• 680 Citations
  • 15 h-Index
20052019
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Research Output 2005 2019

  • 680 Citations
  • 15 h-Index
  • 53 Article
  • 1 Letter
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Article
2019

Alternaria induces airway epithelial cytokine expression independent of protease-activated receptor

Daines, M., Zhu, L., Pereira, R., Zhou, X., Bondy, C., Pryor, B. M., Zhou, J. & Chen, Y., Jan 1 2019, (Accepted/In press) In : Respirology.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Alternaria
PAR-2 Receptor
Cytokines
Asthma

DNA methylation among firefighters

Zhou, J., Jenkins, T. G., Jung, A. M., Jeong, K. S., Zhai, J., Jacobs, E. T., Griffin, S., Dearmon-Moore, D., Littau, S. R., Peate, W. F., Ellis, N., Lance, M. P., Chen, Y. & Burgess, J. L., Mar 1 2019, In : PloS one. 14, 3, e0214282.

Research output: Contribution to journalArticle

Open Access
fire fighters
Firefighters
DNA methylation
DNA Methylation
Methylation

Exact variance component tests for longitudinal microbiome studies

Zhai, J., Knox, K. S., Twigg, H. L., Zhou, H. & Zhou, J., Jan 1 2019, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Microbiota
Longitudinal Studies
Sample Size
Computing Methodologies
Veillonella
2 Citations (Scopus)

Glycaemic variation is a predictor of all-cause mortality in the Veteran Affairs Diabetes Trial

Zhou, J., Koska, J., Bahn, G. & Reaven, P., Mar 1 2019, In : Diabetes and Vascular Disease Research. 16, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

Open Access
Veterans
Glucose
Fasting
Mortality
Type 2 Diabetes Mellitus

MM algorithms for variance component estimation and selection in logistic linear mixed model

Hu, L., Lu, W., Zhou, J. & Zhou, H., Jan 1 2019, In : Statistica Sinica. 29, 3, p. 1585-1605 21 p.

Research output: Contribution to journalArticle

Linear Mixed Model
Variance Components
Logistics
Penalized Maximum Likelihood
Laplace Approximation
1 Citation (Scopus)

MM Algorithms for Variance Components Models

Zhou, H., Hu, L., Zhou, J. & Lange, K., Jan 1 2019, In : Journal of Computational and Graphical Statistics.

Research output: Contribution to journalArticle

Variance Component Model
Variance Components
Maximum Likelihood Estimation
Restricted Estimation
Multivariate Response
3 Citations (Scopus)

OpenMendel: a cooperative programming project for statistical genetics

Zhou, H., Sinsheimer, J. S., Bates, D. M., Chu, B. B., German, C. A., Ji, S. S., Keys, K. L., Kim, J., Ko, S., Mosher, G. D., Papp, J. C., Sobel, E. M., Zhai, J., Zhou, J. & Lange, K., Jan 1 2019, In : Human Genetics.

Research output: Contribution to journalArticle

Molecular Epidemiology
Software
Genome-Wide Association Study
Cloud Computing

Ordered multinomial regression for genetic association analysis of ordinal phenotypes at Biobank scale

German, C. A., Sinsheimer, J. S., Klimentidis, Y. C., Zhou, H. & Zhou, J. J., Jan 1 2019, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Phenotype
Logistic Models
Electronic Health Records
Hypertension
2018

An Algorithm for Generating Individualized Treatment Decision Trees and Random Forests

Doubleday, K., Zhou, H., Fu, H. & Zhou, J., Oct 2 2018, In : Journal of Computational and Graphical Statistics. 27, 4, p. 849-860 12 p.

Research output: Contribution to journalArticle

Random Forest
Decision tree
Reward
Diabetes
Tree Algorithms
16 Citations (Scopus)

Glycemic variation and cardiovascular risk in the Veterans Affairs Diabetes trial

VADT Investigators, Oct 1 2018, In : Diabetes Care. 41, 10, p. 2187-2194 8 p.

Research output: Contribution to journalArticle

Veterans
Fasting
Glucose
Cardiovascular Diseases
Glycosylated Hemoglobin A
3 Citations (Scopus)

MicroRNA Changes in Firefighters

Jeong, K. S., Zhou, J., Griffin, S., Jacobs, E. T., Dearmon-Moore, D., Zhai, J., Littau, S. R., Gulotta, J., Moore, P., Peate, W. F., Richt, C. M. & Burgess, J. L., May 1 2018, In : Journal of Occupational and Environmental Medicine. 60, 5, p. 469-474 6 p.

Research output: Contribution to journalArticle

Firefighters
MicroRNAs
Neoplasms
Carcinogenesis
Obesity
6 Citations (Scopus)

Rat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages

Zhou, T., Xie, X., Li, M., Shi, J., Zhou, J., Knox, K. S., Wang, T., Chen, Q. & Gu, W., Nov 1 2018, In : RNA (New York, N.Y.). 24, 11, p. 1443-1456 14 p.

Research output: Contribution to journalArticle

Transcriptome
Messenger RNA
Organ Specificity
Spermatogenesis
Genes
3 Citations (Scopus)

Variance component selection with applications to microbiome taxonomic data

Zhai, J., Kim, J., Knox, K. S., Twigg, H. L., Zhou, H. & Zhou, J., Mar 28 2018, In : Frontiers in Microbiology. 9, MAR, 509.

Research output: Contribution to journalArticle

Microbiota
Computing Methodologies
Joints
Documentation
Longitudinal Studies
2017
Observational Study
Medicine
Recommendations
Subgroup
Medical problems
16 Citations (Scopus)

Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects

National Emphysema Treatment Trial Genetics, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points, International COPD Genetics Network, COPDGene Investigators, Jul 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 1, p. 35-46 12 p.

Research output: Contribution to journalArticle

Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Meta-Analysis
Polymorphism
Single Nucleotide Polymorphism
3 Citations (Scopus)

Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome

Hammer, M. F., Ishii, A., Johnstone, L., Tchourbanov, A., Lau, B., Sprissler, R., Hallmark, B., Zhang, M., Zhou, J., Watkins, J. C. & Hirose, S., Jul 1 2017, In : PLoS One. 12, 7, e0180485.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Genes
genes
mutation
Mutation
14 Citations (Scopus)

Regression Models for Multivariate Count Data

Zhang, Y., Zhou, H., Zhou, J. & Sun, W., Jan 2 2017, In : Journal of Computational and Graphical Statistics. 26, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Count Data
Multivariate Data
Multinomial Logit Model
Regression Model
Count
2016
7 Citations (Scopus)

Boosting gene mapping power and efficiency with efficient exact variance component tests of single nucleotide polymorphism sets

Zhou, J., Hu, T., Qiao, D., Cho, M. H. & Zhou, H., Nov 1 2016, In : Genetics. 204, 3, p. 921-931 11 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Sample Size
Single Nucleotide Polymorphism
Exome
Computing Methodologies
36 Citations (Scopus)

Effect of advanced HIV infection on the respiratory microbiome

Twigg, H. L., Knox, K. S., Zhou, J., Crothers, K. A., Nelson, D. E., Toh, E., Day, R. B., Lin, H., Gao, X., Dong, Q., Mi, D., Katz, B. P., Sodergren, E. & Weinstock, G. M., Jul 15 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

Microbiota
HIV Infections
Highly Active Antiretroviral Therapy
HIV
Lung
21 Citations (Scopus)

Estimating optimal treatment regimes via subgroup identification in randomized control trials and observational studies

Fu, H., Zhou, J. & Faries, D. E., Aug 30 2016, In : Statistics in Medicine. 35, 19, p. 3285-3302 18 p.

Research output: Contribution to journalArticle

Observational Study
Observational Studies
Subgroup
Precision Medicine
Medicine
4 Citations (Scopus)

FTO association and interaction with time spent sitting

Klimentidis, Y. C., Arora, A., Chougule, A., Zhou, J. & Raichlen, D. A., Mar 1 2016, In : International Journal of Obesity. 40, 3, p. 411-416 6 p.

Research output: Contribution to journalArticle

Body Mass Index
Obesity
Alleles
Women's Health
Energy Metabolism

Genome-wide QTL and eQTL analyses using Mendel

Zhou, H., Zhou, J., Hu, T., Sobel, E. M. & Lange, K., 2016, In : BMC Proceedings. 10, 10.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Pedigree
Genes
Blood pressure
Genome
3 Citations (Scopus)

Genomic analyses identify agents regulating somatotroph and lactotroph functions

Fan, J., Zhang, C., Chen, Q., Zhou, J., Franc, J. L., Chen, Q. & Tong, Y., Nov 1 2016, In : Functional and Integrative Genomics. 16, 6, p. 693-704 12 p.

Research output: Contribution to journalArticle

Lactotrophs
Somatotrophs
Endocrine Cells
Cell Differentiation
Stem Cells
1 Citation (Scopus)

Patient preferences for total knee replacement surgery: Relationship to clinical outcomes and stability of patient preferences over 2 years

Vina, E. R., Ran, D., Ashbeck, E. L., Ibrahim, S. A., Hannon, M. J., Zhou, J. & Kwoh, C. K., 2016, (Accepted/In press) In : Seminars in Arthritis and Rheumatism.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Patient Preference
Logistic Models
Demography
Knee Osteoarthritis
5 Citations (Scopus)

Testing rare variants for hypertension using family-based tests with different weighting schemes

Wang, X., Zhao, X. & Zhou, J., 2016, In : BMC Proceedings. 10, 61.

Research output: Contribution to journalArticle

Hypertension
Testing
Statistical methods
Population
Genes
8 Citations (Scopus)
Abdominal Obesity
African Americans
Waist-Hip Ratio
Atherosclerosis
Obesity
2015
20 Citations (Scopus)

FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion

Zheng, Y., Guo, J., Zhou, J., Lu, J., Chen, Q., Zhang, C., Qing, C., Koeffler, H. P. & Tong, Y., Aug 12 2015, In : BMC Medical Genomics. 8, 1, 126.

Research output: Contribution to journalArticle

Cell Movement
Colorectal Neoplasms
Neoplasm Metastasis
HCT116 Cells
Chromatin Immunoprecipitation
7 Citations (Scopus)

Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales

Gu, W., Gurguis, C. I., Zhou, J., Zhu, Y., Ko, E. A., Ko, J. H., Wang, T. & Zhou, T., Oct 9 2015, In : Genome Biology and Evolution. 7, 10, p. 2929-2940 12 p.

Research output: Contribution to journalArticle

single nucleotide polymorphism
Single Nucleotide Polymorphism
polymorphism
allele
Alleles
32 Citations (Scopus)

Gene signatures of drug resistance predict patient survival in colorectal cancer

Zheng, Y., Zhou, J. & Tong, Y., Apr 25 2015, In : Pharmacogenomics Journal. 15, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Drug Resistance
Colorectal Neoplasms
Survival
12 Citations (Scopus)

Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability

Zhou, J., Cho, M. H., Lange, C., Lutz, S., Silverman, E. K. & Laird, N. M., Jun 20 2015, (Accepted/In press) In : Human Heredity. p. 93-104 12 p.

Research output: Contribution to journalArticle

Phenotype
Single Nucleotide Polymorphism
Genome-Wide Association Study
Principal Component Analysis
Chronic Obstructive Pulmonary Disease
75 Citations (Scopus)

Testing in microbiome-profiling studies with MiRKAT, the microbiome regression-based kernel association test

Zhao, N., Chen, J., Carroll, I. M., Ringel-Kulka, T., Epstein, M. P., Zhou, H., Zhou, J., Ringel, Y., Li, H. & Wu, M. C., May 7 2015, In : American Journal of Human Genetics. 96, 5, p. 797-807 11 p.

Research output: Contribution to journalArticle

Microbiota
Social Adjustment
Peptide Hydrolases
Smoking
Technology
2014
6 Citations (Scopus)

A comparative analysis of family-based and population-based association tests using whole genome sequence data

Zhou, J., Yip, W. K., Cho, M. H., Qiao, D., McDonald, M. L. N. & Laird, N. M., Jun 17 2014, In : BMC Proceedings. 8, S33.

Research output: Contribution to journalArticle

Genes
Genome
Population
Chromosomes, Human, Pair 3
Quantitative Trait Loci
47 Citations (Scopus)

Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study

Kim, V., Davey, A., Comellas, A. P., Han, M. K., Washko, G., Martinez, C. H., Lynch, D., Lee, J. H., Silverman, E. K., Crapo, J. D., Make, B. J., Criner, G. J., Farzadegan, H., Bragan, S., Cayetano, S., Curtis, J., Kazerooni, E., Hanania, N., Alapat, P., Bandi, V. & 168 others, Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Atik, M., Al-Azzawi, H., Willis, M., Pinero, S., Fahr, L., Nachiappan, A., Bray, C., Frigini, L. A., Farinas, C., Katz, D., Freytes, J., Marciel, A. M., DeMeo, D., Hersh, C., Jacobson, F., Hatabu, H., Clarke, P., Gill, R., Hunsaker, A., Trotman-Dickenson, B., Madan, R., Barr, R. G., Thomashow, B., Austin, J., D'Souza, B., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., Bradley, J., Kuong, S., Meller, S., Roland, S., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Horton, K., Casaburi, R., Porszasz, J., Fischer, H., Budoff, M., Rambod, M., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Anderson, Q., Rice, K., Caine, A., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Schroeder, J., Hale, V., Armstrong, J., Dyer, D., Chung, J., Cox, C., Marchetti, N., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Cone, L., Bailey, W., Dransfield, M., Wells, M., Bhatt, S., Nath, H., Singh, S., Ramsdell, J., Friedman, P., Cornellas, A., Newell, J., van Beek, E. J. R., Martinez, F., Wendt, C., Allen, T., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Hooper, D., Anzueto, A., Adams, S., Orozco, C., Ruiz, M., Mumbower, A., Kruger, A., Restrepo, C., Lane, M., Akhavan, J., Al Qaisi, M., Beaty, T., Black-Shinn, J., Bleecker, E. R., Bowler, R. P., Bratschie, S., Castaldic, P. J., Cho, M., Cox, C. W., Coxson, H. O., Croxton, T., Crystal, R. G., Curtis, J. L., Cusick, D., DeMeo, D. L., Dy, J. G., Everett, D., Foreman, M. G., Gan, W., Ginsburg, S., Hansel, N. N., Hardin, M. E., Hersh, C. P., Hetmanski, J., Hoffman, E. A., Hogg, J. C., Hokanson, J., Hokanson, J. E., Jensen, R., Jose Estepar, R. S., Judy, P. F., Kinney, G., Kluiber, A., Knowles, R., Laird, N., Lange, C., Lantz, R., Lutz, S. M., Mattheisen, M., McDonaldc, M. L., McKenzie, A., Melanson, S., Newell, J. D., Parker, M. M., Plant, R., Postow, L., Prieto, D., Province, M. A., Regan, E. A., Reilly, J. J., Rennard, S. I., Rossc, J., Santorico, S., Schroeder, J. D., Sieren, J., Sitek, A., Stepp, L., Stinson, D., Sutherland, E. R., Thomas, D. C., Walsh, J. W., Wan, E. S., Williams, A., Wilson, C., Zach, J., Zhou, J. & van Beek, E., Apr 27 2014, In : Respiratory Research. 15, 1, 52.

Research output: Contribution to journalArticle

Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Cross-Sectional Studies
Bronchitis
Smoking
14 Citations (Scopus)

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators, Nov 1 2014, In : American Journal of Respiratory Cell and Molecular Biology. 51, 5, p. 678-687 10 p.

Research output: Contribution to journalArticle

Pulmonary diseases
Oxygenation
Chronic Obstructive Pulmonary Disease
Genes
Chromosomes
2 Citations (Scopus)

Complex pedigrees in the sequencing era: To track transmissions or decorrelate?

Li, D., Zhou, J., Thomas, D. C. & Fardo, D. W., 2014, In : Genetic Epidemiology. 38, SUPPL.1

Research output: Contribution to journalArticle

Pedigree
Inheritance Patterns
Genetic Testing
Genetic Predisposition to Disease
Population
13 Citations (Scopus)

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease

the COPDGene and ECLIPSE Investigators, Aug 20 2014, In : Respiratory Research. 15, 1, 97.

Research output: Contribution to journalArticle

Total Lung Capacity
Dyneins
Chronic Obstructive Pulmonary Disease
Linear Models
Kartagener Syndrome
62 Citations (Scopus)

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

The COPDGene Investigators, Aug 6 2014, In : Respiratory Research. 15, 1, 89.

Research output: Contribution to journalArticle

Molecular Epidemiology
Spirometry
Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Cluster Analysis
3 Citations (Scopus)

Fast genome-wide pedigree quantitative trait loci analysis using MENDEL

Zhou, H., Zhou, J., Sobel, E. M. & Lange, K., Jun 17 2014, In : BMC Proceedings. 8, S93.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Pedigree
Polymorphism
Nucleotides
Genes
31 Citations (Scopus)

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

COPDGene and ECLIPSE Investigators, Sep 21 2014, In : Respiratory Research. 15, 1, 113.

Research output: Contribution to journalArticle

Chronic Bronchitis
Genetic Predisposition to Disease
Chronic Obstructive Pulmonary Disease
Spirometry
Genome
4 Citations (Scopus)

Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction

Klimentidis, Y. C., Zhou, J. & Wineinger, N. E., Nov 13 2014, In : PLoS One. 9, 11, e113072.

Research output: Contribution to journalArticle

Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Polymorphism
single nucleotide polymorphism
35 Citations (Scopus)

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus

COPDGene and ECLIPSE Investigators, 2014, In : BMC Pulmonary Medicine. 14, 1, 164.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Diabetes Mellitus
Emphysema
Thorax
Tomography
2013
48 Citations (Scopus)

Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers

Zhou, J., Cho, M. H., Castaldi, P. J., Hersh, C. P., Silverman, E. K. & Laird, N. M., Oct 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 188, 8, p. 941-947 7 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Phenotype
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genetic Loci
2012
20 Citations (Scopus)

Genomic characterization of human and rat prolactinomas

Tong, Y., Zheng, Y., Zhou, J., Oyesiku, N. M., Koeffler, H. P. & Melmed, S., Aug 1 2012, In : Endocrinology. 153, 8, p. 3679-3691 13 p.

Research output: Contribution to journalArticle

Prolactinoma
Estrogens
Inbred ACI Rats
Genes
Dopamine Agonists
7 Citations (Scopus)

Quantitative trait loci association mapping by imputation of strain origins in multifounder crosses

Zhou, J., Ghazalpour, A., Sobel, E. M., Sinsheimer, J. S. & Lange, K., Feb 2012, In : Genetics. 190, 2, p. 459-473 15 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Genome
Pedigree
Inbreeding
Research Design
2011
15 Citations (Scopus)

CEBPD suppresses prolactin expression and prolactinoma cell proliferation

Tong, Y., Zhou, J., Mizutani, J., Fukuoka, H., Ren, S. G., Gutierrez-Hartmann, A., Phillip Koeffler, H. & Melmed, S., Nov 1 2011, In : Molecular Endocrinology. 25, 11, p. 1880-1891 12 p.

Research output: Contribution to journalArticle

Prolactinoma
Prolactin
Cell Proliferation
Lactotrophs
Cyclin B2
3 Citations (Scopus)

Dissecting prenatal, postnatal, and inherited effects: ART and design

Zhou, J., Pelka, S., Lange, K., Palmer, C. G. S. & Sinsheimer, J. S., Sep 2011, In : Genetic Epidemiology. 35, 6, p. 437-446 10 p.

Research output: Contribution to journalArticle

Assisted Reproductive Techniques
Research Personnel
Pedigree
2010
23 Citations (Scopus)

Deaf adults' reasons for genetic testing depend on cultural affiliation: Results from a prospective, longitudinal genetic counseling and testing study

Boudreault, P., Baldwin, E. E., Fox, M., Dutton, L., Tullis, L., Linden, J., Kobayashi, Y., Zhou, J., Sinsheimer, J. S., Sininger, Y., Grody, W. W. & Palmer, C. G. S., May 20 2010, In : Journal of Deaf Studies and Deaf Education. 15, 3, p. 209-227 19 p.

Research output: Contribution to journalArticle

Genetic Counseling
Genetic Testing
counseling
Motivation
Hearing
2009
6 Citations (Scopus)

A heterozygote-homozygote test of Hardy-Weinberg equilibrium

Zhou, J., Lange, K., Papp, J. C. & Sinsheimer, J. S., 2009, In : European Journal of Human Genetics. 17, 11, p. 1495-1500 6 p.

Research output: Contribution to journalArticle

Homozygote
Pedigree
Heterozygote
Genotype
Population Genetics
19 Citations (Scopus)

A prospective, longitudinal study of the impact of GJB2/GJB6 genetic testing on the beliefs and attitudes of parents of deaf and hard-of-hearing infants

Palmer, C. G. S., Martinez, A., Fox, M., Zhou, J., Shapiro, N., Sininger, Y., Grody, W. W. & Schimmenti, L. A., Jun 2009, In : American Journal of Medical Genetics, Part A. 149, 6, p. 1169-1182 14 p.

Research output: Contribution to journalArticle

Genetic Testing
Hearing
Longitudinal Studies
Parents
Prospective Studies
11 Citations (Scopus)
Hearing
Parents
Genetic Research
Genetic Testing
Deafness