• 516 Citations
  • 14 h-Index
20072020

Research output per year

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Research Output

  • 516 Citations
  • 14 h-Index
  • 26 Article
  • 6 Review article
  • 4 Comment/debate
  • 1 Chapter
2020

Approach to High Volume Enrollment in Clinical Research: Experiences from an All of Us Research Program Site

Ilori, T. O., Viera, E., Wilson, J., Moreno, F., Menon, U., Ehiri, J., Peterson, R., Vemulapalli, T., StimsonRiahi, S. C., Rosales, C., Calhoun, E., Sokan, A., Karnes, J. H., Reiman, E., Ojo, A., Theodorou, A. & Ojo, T., Jul 1 2020, In : Clinical and Translational Science. 13, 4, p. 685-692 8 p.

Research output: Contribution to journalArticle

Open Access

Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension

Karnes, J. H., Wiener, H. W., Schwantes-An, T. H., Natarajan, B., Sweatt, A. J., Chaturvedi, A., Arora, A., Batai, K., Nair, V., Steiner, H. E., Giles, J. B., Yu, J., Hosseini, M., Pauciulo, M. W., Lutz, K. A., Coleman, A. W., Feldman, J., Vanderpool, R., Tang, H., Garcia, J. G. N. & 9 others, Yuan, J. X. J., Kittles, R., de Jesus Perez, V., Zamanian, R. T., Rischard, F., Tiwari, H. K., Nichols, W. C., Benza, R. L. & Desai, A. A., Jun 1 2020, In : American journal of respiratory and critical care medicine. 201, 11, p. 1407-1415 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions

Karnes, J. H., Miller, M. A., White, K. D., Konvinse, K. C., Pavlos, R. K., Redwood, A. J., Peter, J. G., Lehloenya, R., Mallal, S. A. & Phillips, E. J., Jan 6 2019, In : Annual review of pharmacology and toxicology. 59, p. 463-486 24 p.

Research output: Contribution to journalReview article

12 Scopus citations

Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines

Ramamoorthy, A., Karnes, J. H., Finkel, R., Blanchard, R. & Pacanowski, M., Nov 1 2019, In : Clinical and Translational Science. 12, 6, p. 560-563 4 p.

Research output: Contribution to journalComment/debate

Open Access

From big data to precision medicine

Hulsen, T., Jamuar, S. S., Moody, A. R., Karnes, J. H., Varga, O., Hedensted, S., Spreafico, R., Hafler, D. A. & McKinney, E. F., 2019, In : Frontiers in Medicine. 6, MAR, 34.

Research output: Contribution to journalReview article

Open Access
37 Scopus citations

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium & US PAH Biobank Consortium, Mar 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Psychological and Genetic Predictors of Pain Tolerance

Patanwala, A. E., Norwood, C., Steiner, H., Morrison, D., Li, M., Walsh, K., Martinez, M., Baker, S. E., Snyder, E. M. & Karnes, J. H., Mar 2019, In : Clinical and Translational Science. 12, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Unveiling the Genetic Architecture of Human Disease for Precision Medicine

Ramamoorthy, A., Yee, S. W. & Karnes, J., Jan 2019, In : Clinical and Translational Science. 12, 1, p. 3-5 3 p.

Research output: Contribution to journalComment/debate

Open Access
2018

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

Mosley, J. D., Feng, Q. P., Wells, Q. S., Van Driest, S. L., Shaffer, C. M., Edwards, T. L., Bastarache, L., Wei, W. Q., Davis, L. K., McCarty, C. A., Thompson, W., Chute, C. G., Jarvik, G. P., Gordon, A. S., Palmer, M. R., Crosslin, D. R., Larson, E. B., Carrell, D. S., Kullo, I. J., Pacheco, J. A. & 14 others, Peissig, P. L., Brilliant, M. H., Linneman, J. G., Namjou, B., Williams, M. S., Ritchie, M. D., Borthwick, K. M., Verma, S. S., Karnes, J. H., Weiss, S. T., Wang, T. J., Stein, C. M., Denny, J. C. & Roden, D. M., Dec 1 2018, In : Nature communications. 9, 1, 3522.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations

Genome-wide association study in African Americans with acute respiratory distress syndrome identifies the selectin P ligand gene as a risk factor

Bime, C., Pouladi, N., Sammani, S., Batai, K., Casanova, N., Zhou, T., Kempf, C. L., Sun, X., Camp, S. M., Wang, T., Kittles, R. A., Lussier, Y. A., Jones, T. K., Reilly, J. P., Meyer, N. J., Christie, J. D., Karnes, J. H., Gonzalez-Garay, M., Christiani, D. C., Yates, C. R. & 3 others, Wurfel, M. M., Meduri, G. U. & Garcia, J. G. N., Jun 1 2018, In : American journal of respiratory and critical care medicine. 197, 11, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Pharmacogenetics to prevent heparin-induced thrombocytopenia: What do we know?

Karnes, J. H., Dec 2018, In : Pharmacogenomics. 19, 18, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

Pharmacogenomics of Drug Allergy

Pavlos, R., Karnes, J., Trubiano, J., Peter, J. & Phillips, E., Jan 1 2018, Drug Allergy Testing. Elsevier Inc., p. 39-51 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans

Lynn, H., Sun, X., Ayshiev, D., Siegler, J. H., Rizzo, A. N., Karnes, J. H., Garay, M. G., Wang, T., Casanova, N., Camp, S. M., Ellis, N. A. & Garcia, J. G. N., Aug 2018, In : PloS one. 13, 8, e0200916.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Comparison of HLA allelic imputation programs

Karnes, J. H., Shaffer, C. M., Bastarache, L., Gaudieri, S., Glazer, A. M., Steiner, H. E., Mosley, J. D., Mallal, S., Denny, J. C., Phillips, E. J. & Roden, D. M., Feb 2017, In : PloS one. 12, 2, e0172444.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults

Wells, Q. S., Veatch, O. J., Fessel, J. P., Joon, A. Y., Levinson, R. T., Mosley, J. D., Held, E. P., Lindsay, C. S., Shaffer, C. M., Weeke, P. E., Glazer, A. M., Bersell, K. R., Van Driest, S. L., Karnes, J. H., Blair, M. A., Lagrone, L. W., Su, Y. R., Bowton, E. A., Feng, Z., Ky, B. & 4 others, Lenihan, D. J., Fisch, M. J., Denny, J. C. & Roden, D. M., 2017, In : Pharmacogenetics and Genomics. 27, 7, p. 247-254 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT)

Karnes, J. H., Shaffer, C. M., Cronin, R., Bastarache, L., Gaudieri, S., James, I., Pavlos, R., Steiner, H. E., Mosley, J. D., Mallal, S., Denny, J. C., Phillips, E. J. & Roden, D. M., Sep 2017, In : Pharmacotherapy. 37, 9, p. 1164-1171 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

Karnes, J. H., Bastarache, L., Shaffer, C. M., Gaudieri, S., Xu, Y., Glazer, A. M., Mosley, J. D., Zhao, S., Raychaudhuri, S., Mallal, S., Ye, Z., Mayer, J. G., Brilliant, M. H., Hebbring, S. J., Roden, D. M., Phillips, E. J. & Denny, J. C., May 10 2017, In : Science translational medicine. 9, 389, aai8708.

Research output: Contribution to journalArticle

30 Scopus citations

Warfarin Pharmacogenomics in Diverse Populations

Kaye, J. B., Schultz, L. E., Steiner, H. E., Kittles, R. A., Cavallari, L. H. & Karnes, J. H., Sep 2017, In : Pharmacotherapy. 37, 9, p. 1150-1163 14 p.

Research output: Contribution to journalReview article

25 Scopus citations
2016

A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough

Mosley, J. D., Shaffer, C. M., Van Driest, S. L., Weeke, P. E., Wells, Q. S., Karnes, J. H., Velez Edwards, D. R., Wei, W. Q., Teixeira, P. L., Bastarache, L., Crawford, D. C., Li, R., Manolio, T. A., Bottinger, E. P., McCarty, C. A., Linneman, J. G., Brilliant, M. H., Pacheco, J. A., Thompson, W., Chisholm, R. L. & 27 others, Jarvik, G. P., Crosslin, D. R., Carrell, D. S., Baldwin, E., Ralston, J., Larson, E. B., Grafton, J., Scrol, A., Jouni, H., Kullo, I. J., Tromp, G., Borthwick, K. M., Kuivaniemi, H., Carey, D. J., Ritchie, M. D., Bradford, Y., Verma, S. S., Chute, C. G., Veluchamy, A., Siddiqui, M. K., Palmer, C. N. A., Doney, A., MahmoudPour, S. H., Maitland-van der Zee, A. H., Morris, A. D., Denny, J. C. & Roden, D. M., Jun 1 2016, In : Pharmacogenomics Journal. 16, 3, p. 231-237 7 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States

Aljabri, A., Huckleberry, Y., Karnes, J. H., Gharaibeh, M., Kutbi, H. I., Raz, Y., Yun, S., Abraham, I. & Erstad, B., Dec 29 2016, In : Blood. 128, 26, p. 3043-3051 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Identifying genetically driven clinical phenotypes using linear mixed models

Mosley, J. D., Witte, J. S., Larkin, E. K., Bastarache, L., Shaffer, C. M., Karnes, J. H., Stein, C. M., Phillips, E., Hebbring, S. J., Brilliant, M. H., Mayer, J., Ye, Z., Roden, D. M. & Denny, J. C., Apr 25 2016, In : Nature communications. 7, 11433.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2015

A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record

Karnes, J. H., Cronin, R. M., Rollin, J., Teumer, A., Pouplard, C., Shaffer, C. M., Blanquicett, C., Bowton, E. A., Cowan, J. D., Mosley, J. D., van Driest, S. L., Weeke, P. E., Wells, Q. S., Bakchoul, T., Denny, J. C., Greinacher, A., Gruel, Y. & Roden, D. M., Jan 1 2015, In : Thrombosis and Haemostasis. 113, 4, p. 772-781 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Erratum to Using systems approaches to address challenges for clinical implementation of pharmacogenomics[WIREs Syst Biol Med (2014), 6:125-135. doi: 10.1002/wsbm.1255]

Karnes, J. H., Van Driest, S., Bowton, E. A., Weeke, P. E., Mosley, J. D., Peterson, J. F., Denny, J. C. & Roden, D. M., May 1 2015, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 7, 3, 1 p.

Research output: Contribution to journalComment/debate

2014

Alteration in fasting glucose after prolonged treatment with a thiazide diuretic

Karnes, J. H., Gong, Y., Arwood, M. J., Gums, J. G., Hall, K. L., Limacher, M. C., Johnson, J. A. & Cooper-DeHoff, R. M., Jun 2014, In : Diabetes Research and Clinical Practice. 104, 3, p. 363-369 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biobanks and electronic medical records: Enabling cost-effective research

Bowton, E., Field, J. R., Wang, S., Schildcrout, J. S., Van Driest, S. L., Delaney, J. T., Cowan, J., Weeke, P., Mosley, J. D., Wells, Q. S., Karnes, J. H., Shaffer, C., Peterson, J. F., Denny, J. C., Roden, D. M. & Pulley, J. M., Apr 30 2014, In : Science translational medicine. 6, 234, 234cm3.

Research output: Contribution to journalComment/debate

69 Scopus citations

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome

Weeke, P., Mosley, J. D., Hanna, D., Delaney, J. T., Shaffer, C., Wells, Q. S., Van Driest, S., Karnes, J. H., Ingram, C., Guo, Y., Shyr, Y., Norris, K., Kannankeril, P. J., Ramirez, A. H., Smith, J. D., Mardis, E. R., Nickerson, D., George, A. L. & Roden, D. M., Apr 15 2014, In : Journal of the American College of Cardiology. 63, 14, p. 1430-1437 8 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Innovation in clinical pharmacy practice and opportunities for academic-practice partnership

Gubbins, P. O., Micek, S. T., Badowski, M., Cheng, J., Gallagher, J., Johnson, S. G., Karnes, J. H., Lyons, K., Moore, K. G. & Strnad, K., May 2014, In : Pharmacotherapy. 34, 5, p. e45-e54

Research output: Contribution to journalReview article

15 Scopus citations

PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment

Gong, Y., McDonough, C. W., Beitelshees, A. L., Karnes, J. H., O'Connell, J. R., Turner, S. T., Chapman, A. B., Gums, J. G., Bailey, K. R., Boerwinkle, E., Johnson, J. A. & Cooper-DeHoff, R. M., Feb 2014, In : Pharmacotherapy. 34, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Using systems approaches to address challenges for clinical implementation of pharmacogenomics

Karnes, J. H., Van Driest, S., Bowton, E. A., Weeke, P. E., Mosley, J. D., Peterson, J. F., Denny, J. C. & Roden, D. M., Jan 1 2014, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 6, 2, p. 125-135 11 p.

Research output: Contribution to journalReview article

13 Scopus citations
2013

Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment

Karnes, J. H., McDonough, C. W., Gong, Y., Vo, T. T., Langaee, T. Y., Chapman, A. B., Gums, J. G., Beitelshees, A. L., Bailey, K. R., Del-Aguila, J. L., Boerwinkle, E. A., Pepine, C. J., Turner, S. T., Johnson, J. A. & Cooper-Dehoff, R. M., Oct 1 2013, In : Pharmacogenomics Journal. 13, 5, p. 430-436 7 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide- induced diabetes

Karnes, J. H., Gong, Y., Pacanowski, M. A., McDonough, C. W., Arwood, M. J., Langaee, T. Y., Pepine, C. J., Johnson, J. A. & Cooper-DeHoff, R. M., Dec 2013, In : Pharmacogenetics and Genomics. 23, 12, p. 697-705 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lack of association of the HMGA1 IVS5-13insC variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort

Karnes, J. H., Langaee, T. Y., McDonough, C. W., Chang, S. W., Ramos, M., Catlin, J. R., Casanova, O. E., Gong, Y., Pepine, C. J., Johnson, J. A. & Cooper-DeHoff, R. M., Jan 9 2013, In : Journal of Translational Medicine. 11, 1, 12.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanistic phenotypes: An aggregative phenotyping strategy to identify disease mechanisms using GWAS data

Mosley, J. D., Van Driest, S. L., Larkin, E. K., Weeke, P. E., Witte, J. S., Wells, Q. S., Karnes, J. H., Guo, Y., Bastarache, L., Olson, L. M., McCarty, C. A., Pacheco, J. A., Jarvik, G. P., Carrell, D. S., Larson, E. B., Crosslin, D. R., Kullo, I. J., Tromp, G., Kuivaniemi, H., Carey, D. J. & 3 others, Ritchie, M. D., Denny, J. C. & Roden, D. M., Dec 12 2013, In : PloS one. 8, 12, e81503.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2009

Antihypertensive medications: Benefits of blood pressure lowering and hazards of metabolic effects

Karnes, J. H. & Cooper-DeHoff, R. M., Jun 2009, In : Expert review of cardiovascular therapy. 7, 6, p. 689-702 14 p.

Research output: Contribution to journalReview article

24 Scopus citations
2007

Factors Influencing Blood Pressure Response to Trandolapril Add-On Therapy in Patients Taking Verapamil SR (from the International Verapamil SR/Trandolapril [INVEST] Study)

Brunner, M., Cooper-DeHoff, R. M., Gong, Y., Karnes, J. H., Langaee, T. Y., Pepine, C. J. & Johnson, J. A., Jun 1 2007, In : American Journal of Cardiology. 99, 11, p. 1549-1554 6 p.

Research output: Contribution to journalArticle

21 Scopus citations