• 2697 Citations
  • 28 h-Index
19952019
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Research Output 1995 2017

  • 2697 Citations
  • 28 h-Index
  • 58 Article
  • 3 Chapter
  • 1 Comment/debate
1995
10 Citations (Scopus)

Basic-helix-loop-helix region of tal: Evaluation of structure and DNA affinity

Bishop, P., Ghosh, I., Jones, C. & Chmielewski, J., Aug 9 1995, In : Journal of the American Chemical Society. 117, 31, p. 8283-8284 2 p.

Research output: Contribution to journalArticle

Basic–Helix–Loop–Helix Region of Tal: Evaluation of Structure and DNA Affinity

Bishop, P., Ghosh, I., Jones, C. & Chmielewski, J., 1995, In : Journal of the American Chemical Society. 117, 46, p. 11616 1 p.

Research output: Contribution to journalArticle

DNA
6 Citations (Scopus)
NF-kappa B
Crystal structure
E-Box Elements
Solid-Phase Synthesis Techniques
Size exclusion chromatography
1997
85 Citations (Scopus)

A pH-modulated, self-replicating peptide

Yao, S., Ghosh, I., Zutshi, R. & Chmielewski, J., 1997, In : Journal of the American Chemical Society. 119, 43, p. 10559-10560 2 p.

Research output: Contribution to journalArticle

Peptides
1998
59 Citations (Scopus)

A self-replicating peptide under ionic control

Yao, S., Ghosh, I., Zutshi, R. & Chmielewski, J., Mar 2 1998, In : Angewandte Chemie - International Edition. 37, 4, p. 478-481 4 p.

Research output: Contribution to journalArticle

Peptides
22 Citations (Scopus)

A β-sheet peptide inhibitor of E47 dimerization and DNA binding

Ghosh, I. & Chmielewski, J., Aug 1998, In : Chemistry and Biology. 5, 8, p. 439-445 7 p.

Research output: Contribution to journalArticle

Dimerization
Basic Helix-Loop-Helix Transcription Factors
Transcription Factors
Peptides
DNA
111 Citations (Scopus)

Selective amplification by auto- and cross-catalysis in a replicating peptide system

Yao, S., Ghosh, I., Zutshi, R. & Chmielewski, J., Dec 3 1998, In : Nature. 396, 6710, p. 447-450 4 p.

Research output: Contribution to journalArticle

Catalysis
Peptides
Oligonucleotides
Salts
1999

Erratum: A pH-modulated, self-replicating peptide (Journal of the American Chemical Society (1997) 119 (10559-10560))

Yao, S., Ghosh, I., Zutshi, R. & Chmielewski, J., Sep 8 1999, In : Journal of the American Chemical Society. 121, 35, 1 p.

Research output: Contribution to journalComment/debate

Peptides
98 Citations (Scopus)

Inhibition of spontaneous receptor phosphorylation by residues in a putative α-helix in the KIT intracellular juxtamembrane region

Ma, Y., Cunningham, M. E., Wang, X., Ghosh, I., Regan, L. & Longley, B. J., May 7 1999, In : Journal of Biological Chemistry. 274, 19, p. 13399-13402 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Substitution reactions
Alanine
Conformations
Phosphotransferases
5 Citations (Scopus)

Structure-function relationship in a β-sheet peptide Inhibitor of E47 dimerization and DNA binding

Ghosh, I., Issac, R. & Chmielewski, J., Jan 1999, In : Bioorganic and Medicinal Chemistry. 7, 1, p. 61-66 6 p.

Research output: Contribution to journalArticle

Dimerization
Transcription Factors
Alanine
Peptides
DNA
2000
357 Citations (Scopus)

Antiparallel leucine zipper-directed protein reassembly: Application to the green fluorescent protein [12]

Ghosh, I., Hamilton, A. D. & Regan, L., Jun 14 2000, In : Journal of the American Chemical Society. 122, 23, p. 5658-5659 2 p.

Research output: Contribution to journalArticle

Leucine Zippers
Fasteners
Green Fluorescent Proteins
Proteins
2001
1 Citation (Scopus)

DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47

Ghosh, I., Bishop, P. & Chmielewski, J., 2001, In : Journal of Peptide Research. 57, 5, p. 354-360 7 p.

Research output: Contribution to journalArticle

Fusion reactions
DNA
Helix-Loop-Helix Motifs
Basic Helix-Loop-Helix Transcription Factors
Proteins
2004
7 Citations (Scopus)

Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries

Rajagopal, S., Meza-Romero, R. & Ghosh, I., Mar 22 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 6, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Bacteriophages
Thrombin
Libraries
Epitopes
Immunoglobulin G
86 Citations (Scopus)

Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers

Zhou, M., Bentley, D. & Ghosh, I., Jan 28 2004, In : Journal of the American Chemical Society. 126, 3, p. 734-735 2 p.

Research output: Contribution to journalArticle

Dendrimers
Leucine Zippers
Fasteners
Fibers
Nanotechnology
15 Citations (Scopus)

Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides

Zhou, M. & Ghosh, I., Sep 30 2004, In : Organic Letters. 6, 20, p. 3561-3564 4 p.

Research output: Contribution to journalArticle

zippers
Dendrimers
Leucine Zippers
leucine
dendrimers
32 Citations (Scopus)

Peptide self-assembly as a model of proteins in the pre-genomic world

Ghosh, I. & Chmielewski, J., Dec 2004, In : Current Opinion in Chemical Biology. 8, 6, p. 640-644 5 p.

Research output: Contribution to journalArticle

Self assembly
Peptides
Nucleotide Aptamers
Catalytic RNA
Proteins
2005
301 Citations (Scopus)

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism

Magliery, T. J., Wilson, C. G. M., Pan, W., Mishler, D., Ghosh, I., Hamilton, A. D. & Regan, L., Jan 12 2005, In : Journal of the American Chemical Society. 127, 1, p. 146-157 12 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Proteins
Proteomics
Leucine Zippers
Protein Binding
66 Citations (Scopus)

DNA sequence-enabled reassembly of the green fluorescent protein

Stains, C. I., Porter, J. R., Ooi, A. T., Segal, D. J. & Ghosh, I., Aug 10 2005, In : Journal of the American Chemical Society. 127, 31, p. 10782-10783 2 p.

Research output: Contribution to journalArticle

DNA sequences
Green Fluorescent Proteins
Zinc Fingers
Proteins
Zinc
9 Citations (Scopus)

Single-site mutations in a hyperthermophilic variant of the B1 domain of protein G result in self-assembled oligomers

Meyer, S. C., Huerta, C. & Ghosh, I., Feb 22 2005, In : Biochemistry. 44, 7, p. 2360-2368 9 p.

Research output: Contribution to journalArticle

Point Mutation
Oligomers
Congo Red
Mutation
Fluorescence Spectrometry
2006
12 Citations (Scopus)

A minimalist approach toward protein recognition by epitope transfer from functionally evolved β-sheet surfaces

Rajagopal, S., Meyer, S. C., Goldman, A., Zhou, M. & Ghosh, I., Nov 8 2006, In : Journal of the American Chemical Society. 128, 44, p. 14356-14363 8 p.

Research output: Contribution to journalArticle

Epitopes
Thrombin
Scaffolds
Proteins
Molecules
76 Citations (Scopus)

Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics

Ghosh, I., Stains, C. I., Ooi, A. T. & Segal, D. J., 2006, In : Molecular BioSystems. 2, 11, p. 551-560 10 p.

Research output: Contribution to journalArticle

Zinc Fingers
Zinc
Denaturation
Molecular Pathology
DNA
32 Citations (Scopus)

Highly selective cyclic peptide ligands for neutravidin and avidin identified by phage display

Meyer, S. C., Gaj, T. & Ghosh, I., Jul 2006, In : Chemical Biology and Drug Design. 68, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Bacteriophages
Streptavidin
Avidin
Display devices
38 Citations (Scopus)

Inhibition of β-amyloid fibrillization by directed evolution of a β-sheet presenting miniature protein

Smith, T. J., Stains, C. I., Meyer, S. C. & Ghosh, I., Nov 15 2006, In : Journal of the American Chemical Society. 128, 45, p. 14456-14457 2 p.

Research output: Contribution to journalArticle

Amyloid
Proteins
Protein Transport
Circular dichroism spectroscopy
Denaturation
45 Citations (Scopus)

Sequence-enabled reassembly of β-lactamase (SEER-LAC): A sensitive method for the detection of double-stranded DNA

Ooi, A. T., Stains, C. I., Ghosh, I. & Segal, D. J., Mar 21 2006, In : Biochemistry. 45, 11, p. 3620-3625 6 p.

Research output: Contribution to journalArticle

DNA
DNA sequences
Zinc Fingers
Zinc
Substitution reactions
68 Citations (Scopus)

Site-specific detection of DNA methylation utilizing mCpG-SEER

Stains, C. I., Furman, J. L., Segal, D. J. & Ghosh, I., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9761-9765 5 p.

Research output: Contribution to journalArticle

DNA Methylation
Green Fluorescent Proteins
Proteins
Fluorescence
Zinc Fingers
2007
90 Citations (Scopus)

Current trends in peptide science quantum dots and peptides: A bright future together

Zhou, M. & Ghosh, I., 2007, In : Biopolymers - Peptide Science Section. 88, 3, p. 325-339 15 p.

Research output: Contribution to journalArticle

Quantum Dots
Peptides
Semiconductor quantum dots
Ligands
peptide A
83 Citations (Scopus)

Molecules that target beta-amyloid

Stains, C. I., Mondal, K. & Ghosh, I., Dec 10 2007, In : ChemMedChem. 2, 12, p. 1674-1692 19 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Amyloid
Molecules
Agglomeration
Peptidomimetics
2 Citations (Scopus)
Cell Surface Receptors
Brownian movement
Molecules
Biophysics
Signal transduction
88 Citations (Scopus)

Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules

Zhou, M., Nakatani, E., Gronenberg, L. S., Tokimoto, T., Wirth, M. J., Hruby, V. J., Roberts, A., Lynch, R. & Ghosh, I., Mar 2007, In : Bioconjugate Chemistry. 18, 2, p. 323-332 10 p.

Research output: Contribution to journalArticle

Quantum Dots
GTP-Binding Proteins
Peptides
Semiconductor quantum dots
Proteins
15 Citations (Scopus)

Probing orientations of single fluorescent labels on a peptide reversibly binding to the human delta-opioid receptor

Tokimoto, T., Bethea, T. R. C., Zhou, M., Ghosh, I. & Wirth, M. J., Feb 2007, In : Applied Spectroscopy. 61, 2, p. 130-137 8 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Peptides
peptides
Labels
Polarization
44 Citations (Scopus)

Split β-lactamase sensor for the sequence-specific detection of DNA methylation

Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Sep 1 2007, In : Analytical Chemistry. 79, 17, p. 6702-6708 7 p.

Research output: Contribution to journalArticle

Methylation
Genes
Sensors
Tumors
Green Fluorescent Proteins
48 Citations (Scopus)

Tethering small molecules to a phage display library: Discovery of a selective bivalent inhibitor of protein kinase A

Meyer, S. C., Shomin, C. D., Gaj, T. & Ghosh, I., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 13812-13813 2 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Bacteriophages
Staurosporine
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
14 Citations (Scopus)
Avidin
Recombinant Proteins
Immobilization
Purification
Peptides
4 Citations (Scopus)

When conjugated polymers meet amyloid fibrils

Stains, C. I. & Ghosh, I., Aug 2007, In : ACS Chemical Biology. 2, 8, p. 525-528 4 p.

Research output: Contribution to journalArticle

Conjugated polymers
Amyloid
Alzheimer Disease
Polymers
Poisons
2008
48 Citations (Scopus)
RNA
DNA
Proteins
Cell-Free System
Nucleic acids
2009
53 Citations (Scopus)

An autoinhibited coiled-coil design strategy for split-protein protease sensors

Shekhawat, S. S., Porter, J. R., Sriprasad, A. & Ghosh, I., Oct 28 2009, In : Journal of the American Chemical Society. 131, 42, p. 15284-15290 7 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Proteins
Sensors
Biosensing Techniques
Biosensors
20 Citations (Scopus)

Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): Optimization and selectivity profiling

Shomin, C. D., Meyer, S. C. & Ghosh, I., Sep 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 17, p. 6196-6202 7 p.

Research output: Contribution to journalArticle

Staurosporine
Cyclic AMP-Dependent Protein Kinases
Phosphotransferases
Ligands
Peptides
7 Citations (Scopus)

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA

Furman, J. L., Badran, A. H., Shen, S., Stains, C. I., Hannallah, J., Segal, D. J. & Ghosh, I., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3748-3751 4 p.

Research output: Contribution to journalArticle

Venus
Nucleic Acids
Nucleic acid sequences
Methylation
DNA
116 Citations (Scopus)

Water-based route to ligand-selective synthesis of ZnSe and Cd-doped ZnSe quantum dots with tunable ultraviolet A to blue photoluminescence

Deng, Z., Lie, F. L., Shen, S., Ghosh, I., Mansuripur, M. & Muscat, A. J., Jan 6 2009, In : Langmuir. 25, 1, p. 434-442 9 p.

Research output: Contribution to journalArticle

Semiconductor quantum dots
Photoluminescence
Ligands
quantum dots
routes
2010
44 Citations (Scopus)

A coiled-coil enabled split-luciferase three-hybrid system: Applied toward profiling inhibitors of protein kinases

Jester, B. W., Cox, K. J., Gaj, A., Shomin, C. D., Porter, J. R. & Ghosh, I., Aug 25 2010, In : Journal of the American Chemical Society. 132, 33, p. 11727-11735 9 p.

Research output: Contribution to journalArticle

Protein Kinase Inhibitors
Luciferases
Hybrid systems
Protein Kinases
Proteins
21 Citations (Scopus)

A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly

Stains, C. I., Furman, J. L., Porter, J. R., Rajagopal, S., Li, Y., Wyatt, R. T. & Ghosh, I., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 943-952 10 p.

Research output: Contribution to journalArticle

Luciferases
Antibodies
Single-Chain Antibodies
Proteins
Assays
49 Citations (Scopus)

Direct DNA methylation profiling using methyl binding domain proteins

Yu, Y., Blair, S., Gillespie, D., Jensen, R., Myszka, D., Badran, A. H., Ghosh, I. & Chagovetz, A., Jun 15 2010, In : Analytical Chemistry. 82, 12, p. 5012-5019 8 p.

Research output: Contribution to journalArticle

Methylation
DNA Fingerprinting
DNA Methylation
Carrier Proteins
Proteins
60 Citations (Scopus)

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: Selective inhibition of the p53/MDM2 complex

Henchey, L. K., Porter, J. R., Ghosh, I. & Arora, P. S., Oct 18 2010, In : ChemBioChem. 11, 15, p. 2104-2107 4 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-mdm2
Peptidomimetics
Tumor Suppressor Protein p53
Molecular recognition
X ray crystallography

Phage display technology in biosensor development

Meyer, S. C. & Ghosh, I., 2010, Recognition Receptors in Biosensors. Springer New York, p. 723-749 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacteriophages
Biosensors
Display devices
Peptides
Proteins
13 Citations (Scopus)

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Porter, J. R., Helmers, M. R., Wang, P., Furman, J. L., Joy, S. T., Arora, P. S. & Ghosh, I., Nov 14 2010, In : Chemical Communications. 46, 42, p. 8020-8022 3 p.

Research output: Contribution to journalArticle

Proteins
Molecules
1 Citation (Scopus)

Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER)

Porter, J. R., Lockwood, S. H., Segal, D. J. & Ghosh, I., 2010, Methods in Molecular Biology. Vol. 649. p. 365-382 18 p. (Methods in Molecular Biology; vol. 649).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nucleic Acid Denaturation
Epigenomics
DNA-Binding Proteins
Reading
DNA
26 Citations (Scopus)

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

Furman, J. L., Badran, A. H., Ajulo, O., Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Aug 25 2010, In : Journal of the American Chemical Society. 132, 33, p. 11692-11701 10 p.

Research output: Contribution to journalArticle

Luciferases
RNA
Proteins
Zinc Fingers
Nucleotides
2011
9 Citations (Scopus)

A comprehensive panel of turn-on caspase biosensors for investigating caspase specificity and caspase activation pathways

Shekhawat, S. S., Campbell, S. T. & Ghosh, I., Oct 17 2011, In : ChemBioChem. 12, 15, p. 2353-2364 12 p.

Research output: Contribution to journalArticle

Biosensing Techniques
Caspases
Biosensors
Chemical activation
Caspase 7
4 Citations (Scopus)

A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death

Furman, J. L., Mok, P. W., Shen, S., Stains, C. I. & Ghosh, I., Jan 7 2011, In : Chemical Communications. 47, 1, p. 397-399 3 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Firefly Luciferases
Administrative data processing
Cell death
Luciferases
22 Citations (Scopus)

Evaluating the global CpG methylation status of native DNA utilizing a bipartite split-luciferase sensor

Badran, A. H., Furman, J. L., Ma, A. S., Comi, T. J., Porter, J. R. & Ghosh, I., Sep 15 2011, In : Analytical Chemistry. 83, 18, p. 7151-7157 7 p.

Research output: Contribution to journalArticle

Methylation
Luciferases
decitabine
DNA
Sensors