• 5123 Citations
  • 33 h-Index
19942019

Research output per year

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Research Output

  • 5123 Citations
  • 33 h-Index
  • 65 Article
  • 8 Review article
  • 3 Comment/debate
2019

A Survey of the Structures of US FDA Approved Combination Drugs

Das, P., Delost, M. D., Qureshi, M. H., Smith, D. T. & Njardarson, J. T., May 9 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4265-4311 47 p.

Research output: Contribution to journalReview article

19 Scopus citations
2018

[2.2.2]- to [3.2.1]-Bicycle Skeletal Rearrangement Approach to the Gibberellin Family of Natural Products

Smith, B. R. & Njardarson, J. T., May 18 2018, In : Organic Letters. 20, 10, p. 2993-2996 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

Scott, K. A. & Njardarson, J. T., Feb 1 2018, In : Topics in Current Chemistry. 376, 1, 5.

Research output: Contribution to journalReview article

80 Scopus citations

Asymmetric Vinylogous Aza-Darzens Approach to Vinyl Aziridines

Chogii, I., Das, P., Delost, M. D., Crawford, M. N. & Njardarson, J. T., Aug 17 2018, In : Organic Letters. 20, 16, p. 4942-4945 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

Delost, M. D., Smith, D. T., Anderson, B. J. & Njardarson, J. T., Jun 2 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

33 Scopus citations

Review of synthetic approaches toward maoecrystal v

Smith, B. R. & Njardarson, J. T., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 23, p. 4210-4222 13 p.

Research output: Contribution to journalReview article

1 Scopus citations

Total Synthesis of (±)-Phomoidride D

Leung, J. C., Bedermann, A. A., Njardarson, J. T., Spiegel, D. A., Murphy, G. K., Hama, N., Twenter, B. M., Dong, P., Shirahata, T., McDonald, I. M., Inoue, M., Taniguchi, N., McMahon, T. C., Schneider, C. M., Tao, N., Stoltz, B. M. & Wood, J. L., Feb 12 2018, In : Angewandte Chemie - International Edition. 57, 7, p. 1991-1994 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products

Smith, D. T., Vitaku, E. & Njardarson, J. T., Jul 7 2017, In : Organic Letters. 19, 13, p. 3508-3511 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Double-diels-alder approach to maoecrystal V. unexpected C-C bond-forming fragmentations of the [2.2.2]-bicyclic core

Smith, B. R. & Njardarson, J. T., 2017, In : Organic Letters. 19, 19, p. 5316-5319 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures

Chogii, I., Das, P., Fell, J. S., Scott, K. A., Crawford, M. N., Houk, K. N. & Njardarson, J. T., Sep 20 2017, In : Journal of the American Chemical Society. 139, 37, p. 13141-13146 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers

Vitaku, E. & Njardarson, J. T., 2016, In : European Journal of Organic Chemistry. 2016, 22, p. 3679-3683 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2 Scopus citations

Metal-free synthesis of fluorinated indoles enabled by oxidative dearomatization

Vitaku, E., Smith, D. T. & Njardarson, J. T., Feb 5 2016, In : Angewandte Chemie - International Edition. 55, 6, p. 2243-2247 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015
19 Scopus citations

Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches

Das, P. & Njardarson, J. T., Aug 13 2015, In : Organic Letters. 17, 16, p. 4030-4033 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthetic approaches and total syntheses of vinigrol, a unique diterpenoid

Draghici, C. & Njardarson, J. T., May 26 2015, In : Tetrahedron. 71, 23, p. 3775-3793 19 p.

Research output: Contribution to journalReview article

8 Scopus citations
2014

Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals

Vitaku, E., Smith, D. T. & Njardarson, J. T., Dec 26 2014, In : Journal of Medicinal Chemistry. 57, 24, p. 10257-10274 18 p.

Research output: Contribution to journalArticle

1277 Scopus citations

A scalable rhodium-catalyzed intermolecular aziridination reaction

Smith, D. T. & Njardarson, J. T., Apr 22 2014, In : Angewandte Chemie - International Edition. 53, 17, p. 4278-4280 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Beyond C, H, O, and N! analysis of the elemental composition of U.S. FDA approved drug architectures

Smith, B. R., Eastman, C. M. & Njardarson, J. T., Dec 11 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9764-9773 10 p.

Research output: Contribution to journalReview article

95 Scopus citations

Data-mining for sulfur and fluorine: An evaluation of pharmaceuticals to reveal opportunities for drug design and discovery

Ilardi, E. A., Vitaku, E. & Njardarson, J. T., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 2832-2842 11 p.

Research output: Contribution to journalArticle

453 Scopus citations

Evolution of an oxidative dearomatization enabled total synthesis of vinigrol

Yang, Q., Draghici, C., Njardarson, J. T., Li, F., Smith, B. R. & Das, P., Jan 14 2014, In : Organic and Biomolecular Chemistry. 12, 2, p. 330-344 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Formation of fused aromatic architectures via an oxidative dearomatization - Radical cyclization rearomatization approach

Vitaku, E. & Njardarson, J. T., Dec 15 2014, In : Tetrahedron Letters. 56, 23, p. 3550-3552 3 p., 45780.

Research output: Contribution to journalArticle

4 Scopus citations
6 Scopus citations
2013

An In-pharm-ative educational poster anthology highlighting the therapeutic agents that chronicle our medicinal history

Ilardi, E. A., Vitaku, E. & Njardarson, J. T., Oct 8 2013, In : Journal of Chemical Education. 90, 10, p. 1403-1405 3 p.

Research output: Contribution to journalArticle

28 Scopus citations

Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group

Yang, Q. & Njardarson, J. T., Dec 18 2013, In : Tetrahedron Letters. 54, 51, p. 7080-7082 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Catalytic ring expansion adventures

Njardarson, J. T., Mar 15 2013, In : Synlett. 24, 7, p. 787-803 17 p., ST-2013-A0056-A.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanism and the origins of stereospecificity in copper-catalyzed ring expansion of vinyl oxiranes: A traceless dual transition-metal-mediated process

Mustard, T. J. L., MacK, D. J., Njardarson, J. T. & Cheong, P. H. Y., Jan 30 2013, In : Journal of the American Chemical Society. 135, 4, p. 1471-1475 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Recent advances in the metal-catalyzed ring expansions of three- and four-membered rings

MacK, D. J. & Njardarson, J. T., Feb 1 2013, In : ACS Catalysis. 3, 2, p. 272-286 15 p.

Research output: Contribution to journalReview article

156 Scopus citations
56 Scopus citations
18 Scopus citations

Total synthesis of vinigrol

Yang, Q., Njardarson, J. T., Draghici, C. & Li, F., Aug 12 2013, In : Angewandte Chemie - International Edition. 52, 33, p. 8648-8651 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Z-Selective ring opening of vinyl oxetanes with dialkyl dithiophosphate nucleophiles

Guo, B. & Njardarson, J. T., Oct 24 2013, In : Chemical Communications. 49, 92, p. 10802-10804 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Catalytic ring expansion of vinyl oxetanes: Asymmetric synthesis of dihydropyrans using chiral counterion catalysis

Guo, B., Schwarzwalder, G. & Njardarson, J. T., Jun 4 2012, In : Angewandte Chemie - International Edition. 51, 23, p. 5675-5678 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Chemistry by design: A web-based educational flashcard for exploring synthetic organic chemistry

Draghici, C. & Njardarson, J. T., Jul 10 2012, In : Journal of Chemical Education. 89, 8, p. 1080-1082 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes

MacK, D. J., Isoe, J., Miesfeld, R. L. & Njardarson, J. T., Aug 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 16, p. 5177-5181 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Efficient synthesis of thiopyrans using a sulfur-enabled anionic cascade

Li, F., Calabrese, D., Brichacek, M., Lin, I. & Njardarson, J. T., Feb 20 2012, In : Angewandte Chemie - International Edition. 51, 8, p. 1938-1941 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles

MacK, D. J., Batory, L. A. & Njardarson, J. T., Jan 6 2012, In : Organic Letters. 14, 1, p. 378-381 4 p.

Research output: Contribution to journalArticle

29 Scopus citations
28 Scopus citations

Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C-O reduction approach

Mack, D. J., Guo, B. & Njardarson, J. T., Jul 11 2012, In : Chemical Communications. 48, 63, p. 7844-7846 3 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

McGrath, N. A., Binner, J. R., Markopoulos, G., Brichacek, M. & Njardarson, J. T., Jan 7 2011, In : Chemical Communications. 47, 1, p. 209-211 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin

Lecomte, N., Njardarson, J. T., Nagorny, P., Yang, G., Downey, R., Ouerfelli, O., Moore, M. A. S. & Danishefsky, S. J., Sep 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15074-15078 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Stereospecific ring expansion of chiral vinyl aziridines

Brichacek, M., Navarro Villalobos, M., Plichta, A. & Njardarson, J. T., Mar 4 2011, In : Organic Letters. 13, 5, p. 1110-1113 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Synthetic efforts toward [3.3.1] bridged bicyclic phloroglucinol natural products

Njardarson, J. T., Oct 7 2011, In : Tetrahedron. 67, 40, p. 7631-7666 36 p.

Research output: Contribution to journalReview article

63 Scopus citations
2010

A graphical journey of innovative organic architectures that have improved our lives

McGrath, N. A., Brichacek, M. & Njardarson, J. T., Dec 1 2010, In : Journal of Chemical Education. 87, 12, p. 1348-1349 2 p.

Research output: Contribution to journalComment/debate

338 Scopus citations

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Nagorny, P., Krauss, I., Njardarson, J. T., Perez, L., Gaul, C., Yang, G., Ouerfelli, O. & Danishefsky, S. J., Jul 28 2010, In : Tetrahedron Letters. 51, 30, p. 3873-3875 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Stereoselective ring expansion of vinyl oxiranes: Mechanistic insights and natural product total synthesis

Brichacek, M., Batory, L. A. & Njardarson, J. T., Feb 22 2010, In : Angewandte Chemie - International Edition. 49, 9, p. 1648-1651 4 p.

Research output: Contribution to journalArticle

35 Scopus citations