Janko Nikolich-Zugich

  • 7126 Citations
  • 46 h-Index
1988 …2019

Research output per year

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Research Output

  • 7126 Citations
  • 46 h-Index
  • 150 Article
  • 4 Review article
  • 2 Chapter
  • 1 Short survey
2019
Open Access

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Kim, C., Jadhav, R. R., Gustafson, C. E., Smithey, M. J., Hirsch, A. J., Uhrlaub, J. L., Hildebrand, W. H., Nikolich-Žugich, J., Weyand, C. M. & Goronzy, J. J., Nov 19 2019, In : Cell Reports. 29, 8, p. 2202-2216.e5

Research output: Contribution to journalArticle

Open Access

Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?

Jergović, M., Uhrlaub, J. L., Contreras, N. A. & Nikolich-Zugich, J., Apr 15 2019, In : GeroScience. 41, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Frailty as a prognostic factor for the critically ill older adult trauma patients

Hamidi, M., Zeeshan, M., Leon-Risemberg, V., Nikolich-Zugich, J., Hanna, K., Kulvatunyou, N., Saljuqi, A. T., Fain, M. J. & Joseph, B. A., Jan 1 2019, In : American journal of surgery.

Research output: Contribution to journalArticle

3 Scopus citations

Impact of CMV upon immune aging: facts and fiction

Jergović, M., Contreras, N. A. & Nikolich-Zugich, J., Jan 1 2019, In : Medical Microbiology and Immunology.

Research output: Contribution to journalReview article

6 Scopus citations

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia

Contreras, N. A., Sitnik, K. M., Jeftic, I., Coplen, C. P., Čičin-Šain, L. & Nikolich-Zugich, J., Jun 1 2019, In : PLoS pathogens. 15, 6, p. e1007890

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Menopause and foxp3 treg cell depletion eliminate female protection against t cell-mediated angiotensin ii hypertension

Pollow, D. P., Uhlorn, J. A., Sylvester, M. A., Romero-Aleshire, M. J., Uhrlaub, J. L., Lindsey, M. L., Nikolich-Zugich, J. & Brooks, H. L., Aug 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 2, p. H415-H423

Research output: Contribution to journalArticle

3 Scopus citations

The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty

Palmer, J., Pandit, V., Zeeshan, M., Kulvatunyou, N., Hamidi, M., Hanna, K., Fain, M., Nikolich-Zugich, J., Zakaria, E. R. & Joseph, B., Jul 1 2019, In : Journal of Trauma and Acute Care Surgery. 87, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

Deshpande, N. R., Uhrlaub, J. L., Way, S. S., Nikolich-Žugich, J. & Kuhns, M. S., Jun 1 2018, In : PLoS One. 13, 6, e0198354.

Research output: Contribution to journalArticle

Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

Contreras, N. A., Fontana, L., Tosti, V. & Nikolich-Zugich, J., May 26 2018, (Accepted/In press) In : GeroScience. p. 1-13 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort

Hayashi, T., Lynch, H. E., Geyer, S., Yoshida, K., Furudoi, K., Sasaki, K., Morishita, Y., Nagamura, H., Maki, M., Hu, Y., Hayashi, I., Kyoizumi, S., Kusunoki, Y., Ohishi, W., Fujiwara, S., Misumi, M., Shterev, I., Nikolich-Zugich, J., Murasko, D., Hale, L. P. & 2 others, Sempowski, G. D. & Nakachi, K., Jan 1 2018, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging

Jergović, M., Smithey, M. J. & Nikolich-Zugich, J., May 1 2018, In : Experimental Gerontology. 105, p. 140-145 6 p.

Research output: Contribution to journalReview article

10 Scopus citations
10 Scopus citations

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L. J., Surh, C. D. & Nikolich-Zugich, J., Jan 1 2018, (Accepted/In press) In : Aging Cell. e12865.

Research output: Contribution to journalArticle

5 Scopus citations

Prospective evaluation of frailty and functional independence in older adult trauma patients

Hamidi, M., Zeeshan, M., Okeeffe, T. S., Nisbet, B., Northcutt, A., Nikolich-Zugich, J., Khan, M., Kulvatunyou, N., Fain, M. J. & Joseph, B. A., Jan 1 2018, (Accepted/In press) In : American Journal of Surgery.

Research output: Contribution to journalArticle

5 Scopus citations

Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs

Davies, J. S., Thompson, H. L., Pulko, V., Torres, J. P. & Nikolich-Zugich, J., Jan 1 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 8, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The contribution of cytomegalovirus infection to immune senescence is set by the infectious dose

Redeker, A., Remmerswaal, E. B. M., van der Gracht, E. T. I., Welten, S. P. M., Höllt, T., Koning, F., Cicin-Sain, L., Nikolich-Zugich, J., ten Berge, I. J. M., van Lier, R. A. W., van Unen, V. & Arens, R., Jan 10 2018, In : Frontiers in Immunology. 8, JAN, 1953.

Research output: Contribution to journalArticle

14 Scopus citations

The twilight of immunity: Emerging concepts in aging of the immune system review-article

Nikolich-Zugich, J., Jan 1 2018, In : Nature Immunology. 19, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

96 Scopus citations
2017

Author Correction: Charles D. Surh 1960–2017

Nikolich-Zugich, J., Dec 8 2017, (Accepted/In press) In : Nature Immunology. 1 p.

Research output: Contribution to journalArticle

Charles D. Surh 1960-2017

Nikolich-Žugich, J., Nov 16 2017, In : Nature immunology. 18, 12, 1 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence

Nikolich-Zugich, J. & van Lier, R. A. W., Jun 17 2017, (Accepted/In press) In : GeroScience. p. 1-5 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Functional and homeostatic impact of age-related changes in lymph node stroma

Thompson, H. L., Smithey, M. J., Surh, C. D. & Nikolich-Zugich, J., Jun 14 2017, In : Frontiers in Immunology. 8, JUN, 706.

Research output: Contribution to journalShort survey

11 Scopus citations

Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing

Nikolich-Zugich, J. & Davies, J. S., Mar 1 2017, In : Clinical and Experimental Immunology. 187, 3, p. 337-344 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists

Metcalf, T. U., Wilkinson, P. A., Cameron, M. J., Ghneim, K., Chiang, C., Wertheimer, A. M., Hiscott, J. B., Nikolich-Zugich, J. & Haddad, E. K., Aug 15 2017, In : Journal of Immunology. 199, 4, p. 1405-1417 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
15 Scopus citations
34 Scopus citations
2016

Acute systemic DNA damage in youth does not impair immune defense with aging

Pugh, J. L., Foster, S. A., Sukhina, A. S., Petravic, J., Uhrlaub, J. L., Padilla-Torres, J., Hayashi, T., Nakachi, K., Smithey, M. J. & Nikolich-Zugich, J., Aug 1 2016, In : Aging Cell. 15, 4, p. 686-693 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

Seed, T. M., Xiao, S., Manley, N., Nikolich-Zugich, J., Pugh, J., Van Den Brink, M., Hirabayashi, Y., Yasutomo, K., Iwama, A., Koyasu, S., Shterev, I., Sempowski, G., Macchiarini, F., Nakachi, K., Kunugi, K. C., Hammer, C. G. & Dewerd, L. A., Feb 1 2016, In : International Journal of Radiation Biology. 92, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J. F., Vickers, I., Anzinger, J. J. & Nikolich-Zugich, J., Oct 1 2016, In : PLoS Pathogens. 12, 10, e1005891.

Research output: Contribution to journalArticle

13 Scopus citations

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Pulko, V., Davies, J. S., Martinez, C., Lanteri, M. C., Busch, M. P., Diamond, M. S., Knox, K. S., Bush, E. C., Sims, P. A., Sinari, S., Billheimer, D. D., Haddad, E. K., Murray, K. O., Wertheimer, A. M. & Nikolich-Zugich, J., Jul 19 2016, In : Nature Immunology. 17, 8, p. 966-975 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Preparing for an aging world: Engaging biogerontologists, geriatricians, and the society

Nikolich-Zugich, J., Goldman, D. P., Cohen, P. R., Cortese, D., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T., Perry, D., Richardson, A., Ritchie, C., Wertheimer, A. M., Faragher, R. G. A. & Fain, M. J., Apr 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 4, p. 435-444 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., Park, B. S., Axthelm, M. K., Nikolich-Zugich, J. & Picker, L. J., Nov 1 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., Hiscott, J. B., Diamond, M. S., Wertheimer, A. M., Nikolich-Zugich, J. & Haddad, E. K., Jun 1 2015, In : Aging Cell. 14, 3, p. 421-432 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Marandu, T. F., Oduro, J. D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J. L., Drabig, A., Kröger, A., Nikolich-Zugich, J. & Cicin-Sain, L., 2015, In : Journal of Virology. 89, 22, p. 11715-11717 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

Goldberg, E. L., Romero-Aleshire, M. J., Renkema, K. R., Ventevogel, M. S., Chew, W. M., Uhrlaub, J. L., Smithey, M. J., Limesand, K., Sempowski, G. D., Brooks, H. L. & Nikolich-Zugich, J., Feb 1 2015, In : Aging Cell. 14, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Lost in translation: mice, men and cutaneous immunity in old age

Smithey, M. J., Uhrlaub, J. L., Li, G., Vukmanovic-Stejic, M., Akbar, A. N. & Nikolich-Zugich, J., 2015, In : Biogerontology. 16, 2, p. 203-208 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Zugich, D., Kaye, J. & Nikolich-Zugich, J., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2143-2155 13 p.

Research output: Contribution to journalArticle

120 Scopus citations

Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories

Nikolich-Zugich, J., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 2622-2629 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

Kusne, Y., Goldberg, E. L., Parker, S. S., Hapak, S. M., Maskaykina, I. Y., Chew, W. M., Limesand, K., Brooks, H. L., Price, T. J., Sanai, N., Nikolich-Zugich, J. & Ghosh, S., 2014, In : Age. 36, 1, p. 199-212 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Histone deacetylation critically determines T cell subset radiosensitivity

Pugh, J. L., Sukhina, A. S., SeedG, T. M., Manley, N. R., Sempowski, G. D., Van Den Brink, M. R. M., Smithey, M. J. & Nikolich-Zugich, J., Aug 1 2014, In : Journal of Immunology. 193, 3, p. 1451-1458 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
18 Scopus citations

Naïve and memory CD8 T cell pool homeostasis in advanced aging: Impact of age and of antigen-specific responses to cytomegalovirus

Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., Volpi, R., Monti, D., Franceschi, C., Nikolich-Zugich, J. & Sansoni, P., 2014, In : Age. 36, 2, p. 625-640 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y. L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., Lilleri, D. & 20 others, López-Botet, M., Maier, A. B., Marandu, T., Marchant, A., Matheï, C., Moss, P., Muntasell, A., Remmerswaal, E. B. M., Riddell, N. E., Rothe, K., Sauce, D., Shin, E. C., Simanek, A. M., Smithey, M. J., Söderberg-Nauclér, C., Solana, R., Thomas, P. G., Van Lier, R., Pawelec, G. & Nikolich-Zugich, J., 2014, In : Experimental Gerontology. 55, p. 54-62 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Sex differences in T-lymphocyte tissue infiltration and development of Angiotensin II Hypertension

Pollow, D. P., Uhrlaub, J., Romero-Aleshire, M. J., Sandberg, K., Nikolich-Zugich, J., Brooks, H. L. & Hay, M., 2014, In : Hypertension. 64, 2, p. 384-390 7 p.

Research output: Contribution to journalArticle

70 Scopus citations
45 Scopus citations

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging

Renkema, K. R., Li, G., Wu, A., Smithey, M. J. & Nikolich-Zugich, J., Jan 1 2014, In : Journal of Immunology. 192, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Acute Neonatal Infections 'Lock-In' a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

Rudd, B. D., Venturi, V., Smith, N. L., Nzingha, K., Goldberg, E. L., Li, G., Nikolich-Zugich, J. & Davenport, M. P., Sep 2013, In : PLoS Pathogens. 9, 9, e1003572.

Research output: Contribution to journalArticle

14 Scopus citations

Age-associated increase of low-avidity cytomegalovirus-specific CD8 + T cells that re-express CD45RA

Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A. M., Wallace, D., Sims, S., Rivino, L., Larbi, A., Kemeny, D. M., Nikolich-Zugich, J., Kern, F., Klenerman, P., Emery, V. C. & Akbar, A. N., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5363-5372 10 p.

Research output: Contribution to journalArticle

44 Scopus citations