonates
Knockout Mice
Colon
Intestines
1 Citation (Scopus)

Molecular Physiology of Gastrointestinal Function during Development

Xu, H., Collins, J. F. & Ghishan, F. K., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 415-449 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011
17 Citations (Scopus)

NHE2X3 DKO mice exhibit gender-specific NHE8 compensation

Xu, H., Li, J., Chen, R., Zhang, B., Wang, C., King, N., Chen, H. & Ghishan, F. K., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4

Research output: Contribution to journalArticle

Knockout Mice
Sodium-Hydrogen Antiporter
Caco-2 Cells
Intestinal Absorption
Puberty
17 Citations (Scopus)

Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Wang, C., Xu, H., Chen, H., Li, J., Zhang, B., Tang, C. & Ghishan, F. K., Feb 2011, In : American Journal of Physiology - Cell Physiology. 300, 2

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
p38 Mitogen-Activated Protein Kinases
Somatostatin
Diarrhea
Octreotide
2010
18 Citations (Scopus)

Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription

Xu, H., Zhang, B., Li, J., Chen, H., Tooley, J. & Ghishan, F. K., Jul 2010, In : American Journal of Physiology - Cell Physiology. 299, 1

Research output: Contribution to journalArticle

Epidermal Growth Factor
Caco-2 Cells
Sp3 Transcription Factor
Gene Expression
Messenger RNA
17 Citations (Scopus)
Glucocorticoids
Caco-2 Cells
Electrophoretic Mobility Shift Assay
Intestines
Transcription Factors
2009
22 Citations (Scopus)
Intestinal Absorption
Colitis
Tumor Necrosis Factor-alpha
Phosphates
Inflammatory Bowel Diseases
24 Citations (Scopus)

Tumor necrosis factor-α downregulates intestinal NHE8 expression by reducing basal promoter activity

Xu, H., Chen, H., Dong, J., Li, J., Chen, R., Uno, J. K. & Ghishan, F. K., Mar 2009, In : American Journal of Physiology - Cell Physiology. 296, 3

Research output: Contribution to journalArticle

Trinitrobenzenes
Down-Regulation
Tumor Necrosis Factor-alpha
Caco-2 Cells
Sulfonic Acids
2008
44 Citations (Scopus)
3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride
Sodium-Hydrogen Antiporter
Gastrointestinal Tract
Protein Isoforms
Jejunum
2007
9 Citations (Scopus)

Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells

Hua, P., Xu, H., Uno, J. K., Lipko, M. A., Dong, J., Kiela, P. R. & Ghishan, F. K., Jul 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1

Research output: Contribution to journalArticle

Epithelial Cells
Genetic Promoter Regions
Genes
Kidney
Transcription Factors
2006
35 Citations (Scopus)

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract

Kiela, P. R., Xu, H. & Ghishan, F. K., Nov 2006, In : Journal of Physiology and Pharmacology. 57, SUPPL. 7, p. 51-79 29 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Gastrointestinal Tract
Protein Isoforms
Digestive System Physiological Phenomena
Physiological Phenomena
17 Citations (Scopus)

Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells

Xu, L., Dixit, M. P., Nullmeyer, K. D., Xu, H., Kiela, P. R., Lynch, R. & Ghishan, F. K., Apr 2006, In : BBA - Biomembranes. 1758, 4, p. 519-526 8 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Angiotensin II
Protein Isoforms
Genes
Transcription
41 Citations (Scopus)

The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis

Uno, J. K., Kolek, O. I., Hines, E. R., Xu, H., Timmermann, B. N., Kiela, P. R. & Ghishan, F. K., Aug 2006, In : Gastroenterology. 131, 2, p. 497-509 13 p.

Research output: Contribution to journalArticle

Colitis
Osteoblasts
Down-Regulation
Tumor Necrosis Factor-alpha
Gene Expression
2005
18 Citations (Scopus)
NFI Transcription Factors
Caco-2 Cells
Electrophoretic Mobility Shift Assay
Genetic Promoter Regions
Genes
69 Citations (Scopus)
Sodium-Hydrogen Antiporter
Protein Isoforms
Complementary DNA
Intestinal Absorption
Proteins
2004
36 Citations (Scopus)

Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2

Dixit, M. P., Xu, L., Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K., Jul 1 2004, In : BBA - Biomembranes. 1664, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Angiotensin II
Kidney
Rats
Brushes
2003
58 Citations (Scopus)

Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen

Xu, H., Uno, J. K., Inouye, M., Xu, L., Drees, J. B., Collins, J. F. & Ghishan, F. K., Dec 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 285, 6 48-6

Research output: Contribution to journalArticle

Estrogens
Gene Expression
Microvilli
Messenger RNA
Caco-2 Cells
38 Citations (Scopus)

Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb

Xu, H., Inouye, M., Hines, E. R., Collins, J. F. & Ghishan, F. K., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Caco-2 Cells
Epidermal Growth Factor
Intestinal Absorption
Electrophoretic Mobility Shift Assay
Proto-Oncogene Proteins c-myb
2002
127 Citations (Scopus)
Sodium-Phosphate Cotransporter Proteins
Cholecalciferol
Rats
Messenger RNA
Sodium
19 Citations (Scopus)

Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes

Xu, H., Inouye, M., Missey, T., Collins, J. F. & Ghishan, F. K., Dec 23 2002, In : BBA - Biomembranes. 1567, SUPPL., p. 97-105 9 p.

Research output: Contribution to journalArticle

Fibroblasts
Xenopus
Cricetinae
Oocytes
Phosphates
2001
32 Citations (Scopus)

Epidermal growth factor regulation of rat NHE2 gene expression

Xu, H., Collins, J. F., Bai, L., Kiela, P. R., Lynch, R. & Ghishan, F. K., 2001, In : American Journal of Physiology - Cell Physiology. 281, 2 50-2

Research output: Contribution to journalArticle

Epidermal Growth Factor
Gene expression
Rats
Gene Expression
Messenger RNA
162 Citations (Scopus)

Molecular and Functional Analysis of a Novel Neuronal Vesicular Glutamate Transporter

Bai, L., Xu, H., Collins, J. F. & Ghishan, F. K., Sep 28 2001, In : Journal of Biological Chemistry. 276, 39, p. 36764-36769 6 p.

Research output: Contribution to journalArticle

Vesicular Glutamate Transport Proteins
Functional analysis
Glutamic Acid
Amino Acid Transport System X-AG
Brain
6 Citations (Scopus)

Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter

Bai, L., Collins, J. F., Xu, H., Xu, L. & Ghishan, F. K., Nov 11 2001, In : BBA - Gene Structure and Expression. 1522, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

Sodium-Phosphate Cotransporter Proteins
Cloning
Molecular Cloning
Luciferases
Genes
53 Citations (Scopus)
Sodium-Phosphate Cotransporter Proteins
Epidermal Growth Factor
Genes
Caco-2 Cells
Lung
15 Citations (Scopus)

Transcriptional regulation of rat Na+/H+ exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor

Bai, L., Collins, J. F., Xu, H. & Ghisha, F. K., 2001, In : American Journal of Physiology - Cell Physiology. 280, 5 49-5

Research output: Contribution to journalArticle

Sp1 Transcription Factor
Sodium-Hydrogen Antiporter
Rats
Protein Isoforms
Transcription
2000
32 Citations (Scopus)
Glucocorticoids
Small Intestine
Rats
Tissue
Glucocorticoid Receptors
9 Citations (Scopus)

Expression of rat, renal NHE2 and NHE3 during postnatal developmental

Collins, J. F., Kiela, P. R., Xu, H. & Ghishan, F. K., Mar 15 2000, In : BBA - Biomembranes. 1464, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

Rats
Kidney
Messenger RNA
Proteins
Suckling Animals
1999
23 Citations (Scopus)
Sodium-Hydrogen Antiporter
Genes
Response Elements
Osmoregulation
5' Flanking Region
14 Citations (Scopus)
Sodium-Phosphate Cotransporter Proteins
Methylprednisolone
Glucocorticoids
Rats
Mifepristone
93 Citations (Scopus)
Molecular Cloning
Tissue Distribution
Complementary DNA
Kidney
Xenopus laevis
1998
33 Citations (Scopus)

Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion disease

Michail, S., Collins, J. F., Xu, H., Kaufman, S., Vanderhoof, J. & Ghishan, F. K., Nov 1998, In : Journal of Pediatric Gastroenterology and Nutrition. 27, 5, p. 536-542 7 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Microvilli
microvilli
mucosa
transporters
32 Citations (Scopus)
Intestinal Mucosa
Rats
Brushes
Transcription
Microvilli
22 Citations (Scopus)

Molecular cloning and characterization of the rat NHE-2 gene promoter

Muller, Y. L., Collins, J. F., Bai, L., Xu, H. & Ghishan, F. K., Nov 8 1998, In : BBA - Gene Structure and Expression. 1442, 2-3, p. 314-319 6 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Rats
Genes
Genetic Promoter Regions