• 1711 Citations
  • 15 h-Index
20022019
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Research Output 2002 2019

  • 1711 Citations
  • 15 h-Index
  • 20 Article
  • 1 Chapter
2019

Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage

Kawaguchi, T., Rollins, M. G., Moinpour, M., Morera, A. A., Ebmeier, C. C., Old, W. M. & Schwartz, J. C., Jan 1 2019, (Accepted/In press) In : Journal of Proteome Research.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
DNA Repair
DNA Damage
RNA-Binding Proteins
DNA

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation

Krasnopolsky, S., Marom, L., Victor, R. A., Kuzmina, A., Schwartz, J. C., Fujinaga, K. & Taube, R., Jun 25 2019, In : Retrovirology. 16, 1, 16.

Research output: Contribution to journalArticle

Open Access
Virus Latency
Sarcoma
Transcriptional Activation
HIV
Genes

TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons

Morera, A. A., Ahmed, N. S. & Schwartz, J. C., Oct 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 10, 194434.

Research output: Contribution to journalArticle

Open Access
Retroelements
Transcription
Genes
Post Transcriptional RNA Processing
Alu Elements
2018
1 Citation (Scopus)

Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II

Thompson, V. F., Victor, R. A., Morera, A. A., Moinpour, M., Liu, M. N., Kisiel, C. C., Pickrel, K., Springhower, C. E. & Schwartz, J. C., Jan 1 2018, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

RNA Polymerase II
Transcription
Sarcoma
Holoenzymes
Size exclusion chromatography
2017
33 Citations (Scopus)

Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding

Ozdilek, B. A., Thompson, V. F., Ahmed, N. S., White, C. I., Batey, R. T. & Schwartz, J. C., Jul 1 2017, In : Nucleic Acids Research. 45, 13, p. 7984-7996 13 p.

Research output: Contribution to journalArticle

Sarcoma
RNA
Human Genome
22 Citations (Scopus)

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Coyne, A. N., Lorenzini, I., Chou, C. C., Torvund, M., Rogers, R. S., Starr, A., Zaepfel, B. L., Levy, J., Johannesmeyer, J., Schwartz, J. C., Nishimune, H., Zinsmaier, K. E., Rossoll, W., Sattler, R. & Zarnescu, D. C., Oct 3 2017, In : Cell Reports. 21, 1, p. 110-125 16 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Amyotrophic Lateral Sclerosis
Neurons
Dynamins
Motor Neurons
2015
57 Citations (Scopus)

Biochemical properties and biological functions of FET proteins

Schwartz, J. C., Cech, T. R. & Parker, R. R., Jun 2 2015, In : Annual Review of Biochemistry. 84, p. 355-379 25 p.

Research output: Contribution to journalArticle

Field effect transistors
Proteins
Transcription
RNA
Neurodegenerative diseases
45 Citations (Scopus)

Nucleic acid-binding specificity of human FUS protein

Wang, X., Schwartz, J. C. & Cech, T. R., Jun 19 2015, In : Nucleic Acids Research. 43, 15, p. 7535-7543 9 p.

Research output: Contribution to journalArticle

Nucleic Acids
RNA
Nuclear RNA
Nucleotide Motifs
RNA-Binding Proteins
2014
34 Citations (Scopus)

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts

Schwartz, J. C., Podell, E. R., Han, S. S. W., Berry, J. D., Eggan, K. C. & Cech, T. R., Sep 1 2014, In : Molecular Biology of the Cell. 25, 17, p. 2571-2578 8 p.

Research output: Contribution to journalArticle

RNA-Binding Protein FUS
Amyotrophic Lateral Sclerosis
Fibroblasts
RNA Polymerase II
Mutant Proteins
2013
126 Citations (Scopus)

RNA Seeds Higher-Order Assembly of FUS Protein

Schwartz, J. C., Wang, X., Podell, E. R. & Cech, T. R., Nov 27 2013, In : Cell Reports. 5, 4, p. 918-925 8 p.

Research output: Contribution to journalArticle

RNA-Binding Protein FUS
Seed
Seeds
RNA
Nuclear RNA
2012
105 Citations (Scopus)

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2

Schwartz, J. C., Ebmeier, C. C., Podell, E. R., Heimiller, J., Taatjes, D. J. & Cech, T. R., 2012, In : Genes and Development. 26, 24, p. 2690-2695 6 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Sarcoma
Phosphorylation
RNA Isoforms
Polyadenylation
2011
3 Citations (Scopus)

Practical considerations for analyzing antigene RNAs (agRNAs): RNA immunoprecipitation of argonaute protein

Schwartz, J. C. & Corey, D. R., 2011, Methods in Molecular Biology. Vol. 764. p. 301-315 15 p. (Methods in Molecular Biology; vol. 764).

Research output: Chapter in Book/Report/Conference proceedingChapter

Argonaute Proteins
Immunoprecipitation
RNA
RNA Interference
Untranslated RNA
240 Citations (Scopus)

Regulation of TFEB and V-ATPases by mTORC1

Peña-Llopis, S., Vega-Rubin-De-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X. J., Corey, D. R. & Brugarolas, J., Aug 17 2011, In : EMBO Journal. 30, 16, p. 3242-3258 17 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Endosomes
Endocytosis
Lysosomes
Transcription Factors
2010
74 Citations (Scopus)

Transcriptional regulation by small RNAs at sequences downstream from 3-2 gene termini

Yue, X., Schwartz, J. C., Chu, Y., Younger, S. T., Gagnon, K. T., Elbashir, S., Janowski, B. A. & Corey, D. R., Aug 2010, In : Nature Chemical Biology. 6, 8, p. 621-629 9 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Genes
RNA
Complementary RNA
Messenger RNA
2009
158 Citations (Scopus)

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

Hu, J., Matsui, M., Gagnon, K. T., Schwartz, J. C., Gabillet, S., Arar, K., Wu, J., Bezprozvanny, I. & Corey, D. R., May 2009, In : Nature Biotechnology. 27, 5, p. 478-484 7 p.

Research output: Contribution to journalArticle

Gene Targeting
Machado-Joseph Disease
Peptide Nucleic Acids
Genes
Alleles
2008
218 Citations (Scopus)

Antisense transcripts are targets for activating small RNAs

Schwartz, J. C., Younger, S. T., Nguyen, N. B., Hardy, D. B., Monia, B. P., Corey, D. R. & Janowski, B. A., Aug 2008, In : Nature Structural and Molecular Biology. 15, 8, p. 842-848 7 p.

Research output: Contribution to journalArticle

Progesterone Receptors
RNA
Gene Expression
Argonaute Proteins
Heterogeneous-Nuclear Ribonucleoproteins
2006
252 Citations (Scopus)

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D. & Corey, D. R., Sep 2006, In : Nature Structural and Molecular Biology. 13, 9, p. 787-792 6 p.

Research output: Contribution to journalArticle

Complementary RNA
DNA
Histone Code
Messenger RNA
Transcription Initiation Site
2005
139 Citations (Scopus)

Inhibiting Gene Expression At Transcription Start Sites In Chromosomal Dna With Antigene Rnas

Janowsi, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D. & Corey, D. R., 2005, In : Nature Chemical Biology. 1, 4, p. 180-184 5 p.

Research output: Contribution to journalArticle

Transcription Initiation Site
RNA
Gene Expression
Complementary RNA
TATA Box
124 Citations (Scopus)

Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.

Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R. & Corey, D. R., Sep 2005, In : Nature Chemical Biology. 1, 4, p. 210-215 6 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
DNA
Chromosome Structures
Transcription Initiation Site
Gene Silencing
2002
7 Citations (Scopus)

Ionoluminescence decay measured with single ions

McDaniel, F. D., Doyle, B. L., Seager, C. H., Walsh, D. S., Vizkelethy, G., Brice, D. K., Yang, C., Rossi, P., Nigam, M., El Bouanani, M., Ravi Prasad, G. V., Schwartz, J. C., Mitchell, L. T. & Duggan, J. L., May 2002, In : Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 190, 1-4, p. 1-10 10 p.

Research output: Contribution to journalArticle

Ion beams
Luminescence
ion beams
Ions
luminescence
73 Citations (Scopus)

Phase transition behavior of hydroxypropylcellulose under interpolymer complexation with poly(acrylic acid)

Lu, X., Hu, Z. & Schwartz, J. C., Nov 19 2002, In : Macromolecules. 35, 24, p. 9164-9168 5 p.

Research output: Contribution to journalArticle

carbopol 940
Complexation
Acrylics
Phase transitions
Acids