Janko Nikolich-Zugich

  • 7653 Citations
  • 49 h-Index
1988 …2020

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2019
Open Access

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Kim, C., Jadhav, R. R., Gustafson, C. E., Smithey, M. J., Hirsch, A. J., Uhrlaub, J. L., Hildebrand, W. H., Nikolich-Žugich, J., Weyand, C. M. & Goronzy, J. J., Nov 19 2019, In : Cell Reports. 29, 8, p. 2202-2216.e5

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?

Jergović, M., Uhrlaub, J. L., Contreras, N. A. & Nikolich-Žugich, J., Apr 15 2019, In : GeroScience. 41, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Frailty as a prognostic factor for the critically ill older adult trauma patients

Hamidi, M., Zeeshan, M., Leon-Risemberg, V., Nikolich-Zugich, J., Hanna, K., Kulvatunyou, N., Saljuqi, A. T., Fain, M. J. & Joseph, B. A., Jan 1 2019, In : American journal of surgery.

Research output: Contribution to journalArticle

7 Scopus citations

Life-long control of cytomegalovirus (CMV) by t resident memory cells in the adipose tissue results in inflammation and hyperglycemia

Contreras, N. A., Sitnik, K. M., Jeftic, I., Coplen, C. P., Čičin-šain, L. & Nikolich-žugich, J., Jun 2019, In : PLoS pathogens. 15, 6, e1007890.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L. J., Surh, C. D. & Nikolich-Žugich, J., Feb 1 2019, In : Aging Cell. 18, 1, e12865.

Research output: Contribution to journalArticle

11 Scopus citations

Menopause and foxp3 treg cell depletion eliminate female protection against t cell-mediated angiotensin ii hypertension

Pollow, D. P., Uhlorn, J. A., Sylvester, M. A., Romero-Aleshire, M. J., Uhrlaub, J. L., Lindsey, M. L., Nikolich-Zugich, J. & Brooks, H. L., Aug 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 2, p. H415-H423

Research output: Contribution to journalArticle

6 Scopus citations

The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty

Palmer, J., Pandit, V., Zeeshan, M., Kulvatunyou, N., Hamidi, M., Hanna, K., Fain, M., Nikolich-Zugich, J., Zakaria, E. R. & Joseph, B., Jul 1 2019, In : Journal of Trauma and Acute Care Surgery. 87, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

Deshpande, N. R., Uhrlaub, J. L., Way, S. S., Nikolich-Žugich, J. & Kuhns, M. S., Jun 2018, In : PloS one. 13, 6, e0198354.

Research output: Contribution to journalArticle

1 Scopus citations

Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

Contreras, N. A., Fontana, L., Tosti, V. & Nikolich-Žugich, J., Jun 1 2018, In : GeroScience. 40, 3, p. 279-291 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort

Hayashi, T., Lynch, H. E., Geyer, S., Yoshida, K., Furudoi, K., Sasaki, K., Morishita, Y., Nagamura, H., Maki, M., Hu, Y., Hayashi, I., Kyoizumi, S., Kusunoki, Y., Ohishi, W., Fujiwara, S., Misumi, M., Shterev, I., Nikolich-Žugich, J., Murasko, D., Hale, L. P. & 2 others, Sempowski, G. D. & Nakachi, K., Oct 29 2018, In : Vaccine. 36, 45, p. 6650-6659 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
14 Scopus citations

Prospective evaluation of frailty and functional independence in older adult trauma patients

Hamidi, M., Zeeshan, M., O'Keeffe, T., Nisbet, B., Northcutt, A., Nikolich-Zugich, J., Khan, M., Kulvatunyou, N., Fain, M. & Joseph, B., Dec 2018, In : American journal of surgery. 216, 6, p. 1070-1075 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs

Davies, J. S., Thompson, H. L., Pulko, V., Torres, J. P. & Nikolich-Žugich, J., 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 8, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The contribution of cytomegalovirus infection to immune senescence is set by the infectious dose

Redeker, A., Remmerswaal, E. B. M., van der Gracht, E. T. I., Welten, S. P. M., Höllt, T., Koning, F., Cicin-Sain, L., Nikolich-Žugich, J., ten Berge, I. J. M., van Lier, R. A. W., van Unen, V. & Arens, R., Jan 10 2018, In : Frontiers in immunology. 8, JAN, 1953.

Research output: Contribution to journalArticle

18 Scopus citations

The twilight of immunity: Emerging concepts in aging of the immune system review-article

Nikolich-Zugich, J., Jan 1 2018, In : Nature Immunology. 19, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

165 Scopus citations
2017

Author Correction: Charles D. Surh 1960–2017

Nikolich-Zugich, J., Dec 8 2017, (Accepted/In press) In : Nature Immunology. 1 p.

Research output: Contribution to journalArticle

Charles D. Surh 1960-2017

Nikolich-Žugich, J., Nov 16 2017, In : Nature immunology. 18, 12, p. 1273 1 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence

Nikolich-Zugich, J. & van Lier, R. A. W., Jun 17 2017, (Accepted/In press) In : GeroScience. p. 1-5 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists

Metcalf, T. U., Wilkinson, P. A., Cameron, M. J., Ghneim, K., Chiang, C., Wertheimer, A. M., Hiscott, J. B., Nikolich-Zugich, J. & Haddad, E. K., Aug 15 2017, In : Journal of Immunology. 199, 4, p. 1405-1417 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
55 Scopus citations
2016

Acute systemic DNA damage in youth does not impair immune defense with aging

Pugh, J. L., Foster, S. A., Sukhina, A. S., Petravic, J., Uhrlaub, J. L., Padilla-Torres, J., Hayashi, T., Nakachi, K., Smithey, M. J. & Nikolich-Žugich, J., Aug 1 2016, In : Aging Cell. 15, 4, p. 686-693 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

Seed, T. M., Xiao, S., Manley, N., Nikolich-Zugich, J., Pugh, J., Van Den Brink, M., Hirabayashi, Y., Yasutomo, K., Iwama, A., Koyasu, S., Shterev, I., Sempowski, G., Macchiarini, F., Nakachi, K., Kunugi, K. C., Hammer, C. G. & Dewerd, L. A., Feb 1 2016, In : International Journal of Radiation Biology. 92, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J. F., Vickers, I., Anzinger, J. J. & Nikolich-Žugich, J., Oct 2016, In : PLoS pathogens. 12, 10, e1005891.

Research output: Contribution to journalArticle

16 Scopus citations

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Pulko, V., Davies, J. S., Martinez, C., Lanteri, M. C., Busch, M. P., Diamond, M. S., Knox, K., Bush, E. C., Sims, P. A., Sinari, S., Billheimer, D., Haddad, E. K., Murray, K. O., Wertheimer, A. M. & Nikolich-Žugich, J., Jul 19 2016, In : Nature immunology. 17, 8, p. 966-975 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
2015

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A. A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A. W., Sammader, P., Legasse, A. W., Park, B. S., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Nov 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., Hiscott, J. B., Diamond, M. S., Wertheimer, A. M., Nikolich-Zugich, J. & Haddad, E. K., Jun 1 2015, In : Aging Cell. 14, 3, p. 421-432 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Marandu, T. F., Oduro, J. D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J. L., Drabig, A., Kröger, A., Nikolich-Zugich, J. & Cicin-Sain, L., 2015, In : Journal of virology. 89, 22, p. 11715-11717 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

Goldberg, E. L., Romero-Aleshire, M. J., Renkema, K. R., Ventevogel, M. S., Chew, W. M., Uhrlaub, J. L., Smithey, M. J., Limesand, K. H., Sempowski, G. D., Brooks, H. L. & Nikolich-Žugich, J., Feb 1 2015, In : Aging Cell. 14, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Lost in translation: mice, men and cutaneous immunity in old age

Smithey, M. J., Uhrlaub, J. L., Li, G., Vukmanovic-Stejic, M., Akbar, A. N. & Nikolich-Zugich, J., 2015, In : Biogerontology. 16, 2, p. 203-208 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Zugich, D., Kaye, J. & Nikolich-Zugich, J., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2143-2155 13 p.

Research output: Contribution to journalArticle

131 Scopus citations

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

Kusne, Y., Goldberg, E. L., Parker, S. S., Hapak, S. M., Maskaykina, I. Y., Chew, W. M., Limesand, K. H., Brooks, H. L., Price, T. J., Sanai, N., Nikolich-Zugich, J. & Ghosh, S., Feb 2014, In : Age. 36, 1, p. 199-212 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Histone deacetylation critically determines T cell subset radiosensitivity

Pugh, J. L., Sukhina, A. S., SeedG, T. M., Manley, N. R., Sempowski, G. D., Van Den Brink, M. R. M., Smithey, M. J. & Nikolich-Žugich, J., Aug 1 2014, In : Journal of Immunology. 193, 3, p. 1451-1458 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
19 Scopus citations

Naïve and memory CD8 T cell pool homeostasis in advanced aging: Impact of age and of antigen-specific responses to cytomegalovirus

Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., Volpi, R., Monti, D., Franceschi, C., Nikolich-Žugich, J. & Sansoni, P., Apr 2014, In : Age. 36, 2, p. 625-640 16 p.

Research output: Contribution to journalArticle

27 Scopus citations

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y. L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., Lilleri, D. & 20 others, López-Botet, M., Maier, A. B., Marandu, T., Marchant, A., Matheï, C., Moss, P., Muntasell, A., Remmerswaal, E. B. M., Riddell, N. E., Rothe, K., Sauce, D., Shin, E. C., Simanek, A. M., Smithey, M. J., Söderberg-Nauclér, C., Solana, R., Thomas, P. G., Van Lier, R., Pawelec, G. & Nikolich-Zugich, J., Jul 2014, In : Experimental Gerontology. 55, p. 54-62 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Sex differences in T-lymphocyte tissue infiltration and development of Angiotensin II Hypertension

Pollow, D. P., Uhrlaub, J., Romero-Aleshire, M. J., Sandberg, K., Nikolich-Zugich, J., Brooks, H. L. & Hay, M., Aug 2014, In : Hypertension. 64, 2, p. 384-390 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging

Renkema, K. R., Li, G., Wu, A., Smithey, M. J. & Nikolich-Žugich, J., Jan 1 2014, In : Journal of Immunology. 192, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

Acute Neonatal Infections 'Lock-In' a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

Rudd, B. D., Venturi, V., Smith, N. L., Nzingha, K., Goldberg, E. L., Li, G., Nikolich-Zugich, J. & Davenport, M. P., Sep 1 2013, In : PLoS pathogens. 9, 9, e1003572.

Research output: Contribution to journalArticle

16 Scopus citations

Age-associated increase of low-avidity cytomegalovirus-specific CD8 + T cells that re-express CD45RA

Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., Kemeny, D. M., Nikolich-Zugich, J., Kern, F., Klenerman, P., Emery, V. C. & Akbar, A. N., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5363-5372 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Lazear, H. M., Lancaster, A., Wilkins, C., Suthar, M. S., Huang, A., Vick, S. C., Clepper, L., Thackray, L., Brassil, M. M., Virgin, H. W., Nikolich-Zugich, J., Moses, A. V., Gale, M., Früh, K. & Diamond, M. S., Jan 2013, In : PLoS pathogens. 9, 1, e1003118.

Research output: Contribution to journalArticle

176 Scopus citations

Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans

Vukmanovic-Stejic, M., Sandhu, D., Sobande, T. O., Agius, E., Lacy, K. E., Riddell, N., Montez, S., Dintwe, O. B., Scriba, T. J., Breuer, J., Nikolich-Zugich, J., Ogg, G., Rustin, M. H. A. & Akbar, A. N., Feb 1 2013, In : Journal of Immunology. 190, 3, p. 977-986 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

Li, G., Smithey, M. J., Rudd, B. D. & Nikolich-Žugich, J., Dec 2012, In : Aging Cell. 11, 6, p. 968-977 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

CMV and Immunosenescence: From basics to clinics

Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Cicin-Sain, L., Derhovanessian, E., Ferrando-Martínez, S., Frasca, D., Fulöp, T., Govind, S., Grubeck-Loebenstein, B., Hill, A., Hurme, M., Kern, F., Larbi, A. & 17 others, López-Botet, M., Maier, A. B., McElhaney, J. E., Moss, P., Naumova, E., Nikolich-Zugich, J., Pera, A., Rector, J. L., Riddell, N., Sanchez-Correa, B., Sansoni, P., Sauce, D., van Lier, R., Wang, G. C., Wills, M. R., Zieliński, M. & Pawelec, G., Oct 31 2012, In : Immunity and Ageing. 9, 23.

Research output: Contribution to journalArticle

100 Scopus citations

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F. & Nikolich-Zugich, J., Aug 2012, In : PLoS pathogens. 8, 8, e1002849.

Research output: Contribution to journalArticle

74 Scopus citations

Induction of the cellular microRNA, Hs_154, by west nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

Smith, J. L., Grey, F. E., Uhrlaub, J. L., Nikolich-Zugich, J. & Hirsch, A. J., May 2012, In : Journal of virology. 86, 9, p. 5278-5287 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life

Smithey, M. J., Li, G., Venturi, V., Davenport, M. P. & Nikolich-Žugich, J., Dec 1 2012, In : Journal of Immunology. 189, 11, p. 5356-5366 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2011

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Čičin-Šain, L., Sylwester, A. W., Hagen, S. I., Siess, D. C., Currier, N., Legasse, A. W., Fischer, M. B., Koudelka, C. W., Axthelm, M. K., Nikolich-Žugich, J. & Picker, L. J., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1722-1732 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Evolution of the antigen-specific CD8+ TCR repertoire across the life span: Evidence for clonal homogenization of the old TCR repertoire

Rudd, B. D., Venturi, V., Davenport, M. P. & Nikolich-Žugich, J., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2056-2064 9 p.

Research output: Contribution to journalArticle

45 Scopus citations