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  • 2 Similar Profiles
Adrenergic Receptors Medicine & Life Sciences
Prostaglandins Medicine & Life Sciences
Prostaglandins E Medicine & Life Sciences
Prostaglandins F Medicine & Life Sciences
Ligands Medicine & Life Sciences
Genes Medicine & Life Sciences
Chemical activation Chemical Compounds
Organism Cloning Medicine & Life Sciences

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Projects 1991 2008


Regan, J. W.

National Institutes of Health


Project: Research projectResearch Project

Prostaglandin Receptors
prostaglandin F2alpha receptor
Aquaporin 1
Protein Isoforms
Adrenergic Receptors
Organism Cloning
varespladib methyl
Adrenergic Agents

Research Output 1974 2017

  • 8193 Citations
  • 47 h-Index
  • 138 Article
  • 1 Book

Anti-cancer effects of MW-03, a novel indole compound, by inducing 15-hydroxyprostaglandin dehydrogenase and cellular growth inhibition in the ls174t human colon cancer cell line

Seira, N., Yanagisawa, N., Suganami, A., Honda, T., Wasai, M., Regan, J. W., Fukushima, K., Yamaguchi, N., Tamura, Y., Arai, T., Murayama, T. & Fujino, H. 2017 In : Biological and Pharmaceutical Bulletin. 40, 10, p. 1806-1812 7 p.

Research output: Research - peer-reviewArticle

15-hydroxyprostaglandin dehydrogenase
Colonic Neoplasms
Cell Line

PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors

Araki, Y., Suganami, A., Endo, S., Masuda, Y., Fukushima, K., Regan, J. W., Murayama, T., Tamura, Y. & Fujino, H. 2017 (Accepted/In press) In : FEBS Letters.

Research output: Research - peer-reviewArticle

Receptors, Prostaglandin E, EP4 Subtype
beta Catenin
Prostaglandins E
1 Citations

Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands

Suganami, A., Fujino, H., Okura, I., Yanagisawa, N., Sugiyama, H., Regan, J. W., Tamura, Y. & Murayama, T. Nov 1 2016 In : FEBS Journal. 283, 21, p. 3931-3940 10 p.

Research output: Research - peer-reviewArticle

Prostaglandins E
Prostaglandins D
Prostaglandins F
4 Citations

Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells

Otake, S., Yoshida, K., Seira, N., Sanchez, C. M., Regan, J. W., Fujino, H. & Murayama, T. Feb 1 2015 In : Pharmacology Research and Perspectives. 3, 1, p. 1-13 13 p.

Research output: Research - peer-reviewArticle

Prostaglandins E
Colonic Neoplasms
5 Citations
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
Prostaglandins E
Colonic Neoplasms