• 1845 Citations
  • 23 h-Index
19972019

Research output per year

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Research Output

  • 1845 Citations
  • 23 h-Index
  • 50 Article
  • 2 Chapter

Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion disease

Michail, S., Collins, J. F., Xu, H., Kaufman, S., Vanderhoof, J. & Ghishan, F. K., Nov 1 1998, In : Journal of pediatric gastroenterology and nutrition. 27, 5, p. 536-542 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine

Kiela, P. R., Guner, Y. S., Xu, H., Collins, J. F. & Ghishan, F. K., 2000, In : American Journal of Physiology - Cell Physiology. 278, 4 47-4, p. C629-C637

Research output: Contribution to journalArticle

33 Scopus citations

Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3

Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K., Jul 2 2002, In : American Journal of Physiology - Cell Physiology. 282, 3 51-3, p. C487-C493

Research output: Contribution to journalArticle

137 Scopus citations

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract

Kiela, P. R., Xu, H. & Ghishan, F. K., Nov 1 2006, In : Journal of Physiology and Pharmacology. 57, SUPPL. 7, p. 51-79 29 p.

Research output: Contribution to journalArticle

37 Scopus citations

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjovall, H. & Hansson, G. C., Feb 2014, In : Gut. 63, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

336 Scopus citations

Characterization of 99mTc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways

Liu, Z., Wyffels, L., Barber, C., Wan, L., Xu, H., Hui, M. M., Furenlid, L. R. & Woolfenden, J. M., Oct 1 2012, In : Nuclear Medicine and Biology. 39, 7, p. 905-915 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Characterization of cis-elements required for osmotic response of rat Na+/H+ exchanger-2 (NHE-2) gene

Bai, L., Collins, J. F., Muller, Y. L., Xu, H., Kiela, P. R. & Ghishan, F. K., Oct 1 1999, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 277, 4 46-4, p. R1112-R1119

Research output: Contribution to journalArticle

24 Scopus citations

Differential regulation of renal sodium-phosphate transporter by glucocorticoids during rat ontogeny

Guner, Y. S., Kiela, P. R., Xu, H., Collins, J. F. & Ghishan, F. K., Jan 1 1999, In : American Journal of Physiology - Cell Physiology. 277, 5 46-5, p. C884-C890

Research output: Contribution to journalArticle

15 Scopus citations

Disruption of NHE8 expression impairs Leydig cell function in the testes

Xu, H., Chen, H., Li, J., Zhao, Y. & Ghishan, F. K., 2015, In : American Journal of Physiology - Cell Physiology. 308, 4, p. C330-C338

Research output: Contribution to journalArticle

15 Scopus citations

Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2

Dixit, M. P., Xu, L., Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K., Jul 1 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1664, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription

Xu, H., Zhang, B., Li, J., Chen, H., Tooley, J. & Ghishan, F. K., Jul 2010, In : American Journal of Physiology - Cell Physiology. 299, 1, p. C51-C57

Research output: Contribution to journalArticle

19 Scopus citations

Epidermal growth factor regulation of rat NHE2 gene expression

Xu, H., Collins, J. F., Bai, L., Kiela, P. R., Lynch, R. M. & Ghishan, F. K., Aug 27 2001, In : American Journal of Physiology - Cell Physiology. 281, 2 50-2, p. C504-C513

Research output: Contribution to journalArticle

33 Scopus citations

Expression of rat, renal NHE2 and NHE3 during postnatal developmental

Collins, J. F., Kiela, P. R., Xu, H. & Ghishan, F. K., Mar 15 2000, In : Biochimica et Biophysica Acta - Biomembranes. 1464, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium

Collins, J. F., Xu, H., Kiela, P. R., Zeng, J. & Ghishan, F. K., 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6, p. C1937-C1946

Research output: Contribution to journalArticle

70 Scopus citations

Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes

Xu, H., Inouye, M., Missey, T., Collins, J. F. & Ghishan, F. K., Dec 23 2002, In : Biochimica et Biophysica Acta - Biomembranes. 1567, SUPPL., p. 97-105 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
46 Scopus citations

Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

Xu, H., Zhang, B., Li, J., Wang, C., Chen, H. & Ghishan, F. K., Aug 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 3, p. G335-G343

Research output: Contribution to journalArticle

31 Scopus citations

Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated

Collins, J. F., Kiela, P. R., Xu, H., Zeng, J. & Ghishan, F. K., Oct 1 1998, In : American Journal of Physiology - Cell Physiology. 275, 4 44-4, p. C1143-C1150

Research output: Contribution to journalArticle

32 Scopus citations
10 Scopus citations

Loss of NHE8 expression impairs intestinal mucosal integrity

Wang, A., Li, J., Zhao, Y., Johansson, M. E. V., Xu, H. & Ghishan, F. K., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G855-G864

Research output: Contribution to journalArticle

18 Scopus citations

Loss of NHE8 expression impairs ocular surface function in mice

Xu, H., Zhao, Y., Li, J., Wang, M., Lian, F., Gao, M. & Ghishan, F. K., Jan 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 1, p. C79-C87

Research output: Contribution to journalArticle

11 Scopus citations

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

Li, T., Li, Q., Wu, W., Li, Y., Hou, D. X., Xu, H., Zheng, B., Zeng, S., Shan, Y., Lu, X., Deng, F. & Qin, S., Nov 17 2018, In : Acta Biochimica et Biophysica Sinica. 51, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular and Functional Analysis of a Novel Neuronal Vesicular Glutamate Transporter

Bai, L., Xu, H., Collins, J. F. & Ghishan, F. K., Sep 28 2001, In : Journal of Biological Chemistry. 276, 39, p. 36764-36769 6 p.

Research output: Contribution to journalArticle

165 Scopus citations
101 Scopus citations

Molecular cloning and characterization of the rat NHE-2 gene promoter

Muller, Y. L., Collins, J. F., Bai, L., Xu, H. & Ghishan, F. K., Nov 8 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1442, 2-3, p. 314-319 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter

Bai, L., Collins, J. F., Xu, H., Xu, L. & Ghishan, F. K., Nov 11 2001, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1522, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular Physiology of Gastrointestinal Function during Development

Xu, H., Collins, J. F. & Ghishan, F. K., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 415-449 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Molecular Physiology of Gastrointestinal Function During Development

Xu, H. & Ghishan, F. K., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 235-269 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
20 Scopus citations

NHE2X3 DKO mice exhibit gender-specific NHE8 compensation

Xu, H., Li, J., Chen, R., Zhang, B., Wang, C., King, N., Chen, H. & Ghishan, F. K., Apr 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 4, p. G647-G653

Research output: Contribution to journalArticle

18 Scopus citations

NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

Xu, H., Li, J., Chen, H. & Ghishan, F. K., Jan 1 2019, In : CMGH. 7, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion

Liu, C., Xu, H., Zhang, B., Johansson, M. E. V., Li, J., Hansson, G. C. & Ghishan, F. K., Jul 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 1, p. C121-C128

Research output: Contribution to journalArticle

26 Scopus citations

NHE8 plays important roles in gastric mucosal protection

Xu, H., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Feb 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 3, p. G257-G261

Research output: Contribution to journalArticle

18 Scopus citations
26 Scopus citations

Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen

Xu, H., Uno, J. K., Inouye, M., Xu, L., Drees, J. B., Collins, J. F. & Ghishan, F. K., Dec 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 285, 6 48-6, p. G1317-G1324

Research output: Contribution to journalArticle

62 Scopus citations

Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells

Xu, L., Dixit, M. P., Nullmeyer, K. D., Xu, H., Kiela, P. R., Lynch, R. M. & Ghishan, F. K., Apr 1 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 4, p. 519-526 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor

Xu, H., Collins, J. F., Bai, L., Kiela, P. R. & Ghishan, F. K., Jun 4 2001, In : American Journal of Physiology - Cell Physiology. 280, 3 49-3, p. C628-C636

Research output: Contribution to journalArticle

55 Scopus citations

SLC9 gene family: Function, expression, and regulation

Xu, H., Ghishan, F. K. & Kiela, P. R., Apr 2018, In : Comprehensive Physiology. 8, 2, p. 555-583 29 p.

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice

Li, X., Cai, L., Xu, H., Geng, C., Lu, J., Tao, L., Sun, D., Ghishan, F. K. & Wang, C., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 5, p. G954-G963

Research output: Contribution to journalArticle

16 Scopus citations

Somatostatin regulates tight junction proteins expression in colitis mice

Li, X. X., Wang, Q., Xu, H., Tao, L., Lu, J., Cai, L. & Wang, C., 2014, In : International Journal of Clinical and Experimental Pathology. 7, 5, p. 2153-2162 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Wang, C., Xu, H., Chen, H., Li, J., Zhang, B., Tang, C. & Ghishan, F. K., Feb 2011, In : American Journal of Physiology - Cell Physiology. 300, 2, p. C375-C382

Research output: Contribution to journalArticle

17 Scopus citations

Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells

Hua, P., Xu, H., Uno, J. K., Lipko, M. A., Dong, J., Kiela, P. R. & Ghishan, F. K., Jul 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1, p. G146-G153

Research output: Contribution to journalArticle

9 Scopus citations

SPECT imaging of inflammatory response in ischemic-reperfused rat hearts using a 99mTc-labeled dual-domain cytokine ligand

Liu, Z., Barber, C., Wan, L., Liu, S., Hui, M. M., Furenlid, L. R., Xu, H. & Woolfenden, J. M., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
70 Scopus citations

The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis

Uno, J. K., Kolek, O. I., Hines, E. R., Xu, H., Timmermann, B. N., Kiela, P. R. & Ghishan, F. K., Aug 2006, In : Gastroenterology. 131, 2, p. 497-509 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5

Xu, H., Zhang, B., Li, J., Chen, H., Wang, C. & Ghishan, F. K., Oct 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4, p. G921-G927

Research output: Contribution to journalArticle

18 Scopus citations

Transcriptional regulation of rat Na+/H+ exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor

Bai, L., Collins, J. F., Xu, H. & Ghisha, F. K., May 23 2001, In : American Journal of Physiology - Cell Physiology. 280, 5 49-5, p. C1168-C1175

Research output: Contribution to journalArticle

15 Scopus citations

Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb

Xu, H., Inouye, M., Hines, E. R., Collins, J. F. & Ghishan, F. K., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5, p. C1262-C1271

Research output: Contribution to journalArticle

38 Scopus citations

Tumor necrosis factor-alpha impairs intestinal phosphate absorption in colitis

Chen, H., Xu, H., Dong, J., Li, J. & Ghishan, F. K., Apr 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 4, p. G775-G781

Research output: Contribution to journalArticle

23 Scopus citations