• 2697 Citations
  • 28 h-Index
19952019
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Research Output 1995 2017

  • 2697 Citations
  • 28 h-Index
  • 58 Article
  • 3 Chapter
  • 1 Comment/debate
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Article
2015

A fragment-based selection approach for the discovery of peptide macrocycles targeting protein kinases

Restituyo, E., Camacho-Soto, K. & Ghosh, I., 2015, In : Methods in molecular biology (Clifton, N.J.). 1248, p. 95-104 10 p.

Research output: Contribution to journalArticle

Protein Kinases
Cyclic Peptides
Peptides
Staurosporine
Bacteriophages
5 Citations (Scopus)

Mapping the BH3 binding interface of Bcl-x<inf>L</inf>, Bcl-2, and Mcl-1 using split-luciferase reassembly

Campbell, S. T., Carlson, K. J., Buchholz, C. J., Helmers, M. R. & Ghosh, I., Apr 28 2015, In : Biochemistry. 54, 16, p. 2632-2643 12 p.

Research output: Contribution to journalArticle

Luciferases
Alanine
Apoptosis
Mutation
Puma
2014
16 Citations (Scopus)

Ligand-gated split-kinases

Camacho-Soto, K., Castillo-Montoya, J., Tye, B. & Ghosh, I., Mar 12 2014, In : Journal of the American Chemical Society. 136, 10, p. 3995-4002 8 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Ligands
Proteins
Dissection
9 Citations (Scopus)

Small molecule gated split-tyrosine phosphatases and orthogonal split-tyrosine kinases

Camacho-Soto, K., Castillo-Montoya, J., Tye, B., Ogunleye, L. O. & Ghosh, I., Dec 10 2014, In : Journal of the American Chemical Society. 136, 49, p. 17078-17086 9 p.

Research output: Contribution to journalArticle

Phosphatases
Sirolimus
Phosphoric Monoester Hydrolases
Protein-Tyrosine Kinases
Protein Kinases
1 Citation (Scopus)

When tight is too tight: Dasatinib and its lower affinity analogue for profiling kinase inhibitors in a three-hybrid split-luciferase system

Ogunleye, L. O., Jester, B. W., Riemen, A. J., Badran, A. H., Wang, P. & Ghosh, I., 2014, In : MedChemComm. 5, 3, p. 328-332 5 p.

Research output: Contribution to journalArticle

Dimerization
Luciferases
Phosphotransferases
Staurosporine
Protein Kinase Inhibitors
2012
77 Citations (Scopus)

New directions in targeting protein kinases: Focusing upon true allosteric and bivalent inhibitors

Lamba, V. & Ghosh, I., Jul 2012, In : Current Pharmaceutical Design. 18, 20, p. 2936-2945 10 p.

Research output: Contribution to journalArticle

Protein Kinases
Adenosine Triphosphate
Protein Kinase Inhibitors
Polypharmacology
Sequence Homology
18 Citations (Scopus)

Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen

Jester, B. W., Gaj, A., Shomin, C. D., Cox, K. J. & Ghosh, I., Feb 23 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1526-1537 12 p.

Research output: Contribution to journalArticle

Luciferases
Phosphotransferases
Catalytic Domain
Predictive Value of Tests
Competitive Binding
2011
9 Citations (Scopus)

A comprehensive panel of turn-on caspase biosensors for investigating caspase specificity and caspase activation pathways

Shekhawat, S. S., Campbell, S. T. & Ghosh, I., Oct 17 2011, In : ChemBioChem. 12, 15, p. 2353-2364 12 p.

Research output: Contribution to journalArticle

Biosensing Techniques
Caspases
Biosensors
Chemical activation
Caspase 7
4 Citations (Scopus)

A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death

Furman, J. L., Mok, P. W., Shen, S., Stains, C. I. & Ghosh, I., Jan 7 2011, In : Chemical Communications. 47, 1, p. 397-399 3 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Firefly Luciferases
Administrative data processing
Cell death
Luciferases
22 Citations (Scopus)

Evaluating the global CpG methylation status of native DNA utilizing a bipartite split-luciferase sensor

Badran, A. H., Furman, J. L., Ma, A. S., Comi, T. J., Porter, J. R. & Ghosh, I., Sep 15 2011, In : Analytical Chemistry. 83, 18, p. 7151-7157 7 p.

Research output: Contribution to journalArticle

Methylation
Luciferases
decitabine
DNA
Sensors
11 Citations (Scopus)

Selection of cyclic-peptide inhibitors targeting Aurora kinase A: Problems and solutions

Shomin, C. D., Restituyo, E., Cox, K. J. & Ghosh, I., Nov 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 22, p. 6743-6749 7 p.

Research output: Contribution to journalArticle

Aurora Kinases
Aurora Kinase A
Cyclic Peptides
Catalytic Domain
Adenosine Triphosphate
88 Citations (Scopus)

Split-protein systems: Beyond binary protein-protein interactions

Shekhawat, S. S. & Ghosh, I., Dec 2011, In : Current Opinion in Chemical Biology. 15, 6, p. 790-797 8 p.

Research output: Contribution to journalArticle

Proteins
Ternary Complex Factors
Cataloging
Firefly Luciferases
Protein Engineering
35 Citations (Scopus)

Tinkering outside the kinase ATP box: Allosteric (type IV) and bivalent (type V) inhibitors of protein kinases

Cox, K. J., Shomin, C. D. & Ghosh, I., Jan 2011, In : Future Medicinal Chemistry. 3, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

Protein Kinase Inhibitors
Protein Kinases
Phosphotransferases
Adenosine Triphosphate
Polypharmacology
15 Citations (Scopus)

Turn-on DNA damage sensors for the direct detection of 8-oxoguanine and photoproducts in native DNA

Furman, J. L., Mok, P. W., Badran, A. H. & Ghosh, I., Aug 17 2011, In : Journal of the American Chemical Society. 133, 32, p. 12518-12527 10 p.

Research output: Contribution to journalArticle

DNA Damage
DNA
Luciferases
Sensors
Firefly Luciferases
2010
44 Citations (Scopus)

A coiled-coil enabled split-luciferase three-hybrid system: Applied toward profiling inhibitors of protein kinases

Jester, B. W., Cox, K. J., Gaj, A., Shomin, C. D., Porter, J. R. & Ghosh, I., Aug 25 2010, In : Journal of the American Chemical Society. 132, 33, p. 11727-11735 9 p.

Research output: Contribution to journalArticle

Protein Kinase Inhibitors
Luciferases
Hybrid systems
Protein Kinases
Proteins
21 Citations (Scopus)

A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly

Stains, C. I., Furman, J. L., Porter, J. R., Rajagopal, S., Li, Y., Wyatt, R. T. & Ghosh, I., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 943-952 10 p.

Research output: Contribution to journalArticle

Luciferases
Antibodies
Single-Chain Antibodies
Proteins
Assays
49 Citations (Scopus)

Direct DNA methylation profiling using methyl binding domain proteins

Yu, Y., Blair, S., Gillespie, D., Jensen, R., Myszka, D., Badran, A. H., Ghosh, I. & Chagovetz, A., Jun 15 2010, In : Analytical Chemistry. 82, 12, p. 5012-5019 8 p.

Research output: Contribution to journalArticle

Methylation
DNA Fingerprinting
DNA Methylation
Carrier Proteins
Proteins
60 Citations (Scopus)

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: Selective inhibition of the p53/MDM2 complex

Henchey, L. K., Porter, J. R., Ghosh, I. & Arora, P. S., Oct 18 2010, In : ChemBioChem. 11, 15, p. 2104-2107 4 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-mdm2
Peptidomimetics
Tumor Suppressor Protein p53
Molecular recognition
X ray crystallography
13 Citations (Scopus)

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Porter, J. R., Helmers, M. R., Wang, P., Furman, J. L., Joy, S. T., Arora, P. S. & Ghosh, I., Nov 14 2010, In : Chemical Communications. 46, 42, p. 8020-8022 3 p.

Research output: Contribution to journalArticle

Proteins
Molecules
26 Citations (Scopus)

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

Furman, J. L., Badran, A. H., Ajulo, O., Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Aug 25 2010, In : Journal of the American Chemical Society. 132, 33, p. 11692-11701 10 p.

Research output: Contribution to journalArticle

Luciferases
RNA
Proteins
Zinc Fingers
Nucleotides
2009
53 Citations (Scopus)

An autoinhibited coiled-coil design strategy for split-protein protease sensors

Shekhawat, S. S., Porter, J. R., Sriprasad, A. & Ghosh, I., Oct 28 2009, In : Journal of the American Chemical Society. 131, 42, p. 15284-15290 7 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Proteins
Sensors
Biosensing Techniques
Biosensors
20 Citations (Scopus)

Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): Optimization and selectivity profiling

Shomin, C. D., Meyer, S. C. & Ghosh, I., Sep 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 17, p. 6196-6202 7 p.

Research output: Contribution to journalArticle

Staurosporine
Cyclic AMP-Dependent Protein Kinases
Phosphotransferases
Ligands
Peptides
7 Citations (Scopus)

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA

Furman, J. L., Badran, A. H., Shen, S., Stains, C. I., Hannallah, J., Segal, D. J. & Ghosh, I., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3748-3751 4 p.

Research output: Contribution to journalArticle

Venus
Nucleic Acids
Nucleic acid sequences
Methylation
DNA
116 Citations (Scopus)

Water-based route to ligand-selective synthesis of ZnSe and Cd-doped ZnSe quantum dots with tunable ultraviolet A to blue photoluminescence

Deng, Z., Lie, F. L., Shen, S., Ghosh, I., Mansuripur, M. & Muscat, A. J., Jan 6 2009, In : Langmuir. 25, 1, p. 434-442 9 p.

Research output: Contribution to journalArticle

Semiconductor quantum dots
Photoluminescence
Ligands
quantum dots
routes
2008
48 Citations (Scopus)
RNA
DNA
Proteins
Cell-Free System
Nucleic acids
2007
90 Citations (Scopus)

Current trends in peptide science quantum dots and peptides: A bright future together

Zhou, M. & Ghosh, I., 2007, In : Biopolymers - Peptide Science Section. 88, 3, p. 325-339 15 p.

Research output: Contribution to journalArticle

Quantum Dots
Peptides
Semiconductor quantum dots
Ligands
peptide A
83 Citations (Scopus)

Molecules that target beta-amyloid

Stains, C. I., Mondal, K. & Ghosh, I., Dec 10 2007, In : ChemMedChem. 2, 12, p. 1674-1692 19 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Amyloid
Molecules
Agglomeration
Peptidomimetics
2 Citations (Scopus)
Cell Surface Receptors
Brownian movement
Molecules
Biophysics
Signal transduction
88 Citations (Scopus)

Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules

Zhou, M., Nakatani, E., Gronenberg, L. S., Tokimoto, T., Wirth, M. J., Hruby, V. J., Roberts, A., Lynch, R. & Ghosh, I., Mar 2007, In : Bioconjugate Chemistry. 18, 2, p. 323-332 10 p.

Research output: Contribution to journalArticle

Quantum Dots
GTP-Binding Proteins
Peptides
Semiconductor quantum dots
Proteins
15 Citations (Scopus)

Probing orientations of single fluorescent labels on a peptide reversibly binding to the human delta-opioid receptor

Tokimoto, T., Bethea, T. R. C., Zhou, M., Ghosh, I. & Wirth, M. J., Feb 2007, In : Applied Spectroscopy. 61, 2, p. 130-137 8 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Peptides
peptides
Labels
Polarization
44 Citations (Scopus)

Split β-lactamase sensor for the sequence-specific detection of DNA methylation

Porter, J. R., Stains, C. I., Segal, D. J. & Ghosh, I., Sep 1 2007, In : Analytical Chemistry. 79, 17, p. 6702-6708 7 p.

Research output: Contribution to journalArticle

Methylation
Genes
Sensors
Tumors
Green Fluorescent Proteins
48 Citations (Scopus)

Tethering small molecules to a phage display library: Discovery of a selective bivalent inhibitor of protein kinase A

Meyer, S. C., Shomin, C. D., Gaj, T. & Ghosh, I., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 13812-13813 2 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Bacteriophages
Staurosporine
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
14 Citations (Scopus)
Avidin
Recombinant Proteins
Immobilization
Purification
Peptides
4 Citations (Scopus)

When conjugated polymers meet amyloid fibrils

Stains, C. I. & Ghosh, I., Aug 2007, In : ACS Chemical Biology. 2, 8, p. 525-528 4 p.

Research output: Contribution to journalArticle

Conjugated polymers
Amyloid
Alzheimer Disease
Polymers
Poisons
2006
12 Citations (Scopus)

A minimalist approach toward protein recognition by epitope transfer from functionally evolved β-sheet surfaces

Rajagopal, S., Meyer, S. C., Goldman, A., Zhou, M. & Ghosh, I., Nov 8 2006, In : Journal of the American Chemical Society. 128, 44, p. 14356-14363 8 p.

Research output: Contribution to journalArticle

Epitopes
Thrombin
Scaffolds
Proteins
Molecules
76 Citations (Scopus)

Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics

Ghosh, I., Stains, C. I., Ooi, A. T. & Segal, D. J., 2006, In : Molecular BioSystems. 2, 11, p. 551-560 10 p.

Research output: Contribution to journalArticle

Zinc Fingers
Zinc
Denaturation
Molecular Pathology
DNA
32 Citations (Scopus)

Highly selective cyclic peptide ligands for neutravidin and avidin identified by phage display

Meyer, S. C., Gaj, T. & Ghosh, I., Jul 2006, In : Chemical Biology and Drug Design. 68, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Bacteriophages
Streptavidin
Avidin
Display devices
38 Citations (Scopus)

Inhibition of β-amyloid fibrillization by directed evolution of a β-sheet presenting miniature protein

Smith, T. J., Stains, C. I., Meyer, S. C. & Ghosh, I., Nov 15 2006, In : Journal of the American Chemical Society. 128, 45, p. 14456-14457 2 p.

Research output: Contribution to journalArticle

Amyloid
Proteins
Protein Transport
Circular dichroism spectroscopy
Denaturation
45 Citations (Scopus)

Sequence-enabled reassembly of β-lactamase (SEER-LAC): A sensitive method for the detection of double-stranded DNA

Ooi, A. T., Stains, C. I., Ghosh, I. & Segal, D. J., Mar 21 2006, In : Biochemistry. 45, 11, p. 3620-3625 6 p.

Research output: Contribution to journalArticle

DNA
DNA sequences
Zinc Fingers
Zinc
Substitution reactions
68 Citations (Scopus)

Site-specific detection of DNA methylation utilizing mCpG-SEER

Stains, C. I., Furman, J. L., Segal, D. J. & Ghosh, I., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9761-9765 5 p.

Research output: Contribution to journalArticle

DNA Methylation
Green Fluorescent Proteins
Proteins
Fluorescence
Zinc Fingers
2005
301 Citations (Scopus)

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism

Magliery, T. J., Wilson, C. G. M., Pan, W., Mishler, D., Ghosh, I., Hamilton, A. D. & Regan, L., Jan 12 2005, In : Journal of the American Chemical Society. 127, 1, p. 146-157 12 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Proteins
Proteomics
Leucine Zippers
Protein Binding
66 Citations (Scopus)

DNA sequence-enabled reassembly of the green fluorescent protein

Stains, C. I., Porter, J. R., Ooi, A. T., Segal, D. J. & Ghosh, I., Aug 10 2005, In : Journal of the American Chemical Society. 127, 31, p. 10782-10783 2 p.

Research output: Contribution to journalArticle

DNA sequences
Green Fluorescent Proteins
Zinc Fingers
Proteins
Zinc
9 Citations (Scopus)

Single-site mutations in a hyperthermophilic variant of the B1 domain of protein G result in self-assembled oligomers

Meyer, S. C., Huerta, C. & Ghosh, I., Feb 22 2005, In : Biochemistry. 44, 7, p. 2360-2368 9 p.

Research output: Contribution to journalArticle

Point Mutation
Oligomers
Congo Red
Mutation
Fluorescence Spectrometry
2004
7 Citations (Scopus)

Dual surface selection methodology for the identification of thrombin binding epitopes from hotspot biased phage-display libraries

Rajagopal, S., Meza-Romero, R. & Ghosh, I., Mar 22 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 6, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Bacteriophages
Thrombin
Libraries
Epitopes
Immunoglobulin G
86 Citations (Scopus)

Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers

Zhou, M., Bentley, D. & Ghosh, I., Jan 28 2004, In : Journal of the American Chemical Society. 126, 3, p. 734-735 2 p.

Research output: Contribution to journalArticle

Dendrimers
Leucine Zippers
Fasteners
Fibers
Nanotechnology
15 Citations (Scopus)

Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides

Zhou, M. & Ghosh, I., Sep 30 2004, In : Organic Letters. 6, 20, p. 3561-3564 4 p.

Research output: Contribution to journalArticle

zippers
Dendrimers
Leucine Zippers
leucine
dendrimers
32 Citations (Scopus)

Peptide self-assembly as a model of proteins in the pre-genomic world

Ghosh, I. & Chmielewski, J., Dec 2004, In : Current Opinion in Chemical Biology. 8, 6, p. 640-644 5 p.

Research output: Contribution to journalArticle

Self assembly
Peptides
Nucleotide Aptamers
Catalytic RNA
Proteins
2001
1 Citation (Scopus)

DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47

Ghosh, I., Bishop, P. & Chmielewski, J., 2001, In : Journal of Peptide Research. 57, 5, p. 354-360 7 p.

Research output: Contribution to journalArticle

Fusion reactions
DNA
Helix-Loop-Helix Motifs
Basic Helix-Loop-Helix Transcription Factors
Proteins
2000
357 Citations (Scopus)

Antiparallel leucine zipper-directed protein reassembly: Application to the green fluorescent protein [12]

Ghosh, I., Hamilton, A. D. & Regan, L., Jun 14 2000, In : Journal of the American Chemical Society. 122, 23, p. 5658-5659 2 p.

Research output: Contribution to journalArticle

Leucine Zippers
Fasteners
Green Fluorescent Proteins
Proteins
1999
98 Citations (Scopus)

Inhibition of spontaneous receptor phosphorylation by residues in a putative α-helix in the KIT intracellular juxtamembrane region

Ma, Y., Cunningham, M. E., Wang, X., Ghosh, I., Regan, L. & Longley, B. J., May 7 1999, In : Journal of Biological Chemistry. 274, 19, p. 13399-13402 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Substitution reactions
Alanine
Conformations
Phosphotransferases