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  • 6 Similar Profiles
Mutation Medicine & Life Sciences
Troponin T Medicine & Life Sciences
Familial Hypertrophic Cardiomyopathy Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Cardiomyopathies Medicine & Life Sciences
Hypertrophic Cardiomyopathy Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Myofibrils Medicine & Life Sciences

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Projects 2002 2020

Cardiomyopathies
Mutation
Proteins
Phosphorylation
Research
Mutation
Alleles
Amino Acids
Proteins
Phenotype

Cellular Mechanisms in the Pathogenesis of FHC

Tardiff, J. C.

National Institutes of Health

3/1/022/28/07

Project: Research projectClinical Investigator Award (CIA)

Familial Hypertrophic Cardiomyopathy
Mutation
Troponin T
Alleles
Proteins

Research Output 1985 2017

  • 1869 Citations
  • 21 h-Index
  • 49 Article
  • 1 Comment/debate
  • 1 Review article

Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap

McConnell, M., Tal Grinspan, L., Williams, M. R., Lynn, M. L., Schwartz, B. A., Fass, O. Z., Schwartz, S. D. & Tardiff, J. C. Jul 5 2017 In : Biochemistry. 56, 26, p. 3403-3413 11 p.

Research output: Research - peer-reviewArticle

Tropomyosin
Mutation
Proteins
Sarcomeres
Troponin T

Pathogenesis of hypertrophic cardiomyopathy is mutation rather than disease specific: A comparison of the cardiac troponin T E163R and R92Q mouse models

Ferrantini, C., Coppini, R., Pioner, J. M., Gentile, F., Tosi, B., Mazzoni, L., Scellini, B., Piroddi, N., Laurino, A., Santini, L., Spinelli, V., Sacconi, L., De Tombe, P., Moore, R., Tardiff, J., Mugelli, A., Olivotto, I., Cerbai, E., Tesi, C. & Poggesi, C. Jul 1 2017 In : Journal of the American Heart Association. 6, 7, e005407

Research output: Research - peer-reviewArticle

Troponin T
Myofibrils
Hypertrophic Cardiomyopathy
Mutation
Excitation Contraction Coupling
4 Citations

Ranolazine prevents phenotype development in a mouse model of hypertrophic cardiomyopathy

Coppini, R., Mazzoni, L., Ferrantini, C., Gentile, F., Pioner, J. M., Laurino, T., Santini, L., Bargelli, V., Rotellini, M., Bartolucci, G., Crocini, C., Sacconi, L., Tesi, C., Belardinelli, L., Tardiff, J., Mugelli, A., Olivotto, I., Cerbai, E. & Poggesi, C. Mar 1 2017 In : Circulation: Heart Failure. 10, 3, e003565

Research output: Research - peer-reviewArticle

Hypertrophic Cardiomyopathy
Phenotype
Ranolazine
Mutation
Therapeutics

The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy

Lynn, M. L., Tal Grinspan, L., Holeman, T. A., Jimenez, J., Strom, J. & Tardiff, J. C. Jul 1 2017 In : Journal of Molecular and Cellular Cardiology. 108, p. 127-137 11 p.

Research output: Research - peer-reviewArticle

Tropomyosin
Familial dilated cardiomyopathy
Mutation
Dilated Cardiomyopathy
Aptitude