Jason Yuan

  • 14190 Citations
  • 63 h-Index
1988 …2020

Research output per year

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Research Output

2020

Chloroquine differentially modulates coronary vasodilation in control and diabetic mice

Zhang, Q., Tsuji-Hosokawa, A., Willson, C., Watanabe, M., Si, R., Lai, N., Wang, Z., Yuan, J. X. J., Wang, J. & Makino, A., Jan 1 2020, In : British Journal of Pharmacology. 177, 2, p. 314-327 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis

Badagliacca, R., Rischard, F., Papa, S., Kubba, S., Vanderpool, R., Yuan, J. X. J., Garcia, J. G. N., Airhart, S., Poscia, R., Pezzuto, B., Manzi, G., Miotti, C., Luongo, F., Scoccia, G., Sciomer, S., Torre, R., Fedele, F. & Vizza, C. D., Apr 2020, In : Journal of Heart and Lung Transplantation. 39, 4, p. 310-320 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α

Sun, X., Sun, B. L., Babicheva, A., Vanderpool, R., Oita, R. C., Casanova, N., Tang, H., Gupta, A., Lynn, H., Gupta, G., Rischard, F., Sammani, S., Kempf, C. L., Moreno-Vinasco, L., Ahmed, M., Camp, S. M., Wang, J., Desai, A., Yuan, J. X. J. & Garcia, J. G. N., Jul 1 2020, In : American journal of respiratory cell and molecular biology. 63, 1, p. 92-103 12 p.

Research output: Contribution to journalArticle

Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension

Karnes, J. H., Wiener, H. W., Schwantes-An, T. H., Natarajan, B., Sweatt, A. J., Chaturvedi, A., Arora, A., Batai, K., Nair, V., Steiner, H. E., Giles, J. B., Yu, J., Hosseini, M., Pauciulo, M. W., Lutz, K. A., Coleman, A. W., Feldman, J., Vanderpool, R., Tang, H., Garcia, J. G. N. & 9 others, Yuan, J. X. J., Kittles, R., de Jesus Perez, V., Zamanian, R. T., Rischard, F., Tiwari, H. K., Nichols, W. C., Benza, R. L. & Desai, A. A., Jun 1 2020, In : American journal of respiratory and critical care medicine. 201, 11, p. 1407-1415 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension

Babicheva, A., Ayon, R. J., Zhao, T., Ek Vitorin, J. F., Pohl, N. M., Yamamura, A., Yamamura, H., Quinton, B. A., Ba, M., Wu, L., Ravellette, K. S., Rahimi, S., Balistrieri, F., Harrington, A., Vanderpool, R. R., Thistlethwaite, P. A., Makino, A. & Yuan, J. X. J., Jan 1 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 1, p. L10-L26

Research output: Contribution to journalArticle

1 Scopus citations

mTORC1 in pulmonary arterial hypertension at the crossroads between vasoconstriction and vascular remodeling?

Goncharova, E. A., Simon, M. A. & Yuan, J. X. J., May 15 2020, In : American journal of respiratory and critical care medicine. 201, 10, p. 1177-1179 3 p.

Research output: Contribution to journalReview article

Open Access

Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels

Song, S., Babicheva, A., Zhao, T., Ayon, R. J., Rodriguez, M., Rahimi, S., Balistrieri, F., Harrington, A., Shyy, J. Y. J., Thistlethwaite, P. A., Makino, A. & Yuan, J. X. J., May 1 2020, In : American journal of physiology. Cell physiology. 318, 5, p. C954-C968

Research output: Contribution to journalArticle

Open Access

Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes

Si, R., Zhang, Q., Tsuji-Hosokawa, A., Watanabe, M., Willson, C., Lai, N., Wang, J., Dai, A., Scott, B. T., Dillmann, W. H., Yuan, J. X. J. & Makino, A., May 1 2020, In : Cardiovascular research. 116, 6, p. 1186-1198 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Chen, Y., Lu, W., Yang, K., Duan, X., Li, M., Chen, X., Zhang, J., Kuang, M., Liu, S., Wu, X., Zou, G., Liu, C., Hong, C., He, W., Liao, J., Hou, C., Zhang, Z., Zheng, Q., Chen, J., Zhang, N. & 10 others, Tang, H., Vanderpool, R. R., Desai, A. A., Rischard, F., Black, S. M., Garcia, J. G. N., Makino, A., Yuan, J. X. J., Zhong, N. & Wang, J., Jun 1 2020, In : British Journal of Pharmacology. 177, 12, p. 2743-2764 22 p.

Research output: Contribution to journalArticle

Transplantation of mesenchymal stem cells attenuates pulmonary hypertension by normalizing the endothelial-to-mesenchymal transition

Huang, J., Lu, W., Ouyang, H., Chen, Y., Zhang, C., Luo, X., Li, M., Shu, J., Zheng, Q., Chen, H., Chen, J., Tang, H., Sun, D., Yuan, J. X. J., Yang, K. & Wang, J., Jan 1 2020, In : American journal of respiratory cell and molecular biology. 62, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease

Zemskov, E. A., Lu, Q., Ornatowski, W., Klinger, C. N., Desai, A., Maltepe, E., Yuan, J. X. J., Wang, T., Fineman, J. R. & Black, S. M., Oct 20 2019, In : Antioxidants and Redox Signaling. 31, 12, p. 819-842 24 p.

Research output: Contribution to journalReview article

7 Scopus citations

Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension

Wang, Z., Yang, K., Zheng, Q., Zhang, C., Tang, H., Babicheva, A., Jiang, Q., Li, M., Chen, Y., Carr, S. G., Wu, K., Zhang, Q., Balistrieri, A., Wang, C., Song, S., Ayon, R. J., Desai, A. A., Black, S. M., Garcia, J. G. N., Makino, A. & 3 others, Yuan, J. X. J., Lu, W. & Wang, J., Jan 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 1, p. L216-L228

Research output: Contribution to journalArticle

6 Scopus citations

Endothelial Notch1 in Pulmonary Hypertension

Babicheva, A. & Yuan, J., Jan 18 2019, In : Circulation Research. 124, 2, p. 176-179 4 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension

Rafikov, R., Nair, V., Sinari, S., Babu, H., Sullivan, J. C., Yuan, J. X. J., Desai, A. A. & Rafikova, O., Nov 1 2019, In : Antioxidants and Redox Signaling. 31, 13, p. 917-932 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease

Babicheva, A., Zhao, T. & Yuan, J. X. J., Sep 13 2019, In : Circulation research. 125, 7, p. 696-698 3 p.

Research output: Contribution to journalReview article

Open Access

Pathophysiology of stroke: What do cells of the neurovascular unit have to do with it?

O’donnell, M. E. & Yuan, J., Jan 1 2019, In : American Journal of Physiology - Cell Physiology. 316, 1, p. C1

Research output: Contribution to journalEditorial

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Cao, Y., Zhang, X., Wang, L., Yang, Q., Ma, Q., Xu, J., Wang, J., Kovacs, L., Ayon, R. J., Liu, Z., Zhang, M., Zhou, Y., Zeng, X., Xu, Y., Wang, Y., Fulton, D. J., Weintraub, N. L., Lucas, R., Dong, Z., Yuan, J. X. J. & 8 others, Sullivan, J. C., Meadows, L., Barman, S. A., Wu, C., Quan, J., Hong, M., Su, Y. & Huo, Y., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13394-13403 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Ajp-cell physiology begins landmark reviews in cell physiology: An editorial from the senior editors of ajp-cell physiology

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X. J. & Adams, J. C., Jan 2018, In : American Journal of Physiology - Cell Physiology. 314, 1, p. C1-C2

Research output: Contribution to journalEditorial

Bone marrow-derived endothelial progenitor cells contribute to monocrotaline-induced pulmonary arterial hypertension in rats via inhibition of store-operated Ca2+ channels

Miao, R., Wan, J., Liu, J., Yuan, J. X. J., Wang, J., Xie, W., Zhai, Z. & Wang, C., Jan 1 2018, In : BioMed research international. 2018, 4892349.

Research output: Contribution to journalArticle

1 Scopus citations

Endothelial dysfunction in pulmonary arterial hypertension: An evolving landscape (2017 Grover Conference Series)

Ranchoux, B., Harvey, L. D., Ayon, R. J., Babicheva, A., Bonnet, S., Chan, S. Y., Yuan, J. X. J. & Perez, V. D. J., Jan 1 2018, In : Pulmonary Circulation. 8, 1

Research output: Contribution to journalReview article

25 Scopus citations

Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Tang, H., Babicheva, A., McDermott, K. M., Gu, Y., Ayon, R. J., Song, S., Wang, Z., Gupta, A., Zhou, T., Sun, X., Dash, S., Wang, Z., Balistrieri, A., Zheng, Q., Cordery, A. G., Desai, A. A., Rischard, F., Khalpey, Z., Wang, J., Black, S. M. & 3 others, Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Feb 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 2, p. L256-L275

Research output: Contribution to journalArticle

41 Scopus citations

Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells

He, X., Song, S., Ayon, R. J., Balisterieri, A., Black, S. M., Makino, A., Wier, W. G., Zang, W. J. & Yuan, J. X. J., Apr 2018, In : American Journal of Physiology - Cell Physiology. 314, 4, p. C504-C517

Research output: Contribution to journalArticle

12 Scopus citations

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18

Gross, C. M., Kellner, M., Wang, T., Lu, Q., Sun, X., Zemskov, E. A., Noonepalle, S., Kangath, A., Kumar, S., Gonzalez-Garay, M., Desai, A. A., Aggarwal, S., Gorshkov, B., Klinger, C., Verin, A. D., Catravas, J. D., Jacobson, J. R., Yuan, J. X. J., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., May 1 2018, In : American journal of respiratory cell and molecular biology. 58, 5, p. 614-624 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

New cases of glucose-6-phosphate dehydrogenase deficiency in pulmonary arterial hypertension

Kurdyukov, S., Eccles, C. A., Desai, A. A., Gonzalez-Garay, M., Yuan, J. X. J., Garcia, J. G. N., Rafikova, O. & Rafikov, R., Aug 2018, In : PloS one. 13, 8, e0203493.

Research output: Contribution to journalArticle

6 Scopus citations

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Tang, H., Wu, K., Wang, J., Vinjamuri, S., Gu, Y., Song, S., Wang, Z., Zhang, Q., Balistrieri, A., Ayon, R. J., Rischard, F., Vanderpool, R., Chen, J., Zhou, G., Desai, A. A., Black, S. M., Garcia, J. G. N., Yuan, J. X. J. & Makino, A., Dec 2018, In : JACC: Basic to Translational Science. 3, 6, p. 744-762 19 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pathophysiology of stroke: The many and varied contributions of brain microvasculature

O’Donnell, M. E. & Yuan, J. X. J., Sep 6 2018, In : American Journal of Physiology - Cell Physiology. 315, 3, p. C341-C342

Research output: Contribution to journalEditorial

1 Scopus citations

Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension

Dai, J., Zhou, Q., Tang, H., Chen, T., Li, J., Raychaudhuri, P., Yuan, J. & Zhou, G., Nov 1 2018, In : Cellular Signalling. 51, p. 119-129 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

STIM2 (Stromal Interaction Molecule 2)–mediated increase in resting cytosolic free Ca2+ concentration stimulates PASMC proliferation in pulmonary arterial hypertension

Song, S., Carr, S. G., McDermott, K. M., Rodriguez, M., Babicheva, A., Balistrieri, A., Ayon, R. J., Wang, J., Makino, A. & Yuan, J. X. J., 2018, In : Hypertension. 71, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: Therapeutic implications for pulmonary hypertension (2015 grover conference series)

Pullamsetti, S. S., Perros, F., Chelladurai, P., Yuan, J. & Stenmark, K., Jan 1 2018, In : Pulmonary Circulation. 6, 4, p. 448-464 17 p.

Research output: Contribution to journalReview article

16 Scopus citations
2017

A multi-center study to improve understanding of pulmonary vascular disease through phenomics

Hemnes, A. R., Beck, G. J., Newman, J. H., Abidov, A., Aldred, M. A., Barnard, J., Rosenzweig, E. B., Borlaug, B. A., Chung, W. K., Comhair, S. A. A., Erzurum, S. C., Frantz, R. P., Gray, M. P., Grunig, G., Hassoun, P. M., Hill, N. S., Horn, E. M., Hu, B., Lempel, J. K., Maron, B. A. & 9 others, Mathai, S. C., Olman, M. A., Rischard, F. P., Systrom, D. M., Tang, W. H. W., Waxman, A. B., Xiao, L., Yuan, J. X. J. & Leopold, J. A., Jan 1 2017, In : Circulation research. 121, 10, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH

Song, S., Ayon, R. J., Yamamura, A., Yamamura, H., Dash, S., Babicheva, A., Tang, H., Sun, X., Cordery, A. G., Khalpey, Z., Black, S. M., Desai, A. A., Rischard, F., McDermott, K. M., Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Mar 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 3, p. L309-L325

Research output: Contribution to journalArticle

10 Scopus citations

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension

Wu, K., Zhang, Q., Wu, X., Lu, W., Tang, H., Liang, Z., Gu, Y., Song, S., Ayon, R. J., Wang, Z., McDermott, K. M., Balistrieri, A., Wang, C., Black, S. M., Garcia, J. G. N., Makino, A., Yuan, J. X. J. & Wang, J., Nov 2017, In : British Journal of Pharmacology. 174, 22, p. 4155-4172 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelial cell signaling and ventilator-induced lung injury: Molecular mechanisms, genomic analyses, and therapeutic targets

Wang, T., Gross, C., Desai, A., Zemskov, E., Wu, X., Garcia, A. N., Jacobson, J. R., Yuan, J., Garcia, J. GN. & Black, S. M., Apr 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, p. L452-L476

Research output: Contribution to journalReview article

28 Scopus citations

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension

Vanderpool, R. R., Desai, A. A., Knapp, S. M., Simon, M. A., Abidov, A., Yuan, J. X. J., Garcia, J. G. N., Hansen, L. M., Knoper, S. R., Naeije, R. & Rischard, F. P., Aug 1 2017, In : The European respiratory journal. 50, 2

Research output: Contribution to journalLetter

13 Scopus citations

Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A. A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J. X. J., Catravas, J. D., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., Jan 1 2017, In : Free Radical Biology and Medicine. 102, p. 217-228 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
1 Scopus citations

New people, new publisher, and new perspectives

Yuan, J. X. J., Morrell, N. W., Stenmark, K. R., Lang, I. M., Butrous, G. & Reynolds, M. E., 2017, In : Pulmonary Circulation. 7, 1, p. 5-6 2 p.

Research output: Contribution to journalEditorial

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension

Chen, J., Sysol, J. R., Singla, S., Zhao, S., Yamamura, A., Valdez-Jasso, D., Abbasi, T., Shioura, K. M., Sahni, S., Reddy, V., Sridhar, A., Gao, H., Torres, J., Camp, S. M., Tang, H., Qing Ye, S., Comhair, S., Dweik, R., Hassoun, P., Yuan, J. X. J. & 2 others, Garcia, J. G. N. & Machado, R. F., Apr 18 2017, In : Circulation. 135, 16, p. 1532-1546 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension

Tang, H., Vanderpool, R. R., Wang, J. & Yuan, J., 2017, In : Pulmonary Circulation. 7, 3, p. 569-571 3 p.

Research output: Contribution to journalEditorial

The pulmonary vascular research institute celebrates its first decade

Yuan, J. X. J., Morrell, N. W., Stenmark, K. R., Lang, I. M., Butrous, G. & Reynolds, M. E., 2017, In : Pulmonary Circulation. 7, 2, p. 283-284 2 p.

Research output: Contribution to journalEditorial

2016

Applying pharmacogenomics in the therapeutics of pulmonary diseases

Zhang, W. & Yuan, J. X. J., Jan 6 2016, Applying Pharmacogenomics in Therapeutics. CRC Press, p. 221-242 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Asymmetric dimethylarginine stimulates Akt1 phosphorylation via heat shock protein 70-facilitated carboxyl-terminal modulator protein degradation in pulmonary arterial endothelial cells

Sun, X., Kellner, M., Desai, A., Wang, T., Lu, Q., Kangath, A., Qu, N., Klinger, C., Fratz, S., Yuan, J., Jacobson, J. R., Garcia, J. GN., Rafikov, R., Fineman, J. R. & Black, S. M., Aug 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells

Song, S., Jacobson, K. N., McDermott, K., Reddy, S. P., Cress, A. E., Tang, H., Dudek, S. M., Black, S. M., Garcia, J. GN., Makino, A. & Yuan, J., Jan 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 2, p. C99-C114

Research output: Contribution to journalArticle

36 Scopus citations

Calcium-sensing receptor regulates cytosolic [Ca2+] and plays a major role in the development of pulmonary hypertension

Smith, K. A., Ayon, R. J., Tang, H., Makino, A. & Yuan, J. X. J., Nov 4 2016, In : Frontiers in Physiology. 7, NOV, 517.

Research output: Contribution to journalShort survey

19 Scopus citations

Metabolic changes precede the development of pulmonary hypertension in the monocrotaline exposed rat lung

Rafikova, O., Meadows, M. L., Kinchen, J. M., Mohney, R. P., Maltepe, E., Desai, A. A., Yuan, J. X. J., Garcia, J. G. N., Fineman, J. R., Rafikov, R. & Black, S. M., Mar 2016, In : PloS one. 11, 3, 0150480.

Research output: Contribution to journalArticle

23 Scopus citations

MiR-17/20 controls prolyl hydroxylase 2 (PHD2)/hypoxia-inducible factor 1 (HIF1) to regulate pulmonary artery smooth muscle cell proliferation

Chen, T., Zhou, Q., Tang, H., Bozkanat, M., Yuan, J. X. J., Raj, J. U. & Zhou, G., Dec 1 2016, In : Journal of the American Heart Association. 5, 12, e004510.

Research output: Contribution to journalArticle

13 Scopus citations

Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension

Tang, H., Yamamura, A., Yamamura, H., Song, S., Fraidenburg, D. R., Chen, J., Gu, Y., Pohl, N. M., Zhou, T., Jiménez-Pérez, L., Ayon, R. J., Desai, A. A., Goltzman, D., Rischard, F., Khalpey, Z., Black, S. M., Garcia, J. G. N., Makino, A. & Yuan, J. X. J., Mar 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L846-L859

Research output: Contribution to journalArticle

34 Scopus citations